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Q9URB4

- ALF_CANAL

UniProt

Q9URB4 - ALF_CANAL

Protein

Fructose-bisphosphate aldolase

Gene

FBA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621Glyceraldehyde 3-phosphateBy similarity
    Active sitei109 – 1091Proton donorBy similarity
    Metal bindingi110 – 1101Zinc 1; catalyticBy similarity
    Metal bindingi144 – 1441Zinc 2By similarity
    Metal bindingi174 – 1741Zinc 2By similarity
    Metal bindingi226 – 2261Zinc 1; catalyticBy similarity
    Binding sitei227 – 2271Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi265 – 2651Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. protein binding Source: CGD
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway
    2. induction by symbiont of host defense response Source: CGD
    3. interaction with host Source: CGD

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    37 kDa major allergen
    Fructose-1,6-bisphosphate aldolase
    IgE-binding allergen
    Gene namesi
    Name:FBA1
    ORF Names:CaO19.12088, CaO19.4618
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003619. FBA1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cell surface Source: CGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. fungal-type cell wall Source: CGD
    4. hyphal cell wall Source: CGD
    5. plasma membrane Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei5990. Cand a FPA.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 359358Fructose-bisphosphate aldolasePRO_0000178757Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEQ9URB4.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5476.CAL0003619.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9URB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni266 – 2683Dihydroxyacetone phosphate bindingBy similarity
    Regioni287 – 2904Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    KOiK01624.
    OrthoDBiEOG7HTHSN.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9URB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPAVLSKS GVIYGKDVKD LFDYAQEKGF AIPAINVTSS STVVAALEAA    50
    RDNKAPIILQ TSQGGAAYFA GKGVDNKDQA ASIAGSIAAA HYIRAIAPTY 100
    GIPVVLHTDH CAKKLLPWFD GMLKADEEFF AKTGTPLFSS HMLDLSEETD 150
    DENIATCAKY FERMAKMGQW LEMEIGITGG EEDGVNNEHV EKDALYTSPE 200
    TVFAVYESLH KISPNFSIAA AFGNVHGVYK PGNVQLRPEI LGDHQVYAKK 250
    QIGTDAKHPL YLVFHGGSGS TQEEFNTAIK NGVVKVNLDT DCQYAYLTGI 300
    RDYVTNKIEY LKAPVGNPEG ADKPNKKYFD PRVWVREGEK TMSKRIAEAL 350
    DIFHTKGQL 359
    Length:359
    Mass (Da):39,215
    Last modified:March 3, 2009 - v2
    Checksum:i030943199E4D6C28
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161K → L AA sequence (PubMed:1548078)Curated
    Sequence conflicti39 – 413SSS → WSW AA sequence (PubMed:1548078)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000005 Genomic DNA. Translation: EAL04108.1.
    AACQ01000006 Genomic DNA. Translation: EAL03953.1.
    PIRiA43853.
    RefSeqiXP_722690.1. XM_717597.1.
    XP_722836.1. XM_717743.1.

    Genome annotation databases

    GeneIDi3635548.
    3635585.
    KEGGical:CaO19.12088.
    cal:CaO19.4618.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AACQ01000005 Genomic DNA. Translation: EAL04108.1 .
    AACQ01000006 Genomic DNA. Translation: EAL03953.1 .
    PIRi A43853.
    RefSeqi XP_722690.1. XM_717597.1.
    XP_722836.1. XM_717743.1.

    3D structure databases

    ProteinModelPortali Q9URB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003619.

    Chemistry

    BindingDBi Q9URB4.
    ChEMBLi CHEMBL1287619.

    Protein family/group databases

    Allergomei 5990. Cand a FPA.

    2D gel databases

    COMPLUYEAST-2DPAGE Q9URB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3635548.
    3635585.
    KEGGi cal:CaO19.12088.
    cal:CaO19.4618.

    Organism-specific databases

    CGDi CAL0003619. FBA1.

    Phylogenomic databases

    eggNOGi COG0191.
    KOi K01624.
    OrthoDBi EOG7HTHSN.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. "Identification of Candida albicans antigens reactive with immunoglobulin E antibody of human sera."
      Ishiguro A., Homma M., Torii S., Tanaka K.
      Infect. Immun. 60:1550-1557(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-41, SUBCELLULAR LOCATION, ALLERGEN.
      Strain: C9.
    3. "Analysis of the serologic response to systemic Candida albicans infection in a murine model."
      Pitarch A., Diez-Orejas R., Molero G., Pardo M., Sanchez M., Gil C., Nombela C.
      Proteomics 1:550-559(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiALF_CANAL
    AccessioniPrimary (citable) accession number: Q9URB4
    Secondary accession number(s): Q5AMM8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3