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Q9UQ35

- SRRM2_HUMAN

UniProt

Q9UQ35 - SRRM2_HUMAN

Protein

Serine/arginine repetitive matrix protein 2

Gene

SRRM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate By similarity. Binds to RNA.By similarity1 Publication

    GO - Molecular functioni

    1. C2H2 zinc finger domain binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. protein N-terminus binding Source: UniProtKB

    GO - Biological processi

    1. mRNA splicing, via spliceosome Source: UniProtKB

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/arginine repetitive matrix protein 2
    Alternative name(s):
    300 kDa nuclear matrix antigen
    Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
    Short name:
    SR-related nuclear matrix protein of 300 kDa
    Short name:
    Ser/Arg-related nuclear matrix protein of 300 kDa
    Splicing coactivator subunit SRm300
    Tax-responsive enhancer element-binding protein 803
    Short name:
    TaxREB803
    Gene namesi
    Name:SRRM2
    Synonyms:KIAA0324, SRL300, SRM300
    ORF Names:HSPC075
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:16639. SRRM2.

    Subcellular locationi

    GO - Cellular componenti

    1. Cajal body Source: UniProtKB
    2. catalytic step 2 spliceosome Source: UniProtKB
    3. nuclear speck Source: UniProtKB
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38178.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 27522752Serine/arginine repetitive matrix protein 2PRO_0000248154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine3 Publications
    Modified residuei24 – 241Phosphoserine1 Publication
    Modified residuei101 – 1011N6-acetyllysineBy similarity
    Modified residuei145 – 1451Phosphotyrosine2 Publications
    Modified residuei169 – 1691N6-acetyllysine1 Publication
    Modified residuei220 – 2201Phosphoserine2 Publications
    Modified residuei222 – 2221Phosphoserine2 Publications
    Modified residuei286 – 2861Phosphothreonine2 Publications
    Modified residuei295 – 2951Phosphoserine3 Publications
    Modified residuei297 – 2971Phosphoserine4 Publications
    Modified residuei300 – 3001Phosphoserine2 Publications
    Modified residuei322 – 3221Phosphoserine3 Publications
    Modified residuei323 – 3231Phosphoserine3 Publications
    Modified residuei333 – 3331Phosphoserine2 Publications
    Modified residuei351 – 3511Phosphoserine5 Publications
    Modified residuei353 – 3531Phosphoserine5 Publications
    Modified residuei357 – 3571Phosphoserine2 Publications
    Modified residuei358 – 3581Phosphoserine2 Publications
    Modified residuei359 – 3591Phosphothreonine2 Publications
    Modified residuei367 – 3671Phosphothreonine4 Publications
    Modified residuei377 – 3771Phosphoserine7 Publications
    Modified residuei387 – 3871Phosphoserine2 Publications
    Modified residuei398 – 3981Phosphoserine3 Publications
    Modified residuei404 – 4041Phosphoserine2 Publications
    Modified residuei408 – 4081Phosphoserine2 Publications
    Modified residuei424 – 4241Phosphoserine3 Publications
    Modified residuei435 – 4351Phosphoserine2 Publications
    Modified residuei436 – 4361PhosphoserineBy similarity
    Modified residuei437 – 4371PhosphoserineBy similarity
    Modified residuei440 – 4401Phosphoserine5 Publications
    Modified residuei454 – 4541Phosphoserine2 Publications
    Modified residuei484 – 4841Phosphoserine2 Publications
    Modified residuei486 – 4861Phosphoserine2 Publications
    Modified residuei534 – 5341PhosphoserineBy similarity
    Modified residuei536 – 5361PhosphoserineBy similarity
    Modified residuei778 – 7781Phosphoserine4 Publications
    Modified residuei780 – 7801Phosphoserine2 Publications
    Modified residuei783 – 7831Phosphoserine3 Publications
    Modified residuei846 – 8461Phosphoserine2 Publications
    Modified residuei857 – 8571Phosphoserine3 Publications
    Modified residuei864 – 8641Phosphoserine2 Publications
    Modified residuei866 – 8661Phosphothreonine4 Publications
    Modified residuei871 – 8711Phosphoserine3 Publications
    Modified residuei875 – 8751Phosphoserine2 Publications
    Modified residuei876 – 8761Phosphoserine5 Publications
    Modified residuei908 – 9081Phosphoserine2 Publications
    Modified residuei924 – 9241Phosphoserine1 Publication
    Modified residuei950 – 9501Phosphoserine3 Publications
    Modified residuei952 – 9521Phosphoserine3 Publications
    Modified residuei954 – 9541Phosphoserine4 Publications
    Modified residuei957 – 9571Phosphoserine2 Publications
    Modified residuei968 – 9681Phosphoserine2 Publications
    Modified residuei970 – 9701Phosphoserine2 Publications
    Modified residuei972 – 9721Phosphoserine2 Publications
    Modified residuei973 – 9731Phosphoserine3 Publications
    Modified residuei974 – 9741Phosphoserine4 Publications
    Modified residuei977 – 9771Phosphothreonine2 Publications
    Modified residuei983 – 9831Phosphothreonine3 Publications
    Modified residuei992 – 9921Phosphoserine2 Publications
    Modified residuei994 – 9941Phosphoserine3 Publications
    Modified residuei1003 – 10031Phosphothreonine6 Publications
    Modified residuei1014 – 10141Phosphoserine3 Publications
    Modified residuei1028 – 10281Phosphoserine3 Publications
    Modified residuei1032 – 10321Phosphoserine2 Publications
    Modified residuei1043 – 10431Phosphothreonine2 Publications
    Modified residuei1064 – 10641Phosphoserine2 Publications
    Modified residuei1069 – 10691Phosphoserine3 Publications
    Modified residuei1072 – 10721Phosphoserine3 Publications
    Modified residuei1073 – 10731Phosphoserine3 Publications
    Modified residuei1083 – 10831Phosphoserine3 Publications
    Modified residuei1099 – 10991Phosphoserine5 Publications
    Modified residuei1101 – 11011Phosphoserine5 Publications
    Modified residuei1102 – 11021Phosphoserine4 Publications
    Modified residuei1103 – 11031Phosphoserine5 Publications
    Modified residuei1106 – 11061Phosphothreonine2 Publications
    Modified residuei1112 – 11121Phosphoserine2 Publications
    Modified residuei1122 – 11221Phosphoserine2 Publications
    Modified residuei1124 – 11241Phosphoserine3 Publications
    Modified residuei1129 – 11291Phosphoserine2 Publications
    Modified residuei1132 – 11321Phosphoserine4 Publications
    Modified residuei1152 – 11521Phosphoserine2 Publications
    Modified residuei1179 – 11791Phosphoserine4 Publications
    Modified residuei1188 – 11881Phosphoserine5 Publications
    Modified residuei1208 – 12081Phosphothreonine2 Publications
    Modified residuei1214 – 12141Phosphoserine2 Publications
    Modified residuei1219 – 12191Phosphoserine3 Publications
    Modified residuei1257 – 12571PhosphoserineBy similarity
    Modified residuei1311 – 13111PhosphoserineBy similarity
    Modified residuei1318 – 13181Phosphoserine3 Publications
    Modified residuei1320 – 13201Phosphoserine5 Publications
    Modified residuei1326 – 13261Phosphoserine4 Publications
    Modified residuei1329 – 13291Phosphoserine6 Publications
    Modified residuei1336 – 13361Phosphoserine2 Publications
    Modified residuei1348 – 13481PhosphoserineBy similarity
    Modified residuei1368 – 13681Phosphoserine2 Publications
    Modified residuei1382 – 13821Phosphoserine3 Publications
    Modified residuei1383 – 13831PhosphoserineBy similarity
    Modified residuei1387 – 13871Phosphoserine5 Publications
    Modified residuei1401 – 14011Phosphoserine3 Publications
    Modified residuei1403 – 14031Phosphoserine2 Publications
    Modified residuei1404 – 14041Phosphoserine5 Publications
    Modified residuei1413 – 14131Phosphothreonine4 Publications
    Modified residuei1415 – 14151Phosphoserine4 Publications
    Modified residuei1421 – 14211Phosphoserine2 Publications
    Modified residuei1423 – 14231PhosphoserineBy similarity
    Modified residuei1424 – 14241Phosphoserine2 Publications
    Modified residuei1434 – 14341Phosphothreonine2 Publications
    Modified residuei1444 – 14441Phosphoserine3 Publications
    Modified residuei1451 – 14511Phosphoserine2 Publications
    Modified residuei1453 – 14531Phosphothreonine2 Publications
    Modified residuei1458 – 14581Phosphoserine2 Publications
    Modified residuei1460 – 14601Phosphoserine2 Publications
    Modified residuei1462 – 14621Phosphoserine2 Publications
    Modified residuei1463 – 14631Phosphoserine3 Publications
    Modified residuei1472 – 14721Phosphothreonine2 Publications
    Modified residuei1482 – 14821Phosphoserine2 Publications
    Modified residuei1483 – 14831Phosphoserine2 Publications
    Modified residuei1492 – 14921Phosphothreonine3 Publications
    Modified residuei1497 – 14971Phosphoserine3 Publications
    Modified residuei1499 – 14991Phosphoserine3 Publications
    Modified residuei1501 – 15011Phosphoserine2 Publications
    Modified residuei1502 – 15021Phosphoserine3 Publications
    Modified residuei1511 – 15111Phosphothreonine2 Publications
    Modified residuei1517 – 15171Phosphoserine2 Publications
    Modified residuei1519 – 15191Phosphoserine2 Publications
    Modified residuei1521 – 15211Phosphoserine2 Publications
    Modified residuei1522 – 15221Phosphoserine3 Publications
    Modified residuei1531 – 15311Phosphothreonine3 Publications
    Modified residuei1537 – 15371Phosphoserine2 Publications
    Modified residuei1539 – 15391Phosphoserine2 Publications
    Modified residuei1541 – 15411Phosphoserine2 Publications
    Modified residuei1542 – 15421Phosphoserine3 Publications
    Modified residuei1552 – 15521Phosphoserine3 Publications
    Modified residuei1577 – 15771Phosphoserine2 Publications
    Modified residuei1579 – 15791Phosphoserine2 Publications
    Modified residuei1581 – 15811Phosphoserine2 Publications
    Modified residuei1582 – 15821Phosphoserine2 Publications
    Modified residuei1598 – 15981Phosphoserine2 Publications