Q9UQP3 (TENN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tenascin-N
Short name=TN-N

Gene names

Name:

TNN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in neurite outgrowth and cell migration in hippocampal explants By similarity. UniProtKB Q80Z71
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the tenascin family. Contains 3 EGF-like domains. Contains 1 fibrinogen C-terminal domain. Contains 9 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Polymorphism
Domain	EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell growth Inferred from sequence or structural similarity. Source: UniProtKB cell migration Inferred from sequence or structural similarity. Source: UniProtKB signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: InterPro proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 1299	1271	Tenascin-N		PRO_0000007745
Regions
	Domain	167 – 198	32	EGF-like 1
	Domain	199 – 229	31	EGF-like 2
	Domain	230 – 260	31	EGF-like 3
	Domain	261 – 349	89	Fibronectin type-III 1
	Domain	350 – 441	92	Fibronectin type-III 2
	Domain	442 – 529	88	Fibronectin type-III 3
	Domain	530 – 618	89	Fibronectin type-III 4
	Domain	619 – 706	88	Fibronectin type-III 5
	Domain	707 – 795	89	Fibronectin type-III 6
	Domain	796 – 883	88	Fibronectin type-III 7
	Domain	884 – 971	88	Fibronectin type-III 8
	Domain	972 – 1059	88	Fibronectin type-III 9
	Domain	1061 – 1278	218	Fibrinogen C-terminal
Amino acid modifications
	Glycosylation	1149	1	N-linked (GlcNAc...) Ref.4
	Disulfide bond	171 ↔ 181		Potential
	Disulfide bond	175 ↔ 186		Potential
	Disulfide bond	188 ↔ 197		Potential
	Disulfide bond	202 ↔ 212		Potential
	Disulfide bond	206 ↔ 217		Potential
	Disulfide bond	219 ↔ 228		Potential
	Disulfide bond	233 ↔ 243		Potential
	Disulfide bond	237 ↔ 248		Potential
	Disulfide bond	250 ↔ 259		Potential
Natural variations
	Natural variant	79	1	R → G. Corresponds to variant rs2072032 [ dbSNP | Ensembl ].		VAR_049007
	Natural variant	289	1	D → N. Corresponds to variant rs16847812 [ dbSNP | Ensembl ].		VAR_033832
	Natural variant	440	1	R → S. Corresponds to variant rs6664276 [ dbSNP | Ensembl ].		VAR_049008
	Natural variant	499	1	T → M. Corresponds to variant rs17374761 [ dbSNP | Ensembl ].		VAR_033833
	Natural variant	807	1	W → R. Corresponds to variant rs6696455 [ dbSNP | Ensembl ].		VAR_033834
	Natural variant	859	1	M → V. Corresponds to variant rs6694078 [ dbSNP | Ensembl ].		VAR_059275
	Natural variant	930	1	P → L. Corresponds to variant rs2285215 [ dbSNP | Ensembl ].		VAR_024269
	Natural variant	941	1	T → M. Corresponds to variant rs10798333 [ dbSNP | Ensembl ].		VAR_033835
	Natural variant	1135	1	D → E. Corresponds to variant rs10158841 [ dbSNP | Ensembl ].		VAR_049009
	Natural variant	1156	1	A → V. Corresponds to variant rs2072036 [ dbSNP | Ensembl ].		VAR_049010

Sequences

	Sequence		Length	Mass (Da)
	Q9UQP3 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: CC4BBD5CE47ADBED	FASTA	1,299	144,034
	10 20 30 40 50 60 MSLQEMFRFP MGLLLGSVLL VASAPATLEP PGCSNKEQQV TVSHTYKIDV PKSALVQVDA 70 80 90 100 110 120 DPQPLSDDGA SLLALGEARE EQNIIFRHNI RLQTPQKDCE LAGSVQDLLA RVKKLEEEMV 130 140 150 160 170 180 EMKEQCSAQR CCQGVTDLSR HCSGHGTFSL ETCSCHCEEG REGPACERLA CPGACSGHGR 190 200 210 220 230 240 CVDGRCLCHE PYVGADCGYP ACPENCSGHG ECVRGVCQCH EDFMSEDCSE KRCPGDCSGH 250 260 270 280 290 300 GFCDTGECYC EEGFTGLDCA QVVTPQGLQL LKNTEDSLLV SWEPSSQVDH YLLSYYPLGK 310 320 330 340 350 360 ELSGKQIQVP KEQHSYEILG LLPGTKYIVT LRNVKNEVSS SPQHLLATTD LAVLGTAWVT 370 380 390 400 410 420 DETENSLDVE WENPSTEVDY YKLRYGPMTG QEVAEVTVPK SSDPKSRYDI TGLHPGTEYK 430 440 450 460 470 480 ITVVPMRGEL EGKPILLNGR TEIDSPTNVV TDRVTEDTAT VSWDPVQAVI DKYVVRYTSA 490 500 510 520 530 540 DGDTKEMAVH KDESSTVLTG LKPGEAYKVY VWAERGNQGS KKADTNALTE IDSPANLVTD 550 560 570 580 590 600 RVTENTATIS WDPVQATIDK YVVRYTSADD QETREVLVGK EQSSTVLTGL RPGVEYTVHV 610 620 630 640 650 660 WAQKGDRESK KADTNAPTDI DSPKNLVTDR VTENMATVSW DPVQAAIDKY VVRYTSAGGE 670 680 690 700 710 720 TREVPVGKEQ SSTVLTGLRP GMEYMVHVWA QKGDQESKKA DTKAQTDIDS PQNLVTDRVT 730 740 750 760 770 780 ENMATVSWDP VRATIDRYVV RYTSAKDGET REVPVGKEQS STVLTGLRPG VEYTVHVWAQ 790 800 810 820 830 840 KGAQESKKAD TKAQTDIDSP QNLVTDWVTE NTATVSWDPV QATIDRYVVH YTSANGETRE 850 860 870 880 890 900 VPVGKEQSST VLTGLRPGME YTVHVWAQKG NQESKKADTK AQTEIDGPKN LVTDWVTENM 910 920 930 940 950 960 ATVSWDPVQA TIDKYMVRYT SADGETREVP VGKEHSSTVL TGLRPGMEYM VHVWAQKGAQ 970 980 990 1000 1010 1020 ESKKADTKAQ TELDPPRNLR PSAVTQSGGI LTWTPPSAQI HGYILTYQFP DGTVKEMQLG 1030 1040 1050 1060 1070 1080 REDQRFALQG LEQGATYPVS LVAFKGGRRS RNVSTTLSTV GARFPHPSDC SQVQQNSNAA 1090 1100 1110 1120 1130 1140 SGLYTIYLHG DASRPLQVYC DMETDGGGWI VFQRRNTGQL DFFKRWRSYV EGFGDPMKEF 1150 1160 1170 1180 1190 1200 WLGLDKLHNL TTGTPARYEV RVDLQTANES AYAIYDFFQV ASSKERYKLT VGKYRGTAGD 1210 1220 1230 1240 1250 1260 ALTYHNGWKF TTFDRDNDIA LSNCALTHHG GWWYKNCHLA NPNGRYGETK HSEGVNWEPW 1270 1280 1290 KGHEFSIPYV ELKIRPHGYS REPVLGRKKR TLRGRLRTF

References

[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Rhodes S. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1299.
[4]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1149, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z99297, Z99715 Genomic DNA. Translation: CAI19966.1. Z99715, Z99297 Genomic DNA. Translation: CAI19286.1. BC136619 mRNA. Translation: AAI36620.1. AL049689 mRNA. Translation: CAB41260.1.
IPI	IPI00010814.
RefSeq	NP_071376.1. NM_022093.1.
UniGene	Hs.156369.
3D structure databases
ProteinModelPortal	Q9UQP3.
SMR	Q9UQP3. Positions 139-1277.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UQP3.
PTM databases
PhosphoSite	Q9UQP3.
Polymorphism databases
DMDM	81175198.
Proteomic databases
PeptideAtlas	Q9UQP3.
PRIDE	Q9UQP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000239462; ENSP00000239462; ENSG00000120332.
GeneID	63923.
KEGG	hsa:63923.
UCSC	uc001gkl.1. human.
Organism-specific databases
CTD	63923.
GeneCards	GC01P175036.
H-InvDB	HIX0023596.
HGNC	HGNC:22942. TNN.
HPA	CAB010907. HPA026726. HPA026764.
neXtProt	NX_Q9UQP3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05637.
GeneTree	ENSGT00580000081396.
HOGENOM	HBG714000.
HOVERGEN	HBG106611.
InParanoid	Q9UQP3.
OMA	NTKAPTD.
OrthoDB	EOG49078D.
PhylomeDB	Q9UQP3.
Gene expression databases
ArrayExpress	Q9UQP3.
Bgee	Q9UQP3.
CleanEx	HS_TNN.
Genevestigator	Q9UQP3.
GermOnline	ENSG00000120332. Homo sapiens.
Family and domain databases
InterPro	IPR013032. EGF-like_reg_CS. IPR013111. EGF_extracell. IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. IPR014715. Fibrinogen_a/b/g_C_2. IPR020837. Fibrinogen_CS. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit. G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit. G3DSA:2.60.40.10. Ig-like_fold. 9 hits.
KO	K06252.
Pfam	PF07974. EGF_2. 3 hits. PF00147. Fibrinogen_C. 1 hit. PF00041. fn3. 9 hits. [Graphical view]
SMART	SM00186. FBG. 1 hit. SM00060. FN3. 9 hits. [Graphical view]
SUPFAM	SSF56496. Fibrinogen_a/b/g_C. 1 hit. SSF49265. FN_III-like. 9 hits.
PROSITE	PS00022. EGF_1. 3 hits. PS01186. EGF_2. 2 hits. PS50026. EGF_3. False negative. PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. PS50853. FN3. 9 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	65653.

Entry information

Entry name

TENN_HUMAN

Accession

Primary (citable) accession number: Q9UQP3
Secondary accession number(s): B9EGP3, Q5R360

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.