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Q9UQB9

- AURKC_HUMAN

UniProt

Q9UQB9 - AURKC_HUMAN

Protein

Aurora kinase C

Gene

AURKC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.6 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which acts also as an activator.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPPROSITE-ProRule annotation
    Active sitei166 – 1661Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: UniProtKB
    3. protein serine/threonine/tyrosine kinase activity Source: UniProtKB
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. attachment of spindle microtubules to kinetochore Source: UniProtKB
    2. cytokinesis Source: ProtInc
    3. histone modification Source: UniProtKB
    4. meiotic nuclear division Source: UniProtKB-KW
    5. positive regulation of cytokinesis Source: UniProtKB
    6. protein phosphorylation Source: UniProtKB
    7. spindle midzone assembly involved in mitosis Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Meiosis, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ9UQB9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aurora kinase C (EC:2.7.11.1)
    Alternative name(s):
    Aurora 3
    Aurora/IPL1-related kinase 3
    Short name:
    ARK-3
    Short name:
    Aurora-related kinase 3
    Aurora/IPL1/Eg2 protein 2
    Serine/threonine-protein kinase 13
    Serine/threonine-protein kinase aurora-C
    Gene namesi
    Name:AURKC
    Synonyms:AIE2, AIK3, AIRK3, ARK3, STK13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11391. AURKC.

    Subcellular locationi

    Nucleus. Chromosome. Chromosomecentromere. Cytoplasmcytoskeletonspindle
    Note: Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. chromosome passenger complex Source: UniProtKB
    3. condensed chromosome Source: UniProtKB
    4. cytoplasm Source: UniProtKB-KW
    5. midbody Source: UniProtKB
    6. nucleus Source: UniProtKB-SubCell
    7. spindle Source: UniProtKB
    8. spindle midzone Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi72 – 721K → R: Impairs kinase activity. 2 Publications
    Mutagenesisi166 – 1661D → Y: Impairs kinase activity, and keeps AURKC with the chromosomes until the end of mitosis. 1 Publication
    Mutagenesisi198 – 1981T → A: Impairs kinase activity. 2 Publications

    Organism-specific databases

    MIMi243060. phenotype.
    Orphaneti137893. Male infertility due to large-headed multiflagellar polyploid spermatozoa.
    PharmGKBiPA36200.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Aurora kinase CPRO_0000085660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei198 – 1981Phosphothreonine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9UQB9.
    PRIDEiQ9UQB9.

    PTM databases

    PhosphoSiteiQ9UQB9.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.1 Publication

    Inductioni

    Expression is cell cycle-regulated, with an increase during G2 and M phases.2 Publications

    Gene expression databases

    ArrayExpressiQ9UQB9.
    BgeeiQ9UQB9.
    CleanExiHS_AURKC.
    GenevestigatoriQ9UQB9.

    Organism-specific databases

    HPAiHPA034859.

    Interactioni

    Subunit structurei

    Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts directly with BIRC5/survivin and INCENP. Interacts with TACC1.4 Publications

    Protein-protein interaction databases

    BioGridi112671. 14 interactions.
    IntActiQ9UQB9. 4 interactions.
    STRINGi9606.ENSP00000302898.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQB9.
    SMRiQ9UQB9. Positions 36-303.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 293251Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233016.
    HOVERGENiHBG108519.
    InParanoidiQ9UQB9.
    KOiK11480.
    OMAiILKHPWV.
    OrthoDBiEOG74FF1F.
    PhylomeDBiQ9UQB9.
    TreeFamiTF105331.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UQB9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG    50
    KGKFGNVYLA RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH 100
    PNILRLYNYF HDARRVYLIL EYAPRGELYK ELQKSEKLDE QRTATIIEEL 150
    ADALTYCHDK KVIHRDIKPE NLLLGFRGEV KIADFGWSVH TPSLRRKTMC 200
    GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE SASHSETYRR 250
    ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV 300
    LPPCAQMAS 309
    Length:309
    Mass (Da):35,591
    Last modified:May 1, 2000 - v1
    Checksum:i41B7DFCA91704201
    GO
    Isoform 2 (identifier: Q9UQB9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-34: Missing.

    Show »
    Length:275
    Mass (Da):32,187
    Checksum:i8DF2BDC1F436E266
    GO
    Isoform 3 (identifier: Q9UQB9-3) [UniParc]FASTAAdd to Basket

    Also known as: Aurora C-SV

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MSSPRAVVQLGKAQPAGEEL → M

    Show »
    Length:290
    Mass (Da):33,672
    Checksum:iD07FD6988B208140
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091Y → H in AAC25955. (PubMed:9809744)Curated
    Sequence conflicti150 – 1501L → V in AAC77369. (PubMed:9799611)Curated
    Sequence conflicti193 – 1953SLR → LPE in AAC77369. (PubMed:9799611)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521G → E in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040385
    Natural varianti148 – 1481E → Q in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
    VAR_040386
    Natural varianti244 – 2441H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_040387

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3434Missing in isoform 2. 2 PublicationsVSP_004872Add
    BLAST
    Alternative sequencei1 – 2020MSSPR…AGEEL → M in isoform 3. 1 PublicationVSP_041095Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054621 mRNA. Translation: AAC25955.1.
    AF059681 mRNA. Translation: AAC77369.1.
    AB017332 mRNA. Translation: BAA76292.1.
    AY661554 mRNA. Translation: AAT64422.1.
    AC005261 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72485.1.
    BC075064 mRNA. Translation: AAH75064.2.
    CCDSiCCDS33128.1. [Q9UQB9-1]
    CCDS46205.1. [Q9UQB9-3]
    CCDS46206.1. [Q9UQB9-2]
    RefSeqiNP_001015878.1. NM_001015878.1. [Q9UQB9-1]
    NP_001015879.1. NM_001015879.1. [Q9UQB9-3]
    NP_003151.2. NM_003160.2. [Q9UQB9-2]
    UniGeneiHs.98338.

    Genome annotation databases

    EnsembliENST00000302804; ENSP00000302898; ENSG00000105146. [Q9UQB9-1]
    ENST00000415300; ENSP00000407162; ENSG00000105146. [Q9UQB9-3]
    ENST00000448930; ENSP00000406798; ENSG00000105146. [Q9UQB9-2]
    ENST00000598785; ENSP00000471830; ENSG00000105146. [Q9UQB9-2]
    GeneIDi6795.
    KEGGihsa:6795.
    UCSCiuc002qoc.3. human. [Q9UQB9-3]
    uc002qod.3. human. [Q9UQB9-1]

    Polymorphism databases

    DMDMi27805738.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF054621 mRNA. Translation: AAC25955.1 .
    AF059681 mRNA. Translation: AAC77369.1 .
    AB017332 mRNA. Translation: BAA76292.1 .
    AY661554 mRNA. Translation: AAT64422.1 .
    AC005261 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72485.1 .
    BC075064 mRNA. Translation: AAH75064.2 .
    CCDSi CCDS33128.1. [Q9UQB9-1 ]
    CCDS46205.1. [Q9UQB9-3 ]
    CCDS46206.1. [Q9UQB9-2 ]
    RefSeqi NP_001015878.1. NM_001015878.1. [Q9UQB9-1 ]
    NP_001015879.1. NM_001015879.1. [Q9UQB9-3 ]
    NP_003151.2. NM_003160.2. [Q9UQB9-2 ]
    UniGenei Hs.98338.

    3D structure databases

    ProteinModelPortali Q9UQB9.
    SMRi Q9UQB9. Positions 36-303.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112671. 14 interactions.
    IntActi Q9UQB9. 4 interactions.
    STRINGi 9606.ENSP00000302898.

    Chemistry

    BindingDBi Q9UQB9.
    ChEMBLi CHEMBL3935.
    GuidetoPHARMACOLOGYi 1938.

    PTM databases

    PhosphoSitei Q9UQB9.

    Polymorphism databases

    DMDMi 27805738.

    Proteomic databases

    PaxDbi Q9UQB9.
    PRIDEi Q9UQB9.

    Protocols and materials databases

    DNASUi 6795.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302804 ; ENSP00000302898 ; ENSG00000105146 . [Q9UQB9-1 ]
    ENST00000415300 ; ENSP00000407162 ; ENSG00000105146 . [Q9UQB9-3 ]
    ENST00000448930 ; ENSP00000406798 ; ENSG00000105146 . [Q9UQB9-2 ]
    ENST00000598785 ; ENSP00000471830 ; ENSG00000105146 . [Q9UQB9-2 ]
    GeneIDi 6795.
    KEGGi hsa:6795.
    UCSCi uc002qoc.3. human. [Q9UQB9-3 ]
    uc002qod.3. human. [Q9UQB9-1 ]

    Organism-specific databases

    CTDi 6795.
    GeneCardsi GC19P057743.
    HGNCi HGNC:11391. AURKC.
    HPAi HPA034859.
    MIMi 243060. phenotype.
    603495. gene.
    neXtProti NX_Q9UQB9.
    Orphaneti 137893. Male infertility due to large-headed multiflagellar polyploid spermatozoa.
    PharmGKBi PA36200.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233016.
    HOVERGENi HBG108519.
    InParanoidi Q9UQB9.
    KOi K11480.
    OMAi ILKHPWV.
    OrthoDBi EOG74FF1F.
    PhylomeDBi Q9UQB9.
    TreeFami TF105331.

    Enzyme and pathway databases

    SignaLinki Q9UQB9.

    Miscellaneous databases

    GeneWikii AURKC.
    GenomeRNAii 6795.
    NextBioi 26545.
    PROi Q9UQB9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQB9.
    Bgeei Q9UQB9.
    CleanExi HS_AURKC.
    Genevestigatori Q9UQB9.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators."
      Tseng T.-C., Chen S.-H., Hsu Y.-P.P., Tang T.K.
      DNA Cell Biol. 17:823-833(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
      Tissue: Testis.
    2. "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter."
      Bernard M., Sanseau P., Henry C., Couturier A., Prigent C.
      Genomics 53:406-409(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Placenta.
    3. "Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3."
      Kimura M., Matsuda Y., Yoshioka T., Okano Y.
      J. Biol. Chem. 274:7334-7340(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, SUBCELLULAR LOCATION.
      Tissue: Testis.
    4. "Cloning and characterization of a novel human Aurora C splicing variant."
      Yan X., Wu Y., Li Q., Cao L., Liu X., Saiyin H., Yu L.
      Biochem. Biophys. Res. Commun. 328:353-361(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, FUNCTION, MUTAGENESIS OF THR-198, SUBCELLULAR LOCATION.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    8. "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells."
      Sasai K., Katayama H., Stenoien D.L., Fujii S., Honda R., Kimura M., Okano Y., Tatsuka M., Suzuki F., Nigg E.A., Earnshaw W.C., Brinkley W.R., Sen S.
      Cell Motil. Cytoskeleton 59:249-263(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH INCENP, MUTAGENESIS OF LYS-72.
    9. "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C."
      Li X., Sakashita G., Matsuzaki H., Sugimoto K., Kimura K., Hanaoka F., Taniguchi H., Furukawa K., Urano T.
      J. Biol. Chem. 279:47201-47211(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CDC COMPLEX, SUBCELLULAR LOCATION, ENZYME REGULATION, FUNCTION, MUTAGENESIS OF LYS-72 AND THR-198.
    10. "Aurora C is directly associated with Survivin and required for cytokinesis."
      Yan X., Cao L., Li Q., Wu Y., Zhang H., Saiyin H., Liu X., Zhang X., Shi Q., Yu L.
      Genes Cells 10:617-626(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CDC COMPLEX, INTERACTION WITH BIRC5, SUBCELLULAR LOCATION, FUNCTION, MUTAGENESIS OF ASP-166.
    11. "Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility."
      Dieterich K., Soto Rifo R., Faure A.K., Hennebicq S., Ben Amar B., Zahi M., Perrin J., Martinez D., Sele B., Jouk P.-S., Ohlmann T., Rousseaux S., Lunardi J., Ray P.F.
      Nat. Genet. 39:661-665(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SPGF5.
    12. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TACC1.
    13. "A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development."
      Avo Santos M., van de Werken C., de Vries M., Jahr H., Vromans M.J., Laven J.S., Fauser B.C., Kops G.J., Lens S.M., Baart E.B.
      Hum. Reprod. 26:1868-1881(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    14. "A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis."
      Ben Khelifa M., Zouari R., Harbuz R., Halouani L., Arnoult C., Lunardi J., Ray P.F.
      Mol. Hum. Reprod. 17:762-768(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN SPGF5.
    15. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-52; GLN-148 AND GLN-244.

    Entry informationi

    Entry nameiAURKC_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQB9
    Secondary accession number(s): O60681
    , O75442, Q6AZY8, Q6DLZ0, Q9UPK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3