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Q9UQ10

- DHDH_HUMAN

UniProt

Q9UQ10 - DHDH_HUMAN

Protein

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Gene

DHDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
    D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei71 – 711May play an important role in coenzyme bindingBy similarity
    Sitei79 – 791May play an important role in coenzyme bindingBy similarity
    Sitei97 – 971May play an important role in coenzyme bindingBy similarity
    Sitei176 – 1761May play an important role for the adaptation of the alcohol substrate into the binding siteBy similarity
    Sitei180 – 1801May play an important role in catalytic activityBy similarity

    GO - Molecular functioni

    1. D-xylose 1-dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. electron carrier activity Source: UniProtKB
    3. NAD(P)+ transhydrogenase activity Source: ProtInc
    4. trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: ProtInc
    2. D-xylose catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
    Alternative name(s):
    D-xylose 1-dehydrogenase
    D-xylose-NADP dehydrogenase (EC:1.1.1.179)
    Dimeric dihydrodiol dehydrogenase
    Hum2DD
    Gene namesi
    Name:DHDH
    Synonyms:2DD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17887. DHDH.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27322.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenasePRO_0000315361Add
    BLAST

    Proteomic databases

    PaxDbiQ9UQ10.
    PRIDEiQ9UQ10.

    Expressioni

    Tissue specificityi

    Small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ9UQ10.
    BgeeiQ9UQ10.
    CleanExiHS_DHDH.
    GenevestigatoriQ9UQ10.

    Organism-specific databases

    HPAiHPA044131.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000221403.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQ10.
    SMRiQ9UQ10. Positions 2-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Gfo/Idh/MocA family.Curated

    Phylogenomic databases

    eggNOGiCOG0673.
    HOGENOMiHOG000227440.
    HOVERGENiHBG105348.
    InParanoidiQ9UQ10.
    KOiK00078.
    OMAiKGMYWEA.
    OrthoDBiEOG78D7KF.
    PhylomeDBiQ9UQ10.
    TreeFamiTF324504.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    [Graphical view]
    PfamiPF01408. GFO_IDH_MocA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UQ10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD    50
    IPKAYGSYEE LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG 100
    VNAAEVREMV AEARSRALFL MEAIWTRFFP ASEALRSVLA QGTLGDLRVA 150
    RAEFGKNLIH VPRAVDRAQA GGALLDIGIY CVQFTSMVFG GQKPEKISVV 200
    GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV SGTKGMVQLL 250
    NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM 300
    KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR 334
    Length:334
    Mass (Da):36,382
    Last modified:May 1, 2000 - v1
    Checksum:i1E2E11DF0B55214B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21A → P.
    Corresponds to variant rs10401800 [ dbSNP | Ensembl ].
    VAR_038174
    Natural varianti66 – 661S → N.
    Corresponds to variant rs2270941 [ dbSNP | Ensembl ].
    VAR_038175
    Natural varianti200 – 2001V → M.
    Corresponds to variant rs35453148 [ dbSNP | Ensembl ].
    VAR_038176
    Natural varianti247 – 2471V → A.
    Corresponds to variant rs11666105 [ dbSNP | Ensembl ].
    VAR_038177
    Natural varianti282 – 2821G → R.
    Corresponds to variant rs3765148 [ dbSNP | Ensembl ].
    VAR_038178

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC032730 mRNA. Translation: AAH32730.1.
    AB021933 mRNA. Translation: BAA83490.1.
    CH471177 Genomic DNA. Translation: EAW52414.1.
    CCDSiCCDS12741.1.
    RefSeqiNP_055290.1. NM_014475.3.
    UniGeneiHs.631555.

    Genome annotation databases

    EnsembliENST00000221403; ENSP00000221403; ENSG00000104808.
    GeneIDi27294.
    KEGGihsa:27294.
    UCSCiuc002ple.1. human.

    Polymorphism databases

    DMDMi74735193.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC032730 mRNA. Translation: AAH32730.1 .
    AB021933 mRNA. Translation: BAA83490.1 .
    CH471177 Genomic DNA. Translation: EAW52414.1 .
    CCDSi CCDS12741.1.
    RefSeqi NP_055290.1. NM_014475.3.
    UniGenei Hs.631555.

    3D structure databases

    ProteinModelPortali Q9UQ10.
    SMRi Q9UQ10. Positions 2-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000221403.

    Polymorphism databases

    DMDMi 74735193.

    Proteomic databases

    PaxDbi Q9UQ10.
    PRIDEi Q9UQ10.

    Protocols and materials databases

    DNASUi 27294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221403 ; ENSP00000221403 ; ENSG00000104808 .
    GeneIDi 27294.
    KEGGi hsa:27294.
    UCSCi uc002ple.1. human.

    Organism-specific databases

    CTDi 27294.
    GeneCardsi GC19P049436.
    HGNCi HGNC:17887. DHDH.
    HPAi HPA044131.
    MIMi 606377. gene.
    neXtProti NX_Q9UQ10.
    PharmGKBi PA27322.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0673.
    HOGENOMi HOG000227440.
    HOVERGENi HBG105348.
    InParanoidi Q9UQ10.
    KOi K00078.
    OMAi KGMYWEA.
    OrthoDBi EOG78D7KF.
    PhylomeDBi Q9UQ10.
    TreeFami TF324504.

    Miscellaneous databases

    GenomeRNAii 27294.
    NextBioi 50258.
    PROi Q9UQ10.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQ10.
    Bgeei Q9UQ10.
    CleanExi HS_DHDH.
    Genevestigatori Q9UQ10.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    [Graphical view ]
    Pfami PF01408. GFO_IDH_MocA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases."
      Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A.
      Biochem. J. 342:721-728(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Small intestine.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiDHDH_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQ10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3