Q9UQ98 (Q9UQ98_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Multidrug resistance protein EMBL AAB83982.1

Gene names

Name:

MRP EMBL AAB83982.1

Organism

Homo sapiens (Human) EMBL AAB83982.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1400 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. RuleBase RU000684 Contains 2 ABC transmembrane type-1 domains. SAAS SAAS017940

Ontologies

Keywords
Domain	Repeat SAAS SAAS017940
Ligand	ATP-binding RuleBase RU003299 Nucleotide-binding
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC transport Non-traceable author statement. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro homoaconitate hydratase activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB83982.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UQ98 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: C7C4DBB78DADDAAA	FASTA	1,400	157,211
	10 20 30 40 50 60 DWNVTWNTSN PDFTKCFQNT VLVWVPCFYL WACFPFYFLY LSRHDRGYIQ MTPLNKTKTA 70 80 90 100 110 120 LGFLLWIVCW ADLFYSFWER SRGIFLAPVF LVSPTLLGIT TLLATFLIQL ERRKGVQSSG 130 140 150 160 170 180 IMLTFWLVAL VCALAILRSK IMTALKEDAQ VDLFRDITFY VYFSLLLIQL VLSCFSDRSP 190 200 210 220 230 240 LFSETIHDPN PCPESSASFL SRITFWWITG LIVRGYRQPL EGSDLWSLNK EDTSEQVVPV 250 260 270 280 290 300 LVKNWKKECA KTRKQPVKVV YSSKDPAQPK ESSKVDANEE VEALIVKSPQ KEWNPSLFKV 310 320 330 340 350 360 LYKTFGPYFL MSFFFKAIHD LMMFSGPQIL KLLIKFVNDT KAPDWQGYFY TVLLFVTACL 370 380 390 400 410 420 QTLVLHQYFH ICFVSGMRIK TAVIGAVYRK ALVITNSARK SSTVGEIVNL MSVDAQRFMD 430 440 450 460 470 480 LATYINMIWS APLQVILALY LLWLNLGPSV LAGVAVMVLM VPVNAVMAMK TKTYQVAHMK 490 500 510 520 530 540 SKDNRIKLMN EILNGIKVLK LYAWELAFKD KVLAIRQEEL KVLKKSAYLS AVGTFTWVCT 550 560 570 580 590 600 PFLVALCTFA VYVTIDENNI LDAQTAFVSL ALFNILRFPL NILPMVISSI VQASVSLKRL 610 620 630 640 650 660 RIFLSHEELE PDSIERRPVK DGGGTNSITV RNATFTWARS DPPTLNGITF SIPEGALVAV 670 680 690 700 710 720 VGQVGCGKSS LLSALLAEMD KVEGHVAIKT RILVTHSMSY LPQVDVIIVM SGGKISEMGS 730 740 750 760 770 780 YQELLARDGA FAEFLRTYAS TEQEQDAEEN GVTGVSGPGK EAKQMENGML VTDSAGKQLQ 790 800 810 820 830 840 RQLSSSSSYS GDISRHHNST AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG 850 860 870 880 890 900 LFISFLSIFL FMCNHVSALA SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF 910 920 930 940 950 960 GYSMAVSIGG ILASRCLHVD LLHSILRSPM SFFERTPSGN LVNRFSKELD TVDSMIPEVI 970 980 990 1000 1010 1020 KMFMGSLFNV IGACIVILLA TPIAAIIIPP LGLIYFFVQR FYVASSRQLK RLESVSRSPV 1030 1040 1050 1060 1070 1080 YSHFNETLLG VSVIRAFEEQ ERFIHQSDLK VDENQKAYYP SIVANRWLAV RLECVGNCIV 1090 1100 1110 1120 1130 1140 LFAALFAVIS RHSLSAGLVG LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE 1150 1160 1170 1180 1190 1200 KEAPWQIQET APPSSWPQVG RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA 1210 1220 1230 1240 1250 1260 GKSSLTLGLF RINESAEGEI IIDGINIAKI GLHDLRFKIT IIPQDPVLFS GSLRMNLDPF 1270 1280 1290 1300 1310 1320 SQYSDEEVWT SLELAHLKDF VSALPDKLDH ECAEGGENLS VGQRQLVCLA RALLRKTKIL 1330 1340 1350 1360 1370 1380 VLDEATAAVD LETDDLIQST IRTQFEDCTV LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP 1390 1400 SDLLQQRGLF YSMAKDAGLV

References

[1]	"Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA." Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G. Genomics 45:368-378(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF022853 , AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851, AF022852 Genomic DNA. Translation: AAB83982.1.
IPI	IPI00216264.
UniGene	Hs.391464.
3D structure databases
HSSP	HSSP built from PDB template 1MT0 based on UniProtKB P08716.
ProteinModelPortal	Q9UQ98.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG108314.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005292. Multidrug-R_assoc. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
TIGRFAMs	TIGR00957. MRP_assoc_pro. 1 hit.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9UQ98_HUMAN

Accession

Primary (citable) accession number: Q9UQ98

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.