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Protein

Lysosome-associated membrane glycoprotein 3

Gene

LAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.1 Publication

GO - Biological processi

  • cell proliferation Source: ProtInc
  • immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name:
DC LAMP
Protein TSC403
CD_antigen: CD208
Gene namesi
Name:LAMP3
Synonyms:DCLAMP, TSC403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14582. LAMP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 381354LumenalSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini403 – 41614CytoplasmicPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • alveolar lamellar body membrane Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30286.

Polymorphism and mutation databases

BioMutaiLAMP3.
DMDMi126302564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 416389Lysosome-associated membrane glycoprotein 3PRO_0000223695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi237 ↔ 274PROSITE-ProRule annotation1 Publication
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi291 – 2911N-linked (GlcNAc...)1 Publication
Disulfide bondi339 ↔ 376PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UQV4.
PeptideAtlasiQ9UQV4.
PRIDEiQ9UQV4.

PTM databases

PhosphoSiteiQ9UQV4.

Expressioni

Tissue specificityi

Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.3 Publications

Developmental stagei

Up-regulated during dendritic cell maturation.

Gene expression databases

BgeeiQ9UQV4.
CleanExiHS_LAMP3.
ExpressionAtlasiQ9UQV4. baseline and differential.
GenevestigatoriQ9UQV4.

Organism-specific databases

HPAiCAB025133.
HPA051467.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi117983. 1 interaction.
IntActiQ9UQV4. 6 interactions.
MINTiMINT-7996363.
STRINGi9606.ENSP00000265598.

Structurei

Secondary structure

1
416
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi226 – 2327Combined sources
Beta strandi235 – 24814Combined sources
Beta strandi251 – 2533Combined sources
Beta strandi259 – 2624Combined sources
Helixi265 – 2673Combined sources
Beta strandi269 – 2735Combined sources
Beta strandi276 – 28510Combined sources
Beta strandi288 – 2969Combined sources
Beta strandi301 – 31111Combined sources
Beta strandi313 – 3153Combined sources
Beta strandi318 – 3236Combined sources
Beta strandi328 – 3314Combined sources
Beta strandi337 – 3393Combined sources
Beta strandi343 – 3464Combined sources
Beta strandi348 – 36316Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AKMX-ray2.69A/B222-381[»]
ProteinModelPortaliQ9UQV4.
SMRiQ9UQV4. Positions 222-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 215142Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288611.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ9UQV4.
KOiK06562.
OMAiYYISEVG.
PhylomeDBiQ9UQV4.
TreeFamiTF316339.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK
60 70 80 90 100
PVQQPAKQAP HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI
110 120 130 140 150
TYTLVTTQAT PNNSHTAPPV TEVTVGPSLA PYSLPPTITP PAHTTGTSSS
160 170 180 190 200
TVSHTTGNTT QPSNQTTLPA TLSIALHKST TGQKPVQPTH APGTTAAAHN
210 220 230 240 250
TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA EMGIQLIVQD
260 270 280 290 300
KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES
310 320 330 340 350
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH
360 370 380 390 400
LQVKTTDVQL QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG
410
VYKIRLRCQS SGYQRI
Length:416
Mass (Da):44,346
Last modified:February 20, 2007 - v3
Checksum:iD615895D382B8F88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451T → A in BAA34533 (PubMed:9721848).Curated
Sequence conflicti186 – 1861V → D in BAA34533 (PubMed:9721848).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321E → G.1 Publication
Corresponds to variant rs17853113 [ dbSNP | Ensembl ].
VAR_030827
Natural varianti318 – 3181I → V.2 Publications
Corresponds to variant rs482912 [ dbSNP | Ensembl ].
VAR_025343

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013924 mRNA. Translation: BAA34533.1.
AJ005766 mRNA. Translation: CAA06691.1.
CH471052 Genomic DNA. Translation: EAW78337.1.
CH471052 Genomic DNA. Translation: EAW78338.1.
BC032940 mRNA. Translation: AAH32940.1.
CCDSiCCDS3242.1.
RefSeqiNP_055213.2. NM_014398.3.
UniGeneiHs.518448.

Genome annotation databases

EnsembliENST00000265598; ENSP00000265598; ENSG00000078081.
GeneIDi27074.
KEGGihsa:27074.
UCSCiuc003flh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013924 mRNA. Translation: BAA34533.1.
AJ005766 mRNA. Translation: CAA06691.1.
CH471052 Genomic DNA. Translation: EAW78337.1.
CH471052 Genomic DNA. Translation: EAW78338.1.
BC032940 mRNA. Translation: AAH32940.1.
CCDSiCCDS3242.1.
RefSeqiNP_055213.2. NM_014398.3.
UniGeneiHs.518448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AKMX-ray2.69A/B222-381[»]
ProteinModelPortaliQ9UQV4.
SMRiQ9UQV4. Positions 222-378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117983. 1 interaction.
IntActiQ9UQV4. 6 interactions.
MINTiMINT-7996363.
STRINGi9606.ENSP00000265598.

PTM databases

PhosphoSiteiQ9UQV4.

Polymorphism and mutation databases

BioMutaiLAMP3.
DMDMi126302564.

Proteomic databases

PaxDbiQ9UQV4.
PeptideAtlasiQ9UQV4.
PRIDEiQ9UQV4.

Protocols and materials databases

DNASUi27074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265598; ENSP00000265598; ENSG00000078081.
GeneIDi27074.
KEGGihsa:27074.
UCSCiuc003flh.4. human.

Organism-specific databases

CTDi27074.
GeneCardsiGC03M182840.
HGNCiHGNC:14582. LAMP3.
HPAiCAB025133.
HPA051467.
MIMi605883. gene.
neXtProtiNX_Q9UQV4.
PharmGKBiPA30286.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG288611.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ9UQV4.
KOiK06562.
OMAiYYISEVG.
PhylomeDBiQ9UQV4.
TreeFamiTF316339.

Miscellaneous databases

GeneWikiiLAMP3.
GenomeRNAii27074.
NextBioi49669.
PROiQ9UQV4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UQV4.
CleanExiHS_LAMP3.
ExpressionAtlasiQ9UQV4. baseline and differential.
GenevestigatoriQ9UQV4.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues."
    Ozaki K., Nagata M., Suzuki M., Fujiwara T., Ueda K., Miyoshi Y., Takahashi E., Nakamura Y.
    Cancer Res. 58:3499-3503(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-318.
    Tissue: Lung.
  2. "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment."
    de Saint-Vis B.M., Vincent J., Vandenabeele S., Vanbervliet B., Pin J.J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J., Zurawski S., Davoust J., Caux C., Lebecque S.
    Immunity 9:325-336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-318.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-32.
    Tissue: Testis.
  5. "Reciprocal polarization of T and B cells at the immunological synapse."
    Duchez S., Rodrigues M., Bertrand F., Valitutti S.
    J. Immunol. 187:4571-4580(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx."
    Wilke S., Krausze J., Bussow K.
    BMC Biol. 10:62-62(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 222-381, SUBUNIT, GLYCOSYLATION AT ASN-291, DISULFIDE BONDS.

Entry informationi

Entry nameiLAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9UQV4
Secondary accession number(s): D3DNS4, O94781, Q8NEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 20, 2007
Last modified: April 29, 2015
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.