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Q9UQ98

- Q9UQ98_HUMAN

UniProt

Q9UQ98 - Q9UQ98_HUMAN

Protein
Submitted name:

Multidrug resistance protein

Gene

MRP

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. homoaconitate hydratase activity Source: UniProtKB

    GO - Biological processi

    1. metabolic process Source: GOC

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Multidrug resistance proteinImported
    Gene namesi
    Name:MRPImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9UQ98.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQ98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG108314.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9UQ98-1 [UniParc]FASTAAdd to Basket

    « Hide

    DWNVTWNTSN PDFTKCFQNT VLVWVPCFYL WACFPFYFLY LSRHDRGYIQ     50
    MTPLNKTKTA LGFLLWIVCW ADLFYSFWER SRGIFLAPVF LVSPTLLGIT 100
    TLLATFLIQL ERRKGVQSSG IMLTFWLVAL VCALAILRSK IMTALKEDAQ 150
    VDLFRDITFY VYFSLLLIQL VLSCFSDRSP LFSETIHDPN PCPESSASFL 200
    SRITFWWITG LIVRGYRQPL EGSDLWSLNK EDTSEQVVPV LVKNWKKECA 250
    KTRKQPVKVV YSSKDPAQPK ESSKVDANEE VEALIVKSPQ KEWNPSLFKV 300
    LYKTFGPYFL MSFFFKAIHD LMMFSGPQIL KLLIKFVNDT KAPDWQGYFY 350
    TVLLFVTACL QTLVLHQYFH ICFVSGMRIK TAVIGAVYRK ALVITNSARK 400
    SSTVGEIVNL MSVDAQRFMD LATYINMIWS APLQVILALY LLWLNLGPSV 450
    LAGVAVMVLM VPVNAVMAMK TKTYQVAHMK SKDNRIKLMN EILNGIKVLK 500
    LYAWELAFKD KVLAIRQEEL KVLKKSAYLS AVGTFTWVCT PFLVALCTFA 550
    VYVTIDENNI LDAQTAFVSL ALFNILRFPL NILPMVISSI VQASVSLKRL 600
    RIFLSHEELE PDSIERRPVK DGGGTNSITV RNATFTWARS DPPTLNGITF 650
    SIPEGALVAV VGQVGCGKSS LLSALLAEMD KVEGHVAIKT RILVTHSMSY 700
    LPQVDVIIVM SGGKISEMGS YQELLARDGA FAEFLRTYAS TEQEQDAEEN 750
    GVTGVSGPGK EAKQMENGML VTDSAGKQLQ RQLSSSSSYS GDISRHHNST 800
    AELQKAEAKK EETWKLMEAD KAQTGQVKLS VYWDYMKAIG LFISFLSIFL 850
    FMCNHVSALA SNYWLSLWTD DPIVNGTQEH TKVRLSVYGA LGISQGIAVF 900
    GYSMAVSIGG ILASRCLHVD LLHSILRSPM SFFERTPSGN LVNRFSKELD 950
    TVDSMIPEVI KMFMGSLFNV IGACIVILLA TPIAAIIIPP LGLIYFFVQR 1000
    FYVASSRQLK RLESVSRSPV YSHFNETLLG VSVIRAFEEQ ERFIHQSDLK 1050
    VDENQKAYYP SIVANRWLAV RLECVGNCIV LFAALFAVIS RHSLSAGLVG 1100
    LSVSYSLQVT TYLNWLVRMS SEMETNIVAV ERLKEYSETE KEAPWQIQET 1150
    APPSSWPQVG RVEFRNYCLR YREDLDFVLR HINVTINGGE KVGIVGRTGA 1200
    GKSSLTLGLF RINESAEGEI IIDGINIAKI GLHDLRFKIT IIPQDPVLFS 1250
    GSLRMNLDPF SQYSDEEVWT SLELAHLKDF VSALPDKLDH ECAEGGENLS 1300
    VGQRQLVCLA RALLRKTKIL VLDEATAAVD LETDDLIQST IRTQFEDCTV 1350
    LTIAHRLNTI MDYTRVIVLD KGEIQEYGAP SDLLQQRGLF YSMAKDAGLV 1400
    Length:1,400
    Mass (Da):157,211
    Last modified:May 1, 2000 - v1
    Checksum:iC7C4DBB78DADDAAA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022853
    , AF022824, AF022825, AF022826, AF022827, AF022828, AF022829, AF022830, AF022831, AF022832, AF022833, AF022834, AF022835, AF022836, AF022837, AF022838, AF022841, AF022842, AF022843, AF022844, AF022845, AF022846, AF022847, AF022848, AF022849, AF022850, AF022851, AF022852 Genomic DNA. Translation: AAB83982.1.
    UniGeneiHs.391464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022853
    , AF022824 , AF022825 , AF022826 , AF022827 , AF022828 , AF022829 , AF022830 , AF022831 , AF022832 , AF022833 , AF022834 , AF022835 , AF022836 , AF022837 , AF022838 , AF022841 , AF022842 , AF022843 , AF022844 , AF022845 , AF022846 , AF022847 , AF022848 , AF022849 , AF022850 , AF022851 , AF022852 Genomic DNA. Translation: AAB83982.1 .
    UniGenei Hs.391464.

    3D structure databases

    ProteinModelPortali Q9UQ98.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9UQ98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108314.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA."
      Grant C.E., Kurz E.U., Cole S.P.C., Deeley R.G.
      Genomics 45:368-378(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UQ98_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQ98
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.