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Protein

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Gene

DHDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei71 – 711May play an important role in coenzyme bindingBy similarity
Sitei79 – 791May play an important role in coenzyme bindingBy similarity
Sitei97 – 971May play an important role in coenzyme bindingBy similarity
Sitei176 – 1761May play an important role for the adaptation of the alcohol substrate into the binding siteBy similarity
Sitei180 – 1801May play an important role in catalytic activityBy similarity

GO - Molecular functioni

  1. D-xylose 1-dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. electron carrier activity Source: UniProtKB
  3. NAD(P)+ transhydrogenase activity Source: ProtInc
  4. trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: ProtInc
  2. D-xylose catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase (EC:1.1.1.179)
Dimeric dihydrodiol dehydrogenase
Hum2DD
Gene namesi
Name:DHDH
Synonyms:2DD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17887. DHDH.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenasePRO_0000315361Add
BLAST

Proteomic databases

PaxDbiQ9UQ10.
PRIDEiQ9UQ10.

Expressioni

Tissue specificityi

Small intestine.1 Publication

Gene expression databases

BgeeiQ9UQ10.
CleanExiHS_DHDH.
ExpressionAtlasiQ9UQ10. baseline and differential.
GenevestigatoriQ9UQ10.

Organism-specific databases

HPAiHPA044131.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi118118. 2 interactions.
STRINGi9606.ENSP00000221403.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ10.
SMRiQ9UQ10. Positions 2-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Phylogenomic databases

eggNOGiCOG0673.
GeneTreeiENSGT00390000007946.
HOGENOMiHOG000227440.
HOVERGENiHBG105348.
InParanoidiQ9UQ10.
KOiK00078.
OMAiKGMYWEA.
OrthoDBiEOG78D7KF.
PhylomeDBiQ9UQ10.
TreeFamiTF324504.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UQ10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD
60 70 80 90 100
IPKAYGSYEE LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG
110 120 130 140 150
VNAAEVREMV AEARSRALFL MEAIWTRFFP ASEALRSVLA QGTLGDLRVA
160 170 180 190 200
RAEFGKNLIH VPRAVDRAQA GGALLDIGIY CVQFTSMVFG GQKPEKISVV
210 220 230 240 250
GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV SGTKGMVQLL
260 270 280 290 300
NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM
310 320 330
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR
Length:334
Mass (Da):36,382
Last modified:May 1, 2000 - v1
Checksum:i1E2E11DF0B55214B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21A → P.
Corresponds to variant rs10401800 [ dbSNP | Ensembl ].
VAR_038174
Natural varianti66 – 661S → N.
Corresponds to variant rs2270941 [ dbSNP | Ensembl ].
VAR_038175
Natural varianti200 – 2001V → M.
Corresponds to variant rs35453148 [ dbSNP | Ensembl ].
VAR_038176
Natural varianti247 – 2471V → A.
Corresponds to variant rs11666105 [ dbSNP | Ensembl ].
VAR_038177
Natural varianti282 – 2821G → R.
Corresponds to variant rs3765148 [ dbSNP | Ensembl ].
VAR_038178

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032730 mRNA. Translation: AAH32730.1.
AB021933 mRNA. Translation: BAA83490.1.
CH471177 Genomic DNA. Translation: EAW52414.1.
CCDSiCCDS12741.1.
RefSeqiNP_055290.1. NM_014475.3.
UniGeneiHs.631555.

Genome annotation databases

EnsembliENST00000221403; ENSP00000221403; ENSG00000104808.
GeneIDi27294.
KEGGihsa:27294.
UCSCiuc002ple.1. human.

Polymorphism databases

DMDMi74735193.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032730 mRNA. Translation: AAH32730.1.
AB021933 mRNA. Translation: BAA83490.1.
CH471177 Genomic DNA. Translation: EAW52414.1.
CCDSiCCDS12741.1.
RefSeqiNP_055290.1. NM_014475.3.
UniGeneiHs.631555.

3D structure databases

ProteinModelPortaliQ9UQ10.
SMRiQ9UQ10. Positions 2-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118118. 2 interactions.
STRINGi9606.ENSP00000221403.

Polymorphism databases

DMDMi74735193.

Proteomic databases

PaxDbiQ9UQ10.
PRIDEiQ9UQ10.

Protocols and materials databases

DNASUi27294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221403; ENSP00000221403; ENSG00000104808.
GeneIDi27294.
KEGGihsa:27294.
UCSCiuc002ple.1. human.

Organism-specific databases

CTDi27294.
GeneCardsiGC19P049436.
HGNCiHGNC:17887. DHDH.
HPAiHPA044131.
MIMi606377. gene.
neXtProtiNX_Q9UQ10.
PharmGKBiPA27322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0673.
GeneTreeiENSGT00390000007946.
HOGENOMiHOG000227440.
HOVERGENiHBG105348.
InParanoidiQ9UQ10.
KOiK00078.
OMAiKGMYWEA.
OrthoDBiEOG78D7KF.
PhylomeDBiQ9UQ10.
TreeFamiTF324504.

Miscellaneous databases

GenomeRNAii27294.
NextBioi50258.
PROiQ9UQ10.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UQ10.
CleanExiHS_DHDH.
ExpressionAtlasiQ9UQ10. baseline and differential.
GenevestigatoriQ9UQ10.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases."
    Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A.
    Biochem. J. 342:721-728(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Small intestine.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiDHDH_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.