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Protein
Submitted name:

Alpha-tubulin

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-tubulinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MicrotubuleUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ9UQM3.
PeptideAtlasiQ9UQM3.
PRIDEiQ9UQM3.

Interactioni

Subunit structurei

Dimer of alpha and beta chains.UniRule annotation

Protein-protein interaction databases

IntActiQ9UQM3. 2 interactions.
MINTiMINT-4949314.
STRINGi9606.ENSP00000301071.

Structurei

3D structure databases

ProteinModelPortaliQ9UQM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 123123TubulinInterPro annotationAdd
BLAST
Domaini125 – 270146Tubulin_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tubulin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
HOVERGENiHBG000089.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002452. Alpha_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UQM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GLADQCTGLQ GFLVFHSFGG GTGSGFTSLL MERLSVDYGK KSKLEFSIYP
60 70 80 90 100
APQVSTAVVE PYNSILTTHT TLEHSDCAFM VDNEAIYDIC RRNLDIERPT
110 120 130 140 150
YTNLNRLIGQ IVSSITASLR FDGALNVDLT EFQTNLVPYP RIHFPLATYA
160 170 180 190 200
PVISAEKAYH EQLSVAEITN ACFEPANQMV KCDPRHGKYM ACCLLYRGDV
210 220 230 240 250
VPKDVNAAIA TIKTKRTIQF VDWCPTGFKV GINYQPPTVV PGGDLAKVQR
260 270 280 290 300
AVCMLSNTTA IAEAWARLDH KFDLMYAKRA FVHWYVGEGM EEGEFSEARE
310 320
DMAALEKDYE EVGVDSVEGE GEEEGEEY
Length:328
Mass (Da):36,434
Last modified:May 1, 2000 - v1
Checksum:iC1ABE667684B43B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141348 mRNA. Translation: AAD33872.1.
UniGeneiHs.654422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141348 mRNA. Translation: AAD33872.1.
UniGeneiHs.654422.

3D structure databases

ProteinModelPortaliQ9UQM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UQM3. 2 interactions.
MINTiMINT-4949314.
STRINGi9606.ENSP00000301071.

Proteomic databases

PaxDbiQ9UQM3.
PeptideAtlasiQ9UQM3.
PRIDEiQ9UQM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1376. Eukaryota.
COG5023. LUCA.
HOVERGENiHBG000089.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002452. Alpha_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01162. ALPHATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site."
    Crabtree D.V., Ojima I., Geng X., Adler A.J.
    Bioorg. Med. Chem. 9:1967-1976(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Whole retinaImported.

Entry informationi

Entry nameiQ9UQM3_HUMAN
AccessioniPrimary (citable) accession number: Q9UQM3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.