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Q9UQC2

- GAB2_HUMAN

UniProt

Q9UQC2 - GAB2_HUMAN

Protein

GRB2-associated-binding protein 2

Gene

GAB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.2 Publications

    GO - Molecular functioni

    1. phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
    2. phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. transmembrane receptor protein tyrosine kinase adaptor activity Source: UniProtKB

    GO - Biological processi

    1. Fc-epsilon receptor signaling pathway Source: Reactome
    2. innate immune response Source: Reactome
    3. osteoclast differentiation Source: UniProtKB
    4. phosphatidylinositol-mediated signaling Source: UniProtKB
    5. positive regulation of cell proliferation Source: UniProtKB
    6. positive regulation of mast cell degranulation Source: UniProtKB
    7. transmembrane receptor protein tyrosine kinase signaling pathway Source: GOC

    Enzyme and pathway databases

    ReactomeiREACT_111040. Signaling by SCF-KIT.
    REACT_121141. Signaling by FGFR1 fusion mutants.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_23891. Interleukin receptor SHC signaling.
    SignaLinkiQ9UQC2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRB2-associated-binding protein 2
    Alternative name(s):
    GRB2-associated binder 2
    Growth factor receptor bound protein 2-associated protein 2
    pp100
    Gene namesi
    Name:GAB2
    Synonyms:KIAA0571
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14458. GAB2.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi210 – 2101S → A or E: Impaired interaction with 14-3-3 proteins and increased EGF-independent cell proliferation; when associated with A-391. 1 Publication
    Mutagenesisi391 – 3911T → A or E: Impaired interaction with 14-3-3 proteins and increased EGF-independent cell proliferation; when associated with A-210. 1 Publication

    Organism-specific databases

    PharmGKBiPA28478.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676GRB2-associated-binding protein 2PRO_0000050285Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei133 – 1331Phosphoserine2 Publications
    Modified residuei140 – 1401Phosphoserine2 Publications
    Modified residuei141 – 1411Phosphoserine2 Publications
    Modified residuei148 – 1481Phosphoserine2 Publications
    Modified residuei149 – 1491Phosphoserine2 Publications
    Modified residuei159 – 1591Phosphoserine2 Publications
    Modified residuei164 – 1641Phosphoserine2 Publications
    Modified residuei210 – 2101Phosphoserine2 Publications
    Modified residuei218 – 2181Phosphoserine2 Publications
    Modified residuei223 – 2231Phosphoserine2 Publications
    Modified residuei264 – 2641Phosphoserine2 Publications
    Modified residuei265 – 2651PhosphothreonineBy similarity
    Modified residuei266 – 2661PhosphotyrosineBy similarity
    Modified residuei278 – 2781Phosphothreonine2 Publications
    Modified residuei281 – 2811Phosphoserine2 Publications
    Modified residuei287 – 2871Phosphothreonine2 Publications
    Modified residuei293 – 2931Phosphotyrosine2 Publications
    Modified residuei331 – 3311Phosphothreonine2 Publications
    Modified residuei385 – 3851Phosphothreonine2 Publications
    Modified residuei391 – 3911Phosphothreonine2 Publications
    Modified residuei405 – 4051Phosphoserine2 Publications
    Modified residuei452 – 4521PhosphotyrosineBy similarity
    Modified residuei480 – 4801Phosphoserine2 Publications
    Modified residuei543 – 5431Phosphoserine3 Publications
    Modified residuei622 – 6221Phosphoserine2 Publications
    Modified residuei623 – 6231Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R By similarity. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL By similarity. Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling.By similarity3 Publications
    Dephosphorylated by PTPN11.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UQC2.
    PaxDbiQ9UQC2.
    PRIDEiQ9UQC2.

    PTM databases

    PhosphoSiteiQ9UQC2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UQC2.
    BgeeiQ9UQC2.
    CleanExiHS_GAB2.
    GenevestigatoriQ9UQC2.

    Organism-specific databases

    HPAiCAB022159.
    HPA000271.

    Interactioni

    Subunit structurei

    Interacts with SHC1; may mediate interaction with receptors By similarity. Interacts with SYK By similarity. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GRB2P6299314EBI-975200,EBI-401755
    PTPN11Q061244EBI-975200,EBI-297779
    YWHABP319464EBI-975200,EBI-359815

    Protein-protein interaction databases

    BioGridi115181. 32 interactions.
    DIPiDIP-36653N.
    IntActiQ9UQC2. 12 interactions.
    MINTiMINT-123618.
    STRINGi9606.ENSP00000302452.

    Structurei

    Secondary structure

    1
    676
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi515 – 5173

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VWFX-ray1.58B508-522[»]
    2W0ZX-ray1.70B350-358[»]
    ProteinModelPortaliQ9UQC2.
    SMRiQ9UQC2. Positions 27-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UQC2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 117112PHPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi351 – 3588SH3-binding
    Motifi510 – 51910SH3-binding

    Domaini

    The SH3-binding motifs mediate interaction with SHC1 and GRB2.By similarity
    The PH domain mediates phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate binding.By similarity

    Sequence similaritiesi

    Belongs to the GAB family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG83177.
    HOGENOMiHOG000236270.
    HOVERGENiHBG051685.
    KOiK08091.
    OMAiMQPTLST.
    OrthoDBiEOG7T4MJJ.
    PhylomeDBiQ9UQC2.
    TreeFamiTF329487.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UQC2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGGGDVVCT GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK    50
    NDHSKKPLRI INLNFCEQVD AGLTFNKKEL QDSFVFDIKT SERTFYLVAE 100
    TEEDMNKWVQ SICQICGFNQ AEESTDSLRN VSSAGHGPRS SPAELSSSSQ 150
    HLLRERKSSA PSHSSQPTLF TFEPPVSNHM QPTLSTSAPQ EYLYLHQCIS 200
    RRAENARSAS FSQGTRASFL MRSDTAVQKL AQGNGHCVNG ISGQVHGFYS 250
    LPKPSRHNTE FRDSTYDLPR SLASHGHTKG SLTGSETDNE DVYTFKTPSN 300
    TLCREFGDLL VDNMDVPATP LSAYQIPRTF TLDKNHNAMT VATPGDSAIA 350
    PPPRPPKPSQ AETPRWGSPQ QRPPISENSR SVAATIPRRN TLPAMDNSRL 400
    HRASSCETYE YPQRGGESAG RSAESMSDGV GSFLPGKMIV GRSDSTNSED 450
    NYVPMNPGSS TLLAMERAGD NSQSVYIPMS PGAHHFDSLG YPSTTLPVHR 500
    GPSRGSEIQP PPVNRNLKPD RKAKPTPLDL RNNTVIDELP FKSPITKSWS 550
    RANHTFNSSS SQYCRPISTQ SITSTDSGDS EENYVPMQNP VSASPVPSGT 600
    NSPAPKKSTG SVDYLALDFQ PSSPSPHRKP STSSVTSDEK VDYVQVDKEK 650
    TQALQNTMQE WTDVRQSSEP SKGAKL 676
    Length:676
    Mass (Da):74,458
    Last modified:May 1, 2000 - v1
    Checksum:i107623FD07D884C9
    GO
    Isoform 2 (identifier: Q9UQC2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-38: Missing.

    Show »
    Length:638
    Mass (Da):69,968
    Checksum:iEA3BCC63C00BBAF0
    GO

    Sequence cautioni

    The sequence BAA25497.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti320 – 3201P → L.
    Corresponds to variant rs2279374 [ dbSNP | Ensembl ].
    VAR_053097
    Natural varianti344 – 3441P → L.
    Corresponds to variant rs2279374 [ dbSNP | Ensembl ].
    VAR_020407

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3838Missing in isoform 2. 2 PublicationsVSP_038520Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018413 mRNA. Translation: BAA76737.1.
    AB011143 mRNA. Translation: BAA25497.2. Different initiation.
    AP002985 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW75057.1.
    CH471076 Genomic DNA. Translation: EAW75058.1.
    BC131711 mRNA. Translation: AAI31712.1.
    BC152459 mRNA. Translation: AAI52460.1.
    CCDSiCCDS8259.1. [Q9UQC2-1]
    CCDS8260.1. [Q9UQC2-2]
    RefSeqiNP_036428.1. NM_012296.3. [Q9UQC2-2]
    NP_536739.1. NM_080491.2. [Q9UQC2-1]
    XP_006718816.1. XM_006718753.1. [Q9UQC2-2]
    UniGeneiHs.429434.

    Genome annotation databases

    EnsembliENST00000340149; ENSP00000343959; ENSG00000033327. [Q9UQC2-2]
    ENST00000361507; ENSP00000354952; ENSG00000033327. [Q9UQC2-1]
    GeneIDi9846.
    KEGGihsa:9846.
    UCSCiuc001ozg.3. human. [Q9UQC2-1]

    Polymorphism databases

    DMDMi46396035.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018413 mRNA. Translation: BAA76737.1 .
    AB011143 mRNA. Translation: BAA25497.2 . Different initiation.
    AP002985 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW75057.1 .
    CH471076 Genomic DNA. Translation: EAW75058.1 .
    BC131711 mRNA. Translation: AAI31712.1 .
    BC152459 mRNA. Translation: AAI52460.1 .
    CCDSi CCDS8259.1. [Q9UQC2-1 ]
    CCDS8260.1. [Q9UQC2-2 ]
    RefSeqi NP_036428.1. NM_012296.3. [Q9UQC2-2 ]
    NP_536739.1. NM_080491.2. [Q9UQC2-1 ]
    XP_006718816.1. XM_006718753.1. [Q9UQC2-2 ]
    UniGenei Hs.429434.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VWF X-ray 1.58 B 508-522 [» ]
    2W0Z X-ray 1.70 B 350-358 [» ]
    ProteinModelPortali Q9UQC2.
    SMRi Q9UQC2. Positions 27-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115181. 32 interactions.
    DIPi DIP-36653N.
    IntActi Q9UQC2. 12 interactions.
    MINTi MINT-123618.
    STRINGi 9606.ENSP00000302452.

    PTM databases

    PhosphoSitei Q9UQC2.

    Polymorphism databases

    DMDMi 46396035.

    Proteomic databases

    MaxQBi Q9UQC2.
    PaxDbi Q9UQC2.
    PRIDEi Q9UQC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340149 ; ENSP00000343959 ; ENSG00000033327 . [Q9UQC2-2 ]
    ENST00000361507 ; ENSP00000354952 ; ENSG00000033327 . [Q9UQC2-1 ]
    GeneIDi 9846.
    KEGGi hsa:9846.
    UCSCi uc001ozg.3. human. [Q9UQC2-1 ]

    Organism-specific databases

    CTDi 9846.
    GeneCardsi GC11M077926.
    HGNCi HGNC:14458. GAB2.
    HPAi CAB022159.
    HPA000271.
    MIMi 606203. gene.
    neXtProti NX_Q9UQC2.
    PharmGKBi PA28478.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83177.
    HOGENOMi HOG000236270.
    HOVERGENi HBG051685.
    KOi K08091.
    OMAi MQPTLST.
    OrthoDBi EOG7T4MJJ.
    PhylomeDBi Q9UQC2.
    TreeFami TF329487.

    Enzyme and pathway databases

    Reactomei REACT_111040. Signaling by SCF-KIT.
    REACT_121141. Signaling by FGFR1 fusion mutants.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_23891. Interleukin receptor SHC signaling.
    SignaLinki Q9UQC2.

    Miscellaneous databases

    ChiTaRSi GAB2. human.
    EvolutionaryTracei Q9UQC2.
    GeneWikii GAB2.
    GenomeRNAii 9846.
    NextBioi 37106.
    PROi Q9UQC2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQC2.
    Bgeei Q9UQC2.
    CleanExi HS_GAB2.
    Genevestigatori Q9UQC2.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors."
      Nishida K., Yoshida Y., Itoh M., Fukada T., Ohtani T., Shirogane T., Atsumi T., Takahashi-Tezuka M., Ishihara K., Hibi M., Hirano T.
      Blood 93:1809-1816(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PTPN11.
      Tissue: Myeloma.
    2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    7. "Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells."
      Podar K., Mostoslavsky G., Sattler M., Tai Y.T., Hayashi T., Catley L.P., Hideshima T., Mulligan R.C., Chauhan D., Anderson K.C.
      J. Biol. Chem. 279:21658-21665(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY HCK, INTERACTION WITH HCK; CRKL PTPN11 AND GRB2.
    8. "The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis."
      Wada T., Nakashima T., Oliveira-dos-Santos A.J., Gasser J., Hara H., Schett G., Penninger J.M.
      Nat. Med. 11:394-399(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TNFRSF11A.
    9. "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
      Brummer T., Larance M., Herrera Abreu M.T., Lyons R.J., Timpson P., Emmerich C.H., Fleuren E.D.G., Lehrbach G.M., Schramek D., Guilhaus M., James D.E., Daly R.J.
      EMBO J. 27:2305-2316(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EGFR; GRB2; PTPN11; PI-3 KINASE; SFN; SHC1; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ AND YWHAZ, MUTAGENESIS OF SER-210 AND THR-391, PHOSPHORYLATION AT SER-133; SER-140; SER-141; SER-148; SER-149; SER-159; SER-164; SER-210; SER-218; SER-223; SER-264; THR-278; SER-281; THR-287; TYR-293; THR-331; THR-385; THR-391; SER-405; SER-480; SER-543; SER-622 AND SER-623.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2."
      Harkiolaki M., Tsirka T., Lewitzky M., Simister P.C., Joshi D., Bird L.E., Jones E.Y., O'Reilly N., Feller S.M.
      Structure 17:809-822(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 350-358 IN COMPLEX WITH GRB2, X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 508-522 IN COMPLEX WITH GRB2.

    Entry informationi

    Entry nameiGAB2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQC2
    Secondary accession number(s): A2RRM2
    , A6NEW9, A7MD36, O60317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3