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Protein

Contactin-6

Gene

CNTN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).By similarity

GO - Biological processi

  • cell adhesion Source: ProtInc
  • central nervous system development Source: ProtInc
  • neuron differentiation Source: InterPro
  • Notch signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-447041. CHL1 interactions.
SignaLinkiQ9UQ52.
SIGNORiQ9UQ52.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-6
Alternative name(s):
Neural recognition molecule NB-3
Short name:
hNB-3
Gene namesi
Name:CNTN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2176. CNTN6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26690.

Polymorphism and mutation databases

BioMutaiCNTN6.
DMDMi55976622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 999980Contactin-6PRO_0000014727Add
BLAST
Propeptidei1000 – 102829Removed in mature formSequence analysisPRO_0000014728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi659 – 6591N-linked (GlcNAc...)Sequence analysis
Glycosylationi765 – 7651N-linked (GlcNAc...)Sequence analysis
Glycosylationi860 – 8601N-linked (GlcNAc...)Sequence analysis
Glycosylationi865 – 8651N-linked (GlcNAc...)Sequence analysis
Modified residuei882 – 8821PhosphotyrosineCombined sources
Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence analysis
Glycosylationi931 – 9311N-linked (GlcNAc...)Sequence analysis
Glycosylationi956 – 9561N-linked (GlcNAc...)Sequence analysis
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence analysis
Lipidationi999 – 9991GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UQ52.
PaxDbiQ9UQ52.
PeptideAtlasiQ9UQ52.
PRIDEiQ9UQ52.

PTM databases

iPTMnetiQ9UQ52.
PhosphoSiteiQ9UQ52.

Expressioni

Tissue specificityi

Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.

Gene expression databases

BgeeiQ9UQ52.
CleanExiHS_CNTN6.
ExpressionAtlasiQ9UQ52. baseline and differential.
GenevisibleiQ9UQ52. HS.

Organism-specific databases

HPAiHPA016645.

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000341882.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ52.
SMRiQ9UQ52. Positions 24-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 11792Ig-like C2-type 1Add
BLAST
Domaini122 – 20887Ig-like C2-type 2Add
BLAST
Domaini227 – 30882Ig-like C2-type 3Add
BLAST
Domaini318 – 40285Ig-like C2-type 4Add
BLAST
Domaini408 – 49588Ig-like C2-type 5Add
BLAST
Domaini499 – 58789Ig-like C2-type 6Add
BLAST
Domaini600 – 69899Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini703 – 80098Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini805 – 90197Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini902 – 99695Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9UQ52.
KOiK06764.
OMAiCLNWEHV.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ9UQ52.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR033009. Contactin-6.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF52. PTHR10489:SF52. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQ52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLWKLVIL LPLINSSAGD GLLSRPIFTQ EPHDVIFPLD LSKSEVILNC
60 70 80 90 100
AANGYPSPHY RWKQNGTDID FTMSYHYRLD GGSLAINSPH TDQDIGMYQC
110 120 130 140 150
LATNLLGTIL SRKAKLQFAY IEDFETKTRS TVSVREGQGV VLLCGPPPHF
160 170 180 190 200
GDLSYAWTFN DNPLYVQEDN RRFVSQETGN LYIAKVEPSD VGNYTCFITN
210 220 230 240 250
KEAQRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA KDSSVKLECF
260 270 280 290 300
ALGNPVPDIS WRRLDGSPLP GKVKYSKSQA ILEIPNFQQE DEGFYECIAS
310 320 330 340 350
NLRGRNLAKG QLIFYAPPEW EQKIQNTHLS IYDNLLWECK ASGKPNPWYT
360 370 380 390 400
WLKNGERLNP EERIQIENGT LIITMLNVSD SGVYQCAAEN KYQIIYANAE
410 420 430 440 450
LRVLASAPDF SKSPVKKKSF VQVGGDIVIG CKPNAFPRAA ISWKRGTETL
460 470 480 490 500
RQSKRIFLLE DGSLKIYNIT RSDAGSYTCI ATNQFGTAKN TGSLIVKERT
510 520 530 540 550
VITVPPSKMD VTVGESIVLP CQVSHDPSIE VVFVWFFNGD VIDLKKGVAH
560 570 580 590 600
FERIGGESVG DLMIRNIQLH HSGKYLCTVQ TTLESLSAVA DIIVRGPPGP
610 620 630 640 650
PEDVQVEDIS STTSQLSWRA GPDNNSPIQI FTIQTRTPFS VGWQAVATVP
660 670 680 690 700
EILNGKTYNA TVVGLSPWVE YEFRVVAGNS IGIGEPSEPS ELLRTKASVP
710 720 730 740 750
VVAPVNIHGG GGSRSELVIT WESIPEELQN GEGFGYIIMF RPVGSTTWSK
760 770 780 790 800
EKVSSVESSR FVYRNESIIP LSPFEVKVGV YNNEGEGSLS TVTIVYSGED
810 820 830 840 850
EPQLAPRGTS LQSFSASEME VSWNAIAWNR NTGRVLGYEV LYWTDDSKES
860 870 880 890 900
MIGKIRVSGN VTTKNITGLK ANTIYFASVR AYNTAGTGPS SPPVNVTTKK
910 920 930 940 950
SPPSQPPANI AWKLTNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT
960 970 980 990 1000
HILETNNTSA ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSR
1010 1020
GIQFLEPSTH FLSIVIVIFH CFAIQPLI
Length:1,028
Mass (Da):113,956
Last modified:May 1, 2000 - v1
Checksum:i8B5A2ED2F29936A6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081T → A in a breast cancer sample; somatic mutation. 1 Publication
VAR_035509
Natural varianti150 – 1501F → S.
Corresponds to variant rs6808056 [ dbSNP | Ensembl ].
VAR_033611
Natural varianti303 – 3031R → Q.1 Publication
Corresponds to variant rs41293401 [ dbSNP | Ensembl ].
VAR_065744
Natural varianti314 – 3141F → V.1 Publication
Corresponds to variant rs774763830 [ dbSNP | Ensembl ].
VAR_065745
Natural varianti440 – 4401A → S.
Corresponds to variant rs265771 [ dbSNP | Ensembl ].
VAR_019913
Natural varianti585 – 5851S → C in a breast cancer sample; somatic mutation. 1 Publication
VAR_035510
Natural varianti954 – 9541E → V in a patient with amyotrophic lateral sclerosis. 1 Publication
VAR_065746

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003592 mRNA. Translation: BAA82612.1.
BC113118 mRNA. Translation: AAI13119.1.
CCDSiCCDS2557.1.
RefSeqiNP_001276009.1. NM_001289080.1.
NP_001276010.1. NM_001289081.1.
NP_055276.1. NM_014461.3.
XP_005265115.1. XM_005265058.3.
XP_011531891.1. XM_011533589.1.
XP_011531892.1. XM_011533590.1.
UniGeneiHs.387300.
Hs.590078.

Genome annotation databases

EnsembliENST00000350110; ENSP00000341882; ENSG00000134115.
ENST00000446702; ENSP00000407822; ENSG00000134115.
GeneIDi27255.
KEGGihsa:27255.
UCSCiuc003boz.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003592 mRNA. Translation: BAA82612.1.
BC113118 mRNA. Translation: AAI13119.1.
CCDSiCCDS2557.1.
RefSeqiNP_001276009.1. NM_001289080.1.
NP_001276010.1. NM_001289081.1.
NP_055276.1. NM_014461.3.
XP_005265115.1. XM_005265058.3.
XP_011531891.1. XM_011533589.1.
XP_011531892.1. XM_011533590.1.
UniGeneiHs.387300.
Hs.590078.

3D structure databases

ProteinModelPortaliQ9UQ52.
SMRiQ9UQ52. Positions 24-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341882.

PTM databases

iPTMnetiQ9UQ52.
PhosphoSiteiQ9UQ52.

Polymorphism and mutation databases

BioMutaiCNTN6.
DMDMi55976622.

Proteomic databases

MaxQBiQ9UQ52.
PaxDbiQ9UQ52.
PeptideAtlasiQ9UQ52.
PRIDEiQ9UQ52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350110; ENSP00000341882; ENSG00000134115.
ENST00000446702; ENSP00000407822; ENSG00000134115.
GeneIDi27255.
KEGGihsa:27255.
UCSCiuc003boz.5. human.

Organism-specific databases

CTDi27255.
GeneCardsiCNTN6.
HGNCiHGNC:2176. CNTN6.
HPAiHPA016645.
MIMi607220. gene.
neXtProtiNX_Q9UQ52.
PharmGKBiPA26690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ9UQ52.
KOiK06764.
OMAiCLNWEHV.
OrthoDBiEOG7J17Z5.
PhylomeDBiQ9UQ52.
TreeFamiTF351103.

Enzyme and pathway databases

ReactomeiR-HSA-447041. CHL1 interactions.
SignaLinkiQ9UQ52.
SIGNORiQ9UQ52.

Miscellaneous databases

GeneWikiiCNTN6.
GenomeRNAii27255.
PROiQ9UQ52.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UQ52.
CleanExiHS_CNTN6.
ExpressionAtlasiQ9UQ52. baseline and differential.
GenevisibleiQ9UQ52. HS.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR033009. Contactin-6.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF52. PTHR10489:SF52. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal localization of neural adhesion molecule, NB-3 in human."
    Kamei Y., Tsutsumi O., Taketani Y., Watanabe K.
    J. Neurosci. Res. 51:275-283(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-882, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules."
    Bouyain S., Watkins D.J.
    Proc. Natl. Acad. Sci. U.S.A. 107:2443-2448(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRG.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-108 AND CYS-585.
  6. "Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
    Daoud H., Valdmanis P.N., Gros-Louis F., Belzil V., Spiegelman D., Henrion E., Diallo O., Desjarlais A., Gauthier J., Camu W., Dion P.A., Rouleau G.A.
    Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLN-303; VAL-314 AND VAL-954.

Entry informationi

Entry nameiCNTN6_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ52
Secondary accession number(s): Q2KHM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.