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Q9UQ98

- Q9UQ98_HUMAN

UniProt

Q9UQ98 - Q9UQ98_HUMAN

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Protein
Submitted name:

Multidrug resistance protein

Gene

MRP

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. homoaconitate hydratase activity Source: UniProtKB

GO - Biological processi

  1. metabolic process Source: GOC
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Multidrug resistance proteinImported
Gene namesi
Name:MRPImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9UQ98.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG108314.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9UQ98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DWNVTWNTSN PDFTKCFQNT VLVWVPCFYL WACFPFYFLY LSRHDRGYIQ
60 70 80 90 100
MTPLNKTKTA LGFLLWIVCW ADLFYSFWER SRGIFLAPVF LVSPTLLGIT
110 120 130 140 150
TLLATFLIQL ERRKGVQSSG IMLTFWLVAL VCALAILRSK IMTALKEDAQ
160 170 180 190 200
VDLFRDITFY VYFSLLLIQL VLSCFSDRSP LFSETIHDPN PCPESSASFL
210 220 230 240 250
SRITFWWITG LIVRGYRQPL EGSDLWSLNK EDTSEQVVPV LVKNWKKECA
260 270 280 290 300
KTRKQPVKVV YSSKDPAQPK ESSKVDANEE VEALIVKSPQ KEWNPSLFKV
310 320 330 340 350
LYKTFGPYFL MSFFFKAIHD LMMFSGPQIL KLLIKFVNDT KAPDWQGYFY
360 370 380 390 400
TVLLFVTACL QTLVLHQYFH ICFVSGMRIK TAVIGAVYRK ALVITNSARK
410 420 430 440 450
SSTVGEIVNL MSVDAQRFMD LATYINMIWS APLQVILALY LLWLNLGPSV
460 470 480 490 500
LAGVAVMVLM VPVNAVMAMK TKTYQVAHMK SKDNRIKLMN EILNGIKVLK
510 520 530 540 550
LYAWELAFKD KVLAIRQEEL KVLKKSAYLS AVGTFTWVCT PFLVALCTFA
560 570 580 590 600
VYVTIDENNI LDAQTAFVSL ALFNILRFPL NILPMVISSI VQASVSLKRL
610 620 630 640 650
RIFLSHEELE PDSIERRPVK DGGGTNSITV RNATFTWARS DPPTLNGITF
660 670 680 690 700
SIPEGALVAV VGQVGCGKSS LLSALLAEMD KVEGHVAIKT RILVTHSMSY
710 720 730 740 750
LPQVDVIIVM SGGKISEMGS YQELLARDGA FAEFLRTYAS TEQEQDAEEN
760 770 780 790 800
GVTGVSGPGK EAKQMENGML VTDSAGKQLQ RQLSSSSSYS GDISRHHNST
810 820 830 840 850
AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG LFISFLSIFL
860 870 880 890 900
FMCNHVSALA SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF
910 920 930 940 950
GYSMAVSIGG ILASRCLHVD LLHSILRSPM SFFERTPSGN LVNRFSKELD
960 970 980 990 1000
TVDSMIPEVI KMFMGSLFNV IGACIVILLA TPIAAIIIPP LGLIYFFVQR
1010 1020 1030 1040 1050
FYVASSRQLK RLESVSRSPV YSHFNETLLG VSVIRAFEEQ ERFIHQSDLK
1060 1070 1080 1090 1100
VDENQKAYYP SIVANRWLAV RLECVGNCIV LFAALFAVIS RHSLSAGLVG
1110 1120 1130 1140 1150
LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE KEAPWQIQET
1160 1170 1180 1190 1200
APPSSWPQVG RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA
1210 1220 1230 1240 1250
GKSSLTLGLF RINESAEGEI IIDGINIAKI GLHDLRFKIT IIPQDPVLFS
1260 1270 1280 1290 1300
GSLRMNLDPF SQYSDEEVWT SLELAHLKDF VSALPDKLDH ECAEGGENLS
1310 1320 1330 1340 1350
VGQRQLVCLA RALLRKTKIL VLDEATAAVD LETDDLIQST IRTQFEDCTV
1360 1370 1380 1390 1400
LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP SDLLQQRGLF YSMAKDAGLV
Length:1,400
Mass (Da):157,211
Last modified:May 1, 2000 - v1
Checksum:iC7C4DBB78DADDAAA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022853
, AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851, AF022852 Genomic DNA. Translation: AAB83982.1.
UniGeneiHs.391464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022853
, AF022824 , AF022825 , AF022826 , AF022827 , AF022828 , AF022829 , AF022830 , AF022831 , AF022832 , AF022833 , AF022834 , AF022835 , AF022836 , AF022837 , AF022838 , AF022841 , AF022842 , AF022843 , AF022844 , AF022845 , AF022846 , AF022847 , AF022848 , AF022849 , AF022850 , AF022851 , AF022852 Genomic DNA. Translation: AAB83982.1 .
UniGenei Hs.391464.

3D structure databases

ProteinModelPortali Q9UQ98.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9UQ98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108314.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA."
    Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G.
    Genomics 45:368-378(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UQ98_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ98
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.