Reviewed,
UniProtKB/Swiss-Prot Q9UQ10 (DHDH_HUMAN)
Last modified
February 9, 2010.
Version 63.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase EC=1.3.1.20 Alternative name(s): Dimeric dihydrodiol dehydrogenase D-xylose-NADP dehydrogenase EC=1.1.1.179 D-xylose 1-dehydrogenase Hum2DD | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 334 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH. |
| Subunit structure | Homodimer. Ref.1 |
| Tissue specificity | Small intestine. Ref.1 |
| Sequence similarities | Belongs to the gfo/idh/mocA family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Ref.1 Traceable author statement. Source: ProtInc oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC NAD(P) transhydrogenase activity Ref.1Traceable author statement. Source: ProtInc bindingInferred from electronic annotation. Source: InterPro electron carrier activity Ref.1Traceable author statement. Source: UniProtKB trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 334 | 334 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | PRO_0000315361 | |||||
Sites | |||||||||
| Site | 71 | 1 | May play an important role in coenzyme binding By similarity | ||||||
| Site | 79 | 1 | May play an important role in coenzyme binding By similarity | ||||||
| Site | 97 | 1 | May play an important role in coenzyme binding By similarity | ||||||
| Site | 176 | 1 | May play an important role for the adaptation of the alcohol substrate into the binding site By similarity | ||||||
| Site | 180 | 1 | May play an important role in catalytic activity By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 2 | 1 | A → P: dbSNP rs10401800. | VAR_038174 | |||||
| Natural variant | 66 | 1 | S → N: dbSNP rs2270941. | VAR_038175 | |||||
| Natural variant | 200 | 1 | V → M: dbSNP rs35453148. | VAR_038176 | |||||
| Natural variant | 247 | 1 | V → A: dbSNP rs11666105. | VAR_038177 | |||||
| Natural variant | 282 | 1 | G → R: dbSNP rs3765148. | VAR_038178 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases." Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A. Biochem. J. 342:721-728(1999) [PubMed: 10477285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY. Tissue: Small intestine. |
| [2] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC032730 mRNA. Translation: AAH32730.1. AB021933 mRNA. Translation: BAA83490.1. CH471177 Genomic DNA. Translation: EAW52414.1. |
| IPI | IPI00004470. |
| RefSeq | NP_055290.1. |
| UniGene | Hs.631555 |
3D structure databases | |
| SMR | Q9UQ10. Positions 2-332. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9UQ10. |
Proteomic databases | |
| PRIDE | Q9UQ10. |
Genome annotation databases | |
| Ensembl | ENST00000221403; ENSP00000221403; ENSG00000104808; Homo sapiens. [Genome view] |
| GeneID | 27294. |
| KEGG | hsa:27294. |
| UCSC | uc002ple.1. human. |
Organism-specific databases | |
| CTD | 27294. |
| GeneCards | GC19P054128. |
| HGNC | HGNC:17887. DHDH. |
| MIM | 606377. gene. |
| PharmGKB | PA27322. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG12085. |
| HOGENOM | HBG407231. |
| HOVERGEN | Q9UQ10. |
| InParanoid | Q9UQ10. |
| OMA | DSHAQYA. |
| OrthoDB | EOG9NZXD5. |
| PhylomeDB | Q9UQ10. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.179. 247. 1.3.1.20. 247. |
Gene expression databases | |
| ArrayExpress | Q9UQ10. |
| Bgee | Q9UQ10. |
| CleanEx | HS_DHDH. |
| Genevestigator | Q9UQ10. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF01408. GFO_IDH_MocA. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 50258. |
| SOURCE | Search... |
Entry information
| Entry name | DHDH_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UQ10 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


