Regulating synaptic membrane exocytosis protein 2

Names and origin

Protein names

Recommended name:
    Regulating synaptic membrane exocytosis protein 2
Alternative name(s):
    Rab3-interacting molecule 2
      Short name=RIM 2

Gene names

Name:	RIMS2
Synonyms:	KIAA0751, RAB3IP3, RIM2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	1411 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Rab effector involved in exocytosis. May act as scaffold protein.
Subunit structure	Binds RAB3A and RAB3B that have been activated by GTP-binding. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2. Binds RIM binding proteins 1 and 2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Cell junction › synapse By similarity. Cell junction › synapse › presynaptic cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 PDZ (DHR) domain. Contains 1 RabBD (Rab-binding) domain.

Hide | Top

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	intracellular protein transport Inferred from electronic annotation. Source: InterPro
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	Rab GTPase binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct
FYN	P06241	1	EBI-1756749,EBI-515315
GRB2	P62993	1	EBI-1756749,EBI-401755
NCK1	P16333	1	EBI-1756749,EBI-389883

Hide | Top

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 6 (identifier: Q9UQ26-6) Also known as: RIM2-alpha; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.

Isoform 1 (identifier: Q9UQ26-1) Also known as: RIM2-beta; The sequence of this isoform differs from the canonical sequence as follows: 1-223: Missing. 224-263: SGDLSVPAVE...HHIASDIASD → MQFETLRQVC...ELFGQTLNNA

Isoform 2 (identifier: Q9UQ26-2) The sequence of this isoform differs from the canonical sequence as follows: 1038-1038: S → R 1039-1411: Missing.
Note: May be due to an intron retention. No experimental confirmation available.

Isoform 3 (identifier: Q9UQ26-3) The sequence of this isoform differs from the canonical sequence as follows: 575-642: SQKGKRKTSE...LNEEHSHSDK → MDYNWLDHTSWHSSEASPMSL 1076-1076: D → DSHFLTLPRSRYSQTIDHHHRDG
Note: No experimental confirmation available.

Isoform 4 (identifier: Q9UQ26-4) Also known as: RimL3a; The sequence of this isoform differs from the canonical sequence as follows: 774-882: SSSFESQKMD...NQTFIYSPVH → KFYLCWKKTLFIIAFIRDQMKYLTSNVK 883-1411: Missing.
Note: May be due to an intron retention. No experimental confirmation available.

Isoform 5 (identifier: Q9UQ26-5) Also known as: RimL3c; The sequence of this isoform differs from the canonical sequence as follows: 811-824: IKLWFDKVGHQLIV → VCSHYVYSSFWNIK 825-1411: Missing.
Note: May be due to an intron retention. No experimental confirmation available.

Isoform 7 (identifier: Q9UQ26-7) Also known as: RIM2-gamma; The sequence of this isoform differs from the canonical sequence as follows: 1-1126: Missing. 1127-1174: RSAPPSPALS...LPPKGTLDRK → MGRQGLGGAS...MNSLEEEEGE

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1411

1411

Regulating synaptic membrane exocytosis protein 2

PRO_0000190201

Regions

Domain

26 – 185

160

RabBD

Domain

668 – 754

87

PDZ

Domain

807 – 913

107

C2 1

Domain

1257 – 1359

103

C2 2

Zinc finger

117 – 173

57

FYVE-type

Amino acid modifications

Modified residue

366

1

Phosphoserine By similarity

Modified residue

400

1

Phosphoserine By similarity

Modified residue

427

1

Phosphoserine Ref.6

Modified residue

429

1

Phosphoserine Ref.6

Modified residue

1030

1

Phosphoserine Ref.7

Modified residue

1038

1

Phosphoserine Ref.7

Modified residue

1147

1

Phosphothreonine By similarity

Natural variations

Alternative sequence

1 – 1126

1126

Missing in isoform 7.

VSP_009136

Alternative sequence

1 – 223

223

Missing in isoform 1.

VSP_009135

Alternative sequence

224 – 263

40

SGDLS…DIASD → MQFETLRQVCNSVLSHFHGV FSSPPNILQNELFGQTLNNA in isoform 1.

VSP_009137

Alternative sequence

575 – 642

68

SQKGK…SHSDK → MDYNWLDHTSWHSSEASPMS L in isoform 3.

VSP_008173

Alternative sequence

774 – 882

109

SSSFE…YSPVH → KFYLCWKKTLFIIAFIRDQM KYLTSNVK in isoform 4.

VSP_008174

Alternative sequence

811 – 824

14

IKLWF…HQLIV → VCSHYVYSSFWNIK in isoform 5.

VSP_008175

Alternative sequence

825 – 1411

587

Missing in isoform 5.

VSP_008176

Alternative sequence

883 – 1411

529

Missing in isoform 4.

VSP_008177

Alternative sequence

1038

1

S → R in isoform 2.

VSP_008178

Alternative sequence

1039 – 1411

373

Missing in isoform 2.

VSP_008179

Alternative sequence

1076

1

D → DSHFLTLPRSRYSQTIDHHH RDG in isoform 3.

VSP_008180

Alternative sequence

1127 – 1174

48

RSAPP…TLDRK → MGRQGLGGASAAGRSMQRSQ SRSSLSASFEALAGYFPCMN SLEEEEGE in isoform 7.

VSP_009138

Experimental info

Sequence conflict

309

1

S → F in AAH43144. Ref.2

Sequence conflict

518

1

Q → R in AAH43144. Ref.2

Secondary structure

1

.

1411

Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence		Length	Mass (Da)
Isoform 6 (RIM2-alpha) [UniParc]. Last modified January 16, 2004. Version 2. Checksum: 9D4E83F4CBE4A864 Show »	FASTA	1,411	160,403
10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 790 800 810 820 830 840 KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP 850 860 870 880 890 900 RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR 910 920 930 940 950 960 VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR 970 980 990 1000 1010 1020 LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV 1030 1040 1050 1060 1070 1080 DVIGRTRSWS PSVPPPQSRN VEQGLRGTRT MTGHYNTISR MDRHRVMDDH YSPDRDRDCE 1090 1100 1110 1120 1130 1140 AADRQPYHRS RSTEQRPLLE RTTTRSRSTE RPDTNLMRSM PSLMTGRSAP PSPALSRSHP 1150 1160 1170 1180 1190 1200 RTGSVQTSPS STPVAGRRGR QLPQLPPKGT LDRKAGGKKL RSTVQRSTET GLAVEMRNWM 1210 1220 1230 1240 1250 1260 TRQASRESTD GSMNSYSSEG NLIFPGVRLA SDSQFSDFLD GLGPAQLVGR QTLATPAMGD 1270 1280 1290 1300 1310 1320 IQVGMMDKKG QLEVEIIRAR GLVVKPGSKT LPAPYVKVYL LDNGVCIAKK KTKVARKTLE 1330 1340 1350 1360 1370 1380 PLYQQLLSFE ESPQGKVLQI IVWGDYGRMD HKSFMGVAQI LLDELELSNM VIGWFKLFPP 1390 1400 1410 SSLVDPTLAP LTRRASQSSL ESSTGPSYSR S « Hide
Isoform 1 (RIM2-beta). Checksum: DD65DB32288055AF Show »	FASTA	1,188	135,250
10 20 30 40 50 60 MQFETLRQVC NSVLSHFHGV FSSPPNILQN ELFGQTLNNA RKRSPSVSRD QNRRYDQREE 70 80 90 100 110 120 REEYSQYATS DTAMPRSPSD YADRRSQHEP QFYEDSDHLS YRDSNRRSHR HSKEYIVDDE 130 140 150 160 170 180 DVESRDEYER QRREEEYQSR YRSDPNLARY PVKPQPYEEQ MRIHAEVSRA RHERRHSDVS 190 200 210 220 230 240 LANADLEDSR ISMLRMDRPS RQRSISERRA AMENQRSYSM ERTREAQGPS SYAQRTTNHS 250 260 270 280 290 300 PPTPRRSPLP IDRPDLRRTD SLRKQHHLDP SSAVRKTKRE KMETMLRNDS LSSDQSESVR 310 320 330 340 350 360 PPPPKPHKSK KGGKMRQISL SSSEEELAST PEYTSCDDVE IESESVSEKG DSQKGKRKTS 370 380 390 400 410 420 EQAVLSDSNT RSERQKEMMY FGGHSLEEDL EWSEPQIKDS GVDTCSSTTL NEEHSHSDKH 430 440 450 460 470 480 PVTWQPSKDG DRLIGRILLN KRLKDGSVPR DSGAMLGLKV VGGKMTESGR LCAFITKVKK 490 500 510 520 530 540 GSLADTVGHL RPGDEVLEWN GRLLQGATFE EVYNIILESK PEPQVELVVS RPIGDIPRIP 550 560 570 580 590 600 DSTHAQLESS SSSFESQKMD RPSISVTSPM SPGMLRDVPQ FLSGQLSIKL WFDKVGHQLI 610 620 630 640 650 660 VTILGAKDLP SREDGRPRNP YVKIYFLPDR SDKNKRRTKT VKKTLEPKWN QTFIYSPVHR 670 680 690 700 710 720 REFRERMLEI TLWDQARVRE EESEFLGEIL IELETALLDD EPHWYKLQTH DVSSLPLPHP 730 740 750 760 770 780 SPYMPRRQLH GESPTRRLQR SKRISDSEVS DYDCDDGIGV VSDYRHDGRD LQSSTLSVPE 790 800 810 820 830 840 QVMSSNHCSP SGSPHRVDVI GRTRSWSPSV PPPQSRNVEQ GLRGTRTMTG HYNTISRMDR 850 860 870 880 890 900 HRVMDDHYSP DRDRDCEAAD RQPYHRSRST EQRPLLERTT TRSRSTERPD TNLMRSMPSL 910 920 930 940 950 960 MTGRSAPPSP ALSRSHPRTG SVQTSPSSTP VAGRRGRQLP QLPPKGTLDR KAGGKKLRST 970 980 990 1000 1010 1020 VQRSTETGLA VEMRNWMTRQ ASRESTDGSM NSYSSEGNLI FPGVRLASDS QFSDFLDGLG 1030 1040 1050 1060 1070 1080 PAQLVGRQTL ATPAMGDIQV GMMDKKGQLE VEIIRARGLV VKPGSKTLPA PYVKVYLLDN 1090 1100 1110 1120 1130 1140 GVCIAKKKTK VARKTLEPLY QQLLSFEESP QGKVLQIIVW GDYGRMDHKS FMGVAQILLD 1150 1160 1170 1180 ELELSNMVIG WFKLFPPSSL VDPTLAPLTR RASQSSLESS TGPSYSRS « Hide
Isoform 2. Checksum: 6EFF188912E7C9B7 Show »	FASTA	1,038	119,057
10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 790 800 810 820 830 840 KMDRPSISVT SPMSPGMLRD VPQFLSGQLS IKLWFDKVGH QLIVTILGAK DLPSREDGRP 850 860 870 880 890 900 RNPYVKIYFL PDRSDKNKRR TKTVKKTLEP KWNQTFIYSP VHRREFRERM LEITLWDQAR 910 920 930 940 950 960 VREEESEFLG EILIELETAL LDDEPHWYKL QTHDVSSLPL PHPSPYMPRR QLHGESPTRR 970 980 990 1000 1010 1020 LQRSKRISDS EVSDYDCDDG IGVVSDYRHD GRDLQSSTLS VPEQVMSSNH CSPSGSPHRV 1030 DVIGRTRSWS PSVPPPQR « Hide
Isoform 3. Checksum: 7EC2B33B402998F5 Show »	FASTA	1,386	157,822
10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDMDYNWL DHTSWHSSEA SPMSLHPVTW 610 620 630 640 650 660 QPSKDGDRLI GRILLNKRLK DGSVPRDSGA MLGLKVVGGK MTESGRLCAF ITKVKKGSLA 670 680 690 700 710 720 DTVGHLRPGD EVLEWNGRLL QGATFEEVYN IILESKPEPQ VELVVSRPIG DIPRIPDSTH 730 740 750 760 770 780 AQLESSSSSF ESQKMDRPSI SVTSPMSPGM LRDVPQFLSG QLSIKLWFDK VGHQLIVTIL 790 800 810 820 830 840 GAKDLPSRED GRPRNPYVKI YFLPDRSDKN KRRTKTVKKT LEPKWNQTFI YSPVHRREFR 850 860 870 880 890 900 ERMLEITLWD QARVREEESE FLGEILIELE TALLDDEPHW YKLQTHDVSS LPLPHPSPYM 910 920 930 940 950 960 PRRQLHGESP TRRLQRSKRI SDSEVSDYDC DDGIGVVSDY RHDGRDLQSS TLSVPEQVMS 970 980 990 1000 1010 1020 SNHCSPSGSP HRVDVIGRTR SWSPSVPPPQ SRNVEQGLRG TRTMTGHYNT ISRMDRHRVM 1030 1040 1050 1060 1070 1080 DDHYSPDRDS HFLTLPRSRY SQTIDHHHRD GRDCEAADRQ PYHRSRSTEQ RPLLERTTTR 1090 1100 1110 1120 1130 1140 SRSTERPDTN LMRSMPSLMT GRSAPPSPAL SRSHPRTGSV QTSPSSTPVA GRRGRQLPQL 1150 1160 1170 1180 1190 1200 PPKGTLDRKA GGKKLRSTVQ RSTETGLAVE MRNWMTRQAS RESTDGSMNS YSSEGNLIFP 1210 1220 1230 1240 1250 1260 GVRLASDSQF SDFLDGLGPA QLVGRQTLAT PAMGDIQVGM MDKKGQLEVE IIRARGLVVK 1270 1280 1290 1300 1310 1320 PGSKTLPAPY VKVYLLDNGV CIAKKKTKVA RKTLEPLYQQ LLSFEESPQG KVLQIIVWGD 1330 1340 1350 1360 1370 1380 YGRMDHKSFM GVAQILLDEL ELSNMVIGWF KLFPPSSLVD PTLAPLTRRA SQSSLESSTG PSYSRS « Hide
Isoform 4 (RimL3a). Checksum: AC3B759DF8D4640F Show »	FASTA	801	91,941
10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSKFYLCWK 790 800 KTLFIIAFIR DQMKYLTSNV K « Hide
Isoform 5 (RimL3c). Checksum: 8C1E96D4AA918687 Show »	FASTA	824	94,172
10 20 30 40 50 60 MSAPVGPRGR LAPIPAASQP PLQPEMPDLS HLTEEERKII LAVMDRQKKK VKEEHKPQLT 70 80 90 100 110 120 QWFPFSGITE LVNNVLQPQQ KQQNEKEPQT KLHQQFEMYK EQVKKMGEES QQQQEQKGDA 130 140 150 160 170 180 PTCGICHKTK FADGCGHNCS YCQTKFCARC GGRVSLRSNK VMWVCNLCRK QQEILTKSGA 190 200 210 220 230 240 WFYNSGSNTP QQPDQKVLRG LRNEEAPQEK KPKLHEQTQF QGPSGDLSVP AVEKSRSHGL 250 260 270 280 290 300 TRQHSIKNGS GVKHHIASDI ASDRKRSPSV SRDQNRRYDQ REEREEYSQY ATSDTAMPRS 310 320 330 340 350 360 PSDYADRRSQ HEPQFYEDSD HLSYRDSNRR SHRHSKEYIV DDEDVESRDE YERQRREEEY 370 380 390 400 410 420 QSRYRSDPNL ARYPVKPQPY EEQMRIHAEV SRARHERRHS DVSLANADLE DSRISMLRMD 430 440 450 460 470 480 RPSRQRSISE RRAAMENQRS YSMERTREAQ GPSSYAQRTT NHSPPTPRRS PLPIDRPDLR 490 500 510 520 530 540 RTDSLRKQHH LDPSSAVRKT KREKMETMLR NDSLSSDQSE SVRPPPPKPH KSKKGGKMRQ 550 560 570 580 590 600 ISLSSSEEEL ASTPEYTSCD DVEIESESVS EKGDSQKGKR KTSEQAVLSD SNTRSERQKE 610 620 630 640 650 660 MMYFGGHSLE EDLEWSEPQI KDSGVDTCSS TTLNEEHSHS DKHPVTWQPS KDGDRLIGRI 670 680 690 700 710 720 LLNKRLKDGS VPRDSGAMLG LKVVGGKMTE SGRLCAFITK VKKGSLADTV GHLRPGDEVL 730 740 750 760 770 780 EWNGRLLQGA TFEEVYNIIL ESKPEPQVEL VVSRPIGDIP RIPDSTHAQL ESSSSSFESQ 790 800 810 820 KMDRPSISVT SPMSPGMLRD VPQFLSGQLS VCSHYVYSSF WNIK « Hide
Isoform 7 (RIM2-gamma). Checksum: 6E39DC2A4F246F79 Show »	FASTA	285	30,972
10 20 30 40 50 60 MGRQGLGGAS AAGRSMQRSQ SRSSLSASFE ALAGYFPCMN SLEEEEGEAG GKKLRSTVQR 70 80 90 100 110 120 STETGLAVEM RNWMTRQASR ESTDGSMNSY SSEGNLIFPG VRLASDSQFS DFLDGLGPAQ 130 140 150 160 170 180 LVGRQTLATP AMGDIQVGMM DKKGQLEVEI IRARGLVVKP GSKTLPAPYV KVYLLDNGVC 190 200 210 220 230 240 IAKKKTKVAR KTLEPLYQQL LSFEESPQGK VLQIIVWGDY GRMDHKSFMG VAQILLDELE 250 260 270 280 LSNMVIGWFK LFPPSSLVDP TLAPLTRRAS QSSLESSTGP SYSRS « Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed: 9872452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Yu W., Sarginson J., Gibbs R.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Hypothalamus.
[4]	Ho H.C. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 466-1188 (ISOFORMS 4 AND 5).
[5]	"Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins." Wang Y., Suedhof T.C. Genomics 81:126-137(2003) [PubMed: 12620390] [Abstract] Cited for: ALTERNATIVE SPLICING, GENOMIC ORGANIZATION.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-427 AND SER-429, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1030 AND SER-1038, MASS SPECTROMETRY.
[8]	"PDZ domain and the first C2 domain of human RIM2B." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 637-934.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AB018294 mRNA. Translation: BAA34471.2. Different initiation.
AF007156 mRNA. Translation: AAC19157.1.
BC043144 mRNA. Translation: AAH43144.1.
AY057119 mRNA. Translation: AAL23679.1.
AY057121 mRNA. Translation: AAL23681.1.

IPI

IPI00005698.
IPI00249249.
IPI00339350.
IPI00396227.
IPI00398789.
IPI00873023.
IPI00942680.

RefSeq

NP_001093587.1.
NP_055492.3.

UniGene

Hs.655271

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1V27	NMR	-	A	807-934	[»]
1WFG	NMR	-	A	637-754	[»]

SMR

Q9UQ26. Positions 114-173.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UQ26. 3 interactions.

STRING

Q9UQ26.

PTM databases

PhosphoSite

Q9UQ26.

Proteomic databases

PRIDE

Q9UQ26.

Genome annotation databases

Ensembl

ENST00000402998; ENSP00000383959; ENSG00000176406; Homo sapiens. [Genome view]

GeneID

9699.

KEGG

hsa:9699.

UCSC

uc003ylp.2. human.
uc003ylq.2. human.

Organism-specific databases

CTD

9699.

GeneCards

GC08P104582.

H-InvDB

HIX0020449.

HGNC

HGNC:17283. RIMS2.

MIM

606630. gene.

PharmGKB

PA38445.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9UQ26.

HOVERGEN

Q9UQ26.

Gene expression databases

ArrayExpress

Q9UQ26.

Bgee

Q9UQ26.

CleanEx

HS_RIMS2.

Genevestigator

Q9UQ26.

GermOnline

ENSG00000176406. Homo sapiens.

Family and domain databases

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_reg_CaLB.
IPR018029. C2_membr_targeting.
IPR001478. PDZ/DHR/GLGF.
IPR010911. Rab_bd_domain.
IPR003315. Rabphilin3A_effector_Zn-bd.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
PF02318. RPH3A_effector. 1 hit.
[Graphical view]

SMART

SM00239. C2. 2 hits.
SM00228. PDZ. 1 hit.
[Graphical view]

PROSITE

PS50004. C2. 2 hits.
PS50106. PDZ. 1 hit.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

36445.

SOURCE

Search...

Hide | Top

Entry information

Entry name

RIMS2_HUMAN

Accession

Primary (citable) accession number: Q9UQ26
Secondary accession number(s): O43413

Q8IWW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	January 16, 2004
Last modified:	November 24, 2009
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Hide | Top

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents