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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

sod2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+1 PublicationNote: Binds 1 Mn2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50ManganeseBy similarity1
Metal bindingi96ManganeseBy similarity1
Metal bindingi181ManganeseBy similarity1
Metal bindingi185ManganeseBy similarity1

GO - Molecular functioni

  • manganese ion binding Source: PomBase
  • superoxide dismutase activity Source: PomBase

GO - Biological processi

  • age-dependent response to oxidative stress involved in chronological cell aging Source: PomBase
  • cellular response to reactive oxygen species Source: PomBase
  • removal of superoxide radicals Source: PomBase
  • superoxide metabolic process Source: PomBase

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-2151201 Transcriptional activation of mitochondrial biogenesis
R-SPO-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:sod2
ORF Names:SPAC1486.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1486.01
PomBaseiSPAC1486.01 sod2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21Mitochondrion1 PublicationAdd BLAST21
ChainiPRO_000003288722 – 218Superoxide dismutase [Mn], mitochondrialAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei129Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UQX0
PaxDbiQ9UQX0
PRIDEiQ9UQX0

PTM databases

iPTMnetiQ9UQX0

Expressioni

Inductioni

By high osmolarity and heat.1 Publication

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi279331, 32 interactors
STRINGi4896.SPAC1486.01.1

Structurei

3D structure databases

ProteinModelPortaliQ9UQX0
SMRiQ9UQX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000013583
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG092C4NQ6
PhylomeDBiQ9UQX0

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFLSKNSV AAIRNVSIAR GVHTKATLPP LPYAYNALEP ALSETIMKLH
60 70 80 90 100
HDKHHQTYVN NLNAAQEKLA DPNLDLEGEV ALQAAIKFNG GGHINHSLFW
110 120 130 140 150
KILAPQKEGG GKPVTSGSLH KAITSKWGSL EDFQKEMNAA LASIQGSGWA
160 170 180 190 200
WLIVDKDGSL RITTTANQDT IVKSKPIIGI DAWEHAYYPQ YENRKAEYFK
210
AIWNVINWKE AESRYSNR
Length:218
Mass (Da):24,347
Last modified:May 1, 2000 - v1
Checksum:iF701C8375830DDE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069292 Genomic DNA Translation: AAF19051.1
CU329670 Genomic DNA Translation: CAB62411.1
PIRiT50070
RefSeqiNP_594089.1, NM_001019513.2

Genome annotation databases

EnsemblFungiiSPAC1486.01.1; SPAC1486.01.1:pep; SPAC1486.01
GeneIDi2542886
KEGGispo:SPAC1486.01

Similar proteinsi

Entry informationi

Entry nameiSODM_SCHPO
AccessioniPrimary (citable) accession number: Q9UQX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health