Q9UQQ1 (NALDL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetylated-alpha-linked acidic dipeptidase-like protein
Short name=NAALADase L
EC=3.4.17.21

Alternative name(s):
100 kDa ileum brush border membrane protein
Short name=I100
Ileal dipeptidylpeptidase

Gene names

Name:	NAALADL1
Synonyms:	NAALADASEL, NAALADL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	740 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC By similarity.
Catalytic activity	Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Apical cell membrane; Single-pass type II membrane protein. Note: Ileal brush border membrane.
Tissue specificity	Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon.
Sequence similarities	Belongs to the peptidase M28 family. M28B subfamily.
Sequence caution	The sequence AAB87645.1 differs from that shown. Reason: Frameshift at positions 686 and 693.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Dipeptidase Hydrolase Metalloprotease Protease
PTM	Glycoprotein
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.3. Source: UniProtKB
Molecular function	carboxypeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW dipeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UQQ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UQQ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     161-201: Missing.

Isoform 3 (identifier: Q9UQQ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     296-330: Missing.

Isoform 4 (identifier: Q9UQQ1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     359-359: P → PGEPSSCCLHPRPLLCSGCRCPHPALPLPPPSPAPPAHLSLSSGSLPLFLWP

Isoform 5 (identifier: Q9UQQ1-5)

The sequence of this isoform differs from the canonical sequence as follows:
     502-522: PSLGSLGAGSDYAPFVHFLGI → PRLQQPSGCGPDSGECDSPAQ
     523-740: Missing.

Isoform 6 (identifier: Q9UQQ1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     502-543: PSLGSLGAGS...SKTSARIYPT → PRARLQPGSP...IRLWPGQRGV
     544-740: Missing.

Isoform 7 (identifier: Q9UQQ1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     562-579: FSSHQAVARTAGSVILRL → FEEGDKGHPETRTGEAED
     580-740: Missing.

Isoform 8 (identifier: Q9UQQ1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     619-635: GPLVTAVEKFEAEAAAL → GMHSPDPEVWGALHPHD
     636-740: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 740	740	N-acetylated-alpha-linked acidic dipeptidase-like protein		PRO_0000174123
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 28	22	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	29 – 740	712	Extracellular Potential
	Region	263 – 579	317	NAALADase
Sites
	Active site	416	1	Nucleophile; for NAALADase activity By similarity
	Active site	617	1	Charge relay system Potential
	Active site	657	1	Charge relay system Potential
	Active site	680	1	Charge relay system Potential
	Metal binding	368	1	Zinc 2 By similarity
	Metal binding	378	1	Zinc 1 By similarity
	Metal binding	378	1	Zinc 2 By similarity
	Metal binding	417	1	Zinc 1 By similarity
	Metal binding	445	1	Zinc 2 By similarity
	Metal binding	545	1	Zinc 1 By similarity
Amino acid modifications
	Glycosylation	136	1	N-linked (GlcNAc...) Potential
	Glycosylation	274	1	N-linked (GlcNAc...) Potential
	Glycosylation	299	1	N-linked (GlcNAc...) Potential
	Glycosylation	334	1	N-linked (GlcNAc...) Potential
	Glycosylation	345	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential
	Glycosylation	492	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	161 – 201	41	Missing in isoform 2.		VSP_005343
	Alternative sequence	296 – 330	35	Missing in isoform 3.		VSP_005344
	Alternative sequence	359	1	P → PGEPSSCCLHPRPLLCSGCR CPHPALPLPPPSPAPPAHLS LSSGSLPLFLWP in isoform 4.		VSP_005345
	Alternative sequence	502 – 543	42	PSLGS…RIYPT → PRARLQPGSPPTTQPLTPLT MWTSFWTRASAAIRLWPGQR GV in isoform 6.		VSP_005348
	Alternative sequence	502 – 522	21	PSLGS…HFLGI → PRLQQPSGCGPDSGECDSPA Q in isoform 5.		VSP_005346
	Alternative sequence	523 – 740	218	Missing in isoform 5.		VSP_005347
	Alternative sequence	544 – 740	197	Missing in isoform 6.		VSP_005349
	Alternative sequence	562 – 579	18	FSSHQ…VILRL → FEEGDKGHPETRTGEAED in isoform 7.		VSP_005350
	Alternative sequence	580 – 740	161	Missing in isoform 7.		VSP_005351
	Alternative sequence	619 – 635	17	GPLVT…EAAAL → GMHSPDPEVWGALHPHD in isoform 8.		VSP_005352
	Alternative sequence	636 – 740	105	Missing in isoform 8.		VSP_005353
	Natural variant	2	1	Q → H. Corresponds to variant rs35422506 [ dbSNP | Ensembl ].		VAR_057155
	Natural variant	398	1	K → T. Corresponds to variant rs12223986 [ dbSNP | Ensembl ].		VAR_057156
	Natural variant	611	1	L → V. Corresponds to variant rs36053340 [ dbSNP | Ensembl ].		VAR_057157
Experimental info
	Sequence conflict	420 – 424	5	LIGST → SPGLQ in AAB87645. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 018D59835F2C48AC	FASTA	740	80,558
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 370 380 390 400 410 420 RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 430 440 450 460 470 480 IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 490 500 510 520 530 540 LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG SDYAPFVHFL GISSMDIAYT YDRSKTSARI 550 560 570 580 590 600 YPTYHTAFDT FDYVDKFLDP GFSSHQAVAR TAGSVILRLS DSFFLPLKVS DYSETLRSFL 610 620 630 640 650 660 QAAQQDLGAL LEQHSISLGP LVTAVEKFEA EAAALGQRIS TLQKGSPDPL QVRMLNDQLM 670 680 690 700 710 720 LLERTFLNPR AFPEERYYSH VLWAPRTGSV VTFPGLSNAC SRARDTASGS EAWAEVQRQL 730 740 SIVVTALEGA AATLRPVADL
	Isoform 2 [UniParc]. Checksum: BDF2C67F921ED4CA	FASTA	699	76,195
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ AVNAAKHGVA GVLVYTDPAD 190 200 210 220 230 240 INDGLSSPDE TFPNSWYLPP SGVERGSYYE YFGDPLTPYL PAVPSSFRVD LANVSGFPPI 250 260 270 280 290 300 PTQPIGFQDA RDLLCNLNGT LAPATWQGAL GCHYRLGPGF RPDGDFPADS QVNVSVYNRL 310 320 330 340 350 360 ELRNSSNVLG IIRGAVEPDR YVLYGNHRDS WVHGAVDPSS GTAVLLELSR VLGTLLKKGT 370 380 390 400 410 420 WRPRRSIVFA SWGAEEFGLI GSTEFTEEFF NKLQERTVAY INVDISVFAN ATLRVQGTPP 430 440 450 460 470 480 VQSVVFSATK EIRSPGPGDL SIYDNWIRYF NRSSPVYGLV PSLGSLGAGS DYAPFVHFLG 490 500 510 520 530 540 ISSMDIAYTY DRSKTSARIY PTYHTAFDTF DYVDKFLDPG FSSHQAVART AGSVILRLSD 550 560 570 580 590 600 SFFLPLKVSD YSETLRSFLQ AAQQDLGALL EQHSISLGPL VTAVEKFEAE AAALGQRIST 610 620 630 640 650 660 LQKGSPDPLQ VRMLNDQLML LERTFLNPRA FPEERYYSHV LWAPRTGSVV TFPGLSNACS 670 680 690 RARDTASGSE AWAEVQRQLS IVVTALEGAA ATLRPVADL
	Isoform 3 [UniParc]. Checksum: B043A0DBBDEBFB8D	FASTA	705	76,887
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLSQVNV 310 320 330 340 350 360 SVYNRLELRN SSNVLGIIRG AVEPDRYVLY GNHRDSWVHG AVDPSSGTAV LLELSRVLGT 370 380 390 400 410 420 LLKKGTWRPR RSIVFASWGA EEFGLIGSTE FTEEFFNKLQ ERTVAYINVD ISVFANATLR 430 440 450 460 470 480 VQGTPPVQSV VFSATKEIRS PGPGDLSIYD NWIRYFNRSS PVYGLVPSLG SLGAGSDYAP 490 500 510 520 530 540 FVHFLGISSM DIAYTYDRSK TSARIYPTYH TAFDTFDYVD KFLDPGFSSH QAVARTAGSV 550 560 570 580 590 600 ILRLSDSFFL PLKVSDYSET LRSFLQAAQQ DLGALLEQHS ISLGPLVTAV EKFEAEAAAL 610 620 630 640 650 660 GQRISTLQKG SPDPLQVRML NDQLMLLERT FLNPRAFPEE RYYSHVLWAP RTGSVVTFPG 670 680 690 700 LSNACSRARD TASGSEAWAE VQRQLSIVVT ALEGAAATLR PVADL
	Isoform 4 [UniParc]. Checksum: 8872DB91F3669FD7	FASTA	791	85,832
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPG 370 380 390 400 410 420 EPSSCCLHPR PLLCSGCRCP HPALPLPPPS PAPPAHLSLS SGSLPLFLWP DRYVLYGNHR 430 440 450 460 470 480 DSWVHGAVDP SSGTAVLLEL SRVLGTLLKK GTWRPRRSIV FASWGAEEFG LIGSTEFTEE 490 500 510 520 530 540 FFNKLQERTV AYINVDISVF ANATLRVQGT PPVQSVVFSA TKEIRSPGPG DLSIYDNWIR 550 560 570 580 590 600 YFNRSSPVYG LVPSLGSLGA GSDYAPFVHF LGISSMDIAY TYDRSKTSAR IYPTYHTAFD 610 620 630 640 650 660 TFDYVDKFLD PGFSSHQAVA RTAGSVILRL SDSFFLPLKV SDYSETLRSF LQAAQQDLGA 670 680 690 700 710 720 LLEQHSISLG PLVTAVEKFE AEAAALGQRI STLQKGSPDP LQVRMLNDQL MLLERTFLNP 730 740 750 760 770 780 RAFPEERYYS HVLWAPRTGS VVTFPGLSNA CSRARDTASG SEAWAEVQRQ LSIVVTALEG 790 AAATLRPVAD L
	Isoform 5 [UniParc]. Checksum: D9C30160F01AC93B	FASTA	522	56,573
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 370 380 390 400 410 420 RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 430 440 450 460 470 480 IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 490 500 510 520 LSIYDNWIRY FNRSSPVYGL VPRLQQPSGC GPDSGECDSP AQ
	Isoform 6 [UniParc]. Checksum: 3DEF010A089357C9	FASTA	543	59,132
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 370 380 390 400 410 420 RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 430 440 450 460 470 480 IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 490 500 510 520 530 540 LSIYDNWIRY FNRSSPVYGL VPRARLQPGS PPTTQPLTPL TMWTSFWTRA SAAIRLWPGQ RGV
	Isoform 7 [UniParc]. Checksum: 62FAEF2C2C593E0F	FASTA	579	63,077
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 370 380 390 400 410 420 RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 430 440 450 460 470 480 IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 490 500 510 520 530 540 LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG SDYAPFVHFL GISSMDIAYT YDRSKTSARI 550 560 570 YPTYHTAFDT FDYVDKFLDP GFEEGDKGHP ETRTGEAED
	Isoform 8 [UniParc]. Checksum: 1388AE658E962A2C	FASTA	635	69,188
	10 20 30 40 50 60 MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSLAPQDL DLEILETVMG QLDAHRIREN 70 80 90 100 110 120 LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAS TYEVLLSFPS QEQPNVVDIV 130 140 150 160 170 180 GPTGGIIHSC HRTEENVTGE QGGPDVVQPY AAYAPSGTPQ GLLVYANRGA EEDFKELQTQ 190 200 210 220 230 240 GIKLEGTIAL TRYGGVGRGA KAVNAAKHGV AGVLVYTDPA DINDGLSSPD ETFPNSWYLP 250 260 270 280 290 300 PSGVERGSYY EYFGDPLTPY LPAVPSSFRV DLANVSGFPP IPTQPIGFQD ARDLLCNLNG 310 320 330 340 350 360 TLAPATWQGA LGCHYRLGPG FRPDGDFPAD SQVNVSVYNR LELRNSSNVL GIIRGAVEPD 370 380 390 400 410 420 RYVLYGNHRD SWVHGAVDPS SGTAVLLELS RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL 430 440 450 460 470 480 IGSTEFTEEF FNKLQERTVA YINVDISVFA NATLRVQGTP PVQSVVFSAT KEIRSPGPGD 490 500 510 520 530 540 LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG SDYAPFVHFL GISSMDIAYT YDRSKTSARI 550 560 570 580 590 600 YPTYHTAFDT FDYVDKFLDP GFSSHQAVAR TAGSVILRLS DSFFLPLKVS DYSETLRSFL 610 620 630 QAAQQDLGAL LEQHSISLGM HSPDPEVWGA LHPHD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl peptidase IV activity." Pangalos M.N., Neefs J.-M., Somers M., Verhasselt P., Bekkers M., van der Helm L., Fraiponts E., Ashton D., Gordon R.D. J. Biol. Chem. 274:8470-8483(1999) [PubMed: 10085079] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 8). Tissue: Small intestine.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Cloning and characterization of a novel peptidase from rat and human ileum." Shneider B.L., Thevananther S., Moyer M.S., Walters H.C., Rinaldo P., Devarajan P., Sun A.Q., Dawson P.A., Ananthanarayanan M. J. Biol. Chem. 272:31006-31015(1997) [PubMed: 9388249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 419-740. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ012371 mRNA. Translation: CAB39968.1. AP003068 Genomic DNA. No translation available. AF010141 mRNA. Translation: AAB87645.1. Frameshift.
IPI	IPI00023152. IPI00216497. IPI00216498. IPI00216499. IPI00216500. IPI00216502. IPI00413011. IPI00952635.
RefSeq	NP_005459.2. NM_005468.2.
UniGene	Hs.13967.
3D structure databases
ProteinModelPortal	Q9UQQ1.
SMR	Q9UQQ1. Positions 55-102, 375-431.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UQQ1.
Protein family/group databases
MEROPS	M28.011.
PTM databases
PhosphoSite	Q9UQQ1.
Polymorphism databases
DMDM	20139287.
Proteomic databases
PRIDE	Q9UQQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358658; ENSP00000351484; ENSG00000168060.
GeneID	10004.
KEGG	hsa:10004.
UCSC	uc001ocn.1. human.
Organism-specific databases
CTD	10004.
GeneCards	GC11M064812.
H-InvDB	HIX0035851.
HGNC	HGNC:23536. NAALADL1.
MIM	602640. gene.
neXtProt	NX_Q9UQQ1.
PharmGKB	PA134867982.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09463.
GeneTree	ENSGT00550000074421.
HOVERGEN	HBG051639.
OMA	MDIAYTY.
PhylomeDB	Q9UQQ1.
Gene expression databases
ArrayExpress	Q9UQQ1.
Bgee	Q9UQQ1.
CleanEx	HS_NAALADL1.
Genevestigator	Q9UQQ1.
GermOnline	ENSG00000168060. Homo sapiens.
Family and domain databases
InterPro	IPR007484. Peptidase_M28. IPR003137. Protease-assoc_domain. IPR007365. TFR-like_dimer_dom. [Graphical view]
Gene3D	G3DSA:1.20.930.40. TFR_dimer. 1 hit.
KO	K01301.
Pfam	PF02225. PA. 1 hit. PF04389. Peptidase_M28. 1 hit. PF04253. TFR_dimer. 1 hit. [Graphical view]
SUPFAM	SSF47672. Transferrin_rcpt-like_dimerise. 1 hit.
ProtoNet	Search...
Other
NextBio	37785.
SOURCE	Search...

Entry information

Entry name

NALDL_HUMAN

Accession

Primary (citable) accession number: Q9UQQ1
Secondary accession number(s): C9J8A1 , C9J964, C9JL35, C9JSN0, O43176

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.