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Q9UQ74

- PSG8_HUMAN

UniProt

Q9UQ74 - PSG8_HUMAN

Protein

Pregnancy-specific beta-1-glycoprotein 8

Gene

PSG8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 8
    Short name:
    PS-beta-G-8
    Short name:
    PSBG-8
    Short name:
    Pregnancy-specific glycoprotein 8
    Gene namesi
    Name:PSG8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9525. PSG8.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33870.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 426392Pregnancy-specific beta-1-glycoprotein 8PRO_0000014915Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 217Curated
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi262 ↔ 310Curated
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi354 ↔ 394Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9UQ74.

    Expressioni

    Developmental stagei

    PSBG are produced in high quantity during pregnancy.

    Gene expression databases

    ArrayExpressiQ9UQ74.
    BgeeiQ9UQ74.
    CleanExiHS_PSG8.
    GenevestigatoriQ9UQ74.

    Organism-specific databases

    HPAiHPA046327.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305005.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQ74.
    SMRiQ9UQ74. Positions 34-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 144110Ig-like V-typeAdd
    BLAST
    Domaini147 – 23488Ig-like C2-type 1Add
    BLAST
    Domaini240 – 32788Ig-like C2-type 2Add
    BLAST
    Domaini335 – 41076Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. CEA family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    HOGENOMiHOG000233417.
    HOVERGENiHBG007922.
    InParanoidiQ9UQ74.
    KOiK06500.
    OMAiPMSHRLQ.
    OrthoDBiEOG74BJS7.
    PhylomeDBiQ9UQ74.
    TreeFamiTF336859.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UQ74-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLLSAPPCT QRITWKGLLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD    50
    VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET 100
    IYSNASLLIQ NVTQEDAGSY TLHIIMGGDE NRGVTGHFTF TLYLETPKPS 150
    ISSSKLNPRE AMEAVSLTCD PETPDASYLW WMNGQSLPMS HRLQLSETNR 200
    TLFLLGVTKY TAGPYECEIR NPVSASRSDP FTLNLLPKLP KPYITINNLK 250
    PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV 300
    TRNETGPYQC EIRDQYGGIR SYPVTLNVLY GPDLPRIYPS FTYYRSGEVL 350
    YLSCSADSNP PAQYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA 400
    TGKESSKSMT VKVSGKRIPV SLAIGI 426
    Length:426
    Mass (Da):47,772
    Last modified:May 10, 2004 - v2
    Checksum:iC81C9E026BEC0D59
    GO
    Isoform 2 (identifier: Q9UQ74-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         22-144: ASLLNFWNPP...TGHFTFTLYL → V
         415-426: GKRIPVSLAIGI → DWTLP

    Show »
    Length:297
    Mass (Da):33,511
    Checksum:i4C1624E396410969
    GO
    Isoform 3 (identifier: Q9UQ74-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         415-426: GKRIPVSLAIGI → DWTLP

    Show »
    Length:419
    Mass (Da):47,179
    Checksum:i19D2569E1C265A7A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 123TQR → MQH in CAH18672. (PubMed:17974005)Curated
    Sequence conflicti79 – 791I → T in CAH18672. (PubMed:17974005)Curated
    Sequence conflicti153 – 1531S → I in BAG61998. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti315 – 3151Q → P.
    Corresponds to variant rs11879884 [ dbSNP | Ensembl ].
    VAR_049924
    Natural varianti349 – 3491V → D.
    Corresponds to variant rs1064490 [ dbSNP | Ensembl ].
    VAR_033620

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei22 – 144123ASLLN…FTLYL → V in isoform 2. 1 PublicationVSP_041096Add
    BLAST
    Alternative sequencei415 – 42612GKRIP…LAIGI → DWTLP in isoform 2 and isoform 3. 3 PublicationsVSP_041097Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300230 mRNA. Translation: BAG61998.1.
    CR749812 mRNA. Translation: CAH18672.1.
    AC004654 Genomic DNA. Translation: AAC15514.1.
    BC137500 mRNA. Translation: AAI37501.1.
    BC142628 mRNA. Translation: AAI42629.1.
    AH007519 Genomic DNA. Translation: AAD21022.1.
    CCDSiCCDS33037.1. [Q9UQ74-1]
    CCDS46090.1. [Q9UQ74-2]
    CCDS46091.1. [Q9UQ74-3]
    PIRiA28928.
    RefSeqiNP_001123639.1. NM_001130167.1. [Q9UQ74-3]
    NP_001123640.1. NM_001130168.1. [Q9UQ74-2]
    NP_874366.1. NM_182707.2. [Q9UQ74-1]
    UniGeneiHs.466843.

    Genome annotation databases

    EnsembliENST00000306511; ENSP00000305005; ENSG00000124467. [Q9UQ74-1]
    ENST00000404209; ENSP00000385869; ENSG00000124467. [Q9UQ74-3]
    ENST00000406636; ENSP00000385081; ENSG00000124467. [Q9UQ74-2]
    GeneIDi440533.
    KEGGihsa:440533.
    UCSCiuc002ouh.3. human. [Q9UQ74-3]
    uc002ouo.2. human. [Q9UQ74-1]
    uc010ein.3. human. [Q9UQ74-2]

    Polymorphism databases

    DMDMi47117919.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK300230 mRNA. Translation: BAG61998.1 .
    CR749812 mRNA. Translation: CAH18672.1 .
    AC004654 Genomic DNA. Translation: AAC15514.1 .
    BC137500 mRNA. Translation: AAI37501.1 .
    BC142628 mRNA. Translation: AAI42629.1 .
    AH007519 Genomic DNA. Translation: AAD21022.1 .
    CCDSi CCDS33037.1. [Q9UQ74-1 ]
    CCDS46090.1. [Q9UQ74-2 ]
    CCDS46091.1. [Q9UQ74-3 ]
    PIRi A28928.
    RefSeqi NP_001123639.1. NM_001130167.1. [Q9UQ74-3 ]
    NP_001123640.1. NM_001130168.1. [Q9UQ74-2 ]
    NP_874366.1. NM_182707.2. [Q9UQ74-1 ]
    UniGenei Hs.466843.

    3D structure databases

    ProteinModelPortali Q9UQ74.
    SMRi Q9UQ74. Positions 34-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305005.

    Polymorphism databases

    DMDMi 47117919.

    Proteomic databases

    PRIDEi Q9UQ74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306511 ; ENSP00000305005 ; ENSG00000124467 . [Q9UQ74-1 ]
    ENST00000404209 ; ENSP00000385869 ; ENSG00000124467 . [Q9UQ74-3 ]
    ENST00000406636 ; ENSP00000385081 ; ENSG00000124467 . [Q9UQ74-2 ]
    GeneIDi 440533.
    KEGGi hsa:440533.
    UCSCi uc002ouh.3. human. [Q9UQ74-3 ]
    uc002ouo.2. human. [Q9UQ74-1 ]
    uc010ein.3. human. [Q9UQ74-2 ]

    Organism-specific databases

    CTDi 440533.
    GeneCardsi GC19M043256.
    HGNCi HGNC:9525. PSG8.
    HPAi HPA046327.
    MIMi 176397. gene.
    neXtProti NX_Q9UQ74.
    PharmGKBi PA33870.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000233417.
    HOVERGENi HBG007922.
    InParanoidi Q9UQ74.
    KOi K06500.
    OMAi PMSHRLQ.
    OrthoDBi EOG74BJS7.
    PhylomeDBi Q9UQ74.
    TreeFami TF336859.

    Miscellaneous databases

    GenomeRNAii 440533.
    NextBioi 109332.
    PROi Q9UQ74.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQ74.
    Bgeei Q9UQ74.
    CleanExi HS_PSG8.
    Genevestigatori Q9UQ74.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    5. "Evolution of the carcinoembryonic antigen family. structures of CGM9, CGM11 and pregnancy-specific glycoprotein promoters."
      Fraengsmyr L., Israelsson A., Teglund S., Matsunaga T., Hammarstroem S.
      Tumor Biol. 21:63-81(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144 (ISOFORM 1).

    Entry informationi

    Entry nameiPSG8_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQ74
    Secondary accession number(s): A5PKV3
    , B2RPL4, B4DTI6, O60410, Q68CR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3