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Q9UQV4

- LAMP3_HUMAN

UniProt

Q9UQV4 - LAMP3_HUMAN

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Protein
Lysosome-associated membrane glycoprotein 3
Gene
LAMP3, DCLAMP, TSC403
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.1 Publication

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name:
DC LAMP
Protein TSC403
CD_antigen: CD208
Gene namesi
Name:LAMP3
Synonyms:DCLAMP, TSC403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14582. LAMP3.

Subcellular locationi

Lysosome membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein
Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 381354Lumenal Reviewed prediction
Add
BLAST
Transmembranei382 – 40221Helical; Reviewed prediction
Add
BLAST
Topological domaini403 – 41614Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. alveolar lamellar body membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 416389Lysosome-associated membrane glycoprotein 3
PRO_0000223695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi158 – 1581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi237 ↔ 2741 Publication
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi291 – 2911N-linked (GlcNAc...)1 Publication
Disulfide bondi339 ↔ 3761 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UQV4.
PeptideAtlasiQ9UQV4.
PRIDEiQ9UQV4.

PTM databases

PhosphoSiteiQ9UQV4.

Expressioni

Tissue specificityi

Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.3 Publications

Developmental stagei

Up-regulated during dendritic cell maturation.

Gene expression databases

ArrayExpressiQ9UQV4.
BgeeiQ9UQV4.
CleanExiHS_LAMP3.
GenevestigatoriQ9UQV4.

Organism-specific databases

HPAiCAB025133.
HPA051467.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi117983. 1 interaction.
IntActiQ9UQV4. 6 interactions.
MINTiMINT-7996363.
STRINGi9606.ENSP00000265598.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi226 – 2327
Beta strandi235 – 24814
Beta strandi251 – 2533
Beta strandi259 – 2624
Helixi265 – 2673
Beta strandi269 – 2735
Beta strandi276 – 28510
Beta strandi288 – 2969
Beta strandi301 – 31111
Beta strandi313 – 3153
Beta strandi318 – 3236
Beta strandi328 – 3314
Beta strandi337 – 3393
Beta strandi343 – 3464
Beta strandi348 – 36316

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AKMX-ray2.69A/B222-381[»]
ProteinModelPortaliQ9UQV4.
SMRiQ9UQV4. Positions 222-378.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 215142Thr-rich
Add
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288611.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ9UQV4.
KOiK06562.
OMAiYYISEVG.
PhylomeDBiQ9UQV4.
TreeFamiTF316339.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQV4-1 [UniParc]FASTAAdd to Basket

« Hide

MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK    50
PVQQPAKQAP HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI 100
TYTLVTTQAT PNNSHTAPPV TEVTVGPSLA PYSLPPTITP PAHTTGTSSS 150
TVSHTTGNTT QPSNQTTLPA TLSIALHKST TGQKPVQPTH APGTTAAAHN 200
TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA EMGIQLIVQD 250
KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES 300
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH 350
LQVKTTDVQL QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG 400
VYKIRLRCQS SGYQRI 416
Length:416
Mass (Da):44,346
Last modified:February 20, 2007 - v3
Checksum:iD615895D382B8F88
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321E → G.1 Publication
Corresponds to variant rs17853113 [ dbSNP | Ensembl ].
VAR_030827
Natural varianti318 – 3181I → V.2 Publications
Corresponds to variant rs482912 [ dbSNP | Ensembl ].
VAR_025343

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451T → A in BAA34533. 1 Publication
Sequence conflicti186 – 1861V → D in BAA34533. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013924 mRNA. Translation: BAA34533.1.
AJ005766 mRNA. Translation: CAA06691.1.
CH471052 Genomic DNA. Translation: EAW78337.1.
CH471052 Genomic DNA. Translation: EAW78338.1.
BC032940 mRNA. Translation: AAH32940.1.
CCDSiCCDS3242.1.
RefSeqiNP_055213.2. NM_014398.3.
UniGeneiHs.518448.

Genome annotation databases

EnsembliENST00000265598; ENSP00000265598; ENSG00000078081.
GeneIDi27074.
KEGGihsa:27074.
UCSCiuc003flh.4. human.

Polymorphism databases

DMDMi126302564.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB013924 mRNA. Translation: BAA34533.1 .
AJ005766 mRNA. Translation: CAA06691.1 .
CH471052 Genomic DNA. Translation: EAW78337.1 .
CH471052 Genomic DNA. Translation: EAW78338.1 .
BC032940 mRNA. Translation: AAH32940.1 .
CCDSi CCDS3242.1.
RefSeqi NP_055213.2. NM_014398.3.
UniGenei Hs.518448.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AKM X-ray 2.69 A/B 222-381 [» ]
ProteinModelPortali Q9UQV4.
SMRi Q9UQV4. Positions 222-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117983. 1 interaction.
IntActi Q9UQV4. 6 interactions.
MINTi MINT-7996363.
STRINGi 9606.ENSP00000265598.

PTM databases

PhosphoSitei Q9UQV4.

Polymorphism databases

DMDMi 126302564.

Proteomic databases

PaxDbi Q9UQV4.
PeptideAtlasi Q9UQV4.
PRIDEi Q9UQV4.

Protocols and materials databases

DNASUi 27074.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265598 ; ENSP00000265598 ; ENSG00000078081 .
GeneIDi 27074.
KEGGi hsa:27074.
UCSCi uc003flh.4. human.

Organism-specific databases

CTDi 27074.
GeneCardsi GC03M182840.
HGNCi HGNC:14582. LAMP3.
HPAi CAB025133.
HPA051467.
MIMi 605883. gene.
neXtProti NX_Q9UQV4.
PharmGKBi PA30286.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288611.
HOGENOMi HOG000004835.
HOVERGENi HBG081889.
InParanoidi Q9UQV4.
KOi K06562.
OMAi YYISEVG.
PhylomeDBi Q9UQV4.
TreeFami TF316339.

Miscellaneous databases

GeneWikii LAMP3.
GenomeRNAii 27074.
NextBioi 49669.
PROi Q9UQV4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UQV4.
Bgeei Q9UQV4.
CleanExi HS_LAMP3.
Genevestigatori Q9UQV4.

Family and domain databases

InterProi IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoprotein 1 and 2; significantly increased expression in cancers of various tissues."
    Ozaki K., Nagata M., Suzuki M., Fujiwara T., Ueda K., Miyoshi Y., Takahashi E., Nakamura Y.
    Cancer Res. 58:3499-3503(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT VAL-318.
    Tissue: Lung.
  2. "A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment."
    de Saint-Vis B.M., Vincent J., Vandenabeele S., Vanbervliet B., Pin J.J., Ait-Yahia S., Patel S., Mattei M.-G., Banchereau J., Zurawski S., Davoust J., Caux C., Lebecque S.
    Immunity 9:325-336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-318.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-32.
    Tissue: Testis.
  5. "Reciprocal polarization of T and B cells at the immunological synapse."
    Duchez S., Rodrigues M., Bertrand F., Valitutti S.
    J. Immunol. 187:4571-4580(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx."
    Wilke S., Krausze J., Bussow K.
    BMC Biol. 10:62-62(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS) OF 222-381, SUBUNIT, GLYCOSYLATION AT ASN-291, DISULFIDE BONDS.

Entry informationi

Entry nameiLAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9UQV4
Secondary accession number(s): D3DNS4, O94781, Q8NEC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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