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Q9UQR0

- SCML2_HUMAN

UniProt

Q9UQR0 - SCML2_HUMAN

Protein

Sex comb on midleg-like protein 2

Gene

SCML2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sex comb on midleg-like protein 2
    Gene namesi
    Name:SCML2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:10581. SCML2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. PcG protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34999.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 700700Sex comb on midleg-like protein 2PRO_0000097628Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei256 – 2561Phosphoserine1 Publication
    Modified residuei267 – 2671Phosphoserine1 Publication
    Modified residuei299 – 2991Phosphoserine1 Publication
    Modified residuei300 – 3001Phosphoserine1 Publication
    Modified residuei305 – 3051Phosphothreonine1 Publication
    Modified residuei499 – 4991Phosphoserine4 Publications
    Modified residuei503 – 5031Phosphothreonine2 Publications
    Modified residuei511 – 5111Phosphoserine4 Publications
    Modified residuei583 – 5831Phosphoserine1 Publication
    Modified residuei590 – 5901Phosphoserine4 Publications
    Modified residuei594 – 5941Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UQR0.
    PaxDbiQ9UQR0.
    PeptideAtlasiQ9UQR0.
    PRIDEiQ9UQR0.

    PTM databases

    PhosphoSiteiQ9UQR0.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.1 Publication

    Gene expression databases

    ArrayExpressiQ9UQR0.
    BgeeiQ9UQR0.
    CleanExiHS_SCML2.
    GenevestigatoriQ9UQR0.

    Organism-specific databases

    HPAiHPA001662.

    Interactioni

    Protein-protein interaction databases

    BioGridi115661. 7 interactions.
    DIPiDIP-53760N.
    IntActiQ9UQR0. 2 interactions.
    STRINGi9606.ENSP00000251900.

    Structurei

    Secondary structure

    1
    700
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi35 – 428
    Helixi49 – 513
    Beta strandi52 – 543
    Beta strandi68 – 736
    Beta strandi76 – 8914
    Beta strandi92 – 976
    Beta strandi102 – 1043
    Beta strandi106 – 1094
    Beta strandi115 – 1173
    Helixi120 – 1234
    Helixi138 – 1403
    Helixi141 – 1499
    Helixi157 – 1593
    Beta strandi177 – 1815
    Beta strandi189 – 19810
    Beta strandi201 – 2066
    Helixi211 – 2133
    Beta strandi215 – 2184
    Helixi229 – 2335
    Beta strandi356 – 3594
    Beta strandi369 – 3713
    Helixi373 – 3786
    Beta strandi383 – 3875
    Helixi388 – 40215
    Helixi406 – 4094
    Beta strandi422 – 4276
    Beta strandi430 – 4356
    Helixi442 – 45514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OI1X-ray1.78A24-243[»]
    2BIVX-ray1.70A/B/C1-243[»]
    2MEMNMR-A354-468[»]
    2VYTX-ray1.90A/B24-243[»]
    4EDUX-ray2.58A29-243[»]
    ProteinModelPortaliQ9UQR0.
    SMRiQ9UQR0. Positions 5-269, 628-694.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UQR0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati33 – 13199MBT 1Add
    BLAST
    Repeati139 – 240102MBT 2Add
    BLAST
    Domaini631 – 70070SAMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SCM family.Curated
    Contains 2 MBT repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG315447.
    HOGENOMiHOG000236280.
    HOVERGENiHBG056406.
    InParanoidiQ9UQR0.
    KOiK11465.
    OMAiTSKIVMS.
    OrthoDBiEOG73BVC2.
    PhylomeDBiQ9UQR0.
    TreeFamiTF106488.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    InterProiIPR021987. DUF3588.
    IPR004092. Mbt.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF12140. DUF3588. 1 hit.
    PF02820. MBT. 2 hits.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00561. MBT. 2 hits.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS51079. MBT. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UQR0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGQTVNEDSM DVKKENQEKT PQSSTSSVQR DDFHWEEYLK ETGSISAPSE    50
    CFRQSQIPPV NDFKVGMKLE ARDPRNATSV CIATVIGITG ARLRLRLDGS 100
    DNRNDFWRLV DSPDIQPVGT CEKEGDLLQP PLGYQMNTSS WPMFLLKTLN 150
    GSEMASATLF KKEPPKPPLN NFKVGMKLEA IDKKNPYLIC PATIGDVKGD 200
    EVHITFDGWS GAFDYWCKYD SRDIFPAGWC RLTGDVLQPP GTSVPIVKNI 250
    AKTESSPSEA SQHSMQSPQK TTLILPTQQV RRSSRIKPPG PTAVPKRSSS 300
    VKNITPRKKG PNSGKKEKPL PVICSTSAAS LKSLTRDRGM LYKDVASGPC 350
    KIVMSTVCVY VNKHGNFGPH LDPKRIQQLP DHFGPGPVNV VLRRIVQACV 400
    DCALETKTVF GYLKPDNRGG EVITASFDGE THSIQLPPVN SASFALRFLE 450
    NFCHSLQCDN LLSSQPFSSS RGHTHSSAEH DKNQSAKEDV TERQSTKRSP 500
    QQTVPYVVPL SPKLPKTKEY ASEGEPLFAG GSAIPKEENL SEDSKSSSLN 550
    SGNYLNPACR NPMYIHTSVS QDFSRSVPGT TSSPLVGDIS PKSSPHEVKF 600
    QMQRKSEAPS YIAVPDPSVL KQGFSKDPST WSVDEVIQFM KHTDPQISGP 650
    LADLFRQHEI DGKALFLLKS DVMMKYMGLK LGPALKLCYY IEKLKEGKYS 700
    Length:700
    Mass (Da):77,257
    Last modified:May 1, 2000 - v1
    Checksum:i05E086D4928DEE73
    GO
    Isoform 2 (identifier: Q9UQR0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-562: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:138
    Mass (Da):15,471
    Checksum:iA1FBA9624DF36ABE
    GO

    Sequence cautioni

    The sequence AAH51913.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 562562Missing in isoform 2. 1 PublicationVSP_010277Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18004 mRNA. Translation: CAB38943.1.
    AL833937 mRNA. Translation: CAD38792.1.
    AL096763, AL031007, Z93023 Genomic DNA. Translation: CAI42221.1.
    AL031007, AL096763, Z93023 Genomic DNA. Translation: CAI43048.1.
    Z93023, AL031007, AL096763 Genomic DNA. Translation: CAI43176.1.
    BC040497 mRNA. No translation available.
    CH471074 Genomic DNA. Translation: EAW98937.1.
    BC051913 mRNA. Translation: AAH51913.1. Different initiation.
    BC064617 mRNA. Translation: AAH64617.1.
    CCDSiCCDS14185.1. [Q9UQR0-1]
    RefSeqiNP_006080.1. NM_006089.2. [Q9UQR0-1]
    UniGeneiHs.495774.

    Genome annotation databases

    EnsembliENST00000251900; ENSP00000251900; ENSG00000102098. [Q9UQR0-1]
    GeneIDi10389.
    KEGGihsa:10389.
    UCSCiuc004cyl.2. human. [Q9UQR0-1]

    Polymorphism databases

    DMDMi47117338.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18004 mRNA. Translation: CAB38943.1 .
    AL833937 mRNA. Translation: CAD38792.1 .
    AL096763 , AL031007 , Z93023 Genomic DNA. Translation: CAI42221.1 .
    AL031007 , AL096763 , Z93023 Genomic DNA. Translation: CAI43048.1 .
    Z93023 , AL031007 , AL096763 Genomic DNA. Translation: CAI43176.1 .
    BC040497 mRNA. No translation available.
    CH471074 Genomic DNA. Translation: EAW98937.1 .
    BC051913 mRNA. Translation: AAH51913.1 . Different initiation.
    BC064617 mRNA. Translation: AAH64617.1 .
    CCDSi CCDS14185.1. [Q9UQR0-1 ]
    RefSeqi NP_006080.1. NM_006089.2. [Q9UQR0-1 ]
    UniGenei Hs.495774.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OI1 X-ray 1.78 A 24-243 [» ]
    2BIV X-ray 1.70 A/B/C 1-243 [» ]
    2MEM NMR - A 354-468 [» ]
    2VYT X-ray 1.90 A/B 24-243 [» ]
    4EDU X-ray 2.58 A 29-243 [» ]
    ProteinModelPortali Q9UQR0.
    SMRi Q9UQR0. Positions 5-269, 628-694.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115661. 7 interactions.
    DIPi DIP-53760N.
    IntActi Q9UQR0. 2 interactions.
    STRINGi 9606.ENSP00000251900.

    PTM databases

    PhosphoSitei Q9UQR0.

    Polymorphism databases

    DMDMi 47117338.

    Proteomic databases

    MaxQBi Q9UQR0.
    PaxDbi Q9UQR0.
    PeptideAtlasi Q9UQR0.
    PRIDEi Q9UQR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251900 ; ENSP00000251900 ; ENSG00000102098 . [Q9UQR0-1 ]
    GeneIDi 10389.
    KEGGi hsa:10389.
    UCSCi uc004cyl.2. human. [Q9UQR0-1 ]

    Organism-specific databases

    CTDi 10389.
    GeneCardsi GC0XM018167.
    HGNCi HGNC:10581. SCML2.
    HPAi HPA001662.
    MIMi 300208. gene.
    neXtProti NX_Q9UQR0.
    PharmGKBi PA34999.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315447.
    HOGENOMi HOG000236280.
    HOVERGENi HBG056406.
    InParanoidi Q9UQR0.
    KOi K11465.
    OMAi TSKIVMS.
    OrthoDBi EOG73BVC2.
    PhylomeDBi Q9UQR0.
    TreeFami TF106488.

    Miscellaneous databases

    EvolutionaryTracei Q9UQR0.
    GenomeRNAii 10389.
    NextBioi 39356.
    PROi Q9UQR0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQR0.
    Bgeei Q9UQR0.
    CleanExi HS_SCML2.
    Genevestigatori Q9UQR0.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    InterProi IPR021987. DUF3588.
    IPR004092. Mbt.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF12140. DUF3588. 1 hit.
    PF02820. MBT. 2 hits.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00561. MBT. 2 hits.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS51079. MBT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of SCML2, a second human gene homologous to the Drosophila Sex comb on midleg (Scm): a new gene cluster on Xp22."
      Montini E., Buchner G., Spalluto C., Andolfi G., Caruso A., de Dunnen J.T., Trump D., Rocchi M., Ballabio A., Franco B.
      Genomics 58:65-72(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis and Uterus.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-256; SER-267; SER-299; SER-300; THR-305; SER-499; THR-503; SER-511; SER-583; SER-590 AND SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499; SER-511 AND SER-590, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499; THR-503; SER-511 AND SER-590, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499; SER-511 AND SER-590, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Crystal structure of the malignant brain tumor (MBT) repeats in sex comb on midleg-like 2 (SCML2)."
      Sathyamurthy A., Allen M.D., Murzin A.G., Bycroft M.
      J. Biol. Chem. 278:46968-46973(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 33-243.

    Entry informationi

    Entry nameiSCML2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQR0
    Secondary accession number(s): Q5JXE6
    , Q86U98, Q8IWD0, Q8NDP2, Q9UGC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3