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Q9UQV4

- LAMP3_HUMAN

UniProt

Q9UQV4 - LAMP3_HUMAN

Protein

Lysosome-associated membrane glycoprotein 3

Gene

LAMP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    May play a role in dendritic cell function and in adaptive immunity.1 Publication

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. immune system process Source: UniProtKB-KW

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 3
    Short name:
    LAMP-3
    Short name:
    Lysosomal-associated membrane protein 3
    Alternative name(s):
    DC-lysosome-associated membrane glycoprotein
    Short name:
    DC LAMP
    Protein TSC403
    CD_antigen: CD208
    Gene namesi
    Name:LAMP3
    Synonyms:DCLAMP, TSC403
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14582. LAMP3.

    Subcellular locationi

    Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein
    Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.

    GO - Cellular componenti

    1. alveolar lamellar body membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: ProtInc

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30286.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 416389Lysosome-associated membrane glycoprotein 3PRO_0000223695Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi237 ↔ 2741 PublicationPROSITE-ProRule annotation
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi291 – 2911N-linked (GlcNAc...)1 Publication
    Disulfide bondi339 ↔ 3761 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UQV4.
    PeptideAtlasiQ9UQV4.
    PRIDEiQ9UQV4.

    PTM databases

    PhosphoSiteiQ9UQV4.

    Expressioni

    Tissue specificityi

    Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.3 Publications

    Developmental stagei

    Up-regulated during dendritic cell maturation.

    Gene expression databases

    ArrayExpressiQ9UQV4.
    BgeeiQ9UQV4.
    CleanExiHS_LAMP3.
    GenevestigatoriQ9UQV4.

    Organism-specific databases

    HPAiCAB025133.
    HPA051467.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi117983. 1 interaction.
    IntActiQ9UQV4. 6 interactions.
    MINTiMINT-7996363.
    STRINGi9606.ENSP00000265598.

    Structurei

    Secondary structure

    1
    416
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi226 – 2327
    Beta strandi235 – 24814
    Beta strandi251 – 2533
    Beta strandi259 – 2624
    Helixi265 – 2673
    Beta strandi269 – 2735
    Beta strandi276 – 28510
    Beta strandi288 – 2969
    Beta strandi301 – 31111
    Beta strandi313 – 3153
    Beta strandi318 – 3236
    Beta strandi328 – 3314
    Beta strandi337 – 3393
    Beta strandi343 – 3464
    Beta strandi348 – 36316

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AKMX-ray2.69A/B222-381[»]
    ProteinModelPortaliQ9UQV4.
    SMRiQ9UQV4. Positions 222-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 381354LumenalSequence AnalysisAdd
    BLAST
    Topological domaini403 – 41614CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei382 – 40221HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi74 – 215142Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288611.
    HOGENOMiHOG000004835.
    HOVERGENiHBG081889.
    InParanoidiQ9UQV4.
    KOiK06562.
    OMAiYYISEVG.
    PhylomeDBiQ9UQV4.
    TreeFamiTF316339.

    Family and domain databases

    InterProiIPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UQV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK    50
    PVQQPAKQAP HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI 100
    TYTLVTTQAT PNNSHTAPPV TEVTVGPSLA PYSLPPTITP PAHTTGTSSS 150
    TVSHTTGNTT QPSNQTTLPA TLSIALHKST TGQKPVQPTH APGTTAAAHN 200
    TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA EMGIQLIVQD 250
    KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 300
    YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH 350
    LQVKTTDVQL QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG 400
    VYKIRLRCQS SGYQRI 416
    Length:416
    Mass (Da):44,346
    Last modified:February 20, 2007 - v3
    Checksum:iD615895D382B8F88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451T → A in BAA34533. (PubMed:9721848)Curated
    Sequence conflicti186 – 1861V → D in BAA34533. (PubMed:9721848)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti32 – 321E → G.1 Publication
    Corresponds to variant rs17853113 [ dbSNP | Ensembl ].
    VAR_030827
    Natural varianti318 – 3181I → V.2 Publications
    Corresponds to variant rs482912 [ dbSNP | Ensembl ].
    VAR_025343

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013924 mRNA. Translation: BAA34533.1.
    AJ005766 mRNA. Translation: CAA06691.1.
    CH471052 Genomic DNA. Translation: EAW78337.1.
    CH471052 Genomic DNA. Translation: EAW78338.1.
    BC032940 mRNA. Translation: AAH32940.1.
    CCDSiCCDS3242.1.
    RefSeqiNP_055213.2. NM_014398.3.
    UniGeneiHs.518448.

    Genome annotation databases

    EnsembliENST00000265598; ENSP00000265598; ENSG00000078081.
    GeneIDi27074.
    KEGGihsa:27074.
    UCSCiuc003flh.4. human.

    Polymorphism databases

    DMDMi126302564.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB013924 mRNA. Translation: BAA34533.1 .
    AJ005766 mRNA. Translation: CAA06691.1 .
    CH471052 Genomic DNA. Translation: EAW78337.1 .
    CH471052 Genomic DNA. Translation: EAW78338.1 .
    BC032940 mRNA. Translation: AAH32940.1 .
    CCDSi CCDS3242.1.
    RefSeqi NP_055213.2. NM_014398.3.
    UniGenei Hs.518448.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AKM X-ray 2.69 A/B 222-381 [» ]
    ProteinModelPortali Q9UQV4.
    SMRi Q9UQV4. Positions 222-378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117983. 1 interaction.
    IntActi Q9UQV4. 6 interactions.
    MINTi MINT-7996363.
    STRINGi 9606.ENSP00000265598.

    PTM databases

    PhosphoSitei Q9UQV4.

    Polymorphism databases

    DMDMi 126302564.

    Proteomic databases

    PaxDbi Q9UQV4.
    PeptideAtlasi Q9UQV4.
    PRIDEi Q9UQV4.

    Protocols and materials databases

    DNASUi 27074.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265598 ; ENSP00000265598 ; ENSG00000078081 .
    GeneIDi 27074.
    KEGGi hsa:27074.
    UCSCi uc003flh.4. human.

    Organism-specific databases

    CTDi 27074.
    GeneCardsi GC03M182840.
    HGNCi HGNC:14582. LAMP3.
    HPAi CAB025133.
    HPA051467.
    MIMi 605883. gene.
    neXtProti NX_Q9UQV4.
    PharmGKBi PA30286.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288611.
    HOGENOMi HOG000004835.
    HOVERGENi HBG081889.
    InParanoidi Q9UQV4.
    KOi K06562.
    OMAi YYISEVG.
    PhylomeDBi Q9UQV4.
    TreeFami TF316339.

    Miscellaneous databases

    GeneWikii LAMP3.
    GenomeRNAii 27074.
    NextBioi 49669.
    PROi Q9UQV4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQV4.
    Bgeei Q9UQV4.
    CleanExi HS_LAMP3.
    Genevestigatori Q9UQV4.

    Family and domain databases

    InterProi IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues."
      Ozaki K., Nagata M., Suzuki M., Fujiwara T., Ueda K., Miyoshi Y., Takahashi E., Nakamura Y.
      Cancer Res. 58:3499-3503(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-318.
      Tissue: Lung.
    2. "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment."
      de Saint-Vis B.M., Vincent J., Vandenabeele S., Vanbervliet B., Pin J.J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J., Zurawski S., Davoust J., Caux C., Lebecque S.
      Immunity 9:325-336(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-318.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-32.
      Tissue: Testis.
    5. "Reciprocal polarization of T and B cells at the immunological synapse."
      Duchez S., Rodrigues M., Bertrand F., Valitutti S.
      J. Immunol. 187:4571-4580(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx."
      Wilke S., Krausze J., Bussow K.
      BMC Biol. 10:62-62(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 222-381, SUBUNIT, GLYCOSYLATION AT ASN-291, DISULFIDE BONDS.

    Entry informationi

    Entry nameiLAMP3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQV4
    Secondary accession number(s): D3DNS4, O94781, Q8NEC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3