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Protein

Pregnancy-specific beta-1-glycoprotein 8

Gene

PSG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 8
Short name:
PS-beta-G-8
Short name:
PSBG-8
Short name:
Pregnancy-specific glycoprotein 8
Gene namesi
Name:PSG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000124467.18
HGNCiHGNC:9525 PSG8
MIMi176397 gene
neXtProtiNX_Q9UQ74

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi440533
OpenTargetsiENSG00000124467
PharmGKBiPA33870

Polymorphism and mutation databases

BioMutaiPSG8
DMDMi47117919

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491535 – 426Pregnancy-specific beta-1-glycoprotein 8Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UQ74
PeptideAtlasiQ9UQ74
PRIDEiQ9UQ74

PTM databases

iPTMnetiQ9UQ74
PhosphoSitePlusiQ9UQ74

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000124467
CleanExiHS_PSG8
ExpressionAtlasiQ9UQ74 baseline and differential

Organism-specific databases

HPAiHPA046327

Interactioni

Protein-protein interaction databases

BioGridi136660, 40 interactors
STRINGi9606.ENSP00000305005

Structurei

3D structure databases

ProteinModelPortaliQ9UQ74
SMRiQ9UQ74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini240 – 327Ig-like C2-type 2Add BLAST88
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ9UQ74
KOiK06500
OMAiPMSHRLQ
OrthoDBiEOG091G0AMM
PhylomeDBiQ9UQ74
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLSAPPCT QRITWKGLLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
IYSNASLLIQ NVTQEDAGSY TLHIIMGGDE NRGVTGHFTF TLYLETPKPS
160 170 180 190 200
ISSSKLNPRE AMEAVSLTCD PETPDASYLW WMNGQSLPMS HRLQLSETNR
210 220 230 240 250
TLFLLGVTKY TAGPYECEIR NPVSASRSDP FTLNLLPKLP KPYITINNLK
260 270 280 290 300
PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDQYGGIR SYPVTLNVLY GPDLPRIYPS FTYYRSGEVL
360 370 380 390 400
YLSCSADSNP PAQYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA
410 420
TGKESSKSMT VKVSGKRIPV SLAIGI
Length:426
Mass (Da):47,772
Last modified:May 10, 2004 - v2
Checksum:iC81C9E026BEC0D59
GO
Isoform 2 (identifier: Q9UQ74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-144: ASLLNFWNPP...TGHFTFTLYL → V
     415-426: GKRIPVSLAIGI → DWTLP

Show »
Length:297
Mass (Da):33,511
Checksum:i4C1624E396410969
GO
Isoform 3 (identifier: Q9UQ74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-426: GKRIPVSLAIGI → DWTLP

Show »
Length:419
Mass (Da):47,179
Checksum:i19D2569E1C265A7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 12TQR → MQH in CAH18672 (PubMed:17974005).Curated3
Sequence conflicti79I → T in CAH18672 (PubMed:17974005).Curated1
Sequence conflicti153S → I in BAG61998 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049924315Q → P. Corresponds to variant dbSNP:rs11879884Ensembl.1
Natural variantiVAR_033620349V → D. Corresponds to variant dbSNP:rs1064490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04109622 – 144ASLLN…FTLYL → V in isoform 2. 1 PublicationAdd BLAST123
Alternative sequenceiVSP_041097415 – 426GKRIP…LAIGI → DWTLP in isoform 2 and isoform 3. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300230 mRNA Translation: BAG61998.1
CR749812 mRNA Translation: CAH18672.1
AC004654 Genomic DNA Translation: AAC15514.1
BC137500 mRNA Translation: AAI37501.1
BC142628 mRNA Translation: AAI42629.1
AH007519 Genomic DNA Translation: AAD21022.1
CCDSiCCDS33037.1 [Q9UQ74-1]
CCDS46090.1 [Q9UQ74-2]
CCDS46091.1 [Q9UQ74-3]
PIRiA28928
RefSeqiNP_001123639.1, NM_001130167.1 [Q9UQ74-3]
NP_001123640.1, NM_001130168.1 [Q9UQ74-2]
NP_874366.1, NM_182707.2 [Q9UQ74-1]
UniGeneiHs.466843

Genome annotation databases

EnsembliENST00000306511; ENSP00000305005; ENSG00000124467 [Q9UQ74-1]
ENST00000404209; ENSP00000385869; ENSG00000124467 [Q9UQ74-3]
ENST00000406636; ENSP00000385081; ENSG00000124467 [Q9UQ74-2]
GeneIDi440533
KEGGihsa:440533
UCSCiuc002ouh.4 human [Q9UQ74-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSG8_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ74
Secondary accession number(s): A5PKV3
, B2RPL4, B4DTI6, O60410, Q68CR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2004
Last modified: February 28, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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