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Protein

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Gene

DHDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71May play an important role in coenzyme bindingBy similarity1
Sitei79May play an important role in coenzyme bindingBy similarity1
Sitei97May play an important role in coenzyme bindingBy similarity1
Sitei176May play an important role for the adaptation of the alcohol substrate into the binding siteBy similarity1
Sitei180May play an important role in catalytic activityBy similarity1

GO - Molecular functioni

  • D-xylose 1-dehydrogenase (NADP+) activity Source: GO_Central
  • electron carrier activity Source: UniProtKB
  • NAD(P)+ transhydrogenase activity Source: ProtInc
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  • carbohydrate metabolic process Source: ProtInc
  • D-xylose catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciZFISH:HS02621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase (EC:1.1.1.179)
Dimeric dihydrodiol dehydrogenase
Hum2DD
Gene namesi
Name:DHDH
Synonyms:2DD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17887. DHDH.

Pathology & Biotechi

Organism-specific databases

DisGeNETi27294.
OpenTargetsiENSG00000104808.
PharmGKBiPA27322.

Polymorphism and mutation databases

BioMutaiDHDH.
DMDMi74735193.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003153611 – 334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenaseAdd BLAST334

Proteomic databases

PaxDbiQ9UQ10.
PRIDEiQ9UQ10.

PTM databases

PhosphoSitePlusiQ9UQ10.

Expressioni

Tissue specificityi

Small intestine.1 Publication

Gene expression databases

BgeeiENSG00000104808.
CleanExiHS_DHDH.
ExpressionAtlasiQ9UQ10. baseline and differential.
GenevisibleiQ9UQ10. HS.

Organism-specific databases

HPAiHPA044131.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi118118. 2 interactors.
STRINGi9606.ENSP00000221403.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ10.
SMRiQ9UQ10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Phylogenomic databases

eggNOGiKOG2741. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000007946.
HOGENOMiHOG000227440.
HOVERGENiHBG105348.
InParanoidiQ9UQ10.
KOiK00078.
OMAiYPGEVHG.
OrthoDBiEOG091G0DNU.
PhylomeDBiQ9UQ10.
TreeFamiTF324504.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UQ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD
60 70 80 90 100
IPKAYGSYEE LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG
110 120 130 140 150
VNAAEVREMV AEARSRALFL MEAIWTRFFP ASEALRSVLA QGTLGDLRVA
160 170 180 190 200
RAEFGKNLIH VPRAVDRAQA GGALLDIGIY CVQFTSMVFG GQKPEKISVV
210 220 230 240 250
GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV SGTKGMVQLL
260 270 280 290 300
NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM
310 320 330
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR
Length:334
Mass (Da):36,382
Last modified:May 1, 2000 - v1
Checksum:i1E2E11DF0B55214B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0381742A → P.Corresponds to variant rs10401800dbSNPEnsembl.1
Natural variantiVAR_03817566S → N.Corresponds to variant rs2270941dbSNPEnsembl.1
Natural variantiVAR_038176200V → M.Corresponds to variant rs35453148dbSNPEnsembl.1
Natural variantiVAR_038177247V → A.Corresponds to variant rs11666105dbSNPEnsembl.1
Natural variantiVAR_038178282G → R.Corresponds to variant rs3765148dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032730 mRNA. Translation: AAH32730.1.
AB021933 mRNA. Translation: BAA83490.1.
CH471177 Genomic DNA. Translation: EAW52414.1.
CCDSiCCDS12741.1.
RefSeqiNP_055290.1. NM_014475.3.
UniGeneiHs.631555.

Genome annotation databases

EnsembliENST00000221403; ENSP00000221403; ENSG00000104808.
GeneIDi27294.
KEGGihsa:27294.
UCSCiuc002ple.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032730 mRNA. Translation: AAH32730.1.
AB021933 mRNA. Translation: BAA83490.1.
CH471177 Genomic DNA. Translation: EAW52414.1.
CCDSiCCDS12741.1.
RefSeqiNP_055290.1. NM_014475.3.
UniGeneiHs.631555.

3D structure databases

ProteinModelPortaliQ9UQ10.
SMRiQ9UQ10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118118. 2 interactors.
STRINGi9606.ENSP00000221403.

PTM databases

PhosphoSitePlusiQ9UQ10.

Polymorphism and mutation databases

BioMutaiDHDH.
DMDMi74735193.

Proteomic databases

PaxDbiQ9UQ10.
PRIDEiQ9UQ10.

Protocols and materials databases

DNASUi27294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221403; ENSP00000221403; ENSG00000104808.
GeneIDi27294.
KEGGihsa:27294.
UCSCiuc002ple.1. human.

Organism-specific databases

CTDi27294.
DisGeNETi27294.
GeneCardsiDHDH.
HGNCiHGNC:17887. DHDH.
HPAiHPA044131.
MIMi606377. gene.
neXtProtiNX_Q9UQ10.
OpenTargetsiENSG00000104808.
PharmGKBiPA27322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2741. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000007946.
HOGENOMiHOG000227440.
HOVERGENiHBG105348.
InParanoidiQ9UQ10.
KOiK00078.
OMAiYPGEVHG.
OrthoDBiEOG091G0DNU.
PhylomeDBiQ9UQ10.
TreeFamiTF324504.

Enzyme and pathway databases

BioCyciZFISH:HS02621-MONOMER.

Miscellaneous databases

GenomeRNAii27294.
PROiQ9UQ10.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104808.
CleanExiHS_DHDH.
ExpressionAtlasiQ9UQ10. baseline and differential.
GenevisibleiQ9UQ10. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHDH_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.