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Protein

Fructose-bisphosphate aldolase

Gene

FBA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PGI1)
  3. ATP-dependent 6-phosphofructokinase (PFK2), ATP-dependent 6-phosphofructokinase (PFK1)
  4. Fructose-bisphosphate aldolase (FBA1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62Glyceraldehyde 3-phosphateBy similarity1
Active sitei109Proton donorBy similarity1
Metal bindingi110Zinc 1; catalyticBy similarity1
Metal bindingi144Zinc 2By similarity1
Metal bindingi174Zinc 2By similarity1
Metal bindingi226Zinc 1; catalyticBy similarity1
Binding sitei227Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi265Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • glycolytic process Source: UniProtKB-UniPathway
  • induction by symbiont of host defense response Source: CGD
  • interaction with host Source: CGD

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183

Protein family/group databases

MoonProtiQ9URB4

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
37 kDa major allergen
Fructose-1,6-bisphosphate aldolase
IgE-binding allergen
Gene namesi
Name:FBA1
Ordered Locus Names:CAALFM_C401750CA
ORF Names:CaO19.12088, CaO19.4618
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000186998 FBA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei5990 Cand a FPA

Chemistry databases

ChEMBLiCHEMBL1287619

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001787572 – 359Fructose-bisphosphate aldolaseAdd BLAST358

Proteomic databases

PRIDEiQ9URB4

2D gel databases

COMPLUYEAST-2DPAGEiQ9URB4

Interactioni

Subunit structurei

Homodimer.By similarity

Chemistry databases

BindingDBiQ9URB4

Structurei

3D structure databases

ProteinModelPortaliQ9URB4
SMRiQ9URB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni266 – 268Dihydroxyacetone phosphate bindingBy similarity3
Regioni287 – 290Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9URB4
KOiK01624
OMAiELCKDCI
OrthoDBiEOG092C385G

Family and domain databases

CDDicd00946 FBP_aldolase_IIA, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
IPR006411 Fruct_bisP_bact
PANTHERiPTHR30559 PTHR30559, 1 hit
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
TIGRFAMsiTIGR00167 cbbA, 1 hit
TIGR01520 FruBisAldo_II_A, 1 hit
PROSITEiView protein in PROSITE
PS00602 ALDOLASE_CLASS_II_1, 1 hit
PS00806 ALDOLASE_CLASS_II_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9URB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPAVLSKS GVIYGKDVKD LFDYAQEKGF AIPAINVTSS STVVAALEAA
60 70 80 90 100
RDNKAPIILQ TSQGGAAYFA GKGVDNKDQA ASIAGSIAAA HYIRAIAPTY
110 120 130 140 150
GIPVVLHTDH CAKKLLPWFD GMLKADEEFF AKTGTPLFSS HMLDLSEETD
160 170 180 190 200
DENIATCAKY FERMAKMGQW LEMEIGITGG EEDGVNNEHV EKDALYTSPE
210 220 230 240 250
TVFAVYESLH KISPNFSIAA AFGNVHGVYK PGNVQLRPEI LGDHQVYAKK
260 270 280 290 300
QIGTDAKHPL YLVFHGGSGS TQEEFNTAIK NGVVKVNLDT DCQYAYLTGI
310 320 330 340 350
RDYVTNKIEY LKAPVGNPEG ADKPNKKYFD PRVWVREGEK TMSKRIAEAL

DIFHTKGQL
Length:359
Mass (Da):39,215
Last modified:March 3, 2009 - v2
Checksum:i030943199E4D6C28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16K → L AA sequence (PubMed:1548078).Curated1
Sequence conflicti39 – 41SSS → WSW AA sequence (PubMed:1548078).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA Translation: AOW28947.1
PIRiA43853
RefSeqiXP_722690.1, XM_717597.2

Genome annotation databases

EnsemblFungiiAOW28947; AOW28947; CAALFM_C401750CA
GeneIDi3635585
KEGGical:CAALFM_C401750CA

Similar proteinsi

Entry informationi

Entry nameiALF_CANAL
AccessioniPrimary (citable) accession number: Q9URB4
Secondary accession number(s): A0A1D8PLC4, Q5AMM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health