Q9UQW9 (DCOR_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine decarboxylase
Short name=ODC
EC=4.1.1.17

Gene names

Name:	spe1
ORF Names:	SPAC144.04c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ornithine catabolic process, by decarboxylation Inferred by curator. Source: GeneDB_Spombe pantothenate biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe putrescine biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	ornithine decarboxylase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Ornithine decarboxylase		PRO_0000149908
Sites
	Active site	377	1	Proton donor; shared with dimeric partner By similarity
Amino acid modifications
	Modified residue	98	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UQW9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F91BD81073970AC9	FASTA	432	47,843
	10 20 30 40 50 60 MPAIMEKNML VSESLRTTEL LGHVKPIDSV VTWSSPGSSR QAIGEAFKNT IEEIERAAVR 70 80 90 100 110 120 GEPADSDAFF VADLNGVYRQ LLRWHAKLPR VQPFYAVKCN PDPKVLALLN KFGTGFDCAS 130 140 150 160 170 180 KGELEQILGL GVSPDRIVYA NPCKAITYVR YAASKGINLM TFDNADELYK VKQHHPNSRL 190 200 210 220 230 240 LLRISTDDSN SLCRLSLKFG ASLDDTGKLL DIAKSLELNV VGVSFHVGSG SYDPSAFLDA 250 260 270 280 290 300 IQRSRQVFDQ GLERGFNFDL LDIGGGFMND SFDGVADLIR SALDTYFDPS IRVISEPGRF 310 320 330 340 350 360 FVSSSFTLAV NVIAKRKLDD EEKVMYYVND GVYGSLNCIL FDHQHPVARV LKCGSRFVYN 370 380 390 400 410 420 DLVGTGQHRC FIWGPTCDSL DVIANDAHLP YELNVGDWIY FEDAGAYTVA AASCFNGFKT 430 SRIVYLDTDI LD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterisation of a cDNA for ornithine decarboxylase from Schizosaccharomyces pombe." Franceschetti M., Illingworth C., Mayer M.J., Michael A.J. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ243276 mRNA. Translation: CAB45689.1. CU329670 Genomic DNA. Translation: CAB59684.1.
PIR	T37671.
RefSeq	NP_594665.1. NM_001020094.1.
3D structure databases
ProteinModelPortal	Q9UQW9.
SMR	Q9UQW9. Positions 66-428.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UQW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPAC144.04c.1; SPAC144.04c.1:pep; SPAC144.04c.
GeneID	2542855.
GenomeReviews	Gene locus spe1 in contig CU329670_GR.
KEGG	spo:SPAC144.04c.
NMPDR	fig|4896.1.peg.4635.
Organism-specific databases
GeneDB_Spombe	SPAC144.04c.
Phylogenomic databases
GeneTree	EFGT00050000003448.
HOGENOM	HBG672375.
OMA	MNCILFD.
OrthoDB	EOG47SWPC.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-002751-MONOMER.
Gene expression databases
ArrayExpress	Q9UQW9.
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR022643. De-COase2_C. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. IPR002433. Orn_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01581.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PRINTS	PR01179. ODADCRBXLASE. PR01182. ORNDCRBXLASE.
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_SCHPO

Accession

Primary (citable) accession number: Q9UQW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program