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Protein

Catenin delta-2

Gene

CTNND2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of Wnt signaling (PubMed:25807484). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.By similarity2 Publications

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: ProtInc
  • dendritic spine morphogenesis Source: UniProtKB
  • regulation of canonical Wnt signaling pathway Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • signal transduction Source: ProtInc
  • single organismal cell-cell adhesion Source: InterPro
  • synapse organization Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169862-MONOMER.
SignaLinkiQ9UQB3.

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin delta-2
Alternative name(s):
Delta-catenin
GT24
Neural plakophilin-related ARM-repeat protein
Short name:
NPRAP
Neurojungin
Gene namesi
Name:CTNND2
Synonyms:NPRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2516. CTNND2.

Subcellular locationi

  • Nucleus By similarity
  • Cell junctionadherens junction By similarity
  • Cell projectiondendrite By similarity
  • Perikaryon 1 Publication

GO - Cellular componenti

  • adherens junction Source: UniProtKB-SubCell
  • cytoplasm Source: ProtInc
  • dendrite Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • perikaryon Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in CTNND2, including deleterious missense and copy number variants (CNVs) are involved in autism, a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.

Keywords - Diseasei

Autism, Autism spectrum disorder, Disease mutation

Organism-specific databases

DisGeNETi1501.
MalaCardsiCTNND2.
OpenTargetsiENSG00000169862.
Orphaneti281. Monosomy 5p.
PharmGKBiPA27017.

Polymorphism and mutation databases

DMDMi84028193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642991 – 1225Catenin delta-2Add BLAST1225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209Omega-N-methylarginineBy similarity1
Modified residuei264Omega-N-methylarginineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei282Omega-N-methylarginineBy similarity1
Modified residuei296Omega-N-methylarginineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei514PhosphoserineBy similarity1
Modified residuei516PhosphotyrosineBy similarity1
Modified residuei1065PhosphoserineBy similarity1
Modified residuei1076PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.By similarity
Phosphorylated by CDK5 (By similarity). Phosphorylated by GSK3B (PubMed:19706605).By similarity1 Publication

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9UQB3.
PeptideAtlasiQ9UQB3.
PRIDEiQ9UQB3.

PTM databases

iPTMnetiQ9UQB3.
PhosphoSitePlusiQ9UQB3.

Expressioni

Tissue specificityi

Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).1 Publication

Gene expression databases

BgeeiENSG00000169862.
CleanExiHS_CTNND2.
ExpressionAtlasiQ9UQB3. baseline and differential.
GenevisibleiQ9UQB3. HS.

Organism-specific databases

HPAiCAB037339.
HPA015077.

Interactioni

Subunit structurei

Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain (By similarity). Interacts with PDZD2 (By similarity). Interacts with ZBTB33 (By similarity). Binds to PSEN1 (PubMed:10037471) (PubMed:10208590) (PubMed:9223106). Interacts with ARHGEF28 (PubMed:17993462). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (PubMed:19706687). Interacts with CDK5 (By similarity). Interacts with CTNNB1 (PubMed:25807484). Interacts with GSK3A and GSK3B (PubMed:19706605). Interacts with DNM2 (PubMed:22022388).By similarity8 Publications

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107882. 9 interactors.
DIPiDIP-1138N.
IntActiQ9UQB3. 2 interactors.
MINTiMINT-223241.
STRINGi9606.ENSP00000307134.

Structurei

3D structure databases

ProteinModelPortaliQ9UQB3.
SMRiQ9UQB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati394 – 438ARM 1Add BLAST45
Repeati540 – 579ARM 2Add BLAST40
Repeati582 – 621ARM 3Add BLAST40
Repeati626 – 666ARM 4Add BLAST41
Repeati682 – 724ARM 5Add BLAST43
Repeati728 – 773ARM 6Add BLAST46
Repeati835 – 875ARM 7Add BLAST41
Repeati882 – 921ARM 8Add BLAST40
Repeati975 – 1018ARM 9Add BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 84Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 226Poly-ProAdd BLAST11
Compositional biasi811 – 817Poly-Lys7

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOVERGENiHBG004284.
InParanoidiQ9UQB3.
OMAiDYECTGS.
OrthoDBiEOG091G0S7K.
PhylomeDBiQ9UQB3.
TreeFamiTF321877.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PfamiPF00514. Arm. 4 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9UQB3-1) [UniParc]FASTAAdd to basket
Also known as: NPRAPa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFARKPPGAA PLGAMPVPDQ PSSASEKTSS LSPGLNTSNG DGSETETTSA
60 70 80 90 100
ILASVKEQEL QFERLTRELE AERQIVASQL ERCKLGSETG SMSSMSSAEE
110 120 130 140 150
QFQWQSQDGQ KDIEDELTTG LELVDSCIRS LQESGILDPQ DYSTGERPSL
160 170 180 190 200
LSQSALQLNS KPEGSFQYPA SYHSNQTLAL GETTPSQLPA RGTQARATGQ
210 220 230 240 250
SFSQGTTSRA GHLAGPEPAP PPPPPPREPF APSLGSAFHL PDAPPAAAAA
260 270 280 290 300
ALYYSSSTLP APPRGGSPLA APQGGSPTKL QRGGSAPEGA TYAAPRGSSP
310 320 330 340 350
KQSPSRLAKS YSTSSPINIV VSSAGLSPIR VTSPPTVQST ISSSPIHQLS
360 370 380 390 400
STIGTYATLS PTKRLVHASE QYSKHSQELY ATATLQRPGS LAAGSRASYS
410 420 430 440 450
SQHGHLGPEL RALQSPEHHI DPIYEDRVYQ KPPMRSLSQS QGDPLPPAHT
460 470 480 490 500
GTYRTSTAPS SPGVDSVPLQ RTGSQHGPQN AAAATFQRAS YAAGPASNYA
510 520 530 540 550
DPYRQLQYCP SVESPYSKSG PALPPEGTLA RSPSIDSIQK DPREFGWRDP
560 570 580 590 600
ELPEVIQMLQ HQFPSVQSNA AAYLQHLCFG DNKIKAEIRR QGGIQLLVDL
610 620 630 640 650
LDHRMTEVHR SACGALRNLV YGKANDDNKI ALKNCGGIPA LVRLLRKTTD
660 670 680 690 700
LEIRELVTGV LWNLSSCDAL KMPIIQDALA VLTNAVIIPH SGWENSPLQD
710 720 730 740 750
DRKIQLHSSQ VLRNATGCLR NVSSAGEEAR RRMRECDGLT DALLYVIQSA
760 770 780 790 800
LGSSEIDSKT VENCVCILRN LSYRLAAETS QGQHMGTDEL DGLLCGEANG
810 820 830 840 850
KDAESSGCWG KKKKKKKSQD QWDGVGPLPD CAEPPKGIQM LWHPSIVKPY
860 870 880 890 900
LTLLSECSNP DTLEGAAGAL QNLAAGSWKW SVYIRAAVRK EKGLPILVEL
910 920 930 940 950
LRIDNDRVVC AVATALRNMA LDVRNKELIG KYAMRDLVHR LPGGNNSNNT
960 970 980 990 1000
ASKAMSDDTV TAVCCTLHEV ITKNMENAKA LRDAGGIEKL VGISKSKGDK
1010 1020 1030 1040 1050
HSPKVVKAAS QVLNSMWQYR DLRSLYKKDG WSQYHFVASS STIERDRQRP
1060 1070 1080 1090 1100
YSSSRTPSIS PVRVSPNNRS ASAPASPREM ISLKERKTDY ECTGSNATYH
1110 1120 1130 1140 1150
GAKGEHTSRK DAMTAQNTGI STLYRNSYGA PAEDIKHNQV SAQPVPQEPS
1160 1170 1180 1190 1200
RKDYETYQPF QNSTRNYDES FFEDQVHHRP PASEYTMHLG LKSTGNYVDF
1210 1220
YSAARPYSEL NYETSHYPAS PDSWV
Length:1,225
Mass (Da):132,656
Last modified:December 20, 2005 - v3
Checksum:i4A24ACC3E22BFE83
GO
Isoform 2 (identifier: Q9UQB3-2) [UniParc]FASTAAdd to basket
Also known as: NPRAPc

The sequence of this isoform differs from the canonical sequence as follows:
     823-880: Missing.

Show »
Length:1,167
Mass (Da):126,529
Checksum:iDE45985C1B006DFA
GO

Sequence cautioni

The sequence AAB68599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB88185 differs from that shown. Reason: Frameshift at position 913.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426D → V in AAC63103 (PubMed:9223106).Curated1
Sequence conflicti443D → V in AAC63103 (PubMed:9223106).Curated1
Sequence conflicti725A → P in AAC63103 (PubMed:9223106).Curated1
Sequence conflicti894L → R in AAC63103 (PubMed:9223106).Curated1
Sequence conflicti894L → R in AAB96357 (PubMed:9049630).Curated1
Sequence conflicti909V → A in AAC63103 (PubMed:9223106).Curated1
Sequence conflicti909V → A in AAB96357 (PubMed:9049630).Curated1
Sequence conflicti980A → G in AAB97957 (PubMed:9342840).Curated1
Sequence conflicti1102A → G in AAD00453 (PubMed:10037471).Curated1
Sequence conflicti1102A → G in AAB68599 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07338734G → S Probable disease-associated mutation found in autism; hypomorphic mutation affecting dendritic spines development and maintenance; results in reduced interaction with CTNNB1. 1 PublicationCorresponds to variant rs151129181dbSNPEnsembl.1
Natural variantiVAR_073388189P → L Probable disease-associated mutation found in autism; hypomorphic mutation affecting Wnt signaling. 1 PublicationCorresponds to variant rs149573037dbSNPEnsembl.1
Natural variantiVAR_073389224P → L Probable disease-associated mutation found in autism; hypomorphic mutation affecting Wnt signaling. 1 PublicationCorresponds to variant rs769623284dbSNPEnsembl.1
Natural variantiVAR_062270275G → C Found in patients with autism; unknown pathological significance; has no effect on Wnt signaling. 2 PublicationsCorresponds to variant rs61749844dbSNPEnsembl.1
Natural variantiVAR_073390330R → H Polymorphism; has no effect on Wnt signaling. 1 PublicationCorresponds to variant rs199506424dbSNPEnsembl.1
Natural variantiVAR_073391454R → H Probable disease-associated mutation found in autism; hypomorphic mutation affecting Wnt signaling. 1 PublicationCorresponds to variant rs750266236dbSNPEnsembl.1
Natural variantiVAR_073392465D → N Polymorphism; has no effect on Wnt signaling. 1 PublicationCorresponds to variant rs200377770dbSNPEnsembl.1
Natural variantiVAR_062271482A → T Polymorphism; has no effect on Wnt signaling. 2 PublicationsCorresponds to variant rs61750706dbSNPEnsembl.1
Natural variantiVAR_073393507Q → P Probable disease-associated mutation found in autism; hypomorphic mutation affecting Wnt signaling. 1 PublicationCorresponds to variant rs142843736dbSNPEnsembl.1
Natural variantiVAR_073394713R → C Probable disease-associated mutation found in autism; loss-of-function mutation affecting dendritic spines development and maintenance; results in reduced interaction with CTNNB1. 1 PublicationCorresponds to variant rs768575356dbSNPEnsembl.1
Natural variantiVAR_062272810G → R Polymorphism; has no effect on Wnt signaling. 2 PublicationsCorresponds to variant rs61754599dbSNPEnsembl.1
Natural variantiVAR_073395862T → M Found in patients with autism; unknown pathological significance; has no effect on Wnt signaling. 1 PublicationCorresponds to variant rs773517967dbSNPEnsembl.1
Natural variantiVAR_0361621159P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006746823 – 880Missing in isoform 2. CuratedAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96136 mRNA. Translation: AAC63103.1.
AB013805 mRNA. Translation: BAA36163.1.
AC003089 Genomic DNA. Translation: AAB83940.1.
EU350953 Genomic DNA. Translation: ABY59658.1.
AC003954 Genomic DNA. No translation available.
AC004633 Genomic DNA. No translation available.
AC004648 Genomic DNA. No translation available.
AC005367 Genomic DNA. No translation available.
AC005610 Genomic DNA. No translation available.
AC010433 Genomic DNA. No translation available.
AC010626 Genomic DNA. No translation available.
AC113390 Genomic DNA. No translation available.
AC127460 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08053.1.
U81004 mRNA. Translation: AAD00453.1.
U52351 mRNA. Translation: AAB97957.1.
U72665 mRNA. Translation: AAB68599.1. Different initiation.
AF035302 mRNA. Translation: AAB88185.1. Frameshift.
U52828 mRNA. Translation: AAB96357.1.
CCDSiCCDS3881.1. [Q9UQB3-1]
RefSeqiNP_001275644.1. NM_001288715.1.
NP_001275645.1. NM_001288716.1.
NP_001275646.1. NM_001288717.1.
NP_001323.1. NM_001332.3. [Q9UQB3-1]
UniGeneiHs.314543.

Genome annotation databases

EnsembliENST00000304623; ENSP00000307134; ENSG00000169862. [Q9UQB3-1]
GeneIDi1501.
KEGGihsa:1501.
UCSCiuc003jfa.3. human. [Q9UQB3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96136 mRNA. Translation: AAC63103.1.
AB013805 mRNA. Translation: BAA36163.1.
AC003089 Genomic DNA. Translation: AAB83940.1.
EU350953 Genomic DNA. Translation: ABY59658.1.
AC003954 Genomic DNA. No translation available.
AC004633 Genomic DNA. No translation available.
AC004648 Genomic DNA. No translation available.
AC005367 Genomic DNA. No translation available.
AC005610 Genomic DNA. No translation available.
AC010433 Genomic DNA. No translation available.
AC010626 Genomic DNA. No translation available.
AC113390 Genomic DNA. No translation available.
AC127460 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08053.1.
U81004 mRNA. Translation: AAD00453.1.
U52351 mRNA. Translation: AAB97957.1.
U72665 mRNA. Translation: AAB68599.1. Different initiation.
AF035302 mRNA. Translation: AAB88185.1. Frameshift.
U52828 mRNA. Translation: AAB96357.1.
CCDSiCCDS3881.1. [Q9UQB3-1]
RefSeqiNP_001275644.1. NM_001288715.1.
NP_001275645.1. NM_001288716.1.
NP_001275646.1. NM_001288717.1.
NP_001323.1. NM_001332.3. [Q9UQB3-1]
UniGeneiHs.314543.

3D structure databases

ProteinModelPortaliQ9UQB3.
SMRiQ9UQB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107882. 9 interactors.
DIPiDIP-1138N.
IntActiQ9UQB3. 2 interactors.
MINTiMINT-223241.
STRINGi9606.ENSP00000307134.

PTM databases

iPTMnetiQ9UQB3.
PhosphoSitePlusiQ9UQB3.

Polymorphism and mutation databases

DMDMi84028193.

Proteomic databases

PaxDbiQ9UQB3.
PeptideAtlasiQ9UQB3.
PRIDEiQ9UQB3.

Protocols and materials databases

DNASUi1501.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304623; ENSP00000307134; ENSG00000169862. [Q9UQB3-1]
GeneIDi1501.
KEGGihsa:1501.
UCSCiuc003jfa.3. human. [Q9UQB3-1]

Organism-specific databases

CTDi1501.
DisGeNETi1501.
GeneCardsiCTNND2.
HGNCiHGNC:2516. CTNND2.
HPAiCAB037339.
HPA015077.
MalaCardsiCTNND2.
MIMi604275. gene.
neXtProtiNX_Q9UQB3.
OpenTargetsiENSG00000169862.
Orphaneti281. Monosomy 5p.
PharmGKBiPA27017.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1048. Eukaryota.
ENOG410Y21Q. LUCA.
GeneTreeiENSGT00760000119167.
HOVERGENiHBG004284.
InParanoidiQ9UQB3.
OMAiDYECTGS.
OrthoDBiEOG091G0S7K.
PhylomeDBiQ9UQB3.
TreeFamiTF321877.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169862-MONOMER.
SignaLinkiQ9UQB3.

Miscellaneous databases

ChiTaRSiCTNND2. human.
GenomeRNAii1501.
PROiQ9UQB3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169862.
CleanExiHS_CTNND2.
ExpressionAtlasiQ9UQB3. baseline and differential.
GenevisibleiQ9UQB3. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR028435. Plakophilin/d_Catenin.
[Graphical view]
PANTHERiPTHR10372. PTHR10372. 2 hits.
PfamiPF00514. Arm. 4 hits.
[Graphical view]
SMARTiSM00185. ARM. 7 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTND2_HUMAN
AccessioniPrimary (citable) accession number: Q9UQB3
Secondary accession number(s): B0FTZ7
, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 145 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.