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Serine/arginine repetitive matrix protein 2



Homo sapiens (Human)
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli


Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.By similarity1 Publication

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • mRNA splicing, via spliceosome Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi


Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 2
Alternative name(s):
300 kDa nuclear matrix antigen
Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
Short name:
SR-related nuclear matrix protein of 300 kDa
Short name:
Ser/Arg-related nuclear matrix protein of 300 kDa
Splicing coactivator subunit SRm300
Tax-responsive enhancer element-binding protein 803
Short name:
Gene namesi
Synonyms:KIAA0324, SRL300, SRM300
ORF Names:HSPC075
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases


Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • catalytic step 2 spliceosome Source: UniProtKB
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases


Polymorphism and mutation databases


PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27522752Serine/arginine repetitive matrix protein 2PRO_0000248154Add

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources1 Publication
Modified residuei24 – 241Phosphoserine1 Publication
Modified residuei101 – 1011N6-acetyllysineBy similarity
Modified residuei145 – 1451PhosphotyrosineCombined sources
Modified residuei169 – 1691N6-acetyllysineCombined sources
Modified residuei220 – 2201PhosphoserineCombined sources
Modified residuei222 – 2221PhosphoserineCombined sources
Modified residuei286 – 2861PhosphothreonineCombined sources
Modified residuei295 – 2951PhosphoserineCombined sources
Modified residuei297 – 2971PhosphoserineCombined sources
Modified residuei300 – 3001PhosphoserineCombined sources
Modified residuei322 – 3221PhosphoserineCombined sources
Modified residuei323 – 3231PhosphoserineCombined sources
Modified residuei351 – 3511PhosphoserineCombined sources
Modified residuei353 – 3531PhosphoserineCombined sources
Modified residuei357 – 3571PhosphoserineCombined sources
Modified residuei358 – 3581PhosphoserineCombined sources
Modified residuei359 – 3591PhosphothreonineCombined sources
Modified residuei367 – 3671PhosphothreonineCombined sources
Modified residuei377 – 3771PhosphoserineCombined sources
Modified residuei383 – 3831PhosphothreonineCombined sources
Modified residuei384 – 3841PhosphothreonineCombined sources
Modified residuei387 – 3871PhosphoserineCombined sources
Modified residuei395 – 3951PhosphoserineCombined sources
Modified residuei398 – 3981PhosphoserineCombined sources
Modified residuei404 – 4041PhosphoserineCombined sources
Modified residuei408 – 4081PhosphoserineCombined sources
Modified residuei424 – 4241PhosphoserineCombined sources
Modified residuei435 – 4351PhosphoserineCombined sources
Modified residuei436 – 4361PhosphoserineBy similarity
Modified residuei437 – 4371PhosphoserineBy similarity
Modified residuei440 – 4401PhosphoserineCombined sources
Modified residuei454 – 4541PhosphoserineCombined sources
Modified residuei484 – 4841PhosphoserineCombined sources
Modified residuei486 – 4861PhosphoserineCombined sources
Modified residuei534 – 5341PhosphoserineBy similarity
Modified residuei536 – 5361PhosphoserineBy similarity
Modified residuei778 – 7781PhosphoserineCombined sources
Modified residuei780 – 7801PhosphoserineCombined sources
Modified residuei783 – 7831PhosphoserineCombined sources
Modified residuei846 – 8461PhosphoserineCombined sources
Modified residuei857 – 8571PhosphoserineCombined sources
Modified residuei864 – 8641PhosphoserineCombined sources
Modified residuei866 – 8661PhosphothreonineCombined sources
Modified residuei871 – 8711PhosphoserineCombined sources
Modified residuei875 – 8751PhosphoserineCombined sources
Modified residuei876 – 8761PhosphoserineCombined sources
Modified residuei908 – 9081PhosphoserineCombined sources
Modified residuei924 – 9241Phosphoserine1 Publication
Modified residuei935 – 9351PhosphoserineCombined sources
Modified residuei950 – 9501PhosphoserineCombined sources
Modified residuei952 – 9521PhosphoserineCombined sources
Modified residuei954 – 9541PhosphoserineCombined sources
Modified residuei957 – 9571PhosphoserineCombined sources
Modified residuei968 – 9681PhosphoserineCombined sources
Modified residuei970 – 9701PhosphoserineCombined sources
Modified residuei972 – 9721PhosphoserineCombined sources
Modified residuei973 – 9731PhosphoserineCombined sources
Modified residuei974 – 9741PhosphoserineCombined sources
Modified residuei977 – 9771PhosphothreonineCombined sources
Modified residuei983 – 9831PhosphothreonineCombined sources
Modified residuei994 – 9941PhosphoserineCombined sources
Modified residuei996 – 9961PhosphotyrosineCombined sources
Modified residuei1003 – 10031PhosphothreonineCombined sources
Modified residuei1010 – 10101PhosphoserineCombined sources
Modified residuei1014 – 10141PhosphoserineCombined sources
Modified residuei1028 – 10281PhosphoserineCombined sources
Modified residuei1032 – 10321PhosphoserineCombined sources
Modified residuei1043 – 10431PhosphothreonineCombined sources
Modified residuei1049 – 10491PhosphotyrosineCombined sources
Modified residuei1064 – 10641PhosphoserineCombined sources
Modified residuei1069 – 10691PhosphoserineCombined sources
Modified residuei1072 – 10721PhosphoserineCombined sources
Modified residuei1073 – 10731PhosphoserineCombined sources
Modified residuei1083 – 10831PhosphoserineCombined sources
Modified residuei1099 – 10991PhosphoserineCombined sources
Modified residuei1101 – 11011PhosphoserineCombined sources
Modified residuei1102 – 11021PhosphoserineCombined sources
Modified residuei1103 – 11031PhosphoserineCombined sources
Modified residuei1106 – 11061PhosphothreonineCombined sources
Modified residuei1112 – 11121PhosphoserineCombined sources
Modified residuei1122 – 11221PhosphoserineCombined sources
Modified residuei1124 – 11241PhosphoserineCombined sources
Modified residuei1129 – 11291PhosphoserineCombined sources
Modified residuei1132 – 11321PhosphoserineCombined sources
Modified residuei1152 – 11521PhosphoserineCombined sources
Modified residuei1179 – 11791PhosphoserineCombined sources
Modified residuei1188 – 11881PhosphoserineCombined sources
Modified residuei1208 – 12081PhosphothreonineCombined sources
Modified residuei1214 – 12141PhosphoserineCombined sources
Modified residuei1219 – 12191PhosphoserineCombined sources
Modified residuei1257 – 12571PhosphoserineBy similarity
Modified residuei1311 – 13111PhosphoserineCombined sources
Modified residuei1318 – 13181PhosphoserineCombined sources
Modified residuei1320 – 13201PhosphoserineCombined sources
Modified residuei1326 – 13261PhosphoserineCombined sources
Modified residuei1329 – 13291PhosphoserineCombined sources
Modified residuei1336 – 13361PhosphoserineCombined sources
Modified residuei1348 – 13481PhosphoserineBy similarity
Modified residuei1368 – 13681PhosphoserineCombined sources
Modified residuei1382 – 13821PhosphoserineCombined sources
Modified residuei1383 – 13831PhosphoserineBy similarity
Modified residuei1387 – 13871PhosphoserineCombined sources
Modified residuei1401 – 14011PhosphoserineCombined sources
Modified residuei1403 – 14031PhosphoserineCombined sources
Modified residuei1404 – 14041PhosphoserineCombined sources
Modified residuei1413 – 14131PhosphothreonineCombined sources
Modified residuei1415 – 14151PhosphoserineCombined sources
Modified residuei1421 – 14211PhosphoserineCombined sources
Modified residuei1423 – 14231PhosphoserineBy similarity
Modified residuei1424 – 14241PhosphoserineCombined sources
Modified residuei1434 – 14341PhosphothreonineCombined sources
Modified residuei1444 – 14441PhosphoserineCombined sources
Modified residuei1451 – 14511PhosphoserineCombined sources
Modified residuei1453 – 14531PhosphothreonineCombined sources
Modified residuei1458 – 14581PhosphoserineCombined sources
Modified residuei1460 – 14601PhosphoserineCombined sources
Modified residuei1462 – 14621PhosphoserineCombined sources
Modified residuei1463 – 14631PhosphoserineCombined sources
Modified residuei1472 – 14721PhosphothreonineCombined sources
Modified residuei1482 – 14821PhosphoserineCombined sources
Modified residuei1483 – 14831PhosphoserineCombined sources
Modified residuei1492 – 14921PhosphothreonineCombined sources
Modified residuei1497 – 14971PhosphoserineCombined sources
Modified residuei1499 – 14991PhosphoserineCombined sources
Modified residuei1501 – 15011PhosphoserineCombined sources
Modified residuei1502 – 15021PhosphoserineCombined sources
Modified residuei1511 – 15111PhosphothreonineCombined sources
Modified residuei1517 – 15171PhosphoserineCombined sources
Modified residuei1519 – 15191PhosphoserineCombined sources
Modified residuei1521 – 15211PhosphoserineCombined sources
Modified residuei1522 – 15221PhosphoserineCombined sources
Modified residuei1531 – 15311PhosphothreonineCombined sources
Modified residuei1537 – 15371PhosphoserineCombined sources
Modified residuei1539 – 15391PhosphoserineCombined sources
Modified residuei1541 – 15411PhosphoserineCombined sources
Modified residuei1542 – 15421PhosphoserineCombined sources
Modified residuei1552 – 15521PhosphoserineCombined sources
Modified residuei1577 – 15771PhosphoserineCombined sources
Modified residuei1579 – 15791PhosphoserineCombined sources
Modified residuei1581 – 15811PhosphoserineCombined sources
Modified residuei1582 – 15821PhosphoserineCombined sources
Modified residuei1598 – 15981PhosphoserineCombined sources
Modified residuei1600 – 16001PhosphoserineCombined sources
Modified residuei1601 – 16011PhosphoserineCombined sources
Modified residuei1616 – 16161PhosphoserineBy similarity
Modified residuei1620 – 16201PhosphoserineBy similarity
Modified residuei1621 – 16211PhosphoserineCombined sources
Modified residuei1648 – 16481PhosphoserineCombined sources
Modified residuei1658 – 16581PhosphoserineCombined sources
Modified residuei1691 – 16911PhosphoserineCombined sources
Modified residuei1693 – 16931PhosphoserineCombined sources
Modified residuei1694 – 16941PhosphoserineCombined sources
Modified residuei1698 – 16981PhosphothreonineCombined sources
Modified residuei1727 – 17271PhosphoserineCombined sources
Modified residuei1729 – 17291PhosphoserineCombined sources
Modified residuei1731 – 17311PhosphoserineCombined sources
Modified residuei1732 – 17321PhosphoserineCombined sources
Modified residuei1762 – 17621PhosphoserineCombined sources