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Protein

Serine/arginine repetitive matrix protein 2

Gene

SRRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.By similarity1 Publication

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167978-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 2
Alternative name(s):
300 kDa nuclear matrix antigen
Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
Short name:
SR-related nuclear matrix protein of 300 kDa
Short name:
Ser/Arg-related nuclear matrix protein of 300 kDa
Splicing coactivator subunit SRm300
Tax-responsive enhancer element-binding protein 803
Short name:
TaxREB803
Gene namesi
Name:SRRM2
Synonyms:KIAA0324, SRL300, SRM300
ORF Names:HSPC075
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:16639. SRRM2.

Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • catalytic step 2 spliceosome Source: UniProtKB
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23524.
OpenTargetsiENSG00000167978.
PharmGKBiPA38178.

Polymorphism and mutation databases

BioMutaiSRRM2.
DMDMi143928063.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002481541 – 2752Serine/arginine repetitive matrix protein 2Add BLAST2752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei101N6-acetyllysineBy similarity1
Modified residuei145PhosphotyrosineCombined sources1
Modified residuei169N6-acetyllysineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei286PhosphothreonineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei359PhosphothreonineCombined sources1
Modified residuei367PhosphothreonineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei383PhosphothreonineCombined sources1
Modified residuei384PhosphothreonineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei506PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei704PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei780PhosphoserineCombined sources1
Modified residuei783PhosphoserineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei854PhosphoserineBy similarity1
Modified residuei856PhosphothreonineBy similarity1
Modified residuei857PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei866PhosphothreonineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei876PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei950PhosphoserineCombined sources1
Modified residuei952PhosphoserineCombined sources1
Modified residuei954PhosphoserineCombined sources1
Modified residuei957PhosphoserineCombined sources1
Modified residuei968PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1
Modified residuei972PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei974PhosphoserineCombined sources1
Modified residuei977PhosphothreonineCombined sources1
Modified residuei983PhosphothreonineCombined sources1
Modified residuei992PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei996PhosphotyrosineCombined sources1
Modified residuei1003PhosphothreonineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1024PhosphoserineBy similarity1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1042PhosphoserineBy similarity1
Modified residuei1043PhosphothreonineCombined sources1
Modified residuei1049PhosphotyrosineCombined sources1
Modified residuei1064PhosphoserineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1072PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1083PhosphoserineCombined sources1
Modified residuei1099PhosphoserineCombined sources1
Modified residuei1101PhosphoserineCombined sources1
Modified residuei1102PhosphoserineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1106PhosphothreonineCombined sources1
Modified residuei1112PhosphoserineCombined sources1
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1124PhosphoserineCombined sources1
Modified residuei1129PhosphoserineCombined sources1
Modified residuei1132PhosphoserineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1188PhosphoserineCombined sources1
Modified residuei1198PhosphoserineCombined sources1
Modified residuei1208PhosphothreonineCombined sources1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1219PhosphoserineCombined sources1
Modified residuei1227PhosphoserineCombined sources1
Modified residuei1254PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1258PhosphoserineCombined sources1
Modified residuei1266PhosphoserineBy similarity1
Modified residuei1270PhosphoserineBy similarity1
Modified residuei1271PhosphoserineBy similarity1
Modified residuei1311PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1320PhosphoserineCombined sources1
Modified residuei1326PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1336PhosphoserineCombined sources1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1368PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1383PhosphoserineBy similarity1
Modified residuei1384PhosphoserineBy similarity1
Modified residuei1387PhosphoserineCombined sources1
Modified residuei1401PhosphoserineCombined sources1
Modified residuei1403PhosphoserineCombined sources1
Modified residuei1404PhosphoserineCombined sources1
Modified residuei1413PhosphothreonineCombined sources1
Modified residuei1415PhosphoserineCombined sources1
Modified residuei1421PhosphoserineCombined sources1
Modified residuei1423PhosphoserineBy similarity1
Modified residuei1424PhosphoserineCombined sources1
Modified residuei1434PhosphothreonineCombined sources1
Modified residuei1444PhosphoserineCombined sources1
Modified residuei1451PhosphoserineCombined sources1
Modified residuei1453PhosphothreonineCombined sources1
Modified residuei1458PhosphoserineCombined sources1
Modified residuei1460PhosphoserineCombined sources1
Modified residuei1462PhosphoserineCombined sources