##gff-version 3 Q9UQC2 UniProtKB Chain 1 676 . . . ID=PRO_0000050285;Note=GRB2-associated-binding protein 2 Q9UQC2 UniProtKB Domain 6 117 . . . Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 Q9UQC2 UniProtKB Region 127 178 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Region 341 430 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Region 492 531 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Region 556 643 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Region 656 676 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Motif 351 358 . . . Note=SH3-binding Q9UQC2 UniProtKB Motif 510 519 . . . Note=SH3-binding Q9UQC2 UniProtKB Compositional bias 348 362 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Compositional bias 363 386 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Compositional bias 556 608 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Compositional bias 624 640 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9UQC2 UniProtKB Modified residue 2 2 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UQC2 UniProtKB Modified residue 133 133 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 140 140 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 141 141 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 148 148 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:23186163;Dbxref=PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 149 149 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:23186163;Dbxref=PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 159 159 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 164 164 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 210 210 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 218 218 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 223 223 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:23186163;Dbxref=PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 264 264 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:23186163;Dbxref=PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 265 265 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1S8 Q9UQC2 UniProtKB Modified residue 266 266 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1S8 Q9UQC2 UniProtKB Modified residue 278 278 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 281 281 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 285 285 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UQC2 UniProtKB Modified residue 287 287 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:23186163;Dbxref=PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 293 293 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 331 331 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 368 368 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UQC2 UniProtKB Modified residue 385 385 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 391 391 . . . Note=Phosphothreonine;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:23186163;Dbxref=PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 405 405 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 408 408 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1S8 Q9UQC2 UniProtKB Modified residue 422 422 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UQC2 UniProtKB Modified residue 425 425 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UQC2 UniProtKB Modified residue 452 452 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1S8 Q9UQC2 UniProtKB Modified residue 480 480 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 543 543 . . . Note=Phosphoserine;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:19172738,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:19172738,PMID:23186163 Q9UQC2 UniProtKB Modified residue 622 622 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 623 623 . . . Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Modified residue 643 643 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9UQC2 UniProtKB Alternative sequence 1 38 . . . ID=VSP_038520;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9628581;Dbxref=PMID:15489334,PMID:9628581 Q9UQC2 UniProtKB Natural variant 320 320 . . . ID=VAR_053097;Note=P->L;Dbxref=dbSNP:rs752597583 Q9UQC2 UniProtKB Natural variant 344 344 . . . ID=VAR_020407;Note=P->L;Dbxref=dbSNP:rs2279374 Q9UQC2 UniProtKB Mutagenesis 210 210 . . . Note=Impaired interaction with 14-3-3 proteins and increased EGF-independent cell proliferation%3B when associated with A-391. S->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Mutagenesis 391 391 . . . Note=Impaired interaction with 14-3-3 proteins and increased EGF-independent cell proliferation%3B when associated with A-210. T->A%2CE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19172738;Dbxref=PMID:19172738 Q9UQC2 UniProtKB Helix 515 517 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VWF