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Protein

Pregnancy-specific beta-1-glycoprotein 8

Gene

PSG8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 8
Short name:
PS-beta-G-8
Short name:
PSBG-8
Short name:
Pregnancy-specific glycoprotein 8
Gene namesi
Name:PSG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9525. PSG8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33870.

Polymorphism and mutation databases

BioMutaiPSG8.
DMDMi47117919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 426392Pregnancy-specific beta-1-glycoprotein 8PRO_0000014915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 217Curated
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi262 ↔ 310Curated
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9UQ74.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiQ9UQ74.
CleanExiHS_PSG8.
ExpressionAtlasiQ9UQ74. baseline.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000305005.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ74.
SMRiQ9UQ74. Positions 34-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini240 – 32788Ig-like C2-type 2Add
BLAST
Domaini335 – 41076Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ9UQ74.
KOiK06500.
OMAiFIREITT.
OrthoDBiEOG74BJS7.
PhylomeDBiQ9UQ74.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLSAPPCT QRITWKGLLL TASLLNFWNP PTTAQVTIEA QPTKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
IYSNASLLIQ NVTQEDAGSY TLHIIMGGDE NRGVTGHFTF TLYLETPKPS
160 170 180 190 200
ISSSKLNPRE AMEAVSLTCD PETPDASYLW WMNGQSLPMS HRLQLSETNR
210 220 230 240 250
TLFLLGVTKY TAGPYECEIR NPVSASRSDP FTLNLLPKLP KPYITINNLK
260 270 280 290 300
PRENKDVLNF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDQYGGIR SYPVTLNVLY GPDLPRIYPS FTYYRSGEVL
360 370 380 390 400
YLSCSADSNP PAQYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA
410 420
TGKESSKSMT VKVSGKRIPV SLAIGI
Length:426
Mass (Da):47,772
Last modified:May 10, 2004 - v2
Checksum:iC81C9E026BEC0D59
GO
Isoform 2 (identifier: Q9UQ74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-144: ASLLNFWNPP...TGHFTFTLYL → V
     415-426: GKRIPVSLAIGI → DWTLP

Show »
Length:297
Mass (Da):33,511
Checksum:i4C1624E396410969
GO
Isoform 3 (identifier: Q9UQ74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     415-426: GKRIPVSLAIGI → DWTLP

Show »
Length:419
Mass (Da):47,179
Checksum:i19D2569E1C265A7A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 123TQR → MQH in CAH18672 (PubMed:17974005).Curated
Sequence conflicti79 – 791I → T in CAH18672 (PubMed:17974005).Curated
Sequence conflicti153 – 1531S → I in BAG61998 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti315 – 3151Q → P.
Corresponds to variant rs11879884 [ dbSNP | Ensembl ].
VAR_049924
Natural varianti349 – 3491V → D.
Corresponds to variant rs1064490 [ dbSNP | Ensembl ].
VAR_033620

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 144123ASLLN…FTLYL → V in isoform 2. 1 PublicationVSP_041096Add
BLAST
Alternative sequencei415 – 42612GKRIP…LAIGI → DWTLP in isoform 2 and isoform 3. 3 PublicationsVSP_041097Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300230 mRNA. Translation: BAG61998.1.
CR749812 mRNA. Translation: CAH18672.1.
AC004654 Genomic DNA. Translation: AAC15514.1.
BC137500 mRNA. Translation: AAI37501.1.
BC142628 mRNA. Translation: AAI42629.1.
AH007519 Genomic DNA. Translation: AAD21022.1.
CCDSiCCDS33037.1. [Q9UQ74-1]
CCDS46090.1. [Q9UQ74-2]
CCDS46091.1. [Q9UQ74-3]
PIRiA28928.
RefSeqiNP_001123639.1. NM_001130167.1. [Q9UQ74-3]
NP_001123640.1. NM_001130168.1. [Q9UQ74-2]
NP_874366.1. NM_182707.2. [Q9UQ74-1]
UniGeneiHs.466843.

Genome annotation databases

EnsembliENST00000306511; ENSP00000305005; ENSG00000124467.
ENST00000404209; ENSP00000385869; ENSG00000124467. [Q9UQ74-3]
ENST00000406636; ENSP00000385081; ENSG00000124467. [Q9UQ74-2]
GeneIDi440533.
KEGGihsa:440533.
UCSCiuc002ouh.3. human. [Q9UQ74-3]
uc002ouo.2. human. [Q9UQ74-1]
uc010ein.3. human. [Q9UQ74-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300230 mRNA. Translation: BAG61998.1.
CR749812 mRNA. Translation: CAH18672.1.
AC004654 Genomic DNA. Translation: AAC15514.1.
BC137500 mRNA. Translation: AAI37501.1.
BC142628 mRNA. Translation: AAI42629.1.
AH007519 Genomic DNA. Translation: AAD21022.1.
CCDSiCCDS33037.1. [Q9UQ74-1]
CCDS46090.1. [Q9UQ74-2]
CCDS46091.1. [Q9UQ74-3]
PIRiA28928.
RefSeqiNP_001123639.1. NM_001130167.1. [Q9UQ74-3]
NP_001123640.1. NM_001130168.1. [Q9UQ74-2]
NP_874366.1. NM_182707.2. [Q9UQ74-1]
UniGeneiHs.466843.

3D structure databases

ProteinModelPortaliQ9UQ74.
SMRiQ9UQ74. Positions 34-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000305005.

Polymorphism and mutation databases

BioMutaiPSG8.
DMDMi47117919.

Proteomic databases

PRIDEiQ9UQ74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306511; ENSP00000305005; ENSG00000124467.
ENST00000404209; ENSP00000385869; ENSG00000124467. [Q9UQ74-3]
ENST00000406636; ENSP00000385081; ENSG00000124467. [Q9UQ74-2]
GeneIDi440533.
KEGGihsa:440533.
UCSCiuc002ouh.3. human. [Q9UQ74-3]
uc002ouo.2. human. [Q9UQ74-1]
uc010ein.3. human. [Q9UQ74-2]

Organism-specific databases

CTDi440533.
GeneCardsiGC19M043256.
HGNCiHGNC:9525. PSG8.
HPAiHPA046327.
MIMi176397. gene.
neXtProtiNX_Q9UQ74.
PharmGKBiPA33870.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ9UQ74.
KOiK06500.
OMAiFIREITT.
OrthoDBiEOG74BJS7.
PhylomeDBiQ9UQ74.
TreeFamiTF336859.

Miscellaneous databases

GenomeRNAii440533.
NextBioi109332.
PROiQ9UQ74.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UQ74.
CleanExiHS_PSG8.
ExpressionAtlasiQ9UQ74. baseline.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  5. "Evolution of the carcinoembryonic antigen family. structures of CGM9, CGM11 and pregnancy-specific glycoprotein promoters."
    Fraengsmyr L., Israelsson A., Teglund S., Matsunaga T., Hammarstroem S.
    Tumor Biol. 21:63-81(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-144 (ISOFORM 1).

Entry informationi

Entry nameiPSG8_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ74
Secondary accession number(s): A5PKV3
, B2RPL4, B4DTI6, O60410, Q68CR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2004
Last modified: July 22, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.