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Protein

Zinc finger protein 148

Gene

ZNF148

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • cellular defense response Source: ProtInc
  • gamete generation Source: Ensembl
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • protein complex assembly Source: Ensembl
  • substantia nigra development Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9UQR1.
SIGNORiQ9UQR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 148
Alternative name(s):
Transcription factor ZBP-89
Zinc finger DNA-binding protein 89
Gene namesi
Name:ZNF148
Synonyms:ZBP89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12933. ZNF148.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7707.
OpenTargetsiENSG00000163848.
PharmGKBiPA37520.

Polymorphism and mutation databases

BioMutaiZNF148.
DMDMi12643385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474271 – 794Zinc finger protein 148Add BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1
Modified residuei194PhosphothreonineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei301PhosphoserineBy similarity1
Modified residuei306PhosphoserineCombined sources1
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki356Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei412PhosphoserineCombined sources1
Modified residuei607N6-acetyllysineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei784PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UQR1.
PaxDbiQ9UQR1.
PeptideAtlasiQ9UQR1.
PRIDEiQ9UQR1.

PTM databases

iPTMnetiQ9UQR1.
PhosphoSitePlusiQ9UQR1.

Expressioni

Gene expression databases

BgeeiENSG00000163848.
CleanExiHS_ZNF148.
ExpressionAtlasiQ9UQR1. baseline and differential.
GenevisibleiQ9UQR1. HS.

Organism-specific databases

HPAiCAB017486.
HPA001656.

Interactioni

Subunit structurei

Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC67E9PJR53EBI-2688184,EBI-10177066
CEP70Q8NHQ13EBI-2688184,EBI-739624
FAM22FB7ZLH03EBI-2688184,EBI-10220102
GLRX3O760033EBI-2688184,EBI-374781
GORASP2Q9H8Y83EBI-2688184,EBI-739467
KRT31Q153233EBI-2688184,EBI-948001
SIAH1Q8IUQ43EBI-2688184,EBI-747107
TRIM10Q9UDY63EBI-2688184,EBI-6427325

Protein-protein interaction databases

BioGridi113501. 23 interactors.
IntActiQ9UQR1. 24 interactors.
STRINGi9606.ENSP00000353863.

Structurei

3D structure databases

ProteinModelPortaliQ9UQR1.
SMRiQ9UQR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000143445.
HOVERGENiHBG054247.
InParanoidiQ9UQR1.
OMAiMCHENRD.
OrthoDBiEOG091G02EU.
PhylomeDBiQ9UQR1.
TreeFamiTF331779.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQR1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIDDKLEGL FLKCGGIDEM QSSRTMVVMG GVSGQSTVSG ELQDSVLQDR
60 70 80 90 100
SMPHQEILAA DEVLQESEMR QQDMISHDEL MVHEETVKND EEQMETHERL
110 120 130 140 150
PQGLQYALNV PISVKQEITF TDVSEQLMRD KKQIREPVDL QKKKKRKQRS
160 170 180 190 200
PAKILTINED GSLGLKTPKS HVCEHCNAAF RTNYHLQRHV FIHTGEKPFQ
210 220 230 240 250
CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY HMERHKRTHS
260 270 280 290 300
GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED
310 320 330 340 350
SGFSTSPKDN SLPKKKRQKT EKKSSGMDKE SALDKSDLKK DKNDYLPLYS
360 370 380 390 400
SSTKVKDEYM VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS
410 420 430 440 450
LKQPLEQNQT ISPLSTYEES KVSKYAFELV DKQALLDSEG NADIDQVDNL
460 470 480 490 500
QEGPSKPVHS STNYDDAMQF LKKKRYLQAA SNNSREYALN VGTIASQPSV
510 520 530 540 550
TQAAVASVID ESTTASILES QALNVEIKSN HDKNVIPDEV LQTLLDHYSH
560 570 580 590 600
KANGQHEISF SVADTEVTSS ISINSSEVPE VTPSENVGSS SQASSSDKAN
610 620 630 640 650
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNQ PAFSSIDKQV
660 670 680 690 700
YATMPINSFR SGMNSPLRTT PDKSHFGLIV GDSQHSFPFS GDETNHASAT
710 720 730 740 750
STQDFLDQVT SQKKAEAQPV HQAYQMSSFE QPFRAPYHGS RAGIATQFST
760 770 780 790
ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG MTSSPDATTG QTFG
Length:794
Mass (Da):88,976
Last modified:January 24, 2001 - v2
Checksum:i50413723459EBD1F
GO
Isoform 2 (identifier: Q9UQR1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.
     233-690: Missing.

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):14,473
Checksum:iCD38D10B58EE1E1E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287R → T in CAA15422 (PubMed:10359087).Curated1
Sequence conflicti348L → V in CAA15422 (PubMed:10359087).Curated1
Sequence conflicti379E → K in AAB57692 (Ref. 6) Curated1
Sequence conflicti495A → R in CAA15422 (PubMed:10359087).Curated1
Sequence conflicti616T → N in AAB57692 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559381 – 205Missing in isoform 2. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_055939233 – 690Missing in isoform 2. 1 PublicationAdd BLAST458

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039019 mRNA. Translation: AAC39926.1.
AJ236885 mRNA. Translation: CAA15422.1.
AC108688 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79394.1.
CH471052 Genomic DNA. Translation: EAW79395.1.
CH471052 Genomic DNA. Translation: EAW79396.1.
CH471052 Genomic DNA. Translation: EAW79398.1.
BC018971 mRNA. Translation: AAH18971.1.
BC050260 mRNA. Translation: AAH50260.1.
U96633 Genomic DNA. Translation: AAB57692.1.
CCDSiCCDS3031.1. [Q9UQR1-1]
RefSeqiNP_068799.2. NM_021964.2. [Q9UQR1-1]
UniGeneiHs.592591.

Genome annotation databases

EnsembliENST00000360647; ENSP00000353863; ENSG00000163848. [Q9UQR1-1]
ENST00000484491; ENSP00000420335; ENSG00000163848. [Q9UQR1-1]
ENST00000485866; ENSP00000420448; ENSG00000163848. [Q9UQR1-1]
ENST00000492394; ENSP00000419322; ENSG00000163848. [Q9UQR1-1]
GeneIDi7707.
KEGGihsa:7707.
UCSCiuc003ehx.5. human. [Q9UQR1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039019 mRNA. Translation: AAC39926.1.
AJ236885 mRNA. Translation: CAA15422.1.
AC108688 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79394.1.
CH471052 Genomic DNA. Translation: EAW79395.1.
CH471052 Genomic DNA. Translation: EAW79396.1.
CH471052 Genomic DNA. Translation: EAW79398.1.
BC018971 mRNA. Translation: AAH18971.1.
BC050260 mRNA. Translation: AAH50260.1.
U96633 Genomic DNA. Translation: AAB57692.1.
CCDSiCCDS3031.1. [Q9UQR1-1]
RefSeqiNP_068799.2. NM_021964.2. [Q9UQR1-1]
UniGeneiHs.592591.

3D structure databases

ProteinModelPortaliQ9UQR1.
SMRiQ9UQR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113501. 23 interactors.
IntActiQ9UQR1. 24 interactors.
STRINGi9606.ENSP00000353863.

PTM databases

iPTMnetiQ9UQR1.
PhosphoSitePlusiQ9UQR1.

Polymorphism and mutation databases

BioMutaiZNF148.
DMDMi12643385.

Proteomic databases

EPDiQ9UQR1.
PaxDbiQ9UQR1.
PeptideAtlasiQ9UQR1.
PRIDEiQ9UQR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360647; ENSP00000353863; ENSG00000163848. [Q9UQR1-1]
ENST00000484491; ENSP00000420335; ENSG00000163848. [Q9UQR1-1]
ENST00000485866; ENSP00000420448; ENSG00000163848. [Q9UQR1-1]
ENST00000492394; ENSP00000419322; ENSG00000163848. [Q9UQR1-1]
GeneIDi7707.
KEGGihsa:7707.
UCSCiuc003ehx.5. human. [Q9UQR1-1]

Organism-specific databases

CTDi7707.
DisGeNETi7707.
GeneCardsiZNF148.
HGNCiHGNC:12933. ZNF148.
HPAiCAB017486.
HPA001656.
MIMi601897. gene.
neXtProtiNX_Q9UQR1.
OpenTargetsiENSG00000163848.
PharmGKBiPA37520.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000143445.
HOVERGENiHBG054247.
InParanoidiQ9UQR1.
OMAiMCHENRD.
OrthoDBiEOG091G02EU.
PhylomeDBiQ9UQR1.
TreeFamiTF331779.

Enzyme and pathway databases

SignaLinkiQ9UQR1.
SIGNORiQ9UQR1.

Miscellaneous databases

ChiTaRSiZNF148. human.
GeneWikiiZNF148.
GenomeRNAii7707.
PROiQ9UQR1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163848.
CleanExiHS_ZNF148.
ExpressionAtlasiQ9UQR1. baseline and differential.
GenevisibleiQ9UQR1. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN148_HUMAN
AccessioniPrimary (citable) accession number: Q9UQR1
Secondary accession number(s): D3DN27
, O00389, O43591, Q58EY5, Q6PJ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.