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Protein

MAPK/MAK/MRK overlapping kinase

Gene

MOK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation appears to increase the enzymatic activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  • protein phosphorylation Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01371-MONOMER.
SignaLinkiQ9UQ07.

Names & Taxonomyi

Protein namesi
Recommended name:
MAPK/MAK/MRK overlapping kinase (EC:2.7.11.22)
Alternative name(s):
MOK protein kinase
Renal tumor antigen 1
Short name:
RAGE-1
Gene namesi
Name:MOK
Synonyms:RAGE, RAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9833. MOK.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell projectioncilium By similarity
  • Nucleus By similarity

GO - Cellular componenti

  • ciliary base Source: UniProtKB
  • cilium Source: UniProtKB
  • cytoplasm Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5891.
OpenTargetsiENSG00000080823.
PharmGKBiPA34187.

Polymorphism and mutation databases

BioMutaiMOK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863411 – 419MAPK/MAK/MRK overlapping kinaseAdd BLAST419

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UQ07.
PaxDbiQ9UQ07.
PeptideAtlasiQ9UQ07.
PRIDEiQ9UQ07.
TopDownProteomicsiQ9UQ07-4. [Q9UQ07-4]

PTM databases

iPTMnetiQ9UQ07.
PhosphoSitePlusiQ9UQ07.

Expressioni

Tissue specificityi

Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Gene expression databases

BgeeiENSG00000080823.
CleanExiHS_RAGE.
ExpressionAtlasiQ9UQ07. baseline and differential.
GenevisibleiQ9UQ07. HS.

Organism-specific databases

HPAiHPA027282.
HPA027292.

Interactioni

Protein-protein interaction databases

BioGridi111828. 11 interactors.
IntActiQ9UQ07. 4 interactors.
MINTiMINT-4777240.
STRINGi9606.ENSP00000355304.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ07.
SMRiQ9UQ07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0661. Eukaryota.
ENOG410XPBB. LUCA.
GeneTreeiENSGT00650000093283.
HOGENOMiHOG000233024.
HOVERGENiHBG106271.
InParanoidiQ9UQ07.
KOiK08830.
OMAiTQKDIKP.
OrthoDBiEOG091G0DU3.
PhylomeDBiQ9UQ07.
TreeFamiTF328769.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE
60 70 80 90 100
IQALRRLNPH PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL
110 120 130 140 150
SEKKIMHYMY QLCKSLDHIH RNGIFHRDVK PENILIKQDV LKLGDFGSCR
160 170 180 190 200
SVYSKQPYTE YISTRWYRAP ECLLTDGFYT YKMDLWSAGC VFYEIASLQP
210 220 230 240 250
LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP FKKGSGIPLL
260 270 280 290 300
TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR
310 320 330 340 350
KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP
360 370 380 390 400
KLKLSGVVRL SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD
410
LKPAPQQCRL PTIVRKGGR
Length:419
Mass (Da):48,014
Last modified:May 1, 2000 - v1
Checksum:iCDA7D9C1E80AAE8F
GO
Isoform 2 (identifier: Q9UQ07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-419: Missing.

Note: No experimental confirmation available.
Show »
Length:231
Mass (Da):27,120
Checksum:iD0665FAE077D3B76
GO
Isoform 3 (identifier: Q9UQ07-3) [UniParc]FASTAAdd to basket
Also known as: RAGE-1 ORF5, RAGE-2 ORF5, RAGE-3 ORF5

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):7,879
Checksum:i38B1376ECFEDF351
GO
Isoform 4 (identifier: Q9UQ07-4) [UniParc]FASTAAdd to basket
Also known as: RAGE-4 ORF3

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     290-329: KTEKRALGSH...ISKEGRKQKQ → TQNGSEDEAS...LPGRSVTLLV
     330-419: Missing.

Note: No experimental confirmation available.
Show »
Length:95
Mass (Da):10,482
Checksum:i8B155074ED025D9A
GO
Isoform 5 (identifier: Q9UQ07-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-71: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):44,425
Checksum:i72B60D201632301B
GO
Isoform 6 (identifier: Q9UQ07-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: Missing.

Note: Gene prediction based on EST data.
Show »
Length:418
Mass (Da):47,886
Checksum:i75769950EB76F3F7
GO

Sequence cautioni

The sequence AAB38087 differs from that shown. Reason: Frameshift at position 299.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269D → G in BAG35641 (PubMed:14702039).Curated1
Sequence conflicti313P → L in BAG35641 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04201138R → H.1 PublicationCorresponds to variant rs34114580dbSNPEnsembl.1
Natural variantiVAR_04201286D → N.1 PublicationCorresponds to variant rs34084056dbSNPEnsembl.1
Natural variantiVAR_070930217V → I.1 PublicationCorresponds to variant rs148360666dbSNPEnsembl.1
Natural variantiVAR_042013230K → R.1 PublicationCorresponds to variant rs34965156dbSNPEnsembl.1
Natural variantiVAR_042014248P → S.1 PublicationCorresponds to variant rs34299975dbSNPEnsembl.1
Natural variantiVAR_042015272E → D in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_024576398Q → R.1 PublicationCorresponds to variant rs2236493dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0091431 – 346Missing in isoform 3. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_0091421 – 234Missing in isoform 4. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_05473442 – 71Missing in isoform 5. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_054735138Missing in isoform 6. Curated1
Alternative sequenceiVSP_009144232 – 419Missing in isoform 2. 1 PublicationAdd BLAST188
Alternative sequenceiVSP_009145290 – 329KTEKR…RKQKQ → TQNGSEDEASAVLLPIQTRS SLNPLLSTCMLPGRSVTLLV in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_009146330 – 419Missing in isoform 4. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022694 mRNA. Translation: BAA81688.1.
U46191 mRNA. Translation: AAB38079.1.
U46192 mRNA. Translation: AAB38082.1.
U46193 mRNA. Translation: AAB38085.1.
U46194 mRNA. Translation: AAB38087.1. Frameshift.
AK302349 mRNA. Translation: BAH13682.1.
AK312778 mRNA. Translation: BAG35641.1.
AL352978 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC053536 mRNA. Translation: AAH53536.1.
CCDSiCCDS61552.1. [Q9UQ07-5]
CCDS81854.1. [Q9UQ07-6]
CCDS9971.1. [Q9UQ07-1]
RefSeqiNP_001258940.1. NM_001272011.1. [Q9UQ07-5]
NP_001317163.1. NM_001330234.1.
NP_055041.1. NM_014226.2. [Q9UQ07-1]
UniGeneiHs.104119.

Genome annotation databases

EnsembliENST00000361847; ENSP00000355304; ENSG00000080823. [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823. [Q9UQ07-6]
ENST00000524214; ENSP00000428942; ENSG00000080823. [Q9UQ07-5]
GeneIDi5891.
KEGGihsa:5891.
UCSCiuc001ylm.5. human. [Q9UQ07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022694 mRNA. Translation: BAA81688.1.
U46191 mRNA. Translation: AAB38079.1.
U46192 mRNA. Translation: AAB38082.1.
U46193 mRNA. Translation: AAB38085.1.
U46194 mRNA. Translation: AAB38087.1. Frameshift.
AK302349 mRNA. Translation: BAH13682.1.
AK312778 mRNA. Translation: BAG35641.1.
AL352978 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC053536 mRNA. Translation: AAH53536.1.
CCDSiCCDS61552.1. [Q9UQ07-5]
CCDS81854.1. [Q9UQ07-6]
CCDS9971.1. [Q9UQ07-1]
RefSeqiNP_001258940.1. NM_001272011.1. [Q9UQ07-5]
NP_001317163.1. NM_001330234.1.
NP_055041.1. NM_014226.2. [Q9UQ07-1]
UniGeneiHs.104119.

3D structure databases

ProteinModelPortaliQ9UQ07.
SMRiQ9UQ07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111828. 11 interactors.
IntActiQ9UQ07. 4 interactors.
MINTiMINT-4777240.
STRINGi9606.ENSP00000355304.

PTM databases

iPTMnetiQ9UQ07.
PhosphoSitePlusiQ9UQ07.

Polymorphism and mutation databases

BioMutaiMOK.

Proteomic databases

EPDiQ9UQ07.
PaxDbiQ9UQ07.
PeptideAtlasiQ9UQ07.
PRIDEiQ9UQ07.
TopDownProteomicsiQ9UQ07-4. [Q9UQ07-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361847; ENSP00000355304; ENSG00000080823. [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823. [Q9UQ07-6]
ENST00000524214; ENSP00000428942; ENSG00000080823. [Q9UQ07-5]
GeneIDi5891.
KEGGihsa:5891.
UCSCiuc001ylm.5. human. [Q9UQ07-1]

Organism-specific databases

CTDi5891.
DisGeNETi5891.
GeneCardsiMOK.
H-InvDBHIX0011985.
HGNCiHGNC:9833. MOK.
HPAiHPA027282.
HPA027292.
MIMi605762. gene.
neXtProtiNX_Q9UQ07.
OpenTargetsiENSG00000080823.
PharmGKBiPA34187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0661. Eukaryota.
ENOG410XPBB. LUCA.
GeneTreeiENSGT00650000093283.
HOGENOMiHOG000233024.
HOVERGENiHBG106271.
InParanoidiQ9UQ07.
KOiK08830.
OMAiTQKDIKP.
OrthoDBiEOG091G0DU3.
PhylomeDBiQ9UQ07.
TreeFamiTF328769.

Enzyme and pathway databases

BioCyciZFISH:HS01371-MONOMER.
SignaLinkiQ9UQ07.

Miscellaneous databases

ChiTaRSiMOK. human.
GeneWikiiRAGE_(gene).
GenomeRNAii5891.
PROiQ9UQ07.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080823.
CleanExiHS_RAGE.
ExpressionAtlasiQ9UQ07. baseline and differential.
GenevisibleiQ9UQ07. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOK_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ07
Secondary accession number(s): B2R6Z4
, B7Z7P6, E7ER76, E7ERR8, Q92790, Q93067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.