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Q9URB4

- ALF_CANAL

UniProt

Q9URB4 - ALF_CANAL

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Protein

Fructose-bisphosphate aldolase

Gene

FBA1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Glyceraldehyde 3-phosphateBy similarity
Active sitei109 – 1091Proton donorBy similarity
Metal bindingi110 – 1101Zinc 1; catalyticBy similarity
Metal bindingi144 – 1441Zinc 2By similarity
Metal bindingi174 – 1741Zinc 2By similarity
Metal bindingi226 – 2261Zinc 1; catalyticBy similarity
Binding sitei227 – 2271Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi265 – 2651Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. induction by symbiont of host defense response Source: CGD
  3. interaction with host Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
37 kDa major allergen
Fructose-1,6-bisphosphate aldolase
IgE-binding allergen
Gene namesi
Name:FBA1
ORF Names:CaO19.12088, CaO19.4618
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003619. FBA1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cell surface Source: CGD
  2. cytoplasm Source: UniProtKB-KW
  3. fungal-type cell wall Source: CGD
  4. hyphal cell wall Source: CGD
  5. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei5990. Cand a FPA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 359358Fructose-bisphosphate aldolasePRO_0000178757Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEQ9URB4.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi5476.CAL0003619.

Structurei

3D structure databases

ProteinModelPortaliQ9URB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni266 – 2683Dihydroxyacetone phosphate bindingBy similarity
Regioni287 – 2904Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
InParanoidiQ9URB4.
KOiK01624.
OrthoDBiEOG7HTHSN.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9URB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPAVLSKS GVIYGKDVKD LFDYAQEKGF AIPAINVTSS STVVAALEAA
60 70 80 90 100
RDNKAPIILQ TSQGGAAYFA GKGVDNKDQA ASIAGSIAAA HYIRAIAPTY
110 120 130 140 150
GIPVVLHTDH CAKKLLPWFD GMLKADEEFF AKTGTPLFSS HMLDLSEETD
160 170 180 190 200
DENIATCAKY FERMAKMGQW LEMEIGITGG EEDGVNNEHV EKDALYTSPE
210 220 230 240 250
TVFAVYESLH KISPNFSIAA AFGNVHGVYK PGNVQLRPEI LGDHQVYAKK
260 270 280 290 300
QIGTDAKHPL YLVFHGGSGS TQEEFNTAIK NGVVKVNLDT DCQYAYLTGI
310 320 330 340 350
RDYVTNKIEY LKAPVGNPEG ADKPNKKYFD PRVWVREGEK TMSKRIAEAL

DIFHTKGQL
Length:359
Mass (Da):39,215
Last modified:March 3, 2009 - v2
Checksum:i030943199E4D6C28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161K → L AA sequence (PubMed:1548078)Curated
Sequence conflicti39 – 413SSS → WSW AA sequence (PubMed:1548078)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000005 Genomic DNA. Translation: EAL04108.1.
AACQ01000006 Genomic DNA. Translation: EAL03953.1.
PIRiA43853.
RefSeqiXP_722690.1. XM_717597.1.
XP_722836.1. XM_717743.1.

Genome annotation databases

GeneIDi3635548.
3635585.
KEGGical:CaO19.12088.
cal:CaO19.4618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000005 Genomic DNA. Translation: EAL04108.1 .
AACQ01000006 Genomic DNA. Translation: EAL03953.1 .
PIRi A43853.
RefSeqi XP_722690.1. XM_717597.1.
XP_722836.1. XM_717743.1.

3D structure databases

ProteinModelPortali Q9URB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003619.

Chemistry

BindingDBi Q9URB4.
ChEMBLi CHEMBL1287619.

Protein family/group databases

Allergomei 5990. Cand a FPA.

2D gel databases

COMPLUYEAST-2DPAGE Q9URB4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3635548.
3635585.
KEGGi cal:CaO19.12088.
cal:CaO19.4618.

Organism-specific databases

CGDi CAL0003619. FBA1.

Phylogenomic databases

eggNOGi COG0191.
InParanoidi Q9URB4.
KOi K01624.
OrthoDBi EOG7HTHSN.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "Identification of Candida albicans antigens reactive with immunoglobulin E antibody of human sera."
    Ishiguro A., Homma M., Torii S., Tanaka K.
    Infect. Immun. 60:1550-1557(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-41, SUBCELLULAR LOCATION, ALLERGEN.
    Strain: C9.
  3. "Analysis of the serologic response to systemic Candida albicans infection in a murine model."
    Pitarch A., Diez-Orejas R., Molero G., Pardo M., Sanchez M., Gil C., Nombela C.
    Proteomics 1:550-559(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiALF_CANAL
AccessioniPrimary (citable) accession number: Q9URB4
Secondary accession number(s): Q5AMM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3