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Protein

Dynamin-3

Gene

DNM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity).By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 46GTP1 Publication9
Nucleotide bindingi205 – 211GTP1 Publication7
Nucleotide bindingi236 – 239GTP1 Publication4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.5 2681
ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-2132295 MHC class II antigen presentation
R-HSA-437239 Recycling pathway of L1
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-3 (EC:3.6.5.5)
Alternative name(s):
Dynamin, testicular
T-dynamin
Gene namesi
Name:DNM3
Synonyms:KIAA0820
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197959.13
HGNCiHGNC:29125 DNM3
MIMi611445 gene
neXtProtiNX_Q9UQ16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi26052
OpenTargetsiENSG00000197959
PharmGKBiPA134954683

Polymorphism and mutation databases

DMDMi190358934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065731 – 869Dynamin-3Add BLAST869

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphotyrosineBy similarity1
Modified residuei125Nitrated tyrosine; alternateBy similarity1
Modified residuei125Phosphotyrosine; alternateBy similarity1
Modified residuei231PhosphotyrosineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei306PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei603PhosphotyrosineBy similarity1
Modified residuei604N6-acetyllysineBy similarity1
Modified residuei769PhosphoserineBy similarity1
Modified residuei773PhosphoserineBy similarity1
Modified residuei793Omega-N-methylarginineBy similarity1
Modified residuei853PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Nitration, Phosphoprotein

Proteomic databases

EPDiQ9UQ16
PaxDbiQ9UQ16
PeptideAtlasiQ9UQ16
PRIDEiQ9UQ16

PTM databases

iPTMnetiQ9UQ16
PhosphoSitePlusiQ9UQ16

Expressioni

Gene expression databases

BgeeiENSG00000197959
ExpressionAtlasiQ9UQ16 baseline and differential
GenevisibleiQ9UQ16 HS

Organism-specific databases

HPAiHPA064121

Interactioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • microtubule binding Source: GO_Central
  • nitric-oxide synthase binding Source: Ensembl

Protein-protein interaction databases

BioGridi117515, 50 interactors
DIPiDIP-36244N
IntActiQ9UQ16, 16 interactors
MINTiQ9UQ16
STRINGi9606.ENSP00000350876

Structurei

Secondary structure

1869
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 37Combined sources4
Helixi44 – 52Combined sources9
Beta strandi69 – 75Combined sources7
Beta strandi80 – 86Combined sources7
Helixi94 – 105Combined sources12
Beta strandi120 – 126Combined sources7
Beta strandi131 – 136Combined sources6
Helixi152 – 164Combined sources13
Beta strandi170 – 176Combined sources7
Helixi181 – 183Combined sources3
Helixi185 – 193Combined sources9
Beta strandi200 – 205Combined sources6
Helixi207 – 209Combined sources3
Helixi217 – 220Combined sources4
Beta strandi231 – 233Combined sources3
Helixi239 – 243Combined sources5
Helixi248 – 261Combined sources14
Turni263 – 265Combined sources3
Helixi266 – 271Combined sources6
Helixi274 – 285Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L43X-ray2.27A/B/C/D6-306[»]
5A3FX-ray3.70A/B/C/D1-764[»]
ProteinModelPortaliQ9UQ16
SMRiQ9UQ16
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UQ16

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 294Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini515 – 621PHPROSITE-ProRule annotationAdd BLAST107
Domaini659 – 750GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 45G1 motifPROSITE-ProRule annotation8
Regioni64 – 66G2 motifPROSITE-ProRule annotation3
Regioni136 – 139G3 motifPROSITE-ProRule annotation4
Regioni205 – 208G4 motifPROSITE-ProRule annotation4
Regioni235 – 238G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
GeneTreeiENSGT00760000119213
HOVERGENiHBG107833
InParanoidiQ9UQ16
KOiK01528
OMAiFISRENC
OrthoDBiEOG091G0EIQ
PhylomeDBiQ9UQ16
TreeFamiTF300362

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNREMEELI PLVNRLQDAF SALGQSCLLE LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGRDFLPRG SGIVTRRPLV LQLVTSKAEY AEFLHCKGKK FTDFDEVRLE
110 120 130 140 150
IEAETDRVTG MNKGISSIPI NLRVYSPHVL NLTLIDLPGI TKVPVGDQPP
160 170 180 190 200
DIEYQIREMI MQFITRENCL ILAVTPANTD LANSDALKLA KEVDPQGLRT
210 220 230 240 250
IGVITKLDLM DEGTDARDVL ENKLLPLRRG YVGVVNRSQK DIDGKKDIKA
260 270 280 290 300
AMLAERKFFL SHPAYRHIAD RMGTPHLQKV LNQQLTNHIR DTLPNFRNKL
310 320 330 340 350
QGQLLSIEHE VEAYKNFKPE DPTRKTKALL QMVQQFAVDF EKRIEGSGDQ
360 370 380 390 400
VDTLELSGGA KINRIFHERF PFEIVKMEFN EKELRREISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE AIVKKQIVKL KGPSLKSVDL VIQELINTVK KCTKKLANFP
460 470 480 490 500
RLCEETERIV ANHIREREGK TKDQVLLLID IQVSYINTNH EDFIGFANAQ
510 520 530 540 550
QRSSQVHKKT TVGNQGTNLP PSRQIVIRKG WLTISNIGIM KGGSKGYWFV
560 570 580 590 600
LTAESLSWYK DDEEKEKKYM LPLDNLKVRD VEKSFMSSKH IFALFNTEQR
610 620 630 640 650
NVYKDYRFLE LACDSQEDVD SWKASLLRAG VYPDKSVAEN DENGQAENFS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM SIINKCIRDL IPKTIMHLMI NNVKDFINSE
710 720 730 740 750
LLAQLYSSED QNTLMEESAE QAQRRDEMLR MYQALKEALG IIGDISTATV
760 770 780 790 800
STPAPPPVDD SWIQHSRRSP PPSPTTQRRP TLSAPLARPT SGRGPAPAIP
810 820 830 840 850
SPGPHSGAPP VPFRPGPLPP FPSSSDSFGA PPQVPSRPTR APPSVPSRRP
860
PPSPTRPTII RPLESSLLD
Length:869
Mass (Da):97,746
Last modified:June 10, 2008 - v4
Checksum:i01B376CF1AE6F2FE
GO
Isoform 2 (identifier: Q9UQ16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.

Show »
Length:859
Mass (Da):96,682
Checksum:i922D192B91B47957
GO
Isoform 3 (identifier: Q9UQ16-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     637-637: V → VGNNK

Show »
Length:863
Mass (Da):97,095
Checksum:i42CC8A0553AB65BC
GO
Isoform 4 (identifier: Q9UQ16-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: V → VGNNK

Show »
Length:873
Mass (Da):98,160
Checksum:i95E83DB7F0350A58
GO
Isoform 5 (identifier: Q9UQ16-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     516-525: Missing.
     564-565: EK → NI
     566-869: Missing.

Note: No experimental confirmation available.
Show »
Length:555
Mass (Da):62,824
Checksum:i211E2C707C85520E
GO

Sequence cautioni

The sequence BAA74843 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti323T → S in CAB66647 (PubMed:11230166).Curated1
Sequence conflicti412I → T in CAB66647 (PubMed:11230166).Curated1
Sequence conflicti844S → R in CAB66647 (PubMed:11230166).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034053516 – 525Missing in isoform 2, isoform 3 and isoform 5. 3 Publications10
Alternative sequenceiVSP_054546564 – 565EK → NI in isoform 5. 1 Publication2
Alternative sequenceiVSP_054547566 – 869Missing in isoform 5. 1 PublicationAdd BLAST304
Alternative sequenceiVSP_034054637V → VGNNK in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020627 mRNA Translation: BAA74843.2 Different initiation.
AL136712 mRNA Translation: CAB66647.1
AL031864 Genomic DNA No translation available.
AL121984 Genomic DNA No translation available.
AL133514 Genomic DNA No translation available.
AL137157 Genomic DNA No translation available.
AL445990 Genomic DNA No translation available.
AL512843 Genomic DNA No translation available.
Z97195 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90918.1
BC064546 mRNA Translation: AAH64546.1
CCDSiCCDS44276.1 [Q9UQ16-2]
CCDS53431.1 [Q9UQ16-3]
CCDS60356.1 [Q9UQ16-5]
RefSeqiNP_001129599.1, NM_001136127.2 [Q9UQ16-2]
NP_001265181.1, NM_001278252.1 [Q9UQ16-5]
NP_056384.2, NM_015569.4 [Q9UQ16-3]
XP_005245136.1, XM_005245079.1 [Q9UQ16-4]
XP_005245137.1, XM_005245080.1
UniGeneiHs.654775

Genome annotation databases

EnsembliENST00000355305; ENSP00000347457; ENSG00000197959 [Q9UQ16-1]
ENST00000367731; ENSP00000356705; ENSG00000197959 [Q9UQ16-2]
ENST00000367733; ENSP00000356707; ENSG00000197959 [Q9UQ16-5]
ENST00000627582; ENSP00000486701; ENSG00000197959 [Q9UQ16-3]
GeneIDi26052
KEGGihsa:26052
UCSCiuc001gid.6 human [Q9UQ16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDYN3_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ16
Secondary accession number(s): A9Z1Y1
, O14982, O95555, Q1MTM8, Q5W129, Q6P2G1, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: June 10, 2008
Last modified: May 23, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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