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Q9UQ98

- Q9UQ98_HUMAN

UniProt

Q9UQ98 - Q9UQ98_HUMAN

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Protein
Submitted name: Multidrug resistance protein
Gene
MRP
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  3. homoaconitate hydratase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Multidrug resistance proteinImported
Gene namesi
Name:MRPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9UQ98.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ98.

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG108314.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UQ98-1 [UniParc]FASTAAdd to Basket

« Hide

DWNVTWNTSN PDFTKCFQNT VLVWVPCFYL WACFPFYFLY LSRHDRGYIQ     50
MTPLNKTKTA LGFLLWIVCW ADLFYSFWER SRGIFLAPVF LVSPTLLGIT 100
TLLATFLIQL ERRKGVQSSG IMLTFWLVAL VCALAILRSK IMTALKEDAQ 150
VDLFRDITFY VYFSLLLIQL VLSCFSDRSP LFSETIHDPN PCPESSASFL 200
SRITFWWITG LIVRGYRQPL EGSDLWSLNK EDTSEQVVPV LVKNWKKECA 250
KTRKQPVKVV YSSKDPAQPK ESSKVDANEE VEALIVKSPQ KEWNPSLFKV 300
LYKTFGPYFL MSFFFKAIHD LMMFSGPQIL KLLIKFVNDT KAPDWQGYFY 350
TVLLFVTACL QTLVLHQYFH ICFVSGMRIK TAVIGAVYRK ALVITNSARK 400
SSTVGEIVNL MSVDAQRFMD LATYINMIWS APLQVILALY LLWLNLGPSV 450
LAGVAVMVLM VPVNAVMAMK TKTYQVAHMK SKDNRIKLMN EILNGIKVLK 500
LYAWELAFKD KVLAIRQEEL KVLKKSAYLS AVGTFTWVCT PFLVALCTFA 550
VYVTIDENNI LDAQTAFVSL ALFNILRFPL NILPMVISSI VQASVSLKRL 600
RIFLSHEELE PDSIERRPVK DGGGTNSITV RNATFTWARS DPPTLNGITF 650
SIPEGALVAV VGQVGCGKSS LLSALLAEMD KVEGHVAIKT RILVTHSMSY 700
LPQVDVIIVM SGGKISEMGS YQELLARDGA FAEFLRTYAS TEQEQDAEEN 750
GVTGVSGPGK EAKQMENGML VTDSAGKQLQ RQLSSSSSYS GDISRHHNST 800
AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG LFISFLSIFL 850
FMCNHVSALA SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF 900
GYSMAVSIGG ILASRCLHVD LLHSILRSPM SFFERTPSGN LVNRFSKELD 950
TVDSMIPEVI KMFMGSLFNV IGACIVILLA TPIAAIIIPP LGLIYFFVQR 1000
FYVASSRQLK RLESVSRSPV YSHFNETLLG VSVIRAFEEQ ERFIHQSDLK 1050
VDENQKAYYP SIVANRWLAV RLECVGNCIV LFAALFAVIS RHSLSAGLVG 1100
LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE KEAPWQIQET 1150
APPSSWPQVG RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA 1200
GKSSLTLGLF RINESAEGEI IIDGINIAKI GLHDLRFKIT IIPQDPVLFS 1250
GSLRMNLDPF SQYSDEEVWT SLELAHLKDF VSALPDKLDH ECAEGGENLS 1300
VGQRQLVCLA RALLRKTKIL VLDEATAAVD LETDDLIQST IRTQFEDCTV 1350
LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP SDLLQQRGLF YSMAKDAGLV 1400
Length:1,400
Mass (Da):157,211
Last modified:May 1, 2000 - v1
Checksum:iC7C4DBB78DADDAAA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851, AF022852 Genomic DNA. Translation: AAB83982.1.
UniGeneiHs.391464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022853
, AF022824 , AF022825 , AF022826 , AF022827 , AF022828 , AF022829 , AF022830 , AF022831 , AF022832 , AF022833 , AF022834 , AF022835 , AF022836 , AF022837 , AF022838 , AF022841 , AF022842 , AF022843 , AF022844 , AF022845 , AF022846 , AF022847 , AF022848 , AF022849 , AF022850 , AF022851 , AF022852 Genomic DNA. Translation: AAB83982.1 .
UniGenei Hs.391464.

3D structure databases

ProteinModelPortali Q9UQ98.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9UQ98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108314.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA."
    Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G.
    Genomics 45:368-378(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UQ98_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ98
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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