Q9UQV4 (LAMP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name=LAMP-3
Short name=Lysosomal-associated membrane protein 3

Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name=DC LAMP
Protein TSC403
CD_antigen=CD208

Gene names

Name:	LAMP3
Synonyms:	DCLAMP, TSC403

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Might change the lysosome function after the transfer of peptide-MHC class II molecules to the surface of dendritic cells. Ref.2
Subcellular location	Lysosome membrane; Single-pass type I membrane protein Ref.2.
Tissue specificity	Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. Ref.1 Ref.2
Sequence similarities	Belongs to the LAMP family.

Ontologies

Keywords
Cellular component	Lysosome Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW lysosomal membrane Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 416	389	Lysosome-associated membrane glycoprotein 3		PRO_0000223695
Regions
	Topological domain	28 – 381	354	Lumenal Potential
	Transmembrane	382 – 402	21	Helical; Potential
	Topological domain	403 – 416	14	Cytoplasmic Potential
	Compositional bias	74 – 215	142	Thr-rich
Amino acid modifications
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
	Glycosylation	164	1	N-linked (GlcNAc...) Potential
	Glycosylation	200	1	N-linked (GlcNAc...) Potential
	Glycosylation	232	1	N-linked (GlcNAc...) Potential
	Glycosylation	266	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	32	1	E → G. Ref.4 Corresponds to variant rs17853113 [ dbSNP | Ensembl ].		VAR_030827
	Natural variant	318	1	I → V. Ref.1 Ref.3 Corresponds to variant rs482912 [ dbSNP | Ensembl ].		VAR_025343
Experimental info
	Sequence conflict	145	1	T → A in BAA34533. Ref.1
	Sequence conflict	186	1	V → D in BAA34533. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UQV4 [UniParc]. Last modified February 20, 2007. Version 3. Checksum: D615895D382B8F88	FASTA	416	44,346
	10 20 30 40 50 60 MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP 70 80 90 100 110 120 HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV 130 140 150 160 170 180 TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST 190 200 210 220 230 240 TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA 250 260 270 280 290 300 EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 310 320 330 340 350 360 YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL 370 380 390 400 410 QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues." Ozaki K., Nagata M., Suzuki M., Fujiwara T., Ueda K., Miyoshi Y., Takahashi E., Nakamura Y. Cancer Res. 58:3499-3503(1998) [PubMed: 9721848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-318. Tissue: Lung.
[2]	"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment." de Saint-Vis B.M., Vincent J., Vandenabeele S., Vanbervliet B., Pin J.J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J., Zurawski S., Davoust J., Caux C., Lebecque S. Immunity 9:325-336(1998) [PubMed: 9768752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-318.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-32. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB013924 mRNA. Translation: BAA34533.1. AJ005766 mRNA. Translation: CAA06691.1. CH471052 Genomic DNA. Translation: EAW78337.1. CH471052 Genomic DNA. Translation: EAW78338.1. BC032940 mRNA. Translation: AAH32940.1.
IPI	IPI00004307.
RefSeq	NP_055213.2. NM_014398.3.
UniGene	Hs.518448.
3D structure databases
ProteinModelPortal	Q9UQV4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UQV4. 1 interaction.
STRING	Q9UQV4.
Polymorphism databases
DMDM	126302564.
Proteomic databases
PeptideAtlas	Q9UQV4.
PRIDE	Q9UQV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265598; ENSP00000265598; ENSG00000078081.
GeneID	27074.
KEGG	hsa:27074.
UCSC	uc003flh.2. human.
Organism-specific databases
CTD	27074.
GeneCards	GC03M182840.
H-InvDB	HIX0003896.
HGNC	HGNC:14582. LAMP3.
HPA	CAB025133.
MIM	605883. gene.
neXtProt	NX_Q9UQV4.
PharmGKB	PA30286.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18254.
GeneTree	ENSGT00530000063068.
HOGENOM	HBG125483.
HOVERGEN	HBG081889.
InParanoid	Q9UQV4.
OMA	YYISEVG.
OrthoDB	EOG4NP73T.
PhylomeDB	Q9UQV4.
Gene expression databases
ArrayExpress	Q9UQV4.
Bgee	Q9UQV4.
CleanEx	HS_LAMP3.
Genevestigator	Q9UQV4.
GermOnline	ENSG00000078081. Homo sapiens.
Family and domain databases
InterPro	IPR002000. Lysosome-assoc_membr_glycop. [Graphical view]
KO	K06562.
PANTHER	PTHR11506. Lamp. 1 hit.
Pfam	PF01299. Lamp. 1 hit. [Graphical view]
PRINTS	PR00336. LYSASSOCTDMP.
PROSITE	PS51407. LAMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	49669.
SOURCE	Search...

Entry information

Entry name

LAMP3_HUMAN

Accession

Primary (citable) accession number: Q9UQV4
Secondary accession number(s): D3DNS4, O94781, Q8NEC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2006
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.