Reviewed, UniProtKB/Swiss-Prot Q9URB1 (PEM5_PHACH)

Names and origin

Protein names	Recommended name:     Peroxidase manganese-dependent H5     EC=1.11.1.13
Organism	Phanerochaete chrysosporium (White-rot fungus) (Sporotrichum pruinosum)
Taxonomic identifier	5306 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Corticiales › Corticiaceae › Phanerochaete

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the oxidation of Mn2+ to Mn3+. The latter, acting as a diffusible redox mediator, is capable of oxidizing a variety of lignin compounds.
Catalytic activity	2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O.
Subcellular location	Secreted.
Sequence similarities	Belongs to the peroxidase family. Ligninase subfamily.

Ontologies

Keywords
Biological process	Hydrogen peroxide Lignin degradation
Cellular component	Secreted
Ligand	Iron Manganese Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW lignin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›20	›20	Peroxidase manganese-dependent H5		PRO_0000055614
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	Q9URB1-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A11F41833CF2A933	FASTA	20	2,048
	10 20 AVXHPGTXVS XAAXXXFIPL

References

[1]	"Heterogeneity and regulation of manganese peroxidases from Phanerochaete chrysosporium." Pease E.A., Tien M. J. Bacteriol. 174:3532-3540(1992) [PubMed: 1592808] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	C44907.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.11.1.13. 16698.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PEM5_PHACH

Accession

Primary (citable) accession number: Q9URB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)