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Reviewed, UniProtKB/Swiss-Prot Q9UQB9 (AURKC_HUMAN)

Last modified June 16, 2009. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Serine/threonine-protein kinase 13
    EC=2.7.11.1
Alternative name(s):
    Aurora/Ipl1/Eg2 protein 2
    Aurora/Ipl1-related kinase 3
    Aurora-C
Gene names
Name: AURKC
Synonyms: AIE2, AIK3, STK13
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Centrosome. Note: Localized to centrosome from anaphase to cytokinesis.

Tissue specificity

Expression is limited to testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.

Involvement in disease

Defects in AURKC are the cause of male infertility with large-headed, multiflagellar, polyploid spermatozoa [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

Contains 1 protein kinase domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UQB9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UQB9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Serine/threonine-protein kinase 13
PRO_0000085660

Regions

Domain43 – 293251Protein kinase
Nucleotide binding49 – 579ATP By similarity

Sites

Active site1661Proton acceptor By similarity
Binding site721ATP By similarity

Natural variations

Alternative sequence1 – 3434Missing in isoform 2.
VSP_004872
Natural variant521G → E in a lung adenocarcinoma sample; somatic mutation. Ref.6
VAR_040385
Natural variant1481E → Q in a lung squamous cell carcinoma sample; somatic mutation. Ref.6
VAR_040386
Natural variant2441H → Q in a lung adenocarcinoma sample; somatic mutation. Ref.6
VAR_040387

Experimental info

Sequence conflict1091Y → H in AAC25955. Ref.1
Sequence conflict1501L → V in AAC77369. Ref.2
Sequence conflict193 – 1953SLR → LPE in AAC77369. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 41B7DFCA91704201

FASTA30935,591
        10         20         30         40         50         60 
MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG KGKFGNVYLA 

        70         80         90        100        110        120 
RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH PNILRLYNYF HDARRVYLIL 

       130        140        150        160        170        180 
EYAPRGELYK ELQKSEKLDE QRTATIIEEL ADALTYCHDK KVIHRDIKPE NLLLGFRGEV 

       190        200        210        220        230        240 
KIADFGWSVH TPSLRRKTMC GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE 

       250        260        270        280        290        300 
SASHSETYRR ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV 


LPPCAQMAS 

« Hide

Isoform 2.

Checksum: 8DF2BDC1F436E266
Show »

FASTA27532,187

References

« Hide 'large scale' references
[1]"Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators."
Tseng T.-C., Chen S.-H., Hsu Y.-P.P., Tang T.K.
DNA Cell Biol. 17:823-833(1998) [PubMed: 9809744] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter."
Bernard M., Sanseau P., Henry C., Couturier A., Prigent C.
Genomics 53:406-409(1998) [PubMed: 9799611] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Placenta.
[3]"Cell cycle-dependent expression and centrosome localization of a third human Aurora/Ipl1-related protein kinase, AIK3."
Kimura M., Matsuda Y., Yoshioka T., Okano Y.
J. Biol. Chem. 274:7334-7340(1999) [PubMed: 10066797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Testis.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility."
Dieterich K., Soto Rifo R., Faure A.K., Hennebicq S., Ben Amar B., Zahi M., Perrin J., Martinez D., Sele B., Jouk P.-S., Ohlmann T., Rousseaux S., Lunardi J., Ray P.F.
Nat. Genet. 39:661-665(2007) [PubMed: 17435757] [Abstract]
Cited for: INVOLVEMENT IN MALE INFERTILITY.
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-52; GLN-148 AND GLN-244.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF054621 mRNA. Translation: AAC25955.1.
AF059681 mRNA. Translation: AAC77369.1.
AB017332 mRNA. Translation: BAA76292.1.
AC005261 Genomic DNA. No translation available.
IPIIPI00099756.
IPI00332343.
RefSeqNP_001015878.1.
NP_003151.2.
UniGeneHs.98338

3D structure databases

HSSPHSSP built from PDB template 1KWP based on UniProtKB P49137.
SMRQ9UQB9. Positions 36-303.
ModBaseSearch...

PTM databases

PhosphoSiteQ9UQB9.

Proteomic databases

PRIDEQ9UQB9.

Genome annotation databases

EnsemblENSG00000105146. Homo sapiens. [Contig view]
GeneID6795.
KEGGhsa:6795.

Organism-specific databases

GeneCardsGC19P062433.
H-InvDBHIX0039923.
HGNCHGNC:11391. AURKC.
MIM243060. phenotype.
603495. gene.
Orphanet137893. Male infertility associated with large-headed multiflagellar polyploid spermatozoa.
PharmGKBPA36200.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9UQB9.
HOVERGENQ9UQB9.
OMAQ9UQB9. QPSSPAM.

Enzyme and pathway databases

BRENDA2.7.11.1. 247.
Pathway_Interaction_DBaurora_b_pathway. Aurora B signaling.
aurora_c_pathway. Aurora C signaling.
aurora_kinase_pathway. Signaling by Aurora kinases.

Gene expression databases

ArrayExpressQ9UQB9.
BgeeQ9UQB9.
CleanExHS_AURKC.
GermOnlineENSG00000105146. Homo sapiens.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

BindingDBQ9UQB9.
NextBio26545.
SOURCESearch...

Entry information

Entry nameAURKC_HUMAN
AccessionPrimary (citable) accession number: Q9UQB9
Secondary accession number(s): O60681, O75442, Q9UPK5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: May 1, 2000
Last modified: June 16, 2009
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents