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Q9UQ10 (DHDH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

EC=1.3.1.20
Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
EC=1.1.1.179
Dimeric dihydrodiol dehydrogenase
Hum2DD
Gene names
Name:DHDH
Synonyms:2DD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.

D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Subunit structure

Homodimer. Ref.1

Tissue specificity

Small intestine. Ref.1

Sequence similarities

Belongs to the Gfo/Idh/MocA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
PRO_0000315361

Sites

Site711May play an important role in coenzyme binding By similarity
Site791May play an important role in coenzyme binding By similarity
Site971May play an important role in coenzyme binding By similarity
Site1761May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
Site1801May play an important role in catalytic activity By similarity

Natural variations

Natural variant21A → P.
Corresponds to variant rs10401800 [ dbSNP | Ensembl ].
VAR_038174
Natural variant661S → N.
Corresponds to variant rs2270941 [ dbSNP | Ensembl ].
VAR_038175
Natural variant2001V → M.
Corresponds to variant rs35453148 [ dbSNP | Ensembl ].
VAR_038176
Natural variant2471V → A.
Corresponds to variant rs11666105 [ dbSNP | Ensembl ].
VAR_038177
Natural variant2821G → R.
Corresponds to variant rs3765148 [ dbSNP | Ensembl ].
VAR_038178

Sequences

Sequence LengthMass (Da)Tools
Q9UQ10 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 1E2E11DF0B55214B

FASTA33436,382
        10         20         30         40         50         60 
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD IPKAYGSYEE 

        70         80         90        100        110        120 
LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG VNAAEVREMV AEARSRALFL 

       130        140        150        160        170        180 
MEAIWTRFFP ASEALRSVLA QGTLGDLRVA RAEFGKNLIH VPRAVDRAQA GGALLDIGIY 

       190        200        210        220        230        240 
CVQFTSMVFG GQKPEKISVV GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV 

       250        260        270        280        290        300 
SGTKGMVQLL NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM 

       310        320        330 
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of the cDNA species for mammalian dimeric dihydrodiol dehydrogenases."
Arimitsu E., Aoki S., Ishikura S., Nakanishi K., Matsuura K., Hara A.
Biochem. J. 342:721-728(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY.
Tissue: Small intestine.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC032730 mRNA. Translation: AAH32730.1.
AB021933 mRNA. Translation: BAA83490.1.
CH471177 Genomic DNA. Translation: EAW52414.1.
RefSeqNP_055290.1. NM_014475.3.
UniGeneHs.631555.

3D structure databases

ProteinModelPortalQ9UQ10.
SMRQ9UQ10. Positions 2-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000221403.

Polymorphism databases

DMDM74735193.

Proteomic databases

PaxDbQ9UQ10.
PRIDEQ9UQ10.

Protocols and materials databases

DNASU27294.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221403; ENSP00000221403; ENSG00000104808.
GeneID27294.
KEGGhsa:27294.
UCSCuc002ple.1. human.

Organism-specific databases

CTD27294.
GeneCardsGC19P049436.
HGNCHGNC:17887. DHDH.
HPAHPA044131.
MIM606377. gene.
neXtProtNX_Q9UQ10.
PharmGKBPA27322.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0673.
HOGENOMHOG000227440.
HOVERGENHBG105348.
InParanoidQ9UQ10.
KOK00078.
OMAKGMYWEA.
OrthoDBEOG78D7KF.
PhylomeDBQ9UQ10.
TreeFamTF324504.

Gene expression databases

ArrayExpressQ9UQ10.
BgeeQ9UQ10.
CleanExHS_DHDH.
GenevestigatorQ9UQ10.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi27294.
NextBio50258.
PROQ9UQ10.
SOURCESearch...

Entry information

Entry nameDHDH_HUMAN
AccessionPrimary (citable) accession number: Q9UQ10
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM