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Protein

tRNA-specific adenosine deaminase subunit TAD3

Gene

TAD3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deaminates adenosine-34 to inosine in many tRNAs.

Miscellaneous

Present with 892 molecules/cell in log phase SD medium.1 Publication

Caution

In contrast to other cytidine and deoxycytidylate deaminase, lacks to conserved Glu active site in position 218 which is replaced by a Val residue, suggesting that it acts as a regulatory subunit.Curated

GO - Molecular functioni

GO - Biological processi

  • tRNA modification Source: SGD

Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

BioCyciYEAST:YLR316C-MONOMER
BRENDAi3.5.4.33 984

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase subunit TAD3
Alternative name(s):
tRNA-specific adenosine-34 deaminase subunit TAD3
Gene namesi
Name:TAD3
Ordered Locus Names:YLR316C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR316C
SGDiS000004308 TAD3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717411 – 322tRNA-specific adenosine deaminase subunit TAD3Add BLAST322

Proteomic databases

MaxQBiQ9URQ3
PaxDbiQ9URQ3
PRIDEiQ9URQ3

Interactioni

Subunit structurei

Heterodimer with TAD2.

Binary interactionsi

WithEntry#Exp.IntActNotes
TAD2P470582EBI-2094330,EBI-18939

Protein-protein interaction databases

BioGridi31581, 535 interactors
DIPiDIP-5917N
IntActiQ9URQ3, 1 interactor
STRINGi4932.YLR316C

Structurei

3D structure databases

ProteinModelPortaliQ9URQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 283CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000010706
HOGENOMiHOG000111185
InParanoidiQ9URQ3
KOiK15442
OMAiNPNDQIL
OrthoDBiEOG092C4M86

Family and domain databases

InterProiView protein in InterPro
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9URQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKKVNNPLK IDYQNGIIEN RLLQIRNFKD VNTPKLINVW SIRIDPRDSK
60 70 80 90 100
KVIELIRNDF QKNDPVSLRH LKRIRKDIET STLEVVLCSK EYICDEGEIN
110 120 130 140 150
NKLKSIWVGT KKYELSDDIE VPEFAPSTKE LNNAWSVKYW PLIWNGNPND
160 170 180 190 200
QILNDYKIDM QEVRNELSRA STLSVKMATA GKQFPMVSVF VDPSRKKDKV
210 220 230 240 250
VAEDGRNCEN SLPIDHSVMV GIRAVGERLR EGVDEDANSY LCLDYDVYLT
260 270 280 290 300
HEPCSMCSMA LIHSRVRRVV FLTEMQRTGS LKLTSGDGYC MNDNKQLNST
310 320
YEAFQWIGEE YPVGQVDRDV CC
Length:322
Mass (Da):37,107
Last modified:May 1, 2000 - v1
Checksum:i08D0878F10B36403
GO

Sequence cautioni

The sequence AAB64529 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242668 Genomic DNA Translation: CAB60630.1
U20618 Genomic DNA Translation: AAB64529.1 Different initiation.
BK006945 Genomic DNA Translation: DAA09626.1
RefSeqiNP_013420.2, NM_001182205.1

Genome annotation databases

EnsemblFungiiYLR316C; YLR316C; YLR316C
GeneIDi851027
KEGGisce:YLR316C

Similar proteinsi

Entry informationi

Entry nameiTAD3_YEAST
AccessioniPrimary (citable) accession number: Q9URQ3
Secondary accession number(s): D6VYW0, O13552
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health