Reviewed, UniProtKB/Swiss-Prot Q9UQ10 (DHDH_HUMAN)

Names and origin

Protein names

Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
Alternative name(s):
    Dimeric dihydrodiol dehydrogenase
    D-xylose-NADP dehydrogenase
    EC=1.1.1.179
    D-xylose 1-dehydrogenase
    HUM2DD

Gene names

Name:	DHDH
Synonyms:	2DD

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.
Subunit structure	Homodimer. Ref.1
Tissue specificity	Small intestine. Ref.1
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Ref.1 Traceable author statement. Source: ProtInc oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC NAD(P) transhydrogenase activity Ref.1 Traceable author statement. Source: ProtInc binding Inferred from electronic annotation. Source: InterPro electron carrier activity Ref.1 Traceable author statement. Source: UniProtKB trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase		PRO_0000315361
Sites
	Site	71	1	May play an important role in coenzyme binding By similarity
	Site	79	1	May play an important role in coenzyme binding By similarity
	Site	97	1	May play an important role in coenzyme binding By similarity
	Site	176	1	May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
	Site	180	1	May play an important role in catalytic activity By similarity
Natural variations
	Natural variant	2	1	A → P: dbSNP rs10401800.		VAR_038174
	Natural variant	66	1	S → N: dbSNP rs2270941.		VAR_038175
	Natural variant	200	1	V → M: dbSNP rs35453148.		VAR_038176
	Natural variant	247	1	V → A: dbSNP rs11666105.		VAR_038177
	Natural variant	282	1	G → R: dbSNP rs3765148.		VAR_038178

Sequences

	Sequence		Length	Mass (Da)
	Q9UQ10-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1E2E11DF0B55214B	FASTA	334	36,382
	10 20 30 40 50 60 MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE 70 80 90 100 110 120 LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL 130 140 150 160 170 180 MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY 190 200 210 220 230 240 CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV 250 260 270 280 290 300 SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM 310 320 330 KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases." Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A. Biochem. J. 342:721-728(1999) [PubMed: 10477285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY. Tissue: Small intestine.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC032730 mRNA. Translation: AAH32730.1. AB021933 mRNA. Translation: BAA83490.1. CH471177 Genomic DNA. Translation: EAW52414.1.
IPI	IPI00004470.
RefSeq	NP_055290.1.
UniGene	Hs.631555
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9UQ10.
Genome annotation databases
Ensembl	ENSG00000104808. Homo sapiens. [Contig view]
GeneID	27294.
KEGG	hsa:27294.
Organism-specific databases
GeneCards	GC19P054128.
HGNC	HGNC:17887. DHDH.
MIM	606377. gene.
PharmGKB	PA27322.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9UQ10.
HOVERGEN	Q9UQ10.
OMA	Q9UQ10. DSHAQYA.
Enzyme and pathway databases
BRENDA	1.1.1.179. 247. 1.3.1.20. 247.
Gene expression databases
ArrayExpress	Q9UQ10.
Bgee	Q9UQ10.
CleanEx	HS_DHDH.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	50258.
SOURCE	Search...

Entry information

Entry name

DHDH_HUMAN

Accession

Primary (citable) accession number: Q9UQ10

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)