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Q9UQ74 (PSG8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pregnancy-specific beta-1-glycoprotein 8

Short name=PS-beta-G-8
Short name=PSBG-8
Short name=Pregnancy-specific glycoprotein 8
Gene names
Name:PSG8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Developmental stage

PSBG are produced in high quantity during pregnancy.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UQ74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UQ74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     22-144: ASLLNFWNPP...TGHFTFTLYL → V
     415-426: GKRIPVSLAIGI → DWTLP
Isoform 3 (identifier: Q9UQ74-3)

The sequence of this isoform differs from the canonical sequence as follows:
     415-426: GKRIPVSLAIGI → DWTLP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 426392Pregnancy-specific beta-1-glycoprotein 8
PRO_0000014915

Regions

Domain35 – 144110Ig-like V-type
Domain147 – 23488Ig-like C2-type 1
Domain240 – 32788Ig-like C2-type 2
Domain335 – 41076Ig-like C2-type 3

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2681N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 217 Probable
Disulfide bond262 ↔ 310 Probable
Disulfide bond354 ↔ 394 Probable

Natural variations

Alternative sequence22 – 144123ASLLN…FTLYL → V in isoform 2.
VSP_041096
Alternative sequence415 – 42612GKRIP…LAIGI → DWTLP in isoform 2 and isoform 3.
VSP_041097
Natural variant3151Q → P.
Corresponds to variant rs11879884 [ dbSNP | Ensembl ].
VAR_049924
Natural variant3491V → D.
Corresponds to variant rs1064490 [ dbSNP | Ensembl ].
VAR_033620

Experimental info

Sequence conflict10 – 123TQR → MQH in CAH18672. Ref.2
Sequence conflict791I → T in CAH18672. Ref.2
Sequence conflict1531S → I in BAG61998. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: C81C9E026BEC0D59

FASTA42647,772
        10         20         30         40         50         60 
MGLLSAPPCT QRITWKGLLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD VLLLVHNLPQ 

        70         80         90        100        110        120 
NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET IYSNASLLIQ NVTQEDAGSY 

       130        140        150        160        170        180 
TLHIIMGGDE NRGVTGHFTF TLYLETPKPS ISSSKLNPRE AMEAVSLTCD PETPDASYLW 

       190        200        210        220        230        240 
WMNGQSLPMS HRLQLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP FTLNLLPKLP 

       250        260        270        280        290        300 
KPYITINNLK PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 

       310        320        330        340        350        360 
TRNETGPYQC EIRDQYGGIR SYPVTLNVLY GPDLPRIYPS FTYYRSGEVL YLSCSADSNP 

       370        380        390        400        410        420 
PAQYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGKESSKSMT VKVSGKRIPV 


SLAIGI 

« Hide

Isoform 2 [UniParc].

Checksum: 4C1624E396410969
Show »

FASTA29733,511
Isoform 3 [UniParc].

Checksum: 19D2569E1C265A7A
Show »

FASTA41947,179

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[5]"Evolution of the carcinoembryonic antigen family. structures of CGM9, CGM11 and pregnancy-specific glycoprotein promoters."
Fraengsmyr L., Israelsson A., Teglund S., Matsunaga T., Hammarstroem S.
Tumor Biol. 21:63-81(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144 (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK300230 mRNA. Translation: BAG61998.1.
CR749812 mRNA. Translation: CAH18672.1.
AC004654 Genomic DNA. Translation: AAC15514.1.
BC137500 mRNA. Translation: AAI37501.1.
BC142628 mRNA. Translation: AAI42629.1.
AH007519 Genomic DNA. Translation: AAD21022.1.
PIRA28928.
RefSeqNP_001123639.1. NM_001130167.1.
NP_001123640.1. NM_001130168.1.
NP_874366.1. NM_182707.2.
UniGeneHs.466843.

3D structure databases

ProteinModelPortalQ9UQ74.
SMRQ9UQ74. Positions 34-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000305005.

Polymorphism databases

DMDM47117919.

Proteomic databases

PRIDEQ9UQ74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306511; ENSP00000305005; ENSG00000124467. [Q9UQ74-1]
ENST00000404209; ENSP00000385869; ENSG00000124467. [Q9UQ74-3]
ENST00000406636; ENSP00000385081; ENSG00000124467. [Q9UQ74-2]
GeneID440533.
KEGGhsa:440533.
UCSCuc002ouh.3. human. [Q9UQ74-3]
uc002ouo.2. human. [Q9UQ74-1]
uc010ein.3. human. [Q9UQ74-2]

Organism-specific databases

CTD440533.
GeneCardsGC19M043256.
HGNCHGNC:9525. PSG8.
HPAHPA046327.
MIM176397. gene.
neXtProtNX_Q9UQ74.
PharmGKBPA33870.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000233417.
HOVERGENHBG007922.
InParanoidQ9UQ74.
KOK06500.
OMAPMSHRLQ.
OrthoDBEOG74BJS7.
PhylomeDBQ9UQ74.
TreeFamTF336859.

Gene expression databases

ArrayExpressQ9UQ74.
BgeeQ9UQ74.
CleanExHS_PSG8.
GenevestigatorQ9UQ74.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi440533.
NextBio109332.
PROQ9UQ74.
SOURCESearch...

Entry information

Entry namePSG8_HUMAN
AccessionPrimary (citable) accession number: Q9UQ74
Secondary accession number(s): A5PKV3 expand/collapse secondary AC list , B2RPL4, B4DTI6, O60410, Q68CR6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2004
Last modified: March 19, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM