Q9UQ10 (DHDH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC=1.3.1.20

Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
EC=1.1.1.179
Dimeric dihydrodiol dehydrogenase
Hum2DD

Gene names

Name:	DHDH
Synonyms:	2DD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.
Subunit structure	Homodimer. Ref.1
Tissue specificity	Small intestine. Ref.1
Sequence similarities	Belongs to the Gfo/Idh/MocA family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-xylose catabolic process Inferred from electronic annotation. Source: Compara carbohydrate metabolic process Traceable author statement Ref.1. Source: ProtInc
Molecular_function	D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC NAD(P)+ transhydrogenase activity Traceable author statement Ref.1. Source: ProtInc electron carrier activity Traceable author statement Ref.1. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase		PRO_0000315361
Sites
	Site	71	1	May play an important role in coenzyme binding By similarity
	Site	79	1	May play an important role in coenzyme binding By similarity
	Site	97	1	May play an important role in coenzyme binding By similarity
	Site	176	1	May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
	Site	180	1	May play an important role in catalytic activity By similarity
Natural variations
	Natural variant	2	1	A → P. Corresponds to variant rs10401800 [ dbSNP | Ensembl ].		VAR_038174
	Natural variant	66	1	S → N. Corresponds to variant rs2270941 [ dbSNP | Ensembl ].		VAR_038175
	Natural variant	200	1	V → M. Corresponds to variant rs35453148 [ dbSNP | Ensembl ].		VAR_038176
	Natural variant	247	1	V → A. Corresponds to variant rs11666105 [ dbSNP | Ensembl ].		VAR_038177
	Natural variant	282	1	G → R. Corresponds to variant rs3765148 [ dbSNP | Ensembl ].		VAR_038178

Sequences

	Sequence		Length	Mass (Da)
	Q9UQ10 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1E2E11DF0B55214B	FASTA	334	36,382
	10 20 30 40 50 60 MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE 70 80 90 100 110 120 LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL 130 140 150 160 170 180 MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY 190 200 210 220 230 240 CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV 250 260 270 280 290 300 SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM 310 320 330 KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases." Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A. Biochem. J. 342:721-728(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY. Tissue: Small intestine.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC032730 mRNA. Translation: AAH32730.1. AB021933 mRNA. Translation: BAA83490.1. CH471177 Genomic DNA. Translation: EAW52414.1.
IPI	IPI00004470.
RefSeq	NP_055290.1. NM_014475.3.
UniGene	Hs.631555.
3D structure databases
ProteinModelPortal	Q9UQ10.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000221403.
Polymorphism databases
DMDM	74735193.
Proteomic databases
PaxDb	Q9UQ10.
PRIDE	Q9UQ10.
Protocols and materials databases
DNASU	27294.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221403; ENSP00000221403; ENSG00000104808.
GeneID	27294.
KEGG	hsa:27294.
UCSC	uc002ple.1. human.
Organism-specific databases
CTD	27294.
GeneCards	GC19P049436.
HGNC	HGNC:17887. DHDH.
HPA	HPA044131.
MIM	606377. gene.
neXtProt	NX_Q9UQ10.
PharmGKB	PA27322.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HOG000227440.
HOVERGEN	HBG105348.
InParanoid	Q9UQ10.
KO	K00078.
OMA	TKGMAQI.
OrthoDB	EOG46144D.
PhylomeDB	Q9UQ10.
Gene expression databases
ArrayExpress	Q9UQ10.
Bgee	Q9UQ10.
CleanEx	HS_DHDH.
Genevestigator	Q9UQ10.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27294.
NextBio	50258.
SOURCE	Search...

Entry information

Entry name

DHDH_HUMAN

Accession

Primary (citable) accession number: Q9UQ10

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.