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Protein

Sex comb on midleg-like protein 2

Gene

SCML2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sex comb on midleg-like protein 2
Gene namesi
Name:SCML2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:10581. SCML2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10389.
OpenTargetsiENSG00000102098.
PharmGKBiPA34999.

Polymorphism and mutation databases

BioMutaiSCML2.
DMDMi47117338.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976281 – 700Sex comb on midleg-like protein 2Add BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei256PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei305PhosphothreonineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei503PhosphothreonineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Cross-linki536Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei570PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UQR0.
PaxDbiQ9UQR0.
PeptideAtlasiQ9UQR0.
PRIDEiQ9UQR0.

PTM databases

iPTMnetiQ9UQR0.
PhosphoSitePlusiQ9UQR0.

Expressioni

Tissue specificityi

Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.1 Publication

Gene expression databases

BgeeiENSG00000102098.
CleanExiHS_SCML2.
ExpressionAtlasiQ9UQR0. baseline and differential.
GenevisibleiQ9UQR0. HS.

Organism-specific databases

HPAiHPA001662.

Interactioni

Protein-protein interaction databases

BioGridi115661. 12 interactors.
DIPiDIP-53760N.
IntActiQ9UQR0. 9 interactors.
STRINGi9606.ENSP00000251900.

Structurei

Secondary structure

1700
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 42Combined sources8
Helixi49 – 51Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi68 – 73Combined sources6
Beta strandi76 – 89Combined sources14
Beta strandi92 – 97Combined sources6
Beta strandi102 – 104Combined sources3
Beta strandi106 – 109Combined sources4
Beta strandi115 – 117Combined sources3
Helixi120 – 123Combined sources4
Helixi138 – 140Combined sources3
Helixi141 – 149Combined sources9
Helixi157 – 159Combined sources3
Beta strandi177 – 181Combined sources5
Beta strandi189 – 198Combined sources10
Beta strandi201 – 206Combined sources6
Helixi211 – 213Combined sources3
Beta strandi215 – 218Combined sources4
Helixi229 – 233Combined sources5
Beta strandi356 – 359Combined sources4
Beta strandi369 – 371Combined sources3
Helixi373 – 378Combined sources6
Beta strandi383 – 387Combined sources5
Helixi388 – 402Combined sources15
Helixi406 – 409Combined sources4
Beta strandi422 – 427Combined sources6
Beta strandi430 – 435Combined sources6
Helixi442 – 455Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OI1X-ray1.78A24-243[»]
2BIVX-ray1.70A/B/C1-243[»]
2MEMNMR-A354-468[»]
2VYTX-ray1.90A/B24-243[»]
4EDUX-ray2.58A29-243[»]
ProteinModelPortaliQ9UQR0.
SMRiQ9UQR0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UQR0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 131MBT 1Add BLAST99
Repeati139 – 240MBT 2Add BLAST102
Domaini631 – 700SAMAdd BLAST70

Sequence similaritiesi

Belongs to the SCM family.Curated
Contains 2 MBT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMEZ. Eukaryota.
ENOG410XPKI. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000236280.
HOVERGENiHBG056406.
InParanoidiQ9UQR0.
KOiK11465.
OMAiYDRNKPA.
OrthoDBiEOG091G05BW.
PhylomeDBiQ9UQR0.
TreeFamiTF106488.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR033763. SCML2_RBR.
IPR021987. SLED.
[Graphical view]
PfamiPF02820. MBT. 2 hits.
PF17208. RBR. 1 hit.
PF00536. SAM_1. 1 hit.
PF12140. SLED. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE
60 70 80 90 100
CFRQSQIPPV NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS
110 120 130 140 150
DNRNDFWRLV DSPDIQPVGT CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN
160 170 180 190 200
GSEMASATLF KKEPPKPPLN NFKVGMKLEA IDKKNPYLIC PATIGDVKGD
210 220 230 240 250
EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP GTSVPIVKNI
260 270 280 290 300
AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS
310 320 330 340 350
VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC
360 370 380 390 400
KIVMSTVCVY VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV
410 420 430 440 450
DCALETKTVF GYLKPDNRGG EVITASFDGE THSIQLPPVN SASFALRFLE
460 470 480 490 500
NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH DKNQSAKEDV TERQSTKRSP
510 520 530 540 550
QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL SEDSKSSSLN
560 570 580 590 600
SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF
610 620 630 640 650
QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP
660 670 680 690 700
LADLFRQHEI DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS
Length:700
Mass (Da):77,257
Last modified:May 1, 2000 - v1
Checksum:i05E086D4928DEE73
GO
Isoform 2 (identifier: Q9UQR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-562: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,471
Checksum:iA1FBA9624DF36ABE
GO

Sequence cautioni

The sequence AAH51913 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102771 – 562Missing in isoform 2. 1 PublicationAdd BLAST562

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18004 mRNA. Translation: CAB38943.1.
AL833937 mRNA. Translation: CAD38792.1.
AL096763, AL031007, Z93023 Genomic DNA. Translation: CAI42221.1.
AL031007, AL096763, Z93023 Genomic DNA. Translation: CAI43048.1.
Z93023, AL031007, AL096763 Genomic DNA. Translation: CAI43176.1.
BC040497 mRNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98937.1.
BC051913 mRNA. Translation: AAH51913.1. Different initiation.
BC064617 mRNA. Translation: AAH64617.1.
CCDSiCCDS14185.1. [Q9UQR0-1]
RefSeqiNP_006080.1. NM_006089.2. [Q9UQR0-1]
XP_016884708.1. XM_017029219.1. [Q9UQR0-1]
XP_016884709.1. XM_017029220.1. [Q9UQR0-1]
UniGeneiHs.495774.

Genome annotation databases

EnsembliENST00000251900; ENSP00000251900; ENSG00000102098. [Q9UQR0-1]
ENST00000398048; ENSP00000381126; ENSG00000102098. [Q9UQR0-2]
GeneIDi10389.
KEGGihsa:10389.
UCSCiuc004cyl.3. human. [Q9UQR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18004 mRNA. Translation: CAB38943.1.
AL833937 mRNA. Translation: CAD38792.1.
AL096763, AL031007, Z93023 Genomic DNA. Translation: CAI42221.1.
AL031007, AL096763, Z93023 Genomic DNA. Translation: CAI43048.1.
Z93023, AL031007, AL096763 Genomic DNA. Translation: CAI43176.1.
BC040497 mRNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98937.1.
BC051913 mRNA. Translation: AAH51913.1. Different initiation.
BC064617 mRNA. Translation: AAH64617.1.
CCDSiCCDS14185.1. [Q9UQR0-1]
RefSeqiNP_006080.1. NM_006089.2. [Q9UQR0-1]
XP_016884708.1. XM_017029219.1. [Q9UQR0-1]
XP_016884709.1. XM_017029220.1. [Q9UQR0-1]
UniGeneiHs.495774.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OI1X-ray1.78A24-243[»]
2BIVX-ray1.70A/B/C1-243[»]
2MEMNMR-A354-468[»]
2VYTX-ray1.90A/B24-243[»]
4EDUX-ray2.58A29-243[»]
ProteinModelPortaliQ9UQR0.
SMRiQ9UQR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115661. 12 interactors.
DIPiDIP-53760N.
IntActiQ9UQR0. 9 interactors.
STRINGi9606.ENSP00000251900.

PTM databases

iPTMnetiQ9UQR0.
PhosphoSitePlusiQ9UQR0.

Polymorphism and mutation databases

BioMutaiSCML2.
DMDMi47117338.

Proteomic databases

EPDiQ9UQR0.
PaxDbiQ9UQR0.
PeptideAtlasiQ9UQR0.
PRIDEiQ9UQR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251900; ENSP00000251900; ENSG00000102098. [Q9UQR0-1]
ENST00000398048; ENSP00000381126; ENSG00000102098. [Q9UQR0-2]
GeneIDi10389.
KEGGihsa:10389.
UCSCiuc004cyl.3. human. [Q9UQR0-1]

Organism-specific databases

CTDi10389.
DisGeNETi10389.
GeneCardsiSCML2.
HGNCiHGNC:10581. SCML2.
HPAiHPA001662.
MIMi300208. gene.
neXtProtiNX_Q9UQR0.
OpenTargetsiENSG00000102098.
PharmGKBiPA34999.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMEZ. Eukaryota.
ENOG410XPKI. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000236280.
HOVERGENiHBG056406.
InParanoidiQ9UQR0.
KOiK11465.
OMAiYDRNKPA.
OrthoDBiEOG091G05BW.
PhylomeDBiQ9UQR0.
TreeFamiTF106488.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102098-MONOMER.

Miscellaneous databases

ChiTaRSiSCML2. human.
EvolutionaryTraceiQ9UQR0.
GenomeRNAii10389.
PROiQ9UQR0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102098.
CleanExiHS_SCML2.
ExpressionAtlasiQ9UQR0. baseline and differential.
GenevisibleiQ9UQR0. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR033763. SCML2_RBR.
IPR021987. SLED.
[Graphical view]
PfamiPF02820. MBT. 2 hits.
PF17208. RBR. 1 hit.
PF00536. SAM_1. 1 hit.
PF12140. SLED. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 2 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCML2_HUMAN
AccessioniPrimary (citable) accession number: Q9UQR0
Secondary accession number(s): Q5JXE6
, Q86U98, Q8IWD0, Q8NDP2, Q9UGC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.