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Protein

Pregnancy-specific beta-1-glycoprotein 11

Gene

PSG11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 11
Short name:
PS-beta-G-11
Short name:
PSBG-11
Short name:
Pregnancy-specific glycoprotein 11
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 13
Short name:
PS-beta-G-13
Short name:
PSBG-13
Short name:
Pregnancy-specific glycoprotein 13
Gene namesi
Name:PSG11
Synonyms:PSG13, PSG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9516. PSG11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742300.

Polymorphism and mutation databases

BioMutaiPSG11.
DMDMi296452992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 335301Pregnancy-specific beta-1-glycoprotein 11PRO_0000014918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi169 ↔ 217PROSITE-ProRule annotation
Disulfide bondi261 ↔ 301PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UQ72.
PeptideAtlasiQ9UQ72.
PRIDEiQ9UQ72.

PTM databases

iPTMnetiQ9UQ72.
PhosphoSiteiQ9UQ72.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiQ9UQ72.
CleanExiHS_PSG11.
ExpressionAtlasiQ9UQ72. baseline and differential.
GenevisibleiQ9UQ72. HS.

Organism-specific databases

HPAiHPA042240.

Interactioni

Protein-protein interaction databases

BioGridi111653. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ72.
SMRiQ9UQ72. Positions 33-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini242 – 31776Ig-like C2-type 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1293Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ9UQ72.
KOiK06500.
OrthoDBiEOG74BJS7.
PhylomeDBiQ9UQ72.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLSAPPCT EHIKWKGLLL TALLLNFWNL PTTAQVMIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS
160 170 180 190 200
ISSSNLNPRE AMETVILTCN PETPDASYLW WMNGQSLPMT HRMQLSETNR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIW NSGSASRSDP VTLNLLHGPD LPRIFPSVTS
260 270 280 290 300
YYSGENLDLS CFANSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITPKHNGLYA
310 320 330
CSARNSATGE ESSTSLTIRV IAPPGLGTFA FNNPT
Length:335
Mass (Da):37,146
Last modified:May 18, 2010 - v3
Checksum:i4C58685C2CA0FF29
GO
Isoform 2 (identifier: Q9UQ72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-144: ALLLNFWNLP...TGYFTFTLYL → V

Show »
Length:213
Mass (Da):23,359
Checksum:iF4D06A2D193656FA
GO

Sequence cautioni

The sequence AAA36516.1 differs from that shown. Reason: Frameshift at position 330. Curated
The sequence AAA75299.1 differs from that shown. Reason: Frameshift at position 330. Curated
The sequence AAH20711.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831V → I.1 Publication
Corresponds to variant rs2471952 [ dbSNP | Ensembl ].
VAR_061325
Natural varianti176 – 1761A → T.
Corresponds to variant rs1058085 [ dbSNP | Ensembl ].
VAR_056076
Natural varianti264 – 2641N → D.2 Publications
Corresponds to variant rs10414166 [ dbSNP | Ensembl ].
VAR_060365
Natural varianti310 – 3101E → K.
Corresponds to variant rs10412348 [ dbSNP | Ensembl ].
VAR_061326

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei22 – 144123ALLLN…FTLYL → V in isoform 2. 1 PublicationVSP_007876Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69245 mRNA. Translation: AAA36516.1. Frameshift.
U25988 mRNA. Translation: AAA75299.1. Frameshift.
AC004784 Genomic DNA. No translation available.
AC005947 Genomic DNA. No translation available.
BC020711 mRNA. Translation: AAH20711.2. Different initiation.
AH007522 Genomic DNA. Translation: AAD21024.1.
AF129398 Genomic DNA. Translation: AAD38357.1.
CCDSiCCDS12614.2. [Q9UQ72-1]
CCDS12615.2. [Q9UQ72-2]
PIRiJC4122.
JN0067.
RefSeqiNP_001106881.1. NM_001113410.1. [Q9UQ72-2]
NP_002776.3. NM_002785.2. [Q9UQ72-1]
NP_976032.2. NM_203287.1. [Q9UQ72-2]
UniGeneiHs.741150.

Genome annotation databases

EnsembliENST00000306322; ENSP00000304913; ENSG00000243130. [Q9UQ72-2]
ENST00000320078; ENSP00000319140; ENSG00000243130. [Q9UQ72-1]
ENST00000403486; ENSP00000385427; ENSG00000243130. [Q9UQ72-2]
GeneIDi5680.
KEGGihsa:5680.
UCSCiuc002ovm.2. human. [Q9UQ72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69245 mRNA. Translation: AAA36516.1. Frameshift.
U25988 mRNA. Translation: AAA75299.1. Frameshift.
AC004784 Genomic DNA. No translation available.
AC005947 Genomic DNA. No translation available.
BC020711 mRNA. Translation: AAH20711.2. Different initiation.
AH007522 Genomic DNA. Translation: AAD21024.1.
AF129398 Genomic DNA. Translation: AAD38357.1.
CCDSiCCDS12614.2. [Q9UQ72-1]
CCDS12615.2. [Q9UQ72-2]
PIRiJC4122.
JN0067.
RefSeqiNP_001106881.1. NM_001113410.1. [Q9UQ72-2]
NP_002776.3. NM_002785.2. [Q9UQ72-1]
NP_976032.2. NM_203287.1. [Q9UQ72-2]
UniGeneiHs.741150.

3D structure databases

ProteinModelPortaliQ9UQ72.
SMRiQ9UQ72. Positions 33-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111653. 3 interactions.

PTM databases

iPTMnetiQ9UQ72.
PhosphoSiteiQ9UQ72.

Polymorphism and mutation databases

BioMutaiPSG11.
DMDMi296452992.

Proteomic databases

PaxDbiQ9UQ72.
PeptideAtlasiQ9UQ72.
PRIDEiQ9UQ72.

Protocols and materials databases

DNASUi5680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306322; ENSP00000304913; ENSG00000243130. [Q9UQ72-2]
ENST00000320078; ENSP00000319140; ENSG00000243130. [Q9UQ72-1]
ENST00000403486; ENSP00000385427; ENSG00000243130. [Q9UQ72-2]
GeneIDi5680.
KEGGihsa:5680.
UCSCiuc002ovm.2. human. [Q9UQ72-1]

Organism-specific databases

CTDi5680.
GeneCardsiPSG11.
H-InvDBHIX0212777.
HGNCiHGNC:9516. PSG11.
HPAiHPA042240.
MIMi176401. gene.
neXtProtiNX_Q9UQ72.
PharmGKBiPA164742300.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ9UQ72.
KOiK06500.
OrthoDBiEOG74BJS7.
PhylomeDBiQ9UQ72.
TreeFamiTF336859.

Miscellaneous databases

GenomeRNAii5680.
PROiQ9UQ72.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UQ72.
CleanExiHS_PSG11.
ExpressionAtlasiQ9UQ72. baseline and differential.
GenevisibleiQ9UQ72. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a new pregnancy-specific beta-1-glycoprotein member."
    Plouzek C.A., Watanabe S., Chou J.Y.
    Biochem. Biophys. Res. Commun. 176:1532-1538(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-264.
    Tissue: Placenta.
  2. "Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants."
    Teglund S., Zhou G.Q., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 211:656-664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    Tissue: Liver.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-264.
    Tissue: Placenta.
  5. "Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143, VARIANT ILE-83.
  6. "CGM15-PSG13 intergenic sequence."
    Fraengsmyr L., Teglund S., Israelsson A., Matsunaga T., Hammarstroem S.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.

Entry informationi

Entry nameiPSG11_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ72
Secondary accession number(s): Q13179
, Q15242, Q8WW91, Q9UNE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.