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Q9UQ16 (DYN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynamin-3

EC=3.6.5.5
Alternative name(s):
Dynamin, testicular
T-dynamin
Gene names
Name:DNM3
Synonyms:KIAA0820
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length869 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis By similarity.

Catalytic activity

GTP + H2O = GDP + phosphate.

Subcellular location

Cytoplasm Potential. Cytoplasmcytoskeleton Potential. Note: Microtubule-associated Potential.

Sequence similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Contains 1 GED domain.

Contains 1 PH domain.

Sequence caution

The sequence BAA74843.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UQ16-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UQ16-2)

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
Isoform 3 (identifier: Q9UQ16-3)

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     637-637: V → VGNNK
Isoform 4 (identifier: Q9UQ16-4)

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: V → VGNNK
Isoform 5 (identifier: Q9UQ16-5)

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     564-565: EK → NI
     566-869: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 869869Dynamin-3
PRO_0000206573

Regions

Domain28 – 294267Dynamin-type G
Domain515 – 621107PH
Domain659 – 75092GED
Nucleotide binding38 – 458GTP By similarity
Nucleotide binding136 – 1405GTP By similarity
Nucleotide binding205 – 2084GTP By similarity

Amino acid modifications

Modified residue7691Phosphoserine By similarity
Modified residue7731Phosphoserine By similarity
Modified residue8531Phosphoserine By similarity

Natural variations

Alternative sequence516 – 52510Missing in isoform 2, isoform 3 and isoform 5.
VSP_034053
Alternative sequence564 – 5652EK → NI in isoform 5.
VSP_054546
Alternative sequence566 – 869304Missing in isoform 5.
VSP_054547
Alternative sequence6371V → VGNNK in isoform 3 and isoform 4.
VSP_034054

Experimental info

Sequence conflict3231T → S in CAB66647. Ref.3
Sequence conflict4121I → T in CAB66647. Ref.3
Sequence conflict8441S → R in CAB66647. Ref.3

Secondary structure

........................................ 869
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 10, 2008. Version 4.
Checksum: 01B376CF1AE6F2FE

FASTA86997,746
        10         20         30         40         50         60 
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG 

        70         80         90        100        110        120 
SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRLE IEAETDRVTG MNKGISSIPI 

       130        140        150        160        170        180 
NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP DIEYQIREMI MQFITRENCL ILAVTPANTD 

       190        200        210        220        230        240 
LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK 

       250        260        270        280        290        300 
DIDGKKDIKA AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL 

       310        320        330        340        350        360 
QGQLLSIEHE VEAYKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ VDTLELSGGA 

       370        380        390        400        410        420 
KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT GLFTPDMAFE AIVKKQIVKL 

       430        440        450        460        470        480 
KGPSLKSVDL VIQELINTVK KCTKKLANFP RLCEETERIV ANHIREREGK TKDQVLLLID 

       490        500        510        520        530        540 
IQVSYINTNH EDFIGFANAQ QRSSQVHKKT TVGNQGTNLP PSRQIVIRKG WLTISNIGIM 

       550        560        570        580        590        600 
KGGSKGYWFV LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKSFMSSKH IFALFNTEQR 

       610        620        630        640        650        660 
NVYKDYRFLE LACDSQEDVD SWKASLLRAG VYPDKSVAEN DENGQAENFS MDPQLERQVE 

       670        680        690        700        710        720 
TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE LLAQLYSSED QNTLMEESAE 

       730        740        750        760        770        780 
QAQRRDEMLR MYQALKEALG IIGDISTATV STPAPPPVDD SWIQHSRRSP PPSPTTQRRP 

       790        800        810        820        830        840 
TLSAPLARPT SGRGPAPAIP SPGPHSGAPP VPFRPGPLPP FPSSSDSFGA PPQVPSRPTR 

       850        860 
APPSVPSRRP PPSPTRPTII RPLESSLLD 

« Hide

Isoform 2 [UniParc].

Checksum: 922D192B91B47957
Show »

FASTA85996,682
Isoform 3 [UniParc].

Checksum: 42CC8A0553AB65BC
Show »

FASTA86397,095
Isoform 4 [UniParc].

Checksum: 95E83DB7F0350A58
Show »

FASTA87398,160
Isoform 5 [UniParc].

Checksum: 211E2C707C85520E
Show »

FASTA55562,824

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Kidney.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020627 mRNA. Translation: BAA74843.2. Different initiation.
AL136712 mRNA. Translation: CAB66647.1.
AL031864 expand/collapse EMBL AC list , AL121984, AL133514, AL137157, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAI22007.1.
AL121984 expand/collapse EMBL AC list , AL031864, AL133514, AL137157, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAH71952.1.
AL133514 expand/collapse EMBL AC list , AL031864, AL121984, AL137157, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAH74079.1.
AL137157 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAI19211.1.
AL445990 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL137157, AL512843, Z97195 Genomic DNA. Translation: CAH69969.1.
AL445990 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL137157, AL512843, Z97195 Genomic DNA. Translation: CAH69970.1.
AL512843 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL137157, AL445990, Z97195 Genomic DNA. Translation: CAH71040.1.
AL512843 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL137157, AL445990, Z97195 Genomic DNA. Translation: CAH71041.1.
AL121984 expand/collapse EMBL AC list , AL031864, AL133514, AL137157, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAH71951.1.
AL133514 expand/collapse EMBL AC list , AL031864, AL121984, AL137157, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAH74080.1.
Z97195 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL137157, AL445990, AL512843 Genomic DNA. Translation: CAI19054.1.
Z97195 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL137157, AL445990, AL512843 Genomic DNA. Translation: CAI19055.1.
AL137157 expand/collapse EMBL AC list , AL031864, AL121984, AL133514, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAI19212.1.
AL031864 expand/collapse EMBL AC list , AL121984, AL133514, AL137157, AL445990, AL512843, Z97195 Genomic DNA. Translation: CAI22008.1.
CH471067 Genomic DNA. Translation: EAW90918.1.
BC064546 mRNA. Translation: AAH64546.1.
CCDSCCDS44276.1. [Q9UQ16-2]
CCDS53431.1. [Q9UQ16-3]
RefSeqNP_001129599.1. NM_001136127.2. [Q9UQ16-2]
NP_001265181.1. NM_001278252.1. [Q9UQ16-5]
NP_056384.2. NM_015569.4. [Q9UQ16-3]
XP_005245136.1. XM_005245079.1. [Q9UQ16-4]
XP_005245137.1. XM_005245080.1. [Q9UQ16-1]
UniGeneHs.654775.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3L43X-ray2.27A/B/C/D6-306[»]
ProteinModelPortalQ9UQ16.
SMRQ9UQ16. Positions 6-746.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117515. 7 interactions.
IntActQ9UQ16. 4 interactions.

PTM databases

PhosphoSiteQ9UQ16.

Polymorphism databases

DMDM190358934.

Proteomic databases

MaxQBQ9UQ16.
PaxDbQ9UQ16.
PRIDEQ9UQ16.

Protocols and materials databases

DNASU26052.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355305; ENSP00000347457; ENSG00000197959. [Q9UQ16-1]
ENST00000358155; ENSP00000350876; ENSG00000197959. [Q9UQ16-3]
ENST00000367731; ENSP00000356705; ENSG00000197959. [Q9UQ16-2]
ENST00000367733; ENSP00000356707; ENSG00000197959.
GeneID26052.
KEGGhsa:26052.
UCSCuc001gie.4. human. [Q9UQ16-3]
uc001gif.4. human. [Q9UQ16-2]

Organism-specific databases

CTD26052.
GeneCardsGC01P171810.
HGNCHGNC:29125. DNM3.
MIM611445. gene.
neXtProtNX_Q9UQ16.
PharmGKBPA134954683.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0699.
HOVERGENHBG107833.
InParanoidQ9UQ16.
KOK01528.
OMAANHIRDR.
PhylomeDBQ9UQ16.
TreeFamTF300362.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressQ9UQ16.
BgeeQ9UQ16.
GenevestigatorQ9UQ16.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProIPR027743. Dnm3.
IPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR003130. GED.
IPR020850. GTPase_effector_domain_GED.
IPR027417. P-loop_NTPase.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PANTHERPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF54. PTHR11566:SF54. 1 hit.
PfamPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSPR00195. DYNAMIN.
SMARTSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDNM3. human.
EvolutionaryTraceQ9UQ16.
GeneWikiDNM3.
GenomeRNAi26052.
NextBio47916.
PROQ9UQ16.
SOURCESearch...

Entry information

Entry nameDYN3_HUMAN
AccessionPrimary (citable) accession number: Q9UQ16
Secondary accession number(s): A9Z1Y1 expand/collapse secondary AC list , O14982, O95555, Q1MTM8, Q5W129, Q6P2G1, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: June 10, 2008
Last modified: July 9, 2014
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM