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Q9UQ13

- SHOC2_HUMAN

UniProt

Q9UQ13 - SHOC2_HUMAN

Protein

Leucine-rich repeat protein SHOC-2

Gene

SHOC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.2 Publications

    GO - Molecular functioni

    1. protein phosphatase binding Source: UniProtKB
    2. protein phosphatase regulator activity Source: UniProtKB

    GO - Biological processi

    1. fibroblast growth factor receptor signaling pathway Source: UniProtKB
    2. positive regulation of Ras protein signal transduction Source: UniProtKB
    3. Ras protein signal transduction Source: UniProtKB
    4. regulation of catalytic activity Source: GOC

    Enzyme and pathway databases

    SignaLinkiQ9UQ13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat protein SHOC-2
    Alternative name(s):
    Protein soc-2 homolog
    Protein sur-8 homolog
    Gene namesi
    Name:SHOC2
    Synonyms:KIAA0862
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:15454. SHOC2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Translocates from cytoplasm to nucleus upon growth factor stimulation.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. protein phosphatase type 1 complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Noonan syndrome-like disorder with loose anagen hair (NSLH) [MIM:607721]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21S → G in NSLH; creates a N-myristoylation site, resulting in myristoylation of the protein and aberrant targeting to the plasma membrane. 1 Publication
    VAR_060199

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi607721. phenotype.
    Orphaneti2701. Noonan syndrome-like disorder with loose anagen hair.
    PharmGKBiPA37960.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Leucine-rich repeat protein SHOC-2PRO_0000097737Add
    BLAST

    Proteomic databases

    MaxQBiQ9UQ13.
    PaxDbiQ9UQ13.
    PeptideAtlasiQ9UQ13.
    PRIDEiQ9UQ13.

    PTM databases

    PhosphoSiteiQ9UQ13.

    Expressioni

    Gene expression databases

    BgeeiQ9UQ13.
    CleanExiHS_SHOC2.
    GenevestigatoriQ9UQ13.

    Organism-specific databases

    HPAiHPA009164.

    Interactioni

    Subunit structurei

    Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBB2IP; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS.3 Publications

    Protein-protein interaction databases

    BioGridi113729. 8 interactions.
    IntActiQ9UQ13. 7 interactions.
    MINTiMINT-131517.
    STRINGi9606.ENSP00000358464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQ13.
    SMRiQ9UQ13. Positions 73-576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati101 – 12222LRR 1Add
    BLAST
    Repeati124 – 14522LRR 2Add
    BLAST
    Repeati147 – 16923LRR 3Add
    BLAST
    Repeati170 – 19122LRR 4Add
    BLAST
    Repeati193 – 21422LRR 5Add
    BLAST
    Repeati216 – 23722LRR 6Add
    BLAST
    Repeati239 – 26022LRR 7Add
    BLAST
    Repeati262 – 28322LRR 8Add
    BLAST
    Repeati285 – 30723LRR 9Add
    BLAST
    Repeati308 – 32922LRR 10Add
    BLAST
    Repeati332 – 35322LRR 11Add
    BLAST
    Repeati356 – 37722LRR 12Add
    BLAST
    Repeati380 – 40021LRR 13Add
    BLAST
    Repeati403 – 42422LRR 14Add
    BLAST
    Repeati426 – 44823LRR 15Add
    BLAST
    Repeati449 – 47022LRR 16Add
    BLAST
    Repeati472 – 49423LRR 17Add
    BLAST
    Repeati495 – 51622LRR 18Add
    BLAST
    Repeati518 – 54023LRR 19Add
    BLAST
    Repeati542 – 56322LRR 20Add
    BLAST

    Sequence similaritiesi

    Belongs to the SHOC2 family.Curated
    Contains 20 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000116557.
    HOVERGENiHBG055661.
    InParanoidiQ9UQ13.
    OMAiHGIGNLR.
    OrthoDBiEOG773XFV.
    PhylomeDBiQ9UQ13.
    TreeFamiTF315742.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view]
    PfamiPF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 4 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 17 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UQ13-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSSLGKEKD SKEKDPKVPS AKEREKEAKA SGGFGKESKE KEPKTKGKDA    50
    KDGKKDSSAA QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE 100
    NSMRLDLSKR SIHILPSSIK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT 150
    LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR 200
    FNRITTVEKD IKNLSKLSML SIRENKIKQL PAEIGELCNL ITLDVAHNQL 250
    EHLPKEIGNC TQITNLDLQH NELLDLPDTI GNLSSLSRLG LRYNRLSAIP 300
    RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG 350
    PSQFSTIYSL NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT 400
    WTSMVELNLA TNQLTKIPED VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL 450
    RELDLEENKL ESLPNEIAYL KDLQKLVLTN NQLTTLPRGI GHLTNLTHLG 500
    LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC SKLSIMSIEN 550
    CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV 582
    Length:582
    Mass (Da):64,888
    Last modified:June 20, 2001 - v2
    Checksum:iF3F828646642A855
    GO
    Isoform 2 (identifier: Q9UQ13-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         234-279: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:536
    Mass (Da):59,743
    Checksum:i7F662A1A4580F3B7
    GO

    Sequence cautioni

    The sequence BAA74885.2 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG52235.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAH72813.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti475 – 4751K → E in BAF85522. (PubMed:14702039)Curated
    Sequence conflicti535 – 5351F → L in BAA74885. (PubMed:10048485)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21S → G in NSLH; creates a N-myristoylation site, resulting in myristoylation of the protein and aberrant targeting to the plasma membrane. 1 Publication
    VAR_060199

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei234 – 27946Missing in isoform 2. 1 PublicationVSP_038188Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068920 mRNA. Translation: AAC39856.1.
    AF054828 mRNA. Translation: AAC25698.1.
    AB020669 mRNA. Translation: BAA74885.2. Different initiation.
    AK090820 mRNA. Translation: BAG52235.1. Different initiation.
    AK292833 mRNA. Translation: BAF85522.1.
    AL158163 Genomic DNA. Translation: CAH72812.1.
    AL158163 Genomic DNA. Translation: CAH72813.1. Sequence problems.
    CH471066 Genomic DNA. Translation: EAW49548.1.
    BC050445 mRNA. Translation: AAH50445.1.
    CCDSiCCDS58095.1. [Q9UQ13-2]
    CCDS7568.1. [Q9UQ13-1]
    RefSeqiNP_001255968.1. NM_001269039.1. [Q9UQ13-2]
    NP_031399.2. NM_007373.3. [Q9UQ13-1]
    UniGeneiHs.104315.

    Genome annotation databases

    EnsembliENST00000265277; ENSP00000265277; ENSG00000108061. [Q9UQ13-2]
    ENST00000369452; ENSP00000358464; ENSG00000108061. [Q9UQ13-1]
    GeneIDi8036.
    KEGGihsa:8036.
    UCSCiuc001kzl.4. human. [Q9UQ13-1]
    uc001kzn.3. human. [Q9UQ13-2]

    Polymorphism databases

    DMDMi14423936.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The matchmaker - Issue 121 of September 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF068920 mRNA. Translation: AAC39856.1 .
    AF054828 mRNA. Translation: AAC25698.1 .
    AB020669 mRNA. Translation: BAA74885.2 . Different initiation.
    AK090820 mRNA. Translation: BAG52235.1 . Different initiation.
    AK292833 mRNA. Translation: BAF85522.1 .
    AL158163 Genomic DNA. Translation: CAH72812.1 .
    AL158163 Genomic DNA. Translation: CAH72813.1 . Sequence problems.
    CH471066 Genomic DNA. Translation: EAW49548.1 .
    BC050445 mRNA. Translation: AAH50445.1 .
    CCDSi CCDS58095.1. [Q9UQ13-2 ]
    CCDS7568.1. [Q9UQ13-1 ]
    RefSeqi NP_001255968.1. NM_001269039.1. [Q9UQ13-2 ]
    NP_031399.2. NM_007373.3. [Q9UQ13-1 ]
    UniGenei Hs.104315.

    3D structure databases

    ProteinModelPortali Q9UQ13.
    SMRi Q9UQ13. Positions 73-576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113729. 8 interactions.
    IntActi Q9UQ13. 7 interactions.
    MINTi MINT-131517.
    STRINGi 9606.ENSP00000358464.

    PTM databases

    PhosphoSitei Q9UQ13.

    Polymorphism databases

    DMDMi 14423936.

    Proteomic databases

    MaxQBi Q9UQ13.
    PaxDbi Q9UQ13.
    PeptideAtlasi Q9UQ13.
    PRIDEi Q9UQ13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265277 ; ENSP00000265277 ; ENSG00000108061 . [Q9UQ13-2 ]
    ENST00000369452 ; ENSP00000358464 ; ENSG00000108061 . [Q9UQ13-1 ]
    GeneIDi 8036.
    KEGGi hsa:8036.
    UCSCi uc001kzl.4. human. [Q9UQ13-1 ]
    uc001kzn.3. human. [Q9UQ13-2 ]

    Organism-specific databases

    CTDi 8036.
    GeneCardsi GC10P112679.
    HGNCi HGNC:15454. SHOC2.
    HPAi HPA009164.
    MIMi 602775. gene.
    607721. phenotype.
    neXtProti NX_Q9UQ13.
    Orphaneti 2701. Noonan syndrome-like disorder with loose anagen hair.
    PharmGKBi PA37960.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000116557.
    HOVERGENi HBG055661.
    InParanoidi Q9UQ13.
    OMAi HGIGNLR.
    OrthoDBi EOG773XFV.
    PhylomeDBi Q9UQ13.
    TreeFami TF315742.

    Enzyme and pathway databases

    SignaLinki Q9UQ13.

    Miscellaneous databases

    ChiTaRSi SHOC2. human.
    GeneWikii SHOC2.
    GenomeRNAii 8036.
    NextBioi 30623.
    PROi Q9UQ13.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UQ13.
    CleanExi HS_SHOC2.
    Genevestigatori Q9UQ13.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view ]
    Pfami PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 4 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 17 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans."
      Sieburth D.S., Sun Q., Han M.
      Cell 94:119-130(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH KRAS AND NRAS.
    2. "Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling."
      Selfors L.M., Schutzman J.L., Borland C.Z., Stern M.J.
      Proc. Natl. Acad. Sci. U.S.A. 95:6903-6908(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-582 (ISOFORM 2).
      Tissue: Amygdala and Trachea.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    8. "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf."
      Li W., Han M., Guan K.-L.
      Genes Dev. 14:895-900(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex."
      Dai P., Xiong W.C., Mei L.
      J. Biol. Chem. 281:927-933(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERBB2IP.
    10. "A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity."
      Rodriguez-Viciana P., Oses-Prieto J., Burlingame A., Fried M., McCormick F.
      Mol. Cell 22:217-230(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MRAS AND RAF1, IDENTIFICATION IN A COMPLEX WITH PP1CA; PPP1CB; PPP1CC; RAF1 AND MRAS.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: VARIANT NSLH GLY-2, CHARACTERIZATION OF VARIANT NSLH GLY-2, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiSHOC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQ13
    Secondary accession number(s): A8K9W8
    , B3KR23, O76063, Q5VZS8, Q5VZS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3