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Protein

Lysosome-associated membrane glycoprotein 3

Gene

LAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.1 Publication

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
  • negative regulation of proteasomal protein catabolic process Source: ParkinsonsUK-UCL
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • regulation of autophagy Source: ParkinsonsUK-UCL
  • regulation of viral life cycle Source: ParkinsonsUK-UCL
  • response to interferon-alpha Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name:
DC LAMP
Protein TSC403
CD_antigen: CD208
Gene namesi
Name:LAMP3
Synonyms:DCLAMP, TSC403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14582. LAMP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 381LumenalSequence analysisAdd BLAST354
Transmembranei382 – 402HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini403 – 416CytoplasmicPROSITE-ProRule annotationAdd BLAST14

GO - Cellular componenti

  • alveolar lamellar body membrane Source: ParkinsonsUK-UCL
  • early endosome Source: ParkinsonsUK-UCL
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: ProtInc
  • perinuclear region of cytoplasm Source: ParkinsonsUK-UCL
  • plasma membrane Source: ParkinsonsUK-UCL
  • vesicle Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27074.
OpenTargetsiENSG00000078081.
PharmGKBiPA30286.

Polymorphism and mutation databases

BioMutaiLAMP3.
DMDMi126302564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000022369528 – 416Lysosome-associated membrane glycoprotein 3Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi237 ↔ 274PROSITE-ProRule annotation1 Publication
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Glycosylationi291N-linked (GlcNAc...)1 Publication1
Disulfide bondi339 ↔ 376PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UQV4.
PeptideAtlasiQ9UQV4.
PRIDEiQ9UQV4.

PTM databases

iPTMnetiQ9UQV4.
PhosphoSitePlusiQ9UQV4.

Expressioni

Tissue specificityi

Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.3 Publications

Developmental stagei

Up-regulated during dendritic cell maturation.

Gene expression databases

BgeeiENSG00000078081.
CleanExiHS_LAMP3.
ExpressionAtlasiQ9UQV4. baseline and differential.
GenevisibleiQ9UQV4. HS.

Organism-specific databases

HPAiCAB025133.
HPA051467.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi117983. 64 interactors.
IntActiQ9UQV4. 6 interactors.
MINTiMINT-7996363.
STRINGi9606.ENSP00000265598.

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi226 – 232Combined sources7
Beta strandi235 – 248Combined sources14
Beta strandi251 – 253Combined sources3
Beta strandi259 – 262Combined sources4
Helixi265 – 267Combined sources3
Beta strandi269 – 273Combined sources5
Beta strandi276 – 285Combined sources10
Beta strandi288 – 296Combined sources9
Beta strandi301 – 311Combined sources11
Beta strandi313 – 315Combined sources3
Beta strandi318 – 323Combined sources6
Beta strandi328 – 331Combined sources4
Beta strandi337 – 339Combined sources3
Beta strandi343 – 346Combined sources4
Beta strandi348 – 363Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AKMX-ray2.69A/B222-381[»]
ProteinModelPortaliQ9UQV4.
SMRiQ9UQV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 215Thr-richAdd BLAST142

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ9UQV4.
KOiK06562.
OMAiFEDDHFG.
OrthoDBiEOG091G09EV.
PhylomeDBiQ9UQV4.
TreeFamiTF316339.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK
60 70 80 90 100
PVQQPAKQAP HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI
110 120 130 140 150
TYTLVTTQAT PNNSHTAPPV TEVTVGPSLA PYSLPPTITP PAHTTGTSSS
160 170 180 190 200
TVSHTTGNTT QPSNQTTLPA TLSIALHKST TGQKPVQPTH APGTTAAAHN
210 220 230 240 250
TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA EMGIQLIVQD
260 270 280 290 300
KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES
310 320 330 340 350
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH
360 370 380 390 400
LQVKTTDVQL QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG
410
VYKIRLRCQS SGYQRI
Length:416
Mass (Da):44,346
Last modified:February 20, 2007 - v3
Checksum:iD615895D382B8F88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145T → A in BAA34533 (PubMed:9721848).Curated1
Sequence conflicti186V → D in BAA34533 (PubMed:9721848).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03082732E → G.1 PublicationCorresponds to variant rs17853113dbSNPEnsembl.1
Natural variantiVAR_025343318I → V.2 PublicationsCorresponds to variant rs482912dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013924 mRNA. Translation: BAA34533.1.
AJ005766 mRNA. Translation: CAA06691.1.
CH471052 Genomic DNA. Translation: EAW78337.1.
CH471052 Genomic DNA. Translation: EAW78338.1.
BC032940 mRNA. Translation: AAH32940.1.
CCDSiCCDS3242.1.
RefSeqiNP_055213.2. NM_014398.3.
UniGeneiHs.518448.

Genome annotation databases

EnsembliENST00000265598; ENSP00000265598; ENSG00000078081.
GeneIDi27074.
KEGGihsa:27074.
UCSCiuc003flh.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013924 mRNA. Translation: BAA34533.1.
AJ005766 mRNA. Translation: CAA06691.1.
CH471052 Genomic DNA. Translation: EAW78337.1.
CH471052 Genomic DNA. Translation: EAW78338.1.
BC032940 mRNA. Translation: AAH32940.1.
CCDSiCCDS3242.1.
RefSeqiNP_055213.2. NM_014398.3.
UniGeneiHs.518448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AKMX-ray2.69A/B222-381[»]
ProteinModelPortaliQ9UQV4.
SMRiQ9UQV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117983. 64 interactors.
IntActiQ9UQV4. 6 interactors.
MINTiMINT-7996363.
STRINGi9606.ENSP00000265598.

PTM databases

iPTMnetiQ9UQV4.
PhosphoSitePlusiQ9UQV4.

Polymorphism and mutation databases

BioMutaiLAMP3.
DMDMi126302564.

Proteomic databases

PaxDbiQ9UQV4.
PeptideAtlasiQ9UQV4.
PRIDEiQ9UQV4.

Protocols and materials databases

DNASUi27074.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265598; ENSP00000265598; ENSG00000078081.
GeneIDi27074.
KEGGihsa:27074.
UCSCiuc003flh.5. human.

Organism-specific databases

CTDi27074.
DisGeNETi27074.
GeneCardsiLAMP3.
HGNCiHGNC:14582. LAMP3.
HPAiCAB025133.
HPA051467.
MIMi605883. gene.
neXtProtiNX_Q9UQV4.
OpenTargetsiENSG00000078081.
PharmGKBiPA30286.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ9UQV4.
KOiK06562.
OMAiFEDDHFG.
OrthoDBiEOG091G09EV.
PhylomeDBiQ9UQV4.
TreeFamiTF316339.

Miscellaneous databases

GeneWikiiLAMP3.
GenomeRNAii27074.
PROiQ9UQV4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078081.
CleanExiHS_LAMP3.
ExpressionAtlasiQ9UQV4. baseline and differential.
GenevisibleiQ9UQV4. HS.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9UQV4
Secondary accession number(s): D3DNS4, O94781, Q8NEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.