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Q9UQV4 (LAMP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 3

Short name=LAMP-3
Short name=Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name=DC LAMP
Protein TSC403
CD_antigen=CD208
Gene names
Name:LAMP3
Synonyms:DCLAMP, TSC403
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in dendritic cell function and in adaptive immunity. Ref.2

Subunit structure

Monomer. Ref.6

Subcellular location

Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells. Ref.2 Ref.5

Tissue specificity

Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. Ref.1 Ref.2 Ref.5

Developmental stage

Up-regulated during dendritic cell maturation.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 416389Lysosome-associated membrane glycoprotein 3
PRO_0000223695

Regions

Topological domain28 – 381354Lumenal Potential
Transmembrane382 – 40221Helical; Potential
Topological domain403 – 41614Cytoplasmic Potential
Compositional bias74 – 215142Thr-rich

Amino acid modifications

Glycosylation1121N-linked (GlcNAc...) Potential
Glycosylation1581N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Ref.6
Disulfide bond237 ↔ 274 Ref.6
Disulfide bond339 ↔ 376 Ref.6

Natural variations

Natural variant321E → G. Ref.4
Corresponds to variant rs17853113 [ dbSNP | Ensembl ].
VAR_030827
Natural variant3181I → V. Ref.1 Ref.3
Corresponds to variant rs482912 [ dbSNP | Ensembl ].
VAR_025343

Experimental info

Sequence conflict1451T → A in BAA34533. Ref.1
Sequence conflict1861V → D in BAA34533. Ref.1

Secondary structure

............................... 416
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9UQV4 [UniParc].

Last modified February 20, 2007. Version 3.
Checksum: D615895D382B8F88

FASTA41644,346
        10         20         30         40         50         60 
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK PVQQPAKQAP 

        70         80         90        100        110        120 
HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI TYTLVTTQAT PNNSHTAPPV 

       130        140        150        160        170        180 
TEVTVGPSLA PYSLPPTITP PAHTTGTSSS TVSHTTGNTT QPSNQTTLPA TLSIALHKST 

       190        200        210        220        230        240 
TGQKPVQPTH APGTTAAAHN TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA 

       250        260        270        280        290        300 
EMGIQLIVQD KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 

       310        320        330        340        350        360 
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH LQVKTTDVQL 

       370        380        390        400        410 
QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG VYKIRLRCQS SGYQRI 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues."
Ozaki K., Nagata M., Suzuki M., Fujiwara T., Ueda K., Miyoshi Y., Takahashi E., Nakamura Y.
Cancer Res. 58:3499-3503(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-318.
Tissue: Lung.
[2]"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment."
de Saint-Vis B.M., Vincent J., Vandenabeele S., Vanbervliet B., Pin J.J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J., Zurawski S., Davoust J., Caux C., Lebecque S.
Immunity 9:325-336(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-318.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-32.
Tissue: Testis.
[5]"Reciprocal polarization of T and B cells at the immunological synapse."
Duchez S., Rodrigues M., Bertrand F., Valitutti S.
J. Immunol. 187:4571-4580(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]"Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx."
Wilke S., Krausze J., Bussow K.
BMC Biol. 10:62-62(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 222-381, SUBUNIT, GLYCOSYLATION AT ASN-291, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB013924 mRNA. Translation: BAA34533.1.
AJ005766 mRNA. Translation: CAA06691.1.
CH471052 Genomic DNA. Translation: EAW78337.1.
CH471052 Genomic DNA. Translation: EAW78338.1.
BC032940 mRNA. Translation: AAH32940.1.
RefSeqNP_055213.2. NM_014398.3.
UniGeneHs.518448.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AKMX-ray2.69A/B222-381[»]
ProteinModelPortalQ9UQV4.
SMRQ9UQV4. Positions 222-378.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117983. 1 interaction.
IntActQ9UQV4. 2 interactions.
MINTMINT-7996363.
STRING9606.ENSP00000265598.

PTM databases

PhosphoSiteQ9UQV4.

Polymorphism databases

DMDM126302564.

Proteomic databases

PaxDbQ9UQV4.
PeptideAtlasQ9UQV4.
PRIDEQ9UQV4.

Protocols and materials databases

DNASU27074.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265598; ENSP00000265598; ENSG00000078081.
GeneID27074.
KEGGhsa:27074.
UCSCuc003flh.4. human.

Organism-specific databases

CTD27074.
GeneCardsGC03M182840.
HGNCHGNC:14582. LAMP3.
HPACAB025133.
HPA051467.
MIM605883. gene.
neXtProtNX_Q9UQV4.
PharmGKBPA30286.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288611.
HOGENOMHOG000004835.
HOVERGENHBG081889.
InParanoidQ9UQV4.
KOK06562.
OMAYYISEVG.
PhylomeDBQ9UQV4.
TreeFamTF316339.

Gene expression databases

ArrayExpressQ9UQV4.
BgeeQ9UQV4.
CleanExHS_LAMP3.
GenevestigatorQ9UQV4.

Family and domain databases

InterProIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLAMP3.
GenomeRNAi27074.
NextBio49669.
PROQ9UQV4.
SOURCESearch...

Entry information

Entry nameLAMP3_HUMAN
AccessionPrimary (citable) accession number: Q9UQV4
Secondary accession number(s): D3DNS4, O94781, Q8NEC8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries