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Protein

Tenascin-N

Gene

TNN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity). During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin-NImported
Short name:
TN-N
Alternative name(s):
Tenascin-W1 Publication
Short name:
TN-W
Gene namesi
Name:TNNImported
Synonyms:TNW1 Publication
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000120332.15
HGNCiHGNC:22942 TNN
MIMi617472 gene
neXtProtiNX_Q9UQP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi63923
OpenTargetsiENSG00000120332
PharmGKBiPA134973710

Polymorphism and mutation databases

BioMutaiTNN
DMDMi81175198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000774529 – 1299Tenascin-NAdd BLAST1271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi171 ↔ 181PROSITE-ProRule annotation
Disulfide bondi175 ↔ 186PROSITE-ProRule annotation
Disulfide bondi188 ↔ 197PROSITE-ProRule annotation
Disulfide bondi202 ↔ 212PROSITE-ProRule annotation
Disulfide bondi206 ↔ 217PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi233 ↔ 243PROSITE-ProRule annotation
Disulfide bondi237 ↔ 248PROSITE-ProRule annotation
Disulfide bondi250 ↔ 259PROSITE-ProRule annotation
Glycosylationi1149N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UQP3
PaxDbiQ9UQP3
PeptideAtlasiQ9UQP3
PRIDEiQ9UQP3

PTM databases

iPTMnetiQ9UQP3
PhosphoSitePlusiQ9UQP3

Expressioni

Tissue specificityi

Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).2 Publications

Gene expression databases

BgeeiENSG00000120332
CleanExiHS_TNN
ExpressionAtlasiQ9UQP3 baseline and differential
GenevisibleiQ9UQP3 HS

Organism-specific databases

HPAiCAB010907
HPA026726
HPA026764

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121992, 4 interactors
IntActiQ9UQP3, 1 interactor
STRINGi9606.ENSP00000239462

Structurei

3D structure databases

ProteinModelPortaliQ9UQP3
SMRiQ9UQP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 198EGF-like 1Add BLAST32
Domaini199 – 229EGF-like 2Add BLAST31
Domaini230 – 260EGF-like 3Add BLAST31
Domaini264 – 352Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST89
Domaini353 – 444Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST92
Domaini445 – 532Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST88
Domaini533 – 623Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91
Domaini624 – 709Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST86
Domaini710 – 800Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini801 – 886Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST86
Domaini887 – 976Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST90
Domaini977 – 1063Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST87
Domaini1061 – 1278Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST218

Sequence similaritiesi

Belongs to the tenascin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00830000128240
HOGENOMiHOG000234355
HOVERGENiHBG106611
InParanoidiQ9UQP3
KOiK06252
OMAiVYVWAQK
OrthoDBiEOG091G03M1
PhylomeDBiQ9UQP3
TreeFamiTF329915

Family and domain databases

CDDicd00063 FN3, 9 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 9 hits
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00186 FBG, 1 hit
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 2 hits
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQEMFRFP MGLLLGSVLL VASAPATLEP PGCSNKEQQV TVSHTYKIDV
60 70 80 90 100
PKSALVQVDA DPQPLSDDGA SLLALGEARE EQNIIFRHNI RLQTPQKDCE
110 120 130 140 150
LAGSVQDLLA RVKKLEEEMV EMKEQCSAQR CCQGVTDLSR HCSGHGTFSL
160 170 180 190 200
ETCSCHCEEG REGPACERLA CPGACSGHGR CVDGRCLCHE PYVGADCGYP
210 220 230 240 250
ACPENCSGHG ECVRGVCQCH EDFMSEDCSE KRCPGDCSGH GFCDTGECYC
260 270 280 290 300
EEGFTGLDCA QVVTPQGLQL LKNTEDSLLV SWEPSSQVDH YLLSYYPLGK
310 320 330 340 350
ELSGKQIQVP KEQHSYEILG LLPGTKYIVT LRNVKNEVSS SPQHLLATTD
360 370 380 390 400
LAVLGTAWVT DETENSLDVE WENPSTEVDY YKLRYGPMTG QEVAEVTVPK
410 420 430 440 450
SSDPKSRYDI TGLHPGTEYK ITVVPMRGEL EGKPILLNGR TEIDSPTNVV
460 470 480 490 500
TDRVTEDTAT VSWDPVQAVI DKYVVRYTSA DGDTKEMAVH KDESSTVLTG
510 520 530 540 550
LKPGEAYKVY VWAERGNQGS KKADTNALTE IDSPANLVTD RVTENTATIS
560 570 580 590 600
WDPVQATIDK YVVRYTSADD QETREVLVGK EQSSTVLTGL RPGVEYTVHV
610 620 630 640 650
WAQKGDRESK KADTNAPTDI DSPKNLVTDR VTENMATVSW DPVQAAIDKY
660 670 680 690 700
VVRYTSAGGE TREVPVGKEQ SSTVLTGLRP GMEYMVHVWA QKGDQESKKA
710 720 730 740 750
DTKAQTDIDS PQNLVTDRVT ENMATVSWDP VRATIDRYVV RYTSAKDGET
760 770 780 790 800
REVPVGKEQS STVLTGLRPG VEYTVHVWAQ KGAQESKKAD TKAQTDIDSP
810 820 830 840 850
QNLVTDWVTE NTATVSWDPV QATIDRYVVH YTSANGETRE VPVGKEQSST
860 870 880 890 900
VLTGLRPGME YTVHVWAQKG NQESKKADTK AQTEIDGPKN LVTDWVTENM
910 920 930 940 950
ATVSWDPVQA TIDKYMVRYT SADGETREVP VGKEHSSTVL TGLRPGMEYM
960 970 980 990 1000
VHVWAQKGAQ ESKKADTKAQ TELDPPRNLR PSAVTQSGGI LTWTPPSAQI
1010 1020 1030 1040 1050
HGYILTYQFP DGTVKEMQLG REDQRFALQG LEQGATYPVS LVAFKGGRRS
1060 1070 1080 1090 1100
RNVSTTLSTV GARFPHPSDC SQVQQNSNAA SGLYTIYLHG DASRPLQVYC
1110 1120 1130 1140 1150
DMETDGGGWI VFQRRNTGQL DFFKRWRSYV EGFGDPMKEF WLGLDKLHNL
1160 1170 1180 1190 1200
TTGTPARYEV RVDLQTANES AYAIYDFFQV ASSKERYKLT VGKYRGTAGD
1210 1220 1230 1240 1250
ALTYHNGWKF TTFDRDNDIA LSNCALTHHG GWWYKNCHLA NPNGRYGETK
1260 1270 1280 1290
HSEGVNWEPW KGHEFSIPYV ELKIRPHGYS REPVLGRKKR TLRGRLRTF
Length:1,299
Mass (Da):144,034
Last modified:November 8, 2005 - v2
Checksum:iCC4BBD5CE47ADBED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04900779R → G. Corresponds to variant dbSNP:rs2072032Ensembl.1
Natural variantiVAR_033832289D → N. Corresponds to variant dbSNP:rs16847812Ensembl.1
Natural variantiVAR_049008440R → S. Corresponds to variant dbSNP:rs6664276Ensembl.1
Natural variantiVAR_033833499T → M. Corresponds to variant dbSNP:rs17374761Ensembl.1
Natural variantiVAR_033834807W → R. Corresponds to variant dbSNP:rs6696455Ensembl.1
Natural variantiVAR_059275859M → V. Corresponds to variant dbSNP:rs6694078Ensembl.1
Natural variantiVAR_024269930P → L. Corresponds to variant dbSNP:rs2285215Ensembl.1
Natural variantiVAR_033835941T → M. Corresponds to variant dbSNP:rs10798333Ensembl.1
Natural variantiVAR_0490091135D → E. Corresponds to variant dbSNP:rs10158841Ensembl.1
Natural variantiVAR_0490101156A → V. Corresponds to variant dbSNP:rs2072036Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99297 Genomic DNA No translation available.
Z99715 Genomic DNA No translation available.
BC136619 mRNA Translation: AAI36620.1
AL049689 mRNA Translation: CAB41260.1
CCDSiCCDS30943.1
RefSeqiNP_071376.1, NM_022093.1
UniGeneiHs.156369

Genome annotation databases

EnsembliENST00000239462; ENSP00000239462; ENSG00000120332
GeneIDi63923
KEGGihsa:63923
UCSCiuc001gkl.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTENN_HUMAN
AccessioniPrimary (citable) accession number: Q9UQP3
Secondary accession number(s): A0A0A6YY94, B9EGP3, Q5R360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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