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Q9UQ07 (MOK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MAPK/MAK/MRK overlapping kinase

EC=2.7.11.22
Alternative name(s):
MOK protein kinase
Renal tumor antigen 1
Short name=RAGE-1
Gene names
Name:MOK
Synonyms:RAGE, RAGE1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation appears to increase the enzymatic activity By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAB38087.1 differs from that shown. Reason: Frameshift at position 299.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UQ07-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UQ07-2)

The sequence of this isoform differs from the canonical sequence as follows:
     232-419: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9UQ07-3)

Also known as: RAGE-1 ORF5; RAGE-2 ORF5; RAGE-3 ORF5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9UQ07-4)

Also known as: RAGE-4 ORF3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     290-329: KTEKRALGSH...ISKEGRKQKQ → TQNGSEDEAS...LPGRSVTLLV
     330-419: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9UQ07-5)

The sequence of this isoform differs from the canonical sequence as follows:
     42-71: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q9UQ07-6)

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419MAPK/MAK/MRK overlapping kinase
PRO_0000086341

Regions

Domain4 – 285282Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1281Proton acceptor By similarity
Binding site331ATP By similarity

Natural variations

Alternative sequence1 – 346346Missing in isoform 3.
VSP_009143
Alternative sequence1 – 234234Missing in isoform 4.
VSP_009142
Alternative sequence42 – 7130Missing in isoform 5.
VSP_054734
Alternative sequence1381Missing in isoform 6.
VSP_054735
Alternative sequence232 – 419188Missing in isoform 2.
VSP_009144
Alternative sequence290 – 32940KTEKR…RKQKQ → TQNGSEDEASAVLLPIQTRS SLNPLLSTCMLPGRSVTLLV in isoform 4.
VSP_009145
Alternative sequence330 – 41990Missing in isoform 4.
VSP_009146
Natural variant381R → H. Ref.6
Corresponds to variant rs34114580 [ dbSNP | Ensembl ].
VAR_042011
Natural variant861D → N. Ref.6
Corresponds to variant rs34084056 [ dbSNP | Ensembl ].
VAR_042012
Natural variant2171V → I. Ref.3
Corresponds to variant rs148360666 [ dbSNP | Ensembl ].
VAR_070930
Natural variant2301K → R. Ref.6
Corresponds to variant rs34965156 [ dbSNP | Ensembl ].
VAR_042013
Natural variant2481P → S. Ref.6
Corresponds to variant rs34299975 [ dbSNP | Ensembl ].
VAR_042014
Natural variant2721E → D in a breast pleomorphic lobular carcinoma sample; somatic mutation. Ref.6
VAR_042015
Natural variant3981Q → R. Ref.6
Corresponds to variant rs2236493 [ dbSNP | Ensembl ].
VAR_024576

Experimental info

Sequence conflict2691D → G in BAG35641. Ref.3
Sequence conflict3131P → L in BAG35641. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: CDA7D9C1E80AAE8F

FASTA41948,014
        10         20         30         40         50         60 
MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH 

        70         80         90        100        110        120 
PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH 

       130        140        150        160        170        180 
RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT 

       190        200        210        220        230        240 
YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP 

       250        260        270        280        290        300 
FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR 

       310        320        330        340        350        360 
KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL 

       370        380        390        400        410 
SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR 

« Hide

Isoform 2 [UniParc].

Checksum: D0665FAE077D3B76
Show »

FASTA23127,120
Isoform 3 (RAGE-1 ORF5) (RAGE-2 ORF5) (RAGE-3 ORF5) [UniParc].

Checksum: 38B1376ECFEDF351
Show »

FASTA737,879
Isoform 4 (RAGE-4 ORF3) [UniParc].

Checksum: 8B155074ED025D9A
Show »

FASTA9510,482
Isoform 5 [UniParc].

Checksum: 72B60D201632301B
Show »

FASTA38944,425
Isoform 6 [UniParc].

Checksum: 75769950EB76F3F7
Show »

FASTA41847,886

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel member of the MAP kinase superfamily."
Miyata Y., Akashi M., Nishida E.
Genes Cells 4:299-309(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma."
Gaugler B., Brouwenstijn N., Vantomme V., Szikora J.-P., Van der Spek C.W., Patard J.-J., Boon T., Schrier P., Van den Eynde B.J.
Immunogenetics 44:323-330(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
Tissue: Renal cell carcinoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT ILE-217.
Tissue: Testis.
[4]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain, Lung and Testis.
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-38; ASN-86; ARG-230; SER-248; ASP-272 AND ARG-398.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB022694 mRNA. Translation: BAA81688.1.
U46191 mRNA. Translation: AAB38079.1.
U46192 mRNA. Translation: AAB38082.1.
U46193 mRNA. Translation: AAB38085.1.
U46194 mRNA. Translation: AAB38087.1. Frameshift.
AK302349 mRNA. Translation: BAH13682.1.
AK312778 mRNA. Translation: BAG35641.1.
AL352978 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC053536 mRNA. Translation: AAH53536.1.
CCDSCCDS9971.1. [Q9UQ07-1]
RefSeqNP_001258940.1. NM_001272011.1. [Q9UQ07-5]
NP_055041.1. NM_014226.2. [Q9UQ07-1]
UniGeneHs.104119.

3D structure databases

ProteinModelPortalQ9UQ07.
SMRQ9UQ07. Positions 1-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111828. 8 interactions.
IntActQ9UQ07. 3 interactions.
MINTMINT-4777240.
STRING9606.ENSP00000355304.

PTM databases

PhosphoSiteQ9UQ07.

Proteomic databases

PaxDbQ9UQ07.
PRIDEQ9UQ07.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000193029; ENSP00000193029; ENSG00000080823. [Q9UQ07-4]
ENST00000361847; ENSP00000355304; ENSG00000080823. [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823.
ENST00000524214; ENSP00000428942; ENSG00000080823.
GeneID5891.
KEGGhsa:5891.
UCSCuc001ylm.4. human. [Q9UQ07-1]

Organism-specific databases

CTD5891.
GeneCardsGC14M102690.
H-InvDBHIX0011985.
HGNCHGNC:9833. MOK.
HPAHPA027282.
HPA027292.
MIM605762. gene.
neXtProtNX_Q9UQ07.
PharmGKBPA34187.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG106271.
KOK08830.
OMAYLCVCPS.
PhylomeDBQ9UQ07.
TreeFamTF328769.

Enzyme and pathway databases

SignaLinkQ9UQ07.

Gene expression databases

ArrayExpressQ9UQ07.
BgeeQ9UQ07.
CleanExHS_RAGE.
GenevestigatorQ9UQ07.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMOK. human.
GeneWikiRAGE_(gene).
GenomeRNAi5891.
NextBio22916.
PROQ9UQ07.
SOURCESearch...

Entry information

Entry nameMOK_HUMAN
AccessionPrimary (citable) accession number: Q9UQ07
Secondary accession number(s): B2R6Z4 expand/collapse secondary AC list , B7Z7P6, E7ER76, E7ERR8, Q92790, Q93067
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM