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Q9UQX0

- SODM_SCHPO

UniProt

Q9UQX0 - SODM_SCHPO

Protein

Superoxide dismutase [Mn], mitochondrial

Gene

sod2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

    Catalytic activityi

    2 superoxide + 2 H+ = O2 + H2O2.

    Cofactori

    Binds 1 manganese ion per subunit.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501ManganeseBy similarity
    Metal bindingi96 – 961ManganeseBy similarity
    Metal bindingi181 – 1811ManganeseBy similarity
    Metal bindingi185 – 1851ManganeseBy similarity

    GO - Molecular functioni

    1. manganese ion binding Source: PomBase
    2. superoxide dismutase activity Source: PomBase

    GO - Biological processi

    1. age-dependent response to reactive oxygen species involved in chronological cell aging Source: PomBase
    2. removal of superoxide radicals Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_219607. Detoxification of Reactive Oxygen Species.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
    Gene namesi
    Name:sod2
    ORF Names:SPAC1486.01
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1486.01.

    Subcellular locationi

    Mitochondrion matrix 1 Publication

    GO - Cellular componenti

    1. mitochondrial matrix Source: PomBase
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121Mitochondrion1 PublicationAdd
    BLAST
    Chaini22 – 218197Superoxide dismutase [Mn], mitochondrialPRO_0000032887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UQX0.
    PaxDbiQ9UQX0.

    Expressioni

    Inductioni

    By high osmolarity and heat.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi279331. 32 interactions.
    MINTiMINT-4706830.
    STRINGi4896.SPAC1486.01-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQX0.
    SMRiQ9UQX0. Positions 25-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0605.
    HOGENOMiHOG000013583.
    KOiK04564.
    OMAiTERYTAC.
    PhylomeDBiQ9UQX0.

    Family and domain databases

    InterProiIPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view]
    PANTHERiPTHR11404. PTHR11404. 1 hit.
    PfamiPF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000349. SODismutase. 1 hit.
    PRINTSiPR01703. MNSODISMTASE.
    SUPFAMiSSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEiPS00088. SOD_MN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UQX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRFLSKNSV AAIRNVSIAR GVHTKATLPP LPYAYNALEP ALSETIMKLH    50
    HDKHHQTYVN NLNAAQEKLA DPNLDLEGEV ALQAAIKFNG GGHINHSLFW 100
    KILAPQKEGG GKPVTSGSLH KAITSKWGSL EDFQKEMNAA LASIQGSGWA 150
    WLIVDKDGSL RITTTANQDT IVKSKPIIGI DAWEHAYYPQ YENRKAEYFK 200
    AIWNVINWKE AESRYSNR 218
    Length:218
    Mass (Da):24,347
    Last modified:May 1, 2000 - v1
    Checksum:iF701C8375830DDE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069292 Genomic DNA. Translation: AAF19051.1.
    CU329670 Genomic DNA. Translation: CAB62411.1.
    PIRiT50070.
    RefSeqiNP_594089.1. NM_001019513.2.

    Genome annotation databases

    EnsemblFungiiSPAC1486.01.1; SPAC1486.01.1:pep; SPAC1486.01.
    GeneIDi2542886.
    KEGGispo:SPAC1486.01.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF069292 Genomic DNA. Translation: AAF19051.1 .
    CU329670 Genomic DNA. Translation: CAB62411.1 .
    PIRi T50070.
    RefSeqi NP_594089.1. NM_001019513.2.

    3D structure databases

    ProteinModelPortali Q9UQX0.
    SMRi Q9UQX0. Positions 25-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279331. 32 interactions.
    MINTi MINT-4706830.
    STRINGi 4896.SPAC1486.01-1.

    Proteomic databases

    MaxQBi Q9UQX0.
    PaxDbi Q9UQX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1486.01.1 ; SPAC1486.01.1:pep ; SPAC1486.01 .
    GeneIDi 2542886.
    KEGGi spo:SPAC1486.01.

    Organism-specific databases

    PomBasei SPAC1486.01.

    Phylogenomic databases

    eggNOGi COG0605.
    HOGENOMi HOG000013583.
    KOi K04564.
    OMAi TERYTAC.
    PhylomeDBi Q9UQX0.

    Enzyme and pathway databases

    Reactomei REACT_219607. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    NextBioi 20803926.
    PROi Q9UQX0.

    Family and domain databases

    InterProi IPR001189. Mn/Fe_SOD.
    IPR019833. Mn/Fe_SOD_BS.
    IPR019832. Mn/Fe_SOD_C.
    IPR019831. Mn/Fe_SOD_N.
    [Graphical view ]
    PANTHERi PTHR11404. PTHR11404. 1 hit.
    Pfami PF02777. Sod_Fe_C. 1 hit.
    PF00081. Sod_Fe_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000349. SODismutase. 1 hit.
    PRINTSi PR01703. MNSODISMTASE.
    SUPFAMi SSF46609. SSF46609. 1 hit.
    SSF54719. SSF54719. 1 hit.
    PROSITEi PS00088. SOD_MN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the sod2+ gene encoding a putative mitochondrial manganese superoxide dismutase in Schizosaccharomyces pombe."
      Jeong J.-H., Kwon E.-S., Roe J.-H.
      J. Microbiol. 39:37-41(2001)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe."
      Jeong J.-H., Kwon E.-S., Roe J.-H.
      Biochem. Biophys. Res. Commun. 283:908-914(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 22-34, COFACTOR, SUBUNIT, SUBCELLULAR LOCATION, INDUCTION.
      Strain: JH201.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiSODM_SCHPO
    AccessioniPrimary (citable) accession number: Q9UQX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3