Q9UQ88 (CD11A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 11A
EC=2.7.11.22

Alternative name(s):
Cell division cycle 2-like protein kinase 2
Cell division protein kinase 11A
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L2

Gene names

Name:	CDK11A
Synonyms:	CDC2L2, CDC2L3, PITSLREB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	783 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. Ref.5 Ref.7
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Magnesium.
Enzyme regulation	Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it By similarity.
Subunit structure	The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7. Ref.5 Ref.7
Subcellular location	Cytoplasm. Nucleus Ref.1 Ref.5.
Tissue specificity	Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. Ref.1 Ref.2
Induction	The p58 isoform is specifically induced in G2/M phase of the cell cycle. Ref.6
Post-translational modification	During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.
Miscellaneous	Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
Caution	Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.
Sequence caution	The sequence AAC95297.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC95298.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC95299.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC95300.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC95302.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAC95303.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative initiation Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Non-traceable author statement Ref.2. Source: UniProtKB mitosis Non-traceable author statement PubMed 1639388. Source: UniProtKB regulation of cell growth Inferred from expression pattern Ref.6. Source: UniProtKB regulation of mRNA processing Inferred from direct assay Ref.5. Source: UniProtKB regulation of transcription, DNA-dependent Non-traceable author statement Ref.2. Source: UniProtKB
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	ATP binding Inferred from direct assay Ref.5. Source: UniProtKB cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC protein serine/threonine kinase activity Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform SV6 (identifier: Q9UQ88-1)

Also known as: p110;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform SV1 (identifier: Q9UQ88-2)

Also known as: Pbeta21; Beta 2-1;

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: W → CRHHSHSAEGG
     240-253: GEARPAPAQKPAQL → V

Isoform SV2 (identifier: Q9UQ88-3)

Also known as: Pbeta22;

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: R → RGNDGFCLFR
     240-253: GEARPAPAQKPAQL → V

Isoform SV3 (identifier: Q9UQ88-4)

The sequence of this isoform differs from the canonical sequence as follows:
     240-253: GEARPAPAQKPAQL → V

Isoform SV7 (identifier: Q9UQ88-5)

Also known as: SV8;

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     387-418: SALTEGDYVPDSPALLPIELKQELPKYLPALQ → MKNEKMKTTSWLFQSHGSTEIPGRVKKQRKKW

Isoform SV12 (identifier: Q9UQ88-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-616: Missing.
     617-658: GELLTQKPLF...IWPGYSELPV → MGKTEEKGNG...QDAGAAEGAA

Isoform SV13 (identifier: Q9UQ88-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.
     153-153: R → RGNDGFCLFR
     240-253: GEARPAPAQKPAQL → V
     567-600: GDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGA → SPPPSGPSQGDPPGPTHSRPSVVAGG
     601-783: Missing.

Isoform 4 (identifier: Q9UQ88-10)

Also known as: Beta 1; p58;

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.

Note: Produced by alternative initiation at Met-345 of isoform SV6.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 783	783	Cyclin-dependent kinase 11A		PRO_0000024315
Regions
	Domain	427 – 647	221	Protein kinase
	Nucleotide binding	432 – 440	9	ATP By similarity
	Compositional bias	15 – 381	367	Glu-rich
Sites
	Active site	550	1	Proton acceptor By similarity
	Binding site	455	1	ATP By similarity
Amino acid modifications
	Modified residue	470	1	Phosphoserine; by CDK7 By similarity
	Modified residue	476	1	Phosphothreonine; by CDK7 By similarity
Natural variations
	Alternative sequence	1 – 616	616	Missing in isoform SV12.		VSP_008284
	Alternative sequence	1 – 386	386	Missing in isoform SV7.		VSP_008283
	Alternative sequence	1 – 344	344	Missing in isoform 4.		VSP_018836
	Alternative sequence	1 – 57	57	Missing in isoform SV13.		VSP_008281
	Alternative sequence	109	1	W → CRHHSHSAEGG in isoform SV1.		VSP_008286
	Alternative sequence	153	1	R → RGNDGFCLFR in isoform SV2 and isoform SV13.		VSP_008287
	Alternative sequence	240 – 253	14	GEARP…KPAQL → V in isoform SV1, isoform SV2, isoform SV3 and isoform SV13.		VSP_008288
	Alternative sequence	387 – 418	32	SALTE…LPALQ → MKNEKMKTTSWLFQSHGSTE IPGRVKKQRKKW in isoform SV7.		VSP_008289
	Alternative sequence	567 – 600	34	GDFGL…LLLGA → SPPPSGPSQGDPPGPTHSRP SVVAGG in isoform SV13.		VSP_008290
	Alternative sequence	601 – 783	183	Missing in isoform SV13.		VSP_008291
	Alternative sequence	617 – 658	42	GELLT…SELPV → MGKTEEKGNGKGAFQERKGP LGAVRKEAGAGAQDAGAAEG AA in isoform SV12.		VSP_008292
	Natural variant	57	1	C → R. Corresponds to variant rs17424353 [ dbSNP | Ensembl ].		VAR_060152
	Natural variant	92	1	S → P. Corresponds to variant rs7531938 [ dbSNP | Ensembl ].		VAR_062200
	Natural variant	93	1	R → W. Ref.2 Ref.3 Corresponds to variant rs1059831 [ dbSNP | Ensembl ].		VAR_031716
	Natural variant	402	1	L → S. Ref.1 Corresponds to variant rs1059828 [ dbSNP | Ensembl ].		VAR_031717
	Natural variant	658	1	V → A. Corresponds to variant rs1059811 [ dbSNP | Ensembl ].		VAR_060153
Experimental info
	Sequence conflict	109	1	Missing in AAA19594. Ref.1
	Sequence conflict	109	1	Missing in AAA19595. Ref.1
	Sequence conflict	246	1	P → R in AAC72087. Ref.2
	Sequence conflict	312 – 314	3	Missing in AAA19594. Ref.1
	Sequence conflict	312 – 314	3	Missing in AAA19595. Ref.1
	Sequence conflict	312 – 314	3	Missing in AAC72084. Ref.2
	Sequence conflict	312 – 314	3	Missing in AAC72085. Ref.2
	Sequence conflict	312 – 314	3	Missing in AAC72086. Ref.2
	Sequence conflict	312 – 314	3	Missing in AAC72087. Ref.2
	Sequence conflict	312 – 314	3	Missing in AAC72090. Ref.2
	Sequence conflict	424	1	E → D in AAA19585. Ref.1
	Sequence conflict	424	1	E → D in AAA19594. Ref.1
	Sequence conflict	424	1	E → D in AAA19595. Ref.1
	Sequence conflict	463	1	K → N in AAA19585. Ref.1
	Sequence conflict	463	1	K → N in AAA19594. Ref.1
	Sequence conflict	463	1	K → N in AAA19595. Ref.1
	Sequence conflict	666	1	E → R in AAA19585. Ref.1
	Sequence conflict	666	1	E → R in AAA19594. Ref.1
	Sequence conflict	666	1	E → R in AAA19595. Ref.1
	Sequence conflict	682	1	D → E in AAA19585. Ref.1
	Sequence conflict	682	1	D → E in AAA19594. Ref.1
	Sequence conflict	682	1	D → E in AAA19595. Ref.1
Isoform SV1:
	Sequence conflict	109	1	C → R in AAA19594. Ref.1
	Sequence conflict	112	1	H → R in AAA19594. Ref.1
Isoform SV2:
	Sequence conflict	158	1	F → V in AAA19595. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform SV6 (p110) [UniParc]. Last modified January 11, 2011. Version 4. Checksum: 1BCF67EB180F37C6	FASTA	783	91,362
	10 20 30 40 50 60 MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHCMEI 70 80 90 100 110 120 TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR KDEKRKEKWK HARVKEREHE 130 140 150 160 170 180 RRKRHREEQD KARREWERQK RREMAREHSR RERDRLEQLE RKRERERKMR EQQKEQREQK 190 200 210 220 230 240 ERERRAEERR KEREARREVS AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPG 250 260 270 280 290 300 EARPAPAQKP AQLKEEKMEE RDLLSDLQDI SDSERKTSSA ESSSAESGSG SEEEEEEEEE 310 320 330 340 350 360 EEEEGSTSEE SEEEEEEEEE EEEETGSNSE EASEQSAEEV SEEEMSEDEE RENENHLLVV 370 380 390 400 410 420 PESRFDRDSG ESEEAEEEVG EGTPQSSALT EGDYVPDSPA LLPIELKQEL PKYLPALQGC 430 440 450 460 470 480 RSVEEFQCLN RIEEGTYGVV YRAKDKKTDE IVALKRLKME KEKEGFPITS LREINTILKA 490 500 510 520 530 540 QHPNIVTVRE IVVGSNMDKI YIVMNYVEHD LKSLMETMKQ PFLPGEVKTL MIQLLRGVKH 550 560 570 580 590 600 LHDNWILHRD LKTSNLLLSH AGILKVGDFG LAREYGSPLK AYTPVVVTQW YRAPELLLGA 610 620 630 640 650 660 KEYSTAVDMW SVGCIFGELL TQKPLFPGNS EIDQINKVFK ELGTPSEKIW PGYSELPVVK 670 680 690 700 710 720 KMTFSEHPYN NLRKRFGALL SDQGFDLMNK FLTYFPGRRI SAEDGLKHEY FRETPLPIDP 730 740 750 760 770 780 SMFPTWPAKS EQQRVKRGTS PRPPEGGLGY SQLGDDDLKE TGFHLTTTNQ GASAAGPGFS LKF
	Isoform SV1 (Pbeta21) (Beta 2-1) [UniParc]. Checksum: 5AA5206CBAFAA15B	FASTA	780	91,018
	10 20 30 40 50 60 MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHCMEI 70 80 90 100 110 120 TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR KDEKRKEKCR HHSHSAEGGK 130 140 150 160 170 180 HARVKEREHE RRKRHREEQD KARREWERQK RREMAREHSR RERDRLEQLE RKRERERKMR 190 200 210 220 230 240 EQQKEQREQK ERERRAEERR KEREARREVS AHHRTMREDY SDKVKASHWS RSPPRPPRER 250 260 270 280 290 300 FELGDGRKPV KEEKMEERDL LSDLQDISDS ERKTSSAESS SAESGSGSEE EEEEEEEEEE 310 320 330 340 350 360 EGSTSEESEE EEEEEEEEEE ETGSNSEEAS EQSAEEVSEE EMSEDEEREN ENHLLVVPES 370 380 390 400 410 420 RFDRDSGESE EAEEEVGEGT PQSSALTEGD YVPDSPALLP IELKQELPKY LPALQGCRSV 430 440 450 460 470 480 EEFQCLNRIE EGTYGVVYRA KDKKTDEIVA LKRLKMEKEK EGFPITSLRE INTILKAQHP 490 500 510 520 530 540 NIVTVREIVV GSNMDKIYIV MNYVEHDLKS LMETMKQPFL PGEVKTLMIQ LLRGVKHLHD 550 560 570 580 590 600 NWILHRDLKT SNLLLSHAGI LKVGDFGLAR EYGSPLKAYT PVVVTQWYRA PELLLGAKEY 610 620 630 640 650 660 STAVDMWSVG CIFGELLTQK PLFPGNSEID QINKVFKELG TPSEKIWPGY SELPVVKKMT 670 680 690 700 710 720 FSEHPYNNLR KRFGALLSDQ GFDLMNKFLT YFPGRRISAE DGLKHEYFRE TPLPIDPSMF 730 740 750 760 770 780 PTWPAKSEQQ RVKRGTSPRP PEGGLGYSQL GDDDLKETGF HLTTTNQGAS AAGPGFSLKF
	Isoform SV2 (Pbeta22) [UniParc]. Checksum: 519C680FC20A1250	FASTA	779	91,055
	10 20 30 40 50 60 MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHCMEI 70 80 90 100 110 120 TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR KDEKRKEKWK HARVKEREHE 130 140 150 160 170 180 RRKRHREEQD KARREWERQK RREMAREHSR RERGNDGFCL FRDRLEQLER KRERERKMRE 190 200 210 220 230 240 QQKEQREQKE RERRAEERRK EREARREVSA HHRTMREDYS DKVKASHWSR SPPRPPRERF 250 260 270 280 290 300 ELGDGRKPVK EEKMEERDLL SDLQDISDSE RKTSSAESSS AESGSGSEEE EEEEEEEEEE 310 320 330 340 350 360 GSTSEESEEE EEEEEEEEEE TGSNSEEASE QSAEEVSEEE MSEDEERENE NHLLVVPESR 370 380 390 400 410 420 FDRDSGESEE AEEEVGEGTP QSSALTEGDY VPDSPALLPI ELKQELPKYL PALQGCRSVE 430 440 450 460 470 480 EFQCLNRIEE GTYGVVYRAK DKKTDEIVAL KRLKMEKEKE GFPITSLREI NTILKAQHPN 490 500 510 520 530 540 IVTVREIVVG SNMDKIYIVM NYVEHDLKSL METMKQPFLP GEVKTLMIQL LRGVKHLHDN 550 560 570 580 590 600 WILHRDLKTS NLLLSHAGIL KVGDFGLARE YGSPLKAYTP VVVTQWYRAP ELLLGAKEYS 610 620 630 640 650 660 TAVDMWSVGC IFGELLTQKP LFPGNSEIDQ INKVFKELGT PSEKIWPGYS ELPVVKKMTF 670 680 690 700 710 720 SEHPYNNLRK RFGALLSDQG FDLMNKFLTY FPGRRISAED GLKHEYFRET PLPIDPSMFP 730 740 750 760 770 TWPAKSEQQR VKRGTSPRPP EGGLGYSQLG DDDLKETGFH LTTTNQGASA AGPGFSLKF
	Isoform SV3 [UniParc]. Checksum: 44D5D04CACDB2519	FASTA	770	90,045
	10 20 30 40 50 60 MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHCMEI 70 80 90 100 110 120 TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR KDEKRKEKWK HARVKEREHE 130 140 150 160 170 180 RRKRHREEQD KARREWERQK RREMAREHSR RERDRLEQLE RKRERERKMR EQQKEQREQK 190 200 210 220 230 240 ERERRAEERR KEREARREVS AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPV 250 260 270 280 290 300 KEEKMEERDL LSDLQDISDS ERKTSSAESS SAESGSGSEE EEEEEEEEEE EGSTSEESEE 310 320 330 340 350 360 EEEEEEEEEE ETGSNSEEAS EQSAEEVSEE EMSEDEEREN ENHLLVVPES RFDRDSGESE 370 380 390 400 410 420 EAEEEVGEGT PQSSALTEGD YVPDSPALLP IELKQELPKY LPALQGCRSV EEFQCLNRIE 430 440 450 460 470 480 EGTYGVVYRA KDKKTDEIVA LKRLKMEKEK EGFPITSLRE INTILKAQHP NIVTVREIVV 490 500 510 520 530 540 GSNMDKIYIV MNYVEHDLKS LMETMKQPFL PGEVKTLMIQ LLRGVKHLHD NWILHRDLKT 550 560 570 580 590 600 SNLLLSHAGI LKVGDFGLAR EYGSPLKAYT PVVVTQWYRA PELLLGAKEY STAVDMWSVG 610 620 630 640 650 660 CIFGELLTQK PLFPGNSEID QINKVFKELG TPSEKIWPGY SELPVVKKMT FSEHPYNNLR 670 680 690 700 710 720 KRFGALLSDQ GFDLMNKFLT YFPGRRISAE DGLKHEYFRE TPLPIDPSMF PTWPAKSEQQ 730 740 750 760 770 RVKRGTSPRP PEGGLGYSQL GDDDLKETGF HLTTTNQGAS AAGPGFSLKF
	Isoform SV7 (SV8) [UniParc]. Checksum: 36B4BA8EE75D95C6	FASTA	397	45,229
	10 20 30 40 50 60 MKNEKMKTTS WLFQSHGSTE IPGRVKKQRK KWGCRSVEEF QCLNRIEEGT YGVVYRAKDK 70 80 90 100 110 120 KTDEIVALKR LKMEKEKEGF PITSLREINT ILKAQHPNIV TVREIVVGSN MDKIYIVMNY 130 140 150 160 170 180 VEHDLKSLME TMKQPFLPGE VKTLMIQLLR GVKHLHDNWI LHRDLKTSNL LLSHAGILKV 190 200 210 220 230 240 GDFGLAREYG SPLKAYTPVV VTQWYRAPEL LLGAKEYSTA VDMWSVGCIF GELLTQKPLF 250 260 270 280 290 300 PGNSEIDQIN KVFKELGTPS EKIWPGYSEL PVVKKMTFSE HPYNNLRKRF GALLSDQGFD 310 320 330 340 350 360 LMNKFLTYFP GRRISAEDGL KHEYFRETPL PIDPSMFPTW PAKSEQQRVK RGTSPRPPEG 370 380 390 GLGYSQLGDD DLKETGFHLT TTNQGASAAG PGFSLKF
	Isoform SV12 [UniParc]. Checksum: F769BDEC242A9044	FASTA	167	18,110
	10 20 30 40 50 60 MGKTEEKGNG KGAFQERKGP LGAVRKEAGA GAQDAGAAEG AAVKKMTFSE HPYNNLRKRF 70 80 90 100 110 120 GALLSDQGFD LMNKFLTYFP GRRISAEDGL KHEYFRETPL PIDPSMFPTW PAKSEQQRVK 130 140 150 160 RGTSPRPPEG GLGYSQLGDD DLKETGFHLT TTNQGASAAG PGFSLKF
	Isoform SV13 [UniParc]. Checksum: 1BAA7CD839B07A06	FASTA	531	62,316
	10 20 30 40 50 60 MEITIRNSPY RREDSMEDRG EEDDSLAIKP PQQMSRKEKV HHRKDEKRKE KWKHARVKER 70 80 90 100 110 120 EHERRKRHRE EQDKARREWE RQKRREMARE HSRRERGNDG FCLFRDRLEQ LERKRERERK 130 140 150 160 170 180 MREQQKEQRE QKERERRAEE RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR 190 200 210 220 230 240 ERFELGDGRK PVKEEKMEER DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE 250 260 270 280 290 300 EEEGSTSEES EEEEEEEEEE EEETGSNSEE ASEQSAEEVS EEEMSEDEER ENENHLLVVP 310 320 330 340 350 360 ESRFDRDSGE SEEAEEEVGE GTPQSSALTE GDYVPDSPAL LPIELKQELP KYLPALQGCR 370 380 390 400 410 420 SVEEFQCLNR IEEGTYGVVY RAKDKKTDEI VALKRLKMEK EKEGFPITSL REINTILKAQ 430 440 450 460 470 480 HPNIVTVREI VVGSNMDKIY IVMNYVEHDL KSLMETMKQP FLPGEVKTLM IQLLRGVKHL 490 500 510 520 530 HDNWILHRDL KTSNLLLSHA GILKVSPPPS GPSQGDPPGP THSRPSVVAG G
	Isoform 4 (Beta 1) (p58) [UniParc]. Checksum: 3DCA65216905266A	FASTA	439	49,624
	10 20 30 40 50 60 MSEDEERENE NHLLVVPESR FDRDSGESEE AEEEVGEGTP QSSALTEGDY VPDSPALLPI 70 80 90 100 110 120 ELKQELPKYL PALQGCRSVE EFQCLNRIEE GTYGVVYRAK DKKTDEIVAL KRLKMEKEKE 130 140 150 160 170 180 GFPITSLREI NTILKAQHPN IVTVREIVVG SNMDKIYIVM NYVEHDLKSL METMKQPFLP 190 200 210 220 230 240 GEVKTLMIQL LRGVKHLHDN WILHRDLKTS NLLLSHAGIL KVGDFGLARE YGSPLKAYTP 250 260 270 280 290 300 VVVTQWYRAP ELLLGAKEYS TAVDMWSVGC IFGELLTQKP LFPGNSEIDQ INKVFKELGT 310 320 330 340 350 360 PSEKIWPGYS ELPVVKKMTF SEHPYNNLRK RFGALLSDQG FDLMNKFLTY FPGRRISAED 370 380 390 400 410 420 GLKHEYFRET PLPIDPSMFP TWPAKSEQQR VKRGTSPRPP EGGLGYSQLG DDDLKETGFH 430 LTTTNQGASA AGPGFSLKF

References

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[1]	"Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms." Xiang J., Lahti J.M., Grenet J.A., Easton J.B., Kidd V.J. J. Biol. Chem. 269:15786-15794(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SV1; SV2 AND 4), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT SER-402. Tissue: Cervix carcinoma.
[2]	"Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2." Gururajan R., Lahti J.M., Grenet J.A., Easton J., Gruber I., Ambros P.F., Kidd V.J. Genome Res. 8:929-939(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SV1; SV2; SV3; SV6; SV7; SV12 AND SV13), TISSUE SPECIFICITY, VARIANT TRP-93. Tissue: Cervix carcinoma.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT TRP-93.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SV7). Tissue: Skin.
[5]	"CDK11 complexes promote pre-mRNA splicing." Hu D., Mayeda A., Trembley J.H., Lahti J.M., Kidd V.J. J. Biol. Chem. 278:8623-8629(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCNL1 AND SFRS7.
[6]	"Identification and characterization of a novel cell cycle-regulated internal ribosome entry site." Cornelis S., Bruynooghe Y., Denecker G., Van Huffel S., Tinton S., Beyaert R. Mol. Cell 5:597-605(2000) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE INITIATION (ISOFORM 4), INDUCTION.
[7]	"The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis." Chen S., Yin X., Zhu X., Yan J., Ji S., Chen C., Cai M., Zhang S., Zong H., Hu Y., Yuan Z., Shen Z., Gu J. J. Biol. Chem. 278:20029-20036(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PAK1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U04819 mRNA. Translation: AAA19585.1. U07704 mRNA. Translation: AAA19594.1. U07705 mRNA. Translation: AAA19595.1. AF067518 mRNA. Translation: AAC72083.1. AF067519 mRNA. Translation: AAC72084.1. AF067520 mRNA. Translation: AAC72085.1. AF067521 mRNA. Translation: AAC72086.1. AF067522 mRNA. Translation: AAC72087.1. AF067523 mRNA. Translation: AAC72088.1. AF067524 mRNA. Translation: AAC72089.1. AF067525 mRNA. Translation: AAC72090.1. AF067526 mRNA. Translation: AAC72091.1. AF067527 mRNA. Translation: AAC72092.1. AF067528 mRNA. Translation: AAC72093.1. AF067529 mRNA. Translation: AAC72094.1. AF080694 , AF080695, AF105714, AF080696, AF080697, AF092427, AF092428, AF080689, AF080690, AF080691, AF080692, AF080693 Genomic DNA. Translation: AAC95297.1. Sequence problems. AF080694 , AF080695, AF105714, AF080696, AF080697, AF092427, AF092428, AF080689, AF080690, AF080691, AF080692, AF080693 Genomic DNA. Translation: AAC95298.1. Sequence problems. AF080694 , AF080695, AF105714, AF080696, AF080697, AF092427, AF092428, AF080689, AF080690, AF080691, AF080692, AF080693 Genomic DNA. Translation: AAC95299.1. Sequence problems. AF080694 , AF080695, AF105714, AF080696, AF080697, AF092427, AF092428, AF080689, AF080690, AF080691, AF080692, AF080693 Genomic DNA. Translation: AAC95300.1. Sequence problems. AF080697 , AF080695, AF105714, AF080696 Genomic DNA. Translation: AAC95302.1. Sequence problems. AF080697 , AF080695, AF105714, AF080696 Genomic DNA. Translation: AAC95303.1. Sequence problems. AL031282 Genomic DNA. Translation: CAI20032.1. AL031282 Genomic DNA. Translation: CAI20033.1. AL031282 Genomic DNA. Translation: CAI20034.1. BC110905 mRNA. Translation: AAI10906.1.
IPI	IPI00024413. IPI00024414. IPI00070809. IPI00099746. IPI00219508. IPI00294006. IPI00334381. IPI00954484.
PIR	B54024. E54024. F54024. H54024.
RefSeq	NP_076916.2. NM_024011.2. NP_277071.2. NM_033529.2.
UniGene	Hs.651228. Hs.709182.
3D structure databases
ProteinModelPortal	Q9UQ88.
SMR	Q9UQ88. Positions 374-753.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UQ88. 7 interactions.
PTM databases
PhosphoSite	Q9UQ88.
Polymorphism databases
DMDM	145559452.
Proteomic databases
PaxDb	Q9UQ88.
PRIDE	Q9UQ88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358779; ENSP00000351629; ENSG00000008128. ENST00000378633; ENSP00000367900; ENSG00000008128. ENST00000404249; ENSP00000384442; ENSG00000008128.
GeneID	728642.
KEGG	hsa:728642.
UCSC	uc001ahj.4. human. uc009vkr.3. human. uc009vks.3. human.
Organism-specific databases
CTD	728642.
GeneCards	GC01M001634.
HGNC	HGNC:1730. CDK11A.
HPA	CAB010467. HPA025061.
MIM	116951. gene.
neXtProt	NX_Q9UQ88.
PharmGKB	PA26263.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG014652.
InParanoid	Q9UQ88.
KO	K08818.
OMA	DGRKPVK.
PhylomeDB	Q9UQ88.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle.
SignaLink	Q9UQ88.
Gene expression databases
ArrayExpress	Q9UQ88.
Bgee	Q9UQ88.
Genevestigator	Q9UQ88.
GermOnline	ENSG00000008128. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9UQ88.
ChEMBL	CHEMBL5416.
GenomeRNAi	728642.
NextBio	127852.
SOURCE	Search...

Entry information

Entry name

CD11A_HUMAN

Accession

Primary (citable) accession number: Q9UQ88
Secondary accession number(s): O95227 , O95228, O96012, Q12821, Q12853, Q12854, Q2TAJ0, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	January 11, 2011
Last modified:	May 29, 2013
This is version 124 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.