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Protein

Tenascin-N

Gene

TNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in neurite outgrowth and cell migration in hippocampal explants.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120332-MONOMER.
ReactomeiR-HSA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin-N
Short name:
TN-N
Gene namesi
Name:TNN
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:22942. TNN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi63923.
OpenTargetsiENSG00000120332.
PharmGKBiPA134973710.

Polymorphism and mutation databases

BioMutaiTNN.
DMDMi81175198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000774529 – 1299Tenascin-NAdd BLAST1271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi171 ↔ 181PROSITE-ProRule annotation
Disulfide bondi175 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi202 ↔ 212PROSITE-ProRule annotation
Disulfide bondi206 ↔ 217PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi233 ↔ 243PROSITE-ProRule annotation
Disulfide bondi237 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 259PROSITE-ProRule annotation
Glycosylationi1149N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UQP3.
PaxDbiQ9UQP3.
PeptideAtlasiQ9UQP3.
PRIDEiQ9UQP3.

PTM databases

iPTMnetiQ9UQP3.
PhosphoSitePlusiQ9UQP3.

Expressioni

Gene expression databases

BgeeiENSG00000120332.
CleanExiHS_TNN.
ExpressionAtlasiQ9UQP3. baseline and differential.
GenevisibleiQ9UQP3. HS.

Organism-specific databases

HPAiCAB010907.
HPA026726.
HPA026764.

Interactioni

Protein-protein interaction databases

BioGridi121992. 4 interactors.
STRINGi9606.ENSP00000239462.

Structurei

3D structure databases

ProteinModelPortaliQ9UQP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 198EGF-like 1Add BLAST32
Domaini199 – 229EGF-like 2Add BLAST31
Domaini230 – 260EGF-like 3Add BLAST31
Domaini264 – 352Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini353 – 444Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST92
Domaini445 – 532Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST88
Domaini533 – 623Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91
Domaini624 – 709Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST86
Domaini710 – 800Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini801 – 886Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST86
Domaini887 – 976Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST90
Domaini977 – 1063Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST87
Domaini1061 – 1278Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Belongs to the tenascin family.Curated
Contains 3 EGF-like domains.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotationCurated
Contains 9 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234355.
HOVERGENiHBG106611.
InParanoidiQ9UQP3.
KOiK06252.
OMAiAPIDRYM.
OrthoDBiEOG091G03M1.
PhylomeDBiQ9UQP3.
TreeFamiTF329915.

Family and domain databases

CDDicd00063. FN3. 9 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 9 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033080. TNW.
[Graphical view]
PANTHERiPTHR19143:SF252. PTHR19143:SF252. 3 hits.
PfamiPF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 9 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQEMFRFP MGLLLGSVLL VASAPATLEP PGCSNKEQQV TVSHTYKIDV
60 70 80 90 100
PKSALVQVDA DPQPLSDDGA SLLALGEARE EQNIIFRHNI RLQTPQKDCE
110 120 130 140 150
LAGSVQDLLA RVKKLEEEMV EMKEQCSAQR CCQGVTDLSR HCSGHGTFSL
160 170 180 190 200
ETCSCHCEEG REGPACERLA CPGACSGHGR CVDGRCLCHE PYVGADCGYP
210 220 230 240 250
ACPENCSGHG ECVRGVCQCH EDFMSEDCSE KRCPGDCSGH GFCDTGECYC
260 270 280 290 300
EEGFTGLDCA QVVTPQGLQL LKNTEDSLLV SWEPSSQVDH YLLSYYPLGK
310 320 330 340 350
ELSGKQIQVP KEQHSYEILG LLPGTKYIVT LRNVKNEVSS SPQHLLATTD
360 370 380 390 400
LAVLGTAWVT DETENSLDVE WENPSTEVDY YKLRYGPMTG QEVAEVTVPK
410 420 430 440 450
SSDPKSRYDI TGLHPGTEYK ITVVPMRGEL EGKPILLNGR TEIDSPTNVV
460 470 480 490 500
TDRVTEDTAT VSWDPVQAVI DKYVVRYTSA DGDTKEMAVH KDESSTVLTG
510 520 530 540 550
LKPGEAYKVY VWAERGNQGS KKADTNALTE IDSPANLVTD RVTENTATIS
560 570 580 590 600
WDPVQATIDK YVVRYTSADD QETREVLVGK EQSSTVLTGL RPGVEYTVHV
610 620 630 640 650
WAQKGDRESK KADTNAPTDI DSPKNLVTDR VTENMATVSW DPVQAAIDKY
660 670 680 690 700
VVRYTSAGGE TREVPVGKEQ SSTVLTGLRP GMEYMVHVWA QKGDQESKKA
710 720 730 740 750
DTKAQTDIDS PQNLVTDRVT ENMATVSWDP VRATIDRYVV RYTSAKDGET
760 770 780 790 800
REVPVGKEQS STVLTGLRPG VEYTVHVWAQ KGAQESKKAD TKAQTDIDSP
810 820 830 840 850
QNLVTDWVTE NTATVSWDPV QATIDRYVVH YTSANGETRE VPVGKEQSST
860 870 880 890 900
VLTGLRPGME YTVHVWAQKG NQESKKADTK AQTEIDGPKN LVTDWVTENM
910 920 930 940 950
ATVSWDPVQA TIDKYMVRYT SADGETREVP VGKEHSSTVL TGLRPGMEYM
960 970 980 990 1000
VHVWAQKGAQ ESKKADTKAQ TELDPPRNLR PSAVTQSGGI LTWTPPSAQI
1010 1020 1030 1040 1050
HGYILTYQFP DGTVKEMQLG REDQRFALQG LEQGATYPVS LVAFKGGRRS
1060 1070 1080 1090 1100
RNVSTTLSTV GARFPHPSDC SQVQQNSNAA SGLYTIYLHG DASRPLQVYC
1110 1120 1130 1140 1150
DMETDGGGWI VFQRRNTGQL DFFKRWRSYV EGFGDPMKEF WLGLDKLHNL
1160 1170 1180 1190 1200
TTGTPARYEV RVDLQTANES AYAIYDFFQV ASSKERYKLT VGKYRGTAGD
1210 1220 1230 1240 1250
ALTYHNGWKF TTFDRDNDIA LSNCALTHHG GWWYKNCHLA NPNGRYGETK
1260 1270 1280 1290
HSEGVNWEPW KGHEFSIPYV ELKIRPHGYS REPVLGRKKR TLRGRLRTF
Length:1,299
Mass (Da):144,034
Last modified:November 8, 2005 - v2
Checksum:iCC4BBD5CE47ADBED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04900779R → G.Corresponds to variant rs2072032dbSNPEnsembl.1
Natural variantiVAR_033832289D → N.Corresponds to variant rs16847812dbSNPEnsembl.1
Natural variantiVAR_049008440R → S.Corresponds to variant rs6664276dbSNPEnsembl.1
Natural variantiVAR_033833499T → M.Corresponds to variant rs17374761dbSNPEnsembl.1
Natural variantiVAR_033834807W → R.Corresponds to variant rs6696455dbSNPEnsembl.1
Natural variantiVAR_059275859M → V.Corresponds to variant rs6694078dbSNPEnsembl.1
Natural variantiVAR_024269930P → L.Corresponds to variant rs2285215dbSNPEnsembl.1
Natural variantiVAR_033835941T → M.Corresponds to variant rs10798333dbSNPEnsembl.1
Natural variantiVAR_0490091135D → E.Corresponds to variant rs10158841dbSNPEnsembl.1
Natural variantiVAR_0490101156A → V.Corresponds to variant rs2072036dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99297 Genomic DNA. No translation available.
Z99715 Genomic DNA. No translation available.
BC136619 mRNA. Translation: AAI36620.1.
AL049689 mRNA. Translation: CAB41260.1.
CCDSiCCDS30943.1.
RefSeqiNP_071376.1. NM_022093.1.
UniGeneiHs.156369.

Genome annotation databases

EnsembliENST00000239462; ENSP00000239462; ENSG00000120332.
GeneIDi63923.
KEGGihsa:63923.
UCSCiuc001gkl.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99297 Genomic DNA. No translation available.
Z99715 Genomic DNA. No translation available.
BC136619 mRNA. Translation: AAI36620.1.
AL049689 mRNA. Translation: CAB41260.1.
CCDSiCCDS30943.1.
RefSeqiNP_071376.1. NM_022093.1.
UniGeneiHs.156369.

3D structure databases

ProteinModelPortaliQ9UQP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121992. 4 interactors.
STRINGi9606.ENSP00000239462.

PTM databases

iPTMnetiQ9UQP3.
PhosphoSitePlusiQ9UQP3.

Polymorphism and mutation databases

BioMutaiTNN.
DMDMi81175198.

Proteomic databases

EPDiQ9UQP3.
PaxDbiQ9UQP3.
PeptideAtlasiQ9UQP3.
PRIDEiQ9UQP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239462; ENSP00000239462; ENSG00000120332.
GeneIDi63923.
KEGGihsa:63923.
UCSCiuc001gkl.1. human.

Organism-specific databases

CTDi63923.
DisGeNETi63923.
GeneCardsiTNN.
H-InvDBHIX0023596.
HGNCiHGNC:22942. TNN.
HPAiCAB010907.
HPA026726.
HPA026764.
neXtProtiNX_Q9UQP3.
OpenTargetsiENSG00000120332.
PharmGKBiPA134973710.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234355.
HOVERGENiHBG106611.
InParanoidiQ9UQP3.
KOiK06252.
OMAiAPIDRYM.
OrthoDBiEOG091G03M1.
PhylomeDBiQ9UQP3.
TreeFamiTF329915.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000120332-MONOMER.
ReactomeiR-HSA-3000178. ECM proteoglycans.

Miscellaneous databases

ChiTaRSiTNN. human.
GenomeRNAii63923.
PROiQ9UQP3.

Gene expression databases

BgeeiENSG00000120332.
CleanExiHS_TNN.
ExpressionAtlasiQ9UQP3. baseline and differential.
GenevisibleiQ9UQP3. HS.

Family and domain databases

CDDicd00063. FN3. 9 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 9 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033080. TNW.
[Graphical view]
PANTHERiPTHR19143:SF252. PTHR19143:SF252. 3 hits.
PfamiPF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 9 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENN_HUMAN
AccessioniPrimary (citable) accession number: Q9UQP3
Secondary accession number(s): A0A0A6YY94, B9EGP3, Q5R360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.