Reviewed, UniProtKB/Swiss-Prot Q9UQB9 (AURKC_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase 13
    EC=2.7.11.1
Alternative name(s):
    Aurora/Ipl1/Eg2 protein 2
    Aurora/Ipl1-related kinase 3
    Aurora-C

Gene names

Name:	AURKC
Synonyms:	AIE2, AIK3, STK13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Centrosome. Note: Localized to centrosome from anaphase to cytokinesis.
Tissue specificity	Expression is limited to testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.
Involvement in disease	Defects in AURKC are the cause of male infertility with large-headed, multiflagellar, polyploid spermatozoa [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Ref.3 Traceable author statement. Source: ProtInc protein amino acid phosphorylation Ref.3 Traceable author statement. Source: ProtInc
Cellular component	centrosome Ref.3 Traceable author statement. Source: ProtInc nucleus Ref.3 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UQB9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UQB9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Serine/threonine-protein kinase 13		PRO_0000085660
Regions
	Domain	43 – 293	251	Protein kinase
	Nucleotide binding	49 – 57	9	ATP By similarity
Sites
	Active site	166	1	Proton acceptor By similarity
	Binding site	72	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 34	34	Missing in isoform 2.		VSP_004872
	Natural variant	52	1	G → E in a lung adenocarcinoma sample; somatic mutation. Ref.6		VAR_040385
	Natural variant	148	1	E → Q in a lung squamous cell carcinoma sample; somatic mutation. Ref.6		VAR_040386
	Natural variant	244	1	H → Q in a lung adenocarcinoma sample; somatic mutation. Ref.6		VAR_040387
Experimental info
	Sequence conflict	109	1	Y → H in AAC25955. Ref.1
	Sequence conflict	150	1	L → V in AAC77369. Ref.2
	Sequence conflict	193 – 195	3	SLR → LPE in AAC77369. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 41B7DFCA91704201	FASTA	309	35,591
	10 20 30 40 50 60 MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG KGKFGNVYLA 70 80 90 100 110 120 RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH PNILRLYNYF HDARRVYLIL 130 140 150 160 170 180 EYAPRGELYK ELQKSEKLDE QRTATIIEEL ADALTYCHDK KVIHRDIKPE NLLLGFRGEV 190 200 210 220 230 240 KIADFGWSVH TPSLRRKTMC GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE 250 260 270 280 290 300 SASHSETYRR ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV LPPCAQMAS
	Isoform 2. Checksum: 8DF2BDC1F436E266	FASTA	275	32,187
	10 20 30 40 50 60 MRRLTVDDFE IGRPLGKGKF GNVYLARLKE SHFIVALKVL FKSQIEKEGL EHQLRREIEI 70 80 90 100 110 120 QAHLQHPNIL RLYNYFHDAR RVYLILEYAP RGELYKELQK SEKLDEQRTA TIIEELADAL 130 140 150 160 170 180 TYCHDKKVIH RDIKPENLLL GFRGEVKIAD FGWSVHTPSL RRKTMCGTLD YLPPEMIEGR 190 200 210 220 230 240 TYDEKVDLWC IGVLCYELLV GYPPFESASH SETYRRILKV DVRFPLSMPL GARDLISRLL 250 260 270 RYQPLERLPL AQILKHPWVQ AHSRRVLPPC AQMAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators." Tseng T.-C., Chen S.-H., Hsu Y.-P.P., Tang T.K. DNA Cell Biol. 17:823-833(1998) [PubMed: 9809744] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter." Bernard M., Sanseau P., Henry C., Couturier A., Prigent C. Genomics 53:406-409(1998) [PubMed: 9799611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Placenta.
[3]	"Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3." Kimura M., Matsuda Y., Yoshioka T., Okano Y. J. Biol. Chem. 274:7334-7340(1999) [PubMed: 10066797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility." Dieterich K., Soto Rifo R., Faure A.K., Hennebicq S., Ben Amar B., Zahi M., Perrin J., Martinez D., Sele B., Jouk P.-S., Ohlmann T., Rousseaux S., Lunardi J., Ray P.F. Nat. Genet. 39:661-665(2007) [PubMed: 17435757] [Abstract] Cited for: INVOLVEMENT IN MALE INFERTILITY.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-52; GLN-148 AND GLN-244.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF054621 mRNA. Translation: AAC25955.1. AF059681 mRNA. Translation: AAC77369.1. AB017332 mRNA. Translation: BAA76292.1. AC005261 Genomic DNA. No translation available.
IPI	IPI00099756. IPI00332343.
RefSeq	NP_001015878.1. NP_003151.2.
UniGene	Hs.98338
3D structure databases
HSSP	HSSP built from PDB template 1KWP based on UniProtKB P49137.
SMR	Q9UQB9. Positions 36-303.
ModBase	Search...
PTM databases
PhosphoSite	Q9UQB9.
Proteomic databases
PRIDE	Q9UQB9.
Genome annotation databases
Ensembl	ENSG00000105146. Homo sapiens. [Contig view]
GeneID	6795.
KEGG	hsa:6795.
Organism-specific databases
GeneCards	GC19P062433.
H-InvDB	HIX0039923.
HGNC	HGNC:11391. AURKC.
MIM	243060. phenotype. 603495. gene.
Orphanet	137893. Male infertility associated with large-headed multiflagellar polyploid spermatozoa.
PharmGKB	PA36200.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UQB9.
HOVERGEN	Q9UQB9.
OMA	Q9UQB9. QPSSPAM.
Enzyme and pathway databases
BRENDA	2.7.11.1. 247.
Pathway_Interaction_DB	aurora_b_pathway. Aurora B signaling. aurora_c_pathway. Aurora C signaling. aurora_kinase_pathway. Signaling by Aurora kinases.
Gene expression databases
ArrayExpress	Q9UQB9.
Bgee	Q9UQB9.
CleanEx	HS_AURKC.
GermOnline	ENSG00000105146. Homo sapiens.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	Q9UQB9.
NextBio	26545.
SOURCE	Search...

Entry information

Entry name

AURKC_HUMAN

Accession

Primary (citable) accession number: Q9UQB9
Secondary accession number(s): O60681, O75442, Q9UPK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)