Q9UQ26 (RIMS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulating synaptic membrane exocytosis protein 2

Alternative name(s):
Rab-3-interacting molecule 2
Short name=RIM 2
Rab-3-interacting protein 3

Gene names

Name:	RIMS2
Synonyms:	KIAA0751, RAB3IP3, RIM2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1411 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Rab effector involved in exocytosis. May act as scaffold protein.
Subunit structure	Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2 By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Cell junction › synapse By similarity. Cell junction › synapse › presynaptic cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 PDZ (DHR) domain. Contains 1 RabBD (Rab-binding) domain.
Sequence caution	The sequence BAA34471.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	2	EBI-1756749,EBI-389883

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 6 (identifier: Q9UQ26-6)

Also known as: RIM2-alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 1 (identifier: Q9UQ26-1)

Also known as: RIM2-beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.
     224-263: SGDLSVPAVE...HHIASDIASD → MQFETLRQVC...ELFGQTLNNA

Isoform 2 (identifier: Q9UQ26-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: S → R
     1039-1411: Missing.

Note: May be due to an intron retention. No experimental confirmation available.

Isoform 3 (identifier: Q9UQ26-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-223: Missing.
     224-263: SGDLSVPAVE...HHIASDIASD → MQFETLRQVC...ELFGQTLNNA
     575-642: SQKGKRKTSE...LNEEHSHSDK → MDYNWLDHTSWHSSEASPMSL
     1076-1076: D → DSHFLTLPRSRYSQTIDHHHRDG

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9UQ26-4)

Also known as: RimL3a;

The sequence of this isoform differs from the canonical sequence as follows:
     774-801: SSSFESQKMDRPSISVTSPMSPGMLRDV → KFYLCWKKTLFIIAFIRDQMKYLTSNVK
     802-1411: Missing.

Note: May be due to an intron retention. No experimental confirmation available.

Isoform 5 (identifier: Q9UQ26-5)

Also known as: RimL3c;

The sequence of this isoform differs from the canonical sequence as follows:
     811-824: IKLWFDKVGHQLIV → VCSHYVYSSFWNIK
     825-1411: Missing.

Note: May be due to an intron retention. No experimental confirmation available.

Isoform 7 (identifier: Q9UQ26-7)

Also known as: RIM2-gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1126: Missing.
     1127-1174: RSAPPSPALS...LPPKGTLDRK → MGRQGLGGAS...MNSLEEEEGE

Isoform 8 (identifier: Q9UQ26-8)

The sequence of this isoform differs from the canonical sequence as follows:
     50-90: KVKEEHKPQLTQWFPFSGITELVNNVLQPQQKQQNEKEPQT → EEEKEQSVLK
     575-642: SQKGKRKTSE...LNEEHSHSDK → MDYNWLDHTSWHSSEASPMSL
     810-810: S → SSQSLSRRTTPFVPRVQ

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1411

1411

Regulating synaptic membrane exocytosis protein 2

PRO_0000190201

Regions

Domain

26 – 185

160

RabBD

Domain

668 – 754

87

PDZ

Domain

807 – 913

107

C2 1

Domain

1257 – 1359

103

C2 2

Zinc finger

117 – 173

57

FYVE-type

Amino acid modifications

Modified residue

366

1

Phosphoserine By similarity

Modified residue

400

1

Phosphoserine Ref.9

Modified residue

689

1

Phosphothreonine Ref.8

Modified residue

691

1

Phosphoserine Ref.8

Modified residue

699

1

Phosphothreonine Ref.8

Modified residue

1030

1

Phosphoserine By similarity

Modified residue

1147

1

Phosphothreonine By similarity

Modified residue

1396

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

1 – 1126

1126

Missing in isoform 7.

VSP_040864

Alternative sequence

1 – 223

223

Missing in isoform 1 and isoform 3.

VSP_040865

Alternative sequence

50 – 90

41

KVKEE…KEPQT → EEEKEQSVLK in isoform 8.

VSP_044661

Alternative sequence

224 – 263

40

SGDLS…DIASD → MQFETLRQVCNSVLSHFHGV FSSPPNILQNELFGQTLNNA in isoform 1 and isoform 3.

VSP_040866

Alternative sequence

575 – 642

68

SQKGK…SHSDK → MDYNWLDHTSWHSSEASPMS L in isoform 3 and isoform 8.

VSP_040867

Alternative sequence

774 – 801

28

SSSFE…MLRDV → KFYLCWKKTLFIIAFIRDQM KYLTSNVK in isoform 4.

VSP_040868

Alternative sequence

802 – 1411

610

Missing in isoform 4.

VSP_040871

Alternative sequence

810

1

S → SSQSLSRRTTPFVPRVQ in isoform 8.

VSP_044662

Alternative sequence

811 – 824

14

IKLWF…HQLIV → VCSHYVYSSFWNIK in isoform 5.

VSP_040869

Alternative sequence

825 – 1411

587

Missing in isoform 5.

VSP_040870

Alternative sequence

1038

1

S → R in isoform 2.

VSP_040872

Alternative sequence

1039 – 1411

373

Missing in isoform 2.

VSP_040873

Alternative sequence

1076

1

D → DSHFLTLPRSRYSQTIDHHH RDG in isoform 3.

VSP_040874

Alternative sequence

1127 – 1174

48

RSAPP…TLDRK → MGRQGLGGASAAGRSMQRSQ SRSSLSASFEALAGYFPCMN SLEEEEGE in isoform 7.

VSP_040875

Experimental info

Sequence conflict

309

1

S → F in AAH43144. Ref.5

Sequence conflict

518

1

Q → R in AAH43144. Ref.5

Sequence conflict

947

1

M → V in BAG54403. Ref.3

Secondary structure

1

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1411

Helix Strand Turn

Details...

Beta strand

646 – 649

4

Beta strand

651 – 663

13

Turn

677 – 680

4

Beta strand

681 – 688

8

Beta strand

690 – 692

3

Beta strand

694 – 701

8

Helix

706 – 710

5

Beta strand

718 – 722

5

Helix

732 – 741

10

Beta strand

743 – 754

12

Beta strand

808 – 816

9

Turn

817 – 820

4

Beta strand

821 – 831

11

Beta strand

836 – 838

3

Beta strand

843 – 846

4

Beta strand

854 – 857

4

Helix

885 – 887

3

Beta strand

890 – 898

9

Beta strand

900 – 903

4

Beta strand

910 – 915

6

Helix

916 – 918

3

Beta strand

925 – 929

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 6 (RIM2-alpha) [UniParc]. Last modified January 16, 2004. Version 2. Checksum: 9D4E83F4CBE4A864	FASTA	1,411	160,403
	10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 790 800 810 820 830 840 KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP 850 860 870 880 890 900 RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR 910 920 930 940 950 960 VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR 970 980 990 1000 1010 1020 LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV 1030 1040 1050 1060 1070 1080 DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT MTGHYNTISR MDRHRVMDDH YSPDRDRDCE 1090 1100 1110 1120 1130 1140 AADRQPYHRS RSTEQRPLLE RTTTRSRSTE RPDTNLMRSM PSLMTGRSAP PSPALSRSHP 1150 1160 1170 1180 1190 1200 RTGSVQTSPS STPVAGRRGR QLPQLPPKGT LDRKAGGKKL RSTVQRSTET GLAVEMRNWM 1210 1220 1230 1240 1250 1260 TRQASRESTD GSMNSYSSEG NLIFPGVRLA SDSQFSDFLD GLGPAQLVGR QTLATPAMGD 1270 1280 1290 1300 1310 1320 IQVGMMDKKG QLEVEIIRAR GLVVKPGSKT LPAPYVKVYL LDNGVCIAKK KTKVARKTLE 1330 1340 1350 1360 1370 1380 PLYQQLLSFE ESPQGKVLQI IVWGDYGRMD HKSFMGVAQI LLDELELSNM VIGWFKLFPP 1390 1400 1410 SSLVDPTLAP LTRRASQSSL ESSTGPSYSR S
	Isoform 1 (RIM2-beta) [UniParc]. Checksum: DD65DB32288055AF	FASTA	1,188	135,250
	10 20 30 40 50 60 MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 70 80 90 100 110 120 REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 130 140 150 160 170 180 DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 190 200 210 220 230 240 LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 250 260 270 280 290 300 PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 310 320 330 340 350 360 PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DSQKGKRKTS 370 380 390 400 410 420 EQAVLSDSNT RSERQKEMMY FGGHSLEEDL EWSEPQIKDS GVDTCSSTTL NEEHSHSDKH 430 440 450 460 470 480 PVTWQPSKDG DRLIGRILLN KRLKDGSVPR DSGAMLGLKV VGGKMTESGR LCAFITKVKK 490 500 510 520 530 540 GSLADTVGHL RPGDEVLEWN GRLLQGATFE EVYNIILESK PEPQVELVVS RPIGDIPRIP 550 560 570 580 590 600 DSTHAQLESS SSSFESQKMD RPSISVTSPM SPGMLRDVPQ FLSGQLSIKL WFDKVGHQLI 610 620 630 640 650 660 VTILGAKDLP SREDGRPRNP YVKIYFLPDR SDKNKRRTKT VKKTLEPKWN QTFIYSPVHR 670 680 690 700 710 720 REFRERMLEI TLWDQARVRE EESEFLGEIL IELETALLDD EPHWYKLQTH DVSSLPLPHP 730 740 750 760 770 780 SPYMPRRQLH GESPTRRLQR SKRISDSEVS DYDCDDGIGV VSDYRHDGRD LQSSTLSVPE 790 800 810 820 830 840 QVMSSNHCSP SGSPHRVDVI GRTRSWSPSV PPPQSRNVEQ GLRGTRTMTG HYNTISRMDR 850 860 870 880 890 900 HRVMDDHYSP DRDRDCEAAD RQPYHRSRST EQRPLLERTT TRSRSTERPD TNLMRSMPSL 910 920 930 940 950 960 MTGRSAPPSP ALSRSHPRTG SVQTSPSSTP VAGRRGRQLP QLPPKGTLDR KAGGKKLRST 970 980 990 1000 1010 1020 VQRSTETGLA VEMRNWMTRQ ASRESTDGSM NSYSSEGNLI FPGVRLASDS QFSDFLDGLG 1030 1040 1050 1060 1070 1080 PAQLVGRQTL ATPAMGDIQV GMMDKKGQLE VEIIRARGLV VKPGSKTLPA PYVKVYLLDN 1090 1100 1110 1120 1130 1140 GVCIAKKKTK VARKTLEPLY QQLLSFEESP QGKVLQIIVW GDYGRMDHKS FMGVAQILLD 1150 1160 1170 1180 ELELSNMVIG WFKLFPPSSL VDPTLAPLTR RASQSSLESS TGPSYSRS
	Isoform 2 [UniParc]. Checksum: 6EFF188912E7C9B7	FASTA	1,038	119,057
	10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 790 800 810 820 830 840 KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP 850 860 870 880 890 900 RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR 910 920 930 940 950 960 VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR 970 980 990 1000 1010 1020 LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV 1030 DVIGRTRSWS PSVPPPQR
	Isoform 3 [UniParc]. Checksum: 30E1EB86C76B0998	FASTA	1,163	132,670
	10 20 30 40 50 60 MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 70 80 90 100 110 120 REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 130 140 150 160 170 180 DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 190 200 210 220 230 240 LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 250 260 270 280 290 300 PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 310 320 330 340 350 360 PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DMDYNWLDHT 370 380 390 400 410 420 SWHSSEASPM SLHPVTWQPS KDGDRLIGRI LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE 430 440 450 460 470 480 SGRLCAFITK VKKGSLADTV GHLRPGDEVL EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL 490 500 510 520 530 540 VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ KMDRPSISVT SPMSPGMLRD VPQFLSGQLS 550 560 570 580 590 600 IKLWFDKVGH QLIVTILGAK DLPSREDGRP RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP 610 620 630 640 650 660 KWNQTFIYSP VHRREFRERM LEITLWDQAR VREEESEFLG EILIELETAL LDDEPHWYKL 670 680 690 700 710 720 QTHDVSSLPL PHPSPYMPRR QLHGESPTRR LQRSKRISDS EVSDYDCDDG IGVVSDYRHD 730 740 750 760 770 780 GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT 790 800 810 820 830 840 MTGHYNTISR MDRHRVMDDH YSPDRDSHFL TLPRSRYSQT IDHHHRDGRD CEAADRQPYH 850 860 870 880 890 900 RSRSTEQRPL LERTTTRSRS TERPDTNLMR SMPSLMTGRS APPSPALSRS HPRTGSVQTS 910 920 930 940 950 960 PSSTPVAGRR GRQLPQLPPK GTLDRKAGGK KLRSTVQRST ETGLAVEMRN WMTRQASRES 970 980 990 1000 1010 1020 TDGSMNSYSS EGNLIFPGVR LASDSQFSDF LDGLGPAQLV GRQTLATPAM GDIQVGMMDK 1030 1040 1050 1060 1070 1080 KGQLEVEIIR ARGLVVKPGS KTLPAPYVKV YLLDNGVCIA KKKTKVARKT LEPLYQQLLS 1090 1100 1110 1120 1130 1140 FEESPQGKVL QIIVWGDYGR MDHKSFMGVA QILLDELELS NMVIGWFKLF PPSSLVDPTL 1150 1160 APLTRRASQS SLESSTGPSY SRS
	Isoform 4 (RimL3a) [UniParc]. Checksum: AC3B759DF8D4640F	FASTA	801	91,941
	10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSKFYLCWK 790 800 KTLFIIAFIR DQMKYLTSNV K
	Isoform 5 (RimL3c) [UniParc]. Checksum: 8C1E96D4AA918687	FASTA	824	94,172
	10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 790 800 810 820 KMDRPSISVT SPMSPGMLRD VPQFLSGQLS VCSHYVYSSF WNIK
	Isoform 7 (RIM2-gamma) [UniParc]. Checksum: 6E39DC2A4F246F79	FASTA	285	30,972
	10 20 30 40 50 60 MGRQGLGGAS AAGRSMQRSQ SRSSLSASFE ALAGYFPCMN SLEEEEGEAG GKKLRSTVQR 70 80 90 100 110 120 STETGLAVEM RNWMTRQASR ESTDGSMNSY SSEGNLIFPG VRLASDSQFS DFLDGLGPAQ 130 140 150 160 170 180 LVGRQTLATP AMGDIQVGMM DKKGQLEVEI IRARGLVVKP GSKTLPAPYV KVYLLDNGVC 190 200 210 220 230 240 IAKKKTKVAR KTLEPLYQQL LSFEESPQGK VLQIIVWGDY GRMDHKSFMG VAQILLDELE 250 260 270 280 LSNMVIGWFK LFPPSSLVDP TLAPLTRRAS QSSLESSTGP SYSRS
	Isoform 8 [UniParc]. Checksum: D385AB7B1AB598D6	FASTA	1,349	153,363
	10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKE EEKEQSVLKK 70 80 90 100 110 120 LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF ADGCGHNCSY CQTKFCARCG 130 140 150 160 170 180 GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW FYNSGSNTPQ QPDQKVLRGL RNEEAPQEKK 190 200 210 220 230 240 PKLHEQTQFQ GPSGDLSVPA VEKSRSHGLT RQHSIKNGSG VKHHIASDIA SDRKRSPSVS 250 260 270 280 290 300 RDQNRRYDQR EEREEYSQYA TSDTAMPRSP SDYADRRSQH EPQFYEDSDH LSYRDSNRRS 310 320 330 340 350 360 HRHSKEYIVD DEDVESRDEY ERQRREEEYQ SRYRSDPNLA RYPVKPQPYE EQMRIHAEVS 370 380 390 400 410 420 RARHERRHSD VSLANADLED SRISMLRMDR PSRQRSISER RAAMENQRSY SMERTREAQG 430 440 450 460 470 480 PSSYAQRTTN HSPPTPRRSP LPIDRPDLRR TDSLRKQHHL DPSSAVRKTK REKMETMLRN 490 500 510 520 530 540 DSLSSDQSES VRPPPPKPHK SKKGGKMRQI SLSSSEEELA STPEYTSCDD VEIESESVSE 550 560 570 580 590 600 KGDMDYNWLD HTSWHSSEAS PMSLHPVTWQ PSKDGDRLIG RILLNKRLKD GSVPRDSGAM 610 620 630 640 650 660 LGLKVVGGKM TESGRLCAFI TKVKKGSLAD TVGHLRPGDE VLEWNGRLLQ GATFEEVYNI 670 680 690 700 710 720 ILESKPEPQV ELVVSRPIGD IPRIPDSTHA QLESSSSSFE SQKMDRPSIS VTSPMSPGML 730 740 750 760 770 780 RDVPQFLSGQ LSSQSLSRRT TPFVPRVQIK LWFDKVGHQL IVTILGAKDL PSREDGRPRN 790 800 810 820 830 840 PYVKIYFLPD RSDKNKRRTK TVKKTLEPKW NQTFIYSPVH RREFRERMLE ITLWDQARVR 850 860 870 880 890 900 EEESEFLGEI LIELETALLD DEPHWYKLQT HDVSSLPLPH PSPYMPRRQL HGESPTRRLQ 910 920 930 940 950 960 RSKRISDSEV SDYDCDDGIG VVSDYRHDGR DLQSSTLSVP EQVMSSNHCS PSGSPHRVDV 970 980 990 1000 1010 1020 IGRTRSWSPS VPPPQSRNVE QGLRGTRTMT GHYNTISRMD RHRVMDDHYS PDRDRDCEAA 1030 1040 1050 1060 1070 1080 DRQPYHRSRS TEQRPLLERT TTRSRSTERP DTNLMRSMPS LMTGRSAPPS PALSRSHPRT 1090 1100 1110 1120 1130 1140 GSVQTSPSST PVAGRRGRQL PQLPPKGTLD RKAGGKKLRS TVQRSTETGL AVEMRNWMTR 1150 1160 1170 1180 1190 1200 QASRESTDGS MNSYSSEGNL IFPGVRLASD SQFSDFLDGL GPAQLVGRQT LATPAMGDIQ 1210 1220 1230 1240 1250 1260 VGMMDKKGQL EVEIIRARGL VVKPGSKTLP APYVKVYLLD NGVCIAKKKT KVARKTLEPL 1270 1280 1290 1300 1310 1320 YQQLLSFEES PQGKVLQIIV WGDYGRMDHK SFMGVAQILL DELELSNMVI GWFKLFPPSS 1330 1340 LVDPTLAPLT RRASQSSLES STGPSYSRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Yu W., Sarginson J., Gibbs R.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8). Tissue: Brain.
[4]	"DNA sequence and analysis of human chromosome 8." Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S. Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Hypothalamus.
[6]	Ho H.C. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 689-1411 (ISOFORMS 4 AND 5).
[7]	"Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins." Wang Y., Suedhof T.C. Genomics 81:126-137(2003) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING, GENOMIC ORGANIZATION.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-689; SER-691 AND THR-699, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400 AND SER-1396, MASS SPECTROMETRY.
[10]	"PDZ domain and the first C2 domain of human RIM2B." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 637-934.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB018294 mRNA. Translation: BAA34471.2. Different initiation.
AF007156 mRNA. Translation: AAC19157.1.
AK126939 mRNA. Translation: BAG54403.1.
AC007751 Genomic DNA. No translation available.
AC012213 Genomic DNA. No translation available.
AC090448 Genomic DNA. No translation available.
AC090686 Genomic DNA. No translation available.
AC107933 Genomic DNA. No translation available.
AP001572 Genomic DNA. No translation available.
AP002849 Genomic DNA. No translation available.
BC043144 mRNA. Translation: AAH43144.1.
AY057119 mRNA. Translation: AAL23679.1.
AY057121 mRNA. Translation: AAL23681.1.

IPI

IPI00005698.
IPI00249249.
IPI00339350.
IPI00396227.
IPI00398789.
IPI00873023.
IPI00942680.
IPI00966071.

RefSeq

NP_001093587.1. NM_001100117.2.
NP_055492.3. NM_014677.4.

UniGene

Hs.655271.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V27	NMR	-	A	807-934	[»]
1WFG	NMR	-	A	637-754	[»]

ProteinModelPortal

Q9UQ26.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UQ26. 5 interactions.

MINT

MINT-3083593.

STRING

9606.ENSP00000386228.

PTM databases

PhosphoSite

Q9UQ26.

Polymorphism databases

DMDM

41019522.

Proteomic databases

PaxDb

Q9UQ26.

PRIDE

Q9UQ26.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000262231; ENSP00000262231; ENSG00000176406.
ENST00000339750; ENSP00000342051; ENSG00000176406.
ENST00000406091; ENSP00000384892; ENSG00000176406.
ENST00000507740; ENSP00000423559; ENSG00000176406.

GeneID

9699.

KEGG

hsa:9699.

UCSC

uc003ylq.3. human.
uc003ylr.3. human.

Organism-specific databases

CTD

9699.

GeneCards

GC08P104582.

H-InvDB

HIX0020449.

HGNC

HGNC:17283. RIMS2.

HPA

HPA046538.
HPA053672.

MIM

606630. gene.

neXtProt

NX_Q9UQ26.

PharmGKB

PA38445.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG286957.

HOGENOM

HOG000082403.

HOVERGEN

HBG058147.

InParanoid

Q9UQ26.

KO

K15297.

Gene expression databases

ArrayExpress

Q9UQ26.

Bgee

Q9UQ26.

CleanEx

HS_RIMS2.

Genevestigator

Q9UQ26.

GermOnline

ENSG00000176406. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 2 hits.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001478. PDZ.
IPR010911. Rab-bd_domain.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
PF00595. PDZ. 1 hit.
[Graphical view]

SMART

SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 1 hit.
SSF50156. PDZ. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9UQ26.

GenomeRNAi

9699.

NextBio

36445.

SOURCE

Search...

Entry information

Entry name

RIMS2_HUMAN

Accession

Primary (citable) accession number: Q9UQ26
Secondary accession number(s): B3KX91 , F8WD47, O43413, Q86XL9, Q8IWV9, Q8IWW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	January 16, 2004
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.