Reviewed, UniProtKB/Swiss-Prot Q9UQB3 (CTND2_HUMAN)

Names and origin

Protein names

Recommended name:
    Catenin delta-2
Alternative name(s):
    Delta-catenin
    Neural plakophilin-related ARM-repeat protein
      Short name=NPRAP
    Neurojungin
    GT24

Gene names

Name:	CTNND2
Synonyms:	NPRAP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions as a transcriptional activator when bound to ZBTB33 By similarity. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
Subunit structure	Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 By similarity. Binds to PSEN1. Interacts with RGNEF.
Subcellular location	Nucleus By similarity. Cell junction › adherens junction By similarity.
Tissue specificity	Predominantly expressed in brain.
Post-translational modification	O-glycosylated By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.10
Sequence similarities	Belongs to the beta-catenin family. Contains 9 ARM repeats.
Sequence caution	The sequence AAB88185.1 differs from that shown. Reason: Frameshift at position 913.

Ontologies

Keywords
Biological process	Cell adhesion Transcription Transcription regulation
Cellular component	Cell junction Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Molecular function	Developmental protein
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW neuron adhesion Non-traceable author statement. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Ref.1 Traceable author statement. Source: ProtInc transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	adherens junction Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasm Ref.6 Traceable author statement. Source: ProtInc nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9UQB3-1)

Also known as: NPRAPa;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UQB3-2)

Also known as: NPRAPc;

The sequence of this isoform differs from the canonical sequence as follows:
     823-880: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1225	1225	Catenin delta-2		PRO_0000064299
Regions
	Repeat	394 – 438	45	ARM 1
	Repeat	540 – 579	40	ARM 2
	Repeat	582 – 621	40	ARM 3
	Repeat	626 – 666	41	ARM 4
	Repeat	682 – 724	43	ARM 5
	Repeat	728 – 773	46	ARM 6
	Repeat	835 – 875	41	ARM 7
	Repeat	882 – 921	40	ARM 8
	Repeat	975 – 1018	44	ARM 9
	Coiled coil	49 – 84	36	Potential
	Compositional bias	216 – 226	11	Poly-Pro
	Compositional bias	811 – 817	7	Poly-Lys
Amino acid modifications
	Modified residue	32	1	Phosphoserine By similarity
	Modified residue	267	1	Phosphoserine By similarity
	Modified residue	276	1	Phosphoserine By similarity
	Modified residue	415	1	Phosphoserine By similarity
	Modified residue	474	1	Phosphoserine Ref.10
	Modified residue	516	1	Phosphotyrosine By similarity
	Modified residue	534	1	Phosphoserine By similarity
	Modified residue	537	1	Phosphoserine By similarity
	Modified residue	1072	1	Phosphoserine By similarity
	Modified residue	1076	1	Phosphoserine By similarity
	Modified residue	1127	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	823 – 880	58	Missing in isoform 2.		VSP_006746
	Natural variant	1159	1	P → S in a colorectal cancer sample; somatic mutation. Ref.12		VAR_036162
Experimental info
	Sequence conflict	426	1	D → V in AAC63103. Ref.1
	Sequence conflict	443	1	D → V in AAC63103. Ref.1
	Sequence conflict	725	1	A → P in AAC63103. Ref.1
	Sequence conflict	894	1	L → R Ref.1
	Sequence conflict	894	1	L → R Ref.9
	Sequence conflict	909	1	V → A Ref.1
	Sequence conflict	909	1	V → A Ref.9
	Sequence conflict	980	1	A → G in AAB97957. Ref.6
	Sequence conflict	1102	1	A → G Ref.5
	Sequence conflict	1102	1	A → G Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (NPRAPa) [UniParc]. Last modified December 20, 2005. Version 3. Checksum: 4A24ACC3E22BFE83	FASTA	1,225	132,656
	10 20 30 40 50 60 MFARKPPGAA PLGAMPVPDQ PSSASEKTSS LSPGLNTSNG DGSETETTSA ILASVKEQEL 70 80 90 100 110 120 QFERLTRELE AERQIVASQL ERCKLGSETG SMSSMSSAEE QFQWQSQDGQ KDIEDELTTG 130 140 150 160 170 180 LELVDSCIRS LQESGILDPQ DYSTGERPSL LSQSALQLNS KPEGSFQYPA SYHSNQTLAL 190 200 210 220 230 240 GETTPSQLPA RGTQARATGQ SFSQGTTSRA GHLAGPEPAP PPPPPPREPF APSLGSAFHL 250 260 270 280 290 300 PDAPPAAAAA ALYYSSSTLP APPRGGSPLA APQGGSPTKL QRGGSAPEGA TYAAPRGSSP 310 320 330 340 350 360 KQSPSRLAKS YSTSSPINIV VSSAGLSPIR VTSPPTVQST ISSSPIHQLS STIGTYATLS 370 380 390 400 410 420 PTKRLVHASE QYSKHSQELY ATATLQRPGS LAAGSRASYS SQHGHLGPEL RALQSPEHHI 430 440 450 460 470 480 DPIYEDRVYQ KPPMRSLSQS QGDPLPPAHT GTYRTSTAPS SPGVDSVPLQ RTGSQHGPQN 490 500 510 520 530 540 AAAATFQRAS YAAGPASNYA DPYRQLQYCP SVESPYSKSG PALPPEGTLA RSPSIDSIQK 550 560 570 580 590 600 DPREFGWRDP ELPEVIQMLQ HQFPSVQSNA AAYLQHLCFG DNKIKAEIRR QGGIQLLVDL 610 620 630 640 650 660 LDHRMTEVHR SACGALRNLV YGKANDDNKI ALKNCGGIPA LVRLLRKTTD LEIRELVTGV 670 680 690 700 710 720 LWNLSSCDAL KMPIIQDALA VLTNAVIIPH SGWENSPLQD DRKIQLHSSQ VLRNATGCLR 730 740 750 760 770 780 NVSSAGEEAR RRMRECDGLT DALLYVIQSA LGSSEIDSKT VENCVCILRN LSYRLAAETS 790 800 810 820 830 840 QGQHMGTDEL DGLLCGEANG KDAESSGCWG KKKKKKKSQD QWDGVGPLPD CAEPPKGIQM 850 860 870 880 890 900 LWHPSIVKPY LTLLSECSNP DTLEGAAGAL QNLAAGSWKW SVYIRAAVRK EKGLPILVEL 910 920 930 940 950 960 LRIDNDRVVC AVATALRNMA LDVRNKELIG KYAMRDLVHR LPGGNNSNNT ASKAMSDDTV 970 980 990 1000 1010 1020 TAVCCTLHEV ITKNMENAKA LRDAGGIEKL VGISKSKGDK HSPKVVKAAS QVLNSMWQYR 1030 1040 1050 1060 1070 1080 DLRSLYKKDG WSQYHFVASS STIERDRQRP YSSSRTPSIS PVRVSPNNRS ASAPASPREM 1090 1100 1110 1120 1130 1140 ISLKERKTDY ECTGSNATYH GAKGEHTSRK DAMTAQNTGI STLYRNSYGA PAEDIKHNQV 1150 1160 1170 1180 1190 1200 SAQPVPQEPS RKDYETYQPF QNSTRNYDES FFEDQVHHRP PASEYTMHLG LKSTGNYVDF 1210 1220 YSAARPYSEL NYETSHYPAS PDSWV
	Isoform 2 (NPRAPc). Checksum: DE45985C1B006DFA	FASTA	1,167	126,529
	10 20 30 40 50 60 MFARKPPGAA PLGAMPVPDQ PSSASEKTSS LSPGLNTSNG DGSETETTSA ILASVKEQEL 70 80 90 100 110 120 QFERLTRELE AERQIVASQL ERCKLGSETG SMSSMSSAEE QFQWQSQDGQ KDIEDELTTG 130 140 150 160 170 180 LELVDSCIRS LQESGILDPQ DYSTGERPSL LSQSALQLNS KPEGSFQYPA SYHSNQTLAL 190 200 210 220 230 240 GETTPSQLPA RGTQARATGQ SFSQGTTSRA GHLAGPEPAP PPPPPPREPF APSLGSAFHL 250 260 270 280 290 300 PDAPPAAAAA ALYYSSSTLP APPRGGSPLA APQGGSPTKL QRGGSAPEGA TYAAPRGSSP 310 320 330 340 350 360 KQSPSRLAKS YSTSSPINIV VSSAGLSPIR VTSPPTVQST ISSSPIHQLS STIGTYATLS 370 380 390 400 410 420 PTKRLVHASE QYSKHSQELY ATATLQRPGS LAAGSRASYS SQHGHLGPEL RALQSPEHHI 430 440 450 460 470 480 DPIYEDRVYQ KPPMRSLSQS QGDPLPPAHT GTYRTSTAPS SPGVDSVPLQ RTGSQHGPQN 490 500 510 520 530 540 AAAATFQRAS YAAGPASNYA DPYRQLQYCP SVESPYSKSG PALPPEGTLA RSPSIDSIQK 550 560 570 580 590 600 DPREFGWRDP ELPEVIQMLQ HQFPSVQSNA AAYLQHLCFG DNKIKAEIRR QGGIQLLVDL 610 620 630 640 650 660 LDHRMTEVHR SACGALRNLV YGKANDDNKI ALKNCGGIPA LVRLLRKTTD LEIRELVTGV 670 680 690 700 710 720 LWNLSSCDAL KMPIIQDALA VLTNAVIIPH SGWENSPLQD DRKIQLHSSQ VLRNATGCLR 730 740 750 760 770 780 NVSSAGEEAR RRMRECDGLT DALLYVIQSA LGSSEIDSKT VENCVCILRN LSYRLAAETS 790 800 810 820 830 840 QGQHMGTDEL DGLLCGEANG KDAESSGCWG KKKKKKKSQD QWSVYIRAAV RKEKGLPILV 850 860 870 880 890 900 ELLRIDNDRV VCAVATALRN MALDVRNKEL IGKYAMRDLV HRLPGGNNSN NTASKAMSDD 910 920 930 940 950 960 TVTAVCCTLH EVITKNMENA KALRDAGGIE KLVGISKSKG DKHSPKVVKA ASQVLNSMWQ 970 980 990 1000 1010 1020 YRDLRSLYKK DGWSQYHFVA SSSTIERDRQ RPYSSSRTPS ISPVRVSPNN RSASAPASPR 1030 1040 1050 1060 1070 1080 EMISLKERKT DYECTGSNAT YHGAKGEHTS RKDAMTAQNT GISTLYRNSY GAPAEDIKHN 1090 1100 1110 1120 1130 1140 QVSAQPVPQE PSRKDYETYQ PFQNSTRNYD ESFFEDQVHH RPPASEYTMH LGLKSTGNYV 1150 1160 DFYSAARPYS ELNYETSHYP ASPDSWV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Presenilin 1 interaction in the brain with a novel member of the Armadillo family." Zhou J., Liyanage U., Medina M., Ho C., Simmons A.D., Lovett M., Kosik K.S. NeuroReport 8:2085-2090(1997) [PubMed: 9223106] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PSEN1.
[2]	"Delta-catenin, an adhesive junction-associated protein which promotes cell scattering." Lu Q., Paredes M., Medina M., Zhou J., Cavallo R., Peifer M., Orecchio L., Kosik K.S. J. Cell Biol. 144:519-532(1999) [PubMed: 9971746] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION. Tissue: Brain.
[3]	"Isolation of human delta-catenin and its binding specificity with presenilin 1." Tanahashi H., Tabira T. NeuroReport 10:563-568(1999) [PubMed: 10208590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PSEN1. Tissue: Fetal brain.
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin." Levesque G., Yu G., Nishimura M., Zhang D.M., Levesque L., Yu H., Xu D., Liang Y., Rogaeva E.A., Ikeda M., Duthie M., Murgolo N., Wang L., VanderVere P., Bayne M.L., Strader C.D., Rommens J.M., Fraser P.E., St George-Hyslop P.H. J. Neurochem. 72:999-1008(1999) [PubMed: 10037471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 186-1225 (ISOFORM 1), INTERACTION WITH PSEN1. Tissue: Brain.
[6]	"Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family." Paffenholz R., Franke W.W. Differentiation 61:293-304(1997) [PubMed: 9342840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-1225 (ISOFORM 1), ALTERNATIVE SPLICING. Tissue: Fetal brain.
[7]	"A novel gene from the arm family." Fraser P.E., Levesque G., Rogaeva E.A., Yu G., St George-Hyslop P.H. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1225 (ISOFORM 1).
[8]	Yu W., Sarginson J., Gibbs R.A. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 746-1225 (ISOFORM 1). Tissue: Brain.
[9]	"Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library." Simmons A.D., Overhauser J., Lovett M. Genome Res. 7:118-127(1997) [PubMed: 9049630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 865-1225 (ISOFORMS 1/2).
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-474, MASS SPECTROMETRY.
[11]	"Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation." Kim H., Han J.-R., Park J., Oh M., James S.E., Chang S., Lu Q., Lee K.Y., Ki H., Song W.-J., Kim K. J. Biol. Chem. 283:977-987(2008) [PubMed: 17993462] [Abstract] Cited for: INTERACTION WITH RGNEF.
[12]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1159.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U96136 mRNA. Translation: AAC63103.1. AB013805 mRNA. Translation: BAA36163.1. AC003089 Genomic DNA. Translation: AAB83940.1. AC003954 Genomic DNA. No translation available. AC004633 Genomic DNA. No translation available. AC004648 Genomic DNA. No translation available. AC005367 Genomic DNA. No translation available. AC005610 Genomic DNA. No translation available. AC010433 Genomic DNA. No translation available. AC010626 Genomic DNA. No translation available. AC113390 Genomic DNA. No translation available. AC127460 Genomic DNA. No translation available. U81004 mRNA. Translation: AAD00453.1. U52351 mRNA. Translation: AAB97957.1. U72665 mRNA. Translation: AAB68599.1. Different initiation. AF035302 mRNA. Translation: AAB88185.1. Frameshift. U52828 mRNA. Translation: AAB96357.1.
IPI	IPI00220032. IPI00301317.
RefSeq	NP_001323.1.
UniGene	Hs.314543
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9UQB3.
Proteomic databases
PRIDE	Q9UQB3.
Genome annotation databases
Ensembl	ENSG00000169862. Homo sapiens. [Contig view]
GeneID	1501.
KEGG	hsa:1501.
Organism-specific databases
GeneCards	GC05M011024.
H-InvDB	HIX0024778.
HGNC	HGNC:2516. CTNND2.
MIM	604275. gene.
Orphanet	281. Monosomy 5p.
PharmGKB	PA27017.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9UQB3.
OMA	Q9UQB3. LPPAHTG.
Gene expression databases
ArrayExpress	Q9UQB3.
Bgee	Q9UQB3.
CleanEx	HS_CTNND2.
GermOnline	ENSG00000169862. Homo sapiens.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR000225. Armadillo. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 1 hit.
Pfam	PF00514. Arm. 5 hits. [Graphical view]
SMART	SM00185. ARM. 7 hits. [Graphical view]
PROSITE	PS50176. ARM_REPEAT. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	6217.
SOURCE	Search...

Entry information

Entry name

CTND2_HUMAN

Accession

Primary (citable) accession number: Q9UQB3
Secondary accession number(s): O00379 , O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	December 20, 2005
Last modified:	June 16, 2009
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)