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Protein

MAPK/MAK/MRK overlapping kinase

Gene

MOK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation appears to increase the enzymatic activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei128 – 1281Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  • protein phosphorylation Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9UQ07.

Names & Taxonomyi

Protein namesi
Recommended name:
MAPK/MAK/MRK overlapping kinase (EC:2.7.11.22)
Alternative name(s):
MOK protein kinase
Renal tumor antigen 1
Short name:
RAGE-1
Gene namesi
Name:MOK
Synonyms:RAGE, RAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9833. MOK.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34187.

Polymorphism and mutation databases

BioMutaiMOK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419MAPK/MAK/MRK overlapping kinasePRO_0000086341Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UQ07.
PRIDEiQ9UQ07.

PTM databases

PhosphoSiteiQ9UQ07.

Expressioni

Tissue specificityi

Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Gene expression databases

BgeeiQ9UQ07.
CleanExiHS_RAGE.
ExpressionAtlasiQ9UQ07. baseline and differential.
GenevisibleiQ9UQ07. HS.

Organism-specific databases

HPAiHPA027282.
HPA027292.

Interactioni

Protein-protein interaction databases

BioGridi111828. 13 interactions.
IntActiQ9UQ07. 4 interactions.
MINTiMINT-4777240.
STRINGi9606.ENSP00000355304.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ07.
SMRiQ9UQ07. Positions 1-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 285282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00650000093283.
HOGENOMiHOG000233024.
HOVERGENiHBG106271.
InParanoidiQ9UQ07.
KOiK08830.
OMAiILMLHEV.
PhylomeDBiQ9UQ07.
TreeFamiTF328769.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE
60 70 80 90 100
IQALRRLNPH PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL
110 120 130 140 150
SEKKIMHYMY QLCKSLDHIH RNGIFHRDVK PENILIKQDV LKLGDFGSCR
160 170 180 190 200
SVYSKQPYTE YISTRWYRAP ECLLTDGFYT YKMDLWSAGC VFYEIASLQP
210 220 230 240 250
LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP FKKGSGIPLL
260 270 280 290 300
TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR
310 320 330 340 350
KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP
360 370 380 390 400
KLKLSGVVRL SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD
410
LKPAPQQCRL PTIVRKGGR
Length:419
Mass (Da):48,014
Last modified:May 1, 2000 - v1
Checksum:iCDA7D9C1E80AAE8F
GO
Isoform 2 (identifier: Q9UQ07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-419: Missing.

Note: No experimental confirmation available.
Show »
Length:231
Mass (Da):27,120
Checksum:iD0665FAE077D3B76
GO
Isoform 3 (identifier: Q9UQ07-3) [UniParc]FASTAAdd to basket

Also known as: RAGE-1 ORF5, RAGE-2 ORF5, RAGE-3 ORF5

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):7,879
Checksum:i38B1376ECFEDF351
GO
Isoform 4 (identifier: Q9UQ07-4) [UniParc]FASTAAdd to basket

Also known as: RAGE-4 ORF3

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     290-329: KTEKRALGSH...ISKEGRKQKQ → TQNGSEDEAS...LPGRSVTLLV
     330-419: Missing.

Note: No experimental confirmation available.
Show »
Length:95
Mass (Da):10,482
Checksum:i8B155074ED025D9A
GO
Isoform 5 (identifier: Q9UQ07-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-71: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):44,425
Checksum:i72B60D201632301B
GO
Isoform 6 (identifier: Q9UQ07-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: Missing.

Note: Gene prediction based on EST data.
Show »
Length:418
Mass (Da):47,886
Checksum:i75769950EB76F3F7
GO

Sequence cautioni

The sequence AAB38087.1 differs from that shown. Reason: Frameshift at position 299. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2691D → G in BAG35641 (PubMed:14702039).Curated
Sequence conflicti313 – 3131P → L in BAG35641 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381R → H.1 Publication
Corresponds to variant rs34114580 [ dbSNP | Ensembl ].
VAR_042011
Natural varianti86 – 861D → N.1 Publication
Corresponds to variant rs34084056 [ dbSNP | Ensembl ].
VAR_042012
Natural varianti217 – 2171V → I.1 Publication
Corresponds to variant rs148360666 [ dbSNP | Ensembl ].
VAR_070930
Natural varianti230 – 2301K → R.1 Publication
Corresponds to variant rs34965156 [ dbSNP | Ensembl ].
VAR_042013
Natural varianti248 – 2481P → S.1 Publication
Corresponds to variant rs34299975 [ dbSNP | Ensembl ].
VAR_042014
Natural varianti272 – 2721E → D in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication
VAR_042015
Natural varianti398 – 3981Q → R.1 Publication
Corresponds to variant rs2236493 [ dbSNP | Ensembl ].
VAR_024576

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 346346Missing in isoform 3. 1 PublicationVSP_009143Add
BLAST
Alternative sequencei1 – 234234Missing in isoform 4. 1 PublicationVSP_009142Add
BLAST
Alternative sequencei42 – 7130Missing in isoform 5. 1 PublicationVSP_054734Add
BLAST
Alternative sequencei138 – 1381Missing in isoform 6. CuratedVSP_054735
Alternative sequencei232 – 419188Missing in isoform 2. 1 PublicationVSP_009144Add
BLAST
Alternative sequencei290 – 32940KTEKR…RKQKQ → TQNGSEDEASAVLLPIQTRS SLNPLLSTCMLPGRSVTLLV in isoform 4. 1 PublicationVSP_009145Add
BLAST
Alternative sequencei330 – 41990Missing in isoform 4. 1 PublicationVSP_009146Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022694 mRNA. Translation: BAA81688.1.
U46191 mRNA. Translation: AAB38079.1.
U46192 mRNA. Translation: AAB38082.1.
U46193 mRNA. Translation: AAB38085.1.
U46194 mRNA. Translation: AAB38087.1. Frameshift.
AK302349 mRNA. Translation: BAH13682.1.
AK312778 mRNA. Translation: BAG35641.1.
AL352978 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC053536 mRNA. Translation: AAH53536.1.
CCDSiCCDS61552.1. [Q9UQ07-5]
CCDS9971.1. [Q9UQ07-1]
RefSeqiNP_001258940.1. NM_001272011.1. [Q9UQ07-5]
NP_055041.1. NM_014226.2. [Q9UQ07-1]
UniGeneiHs.104119.

Genome annotation databases

EnsembliENST00000361847; ENSP00000355304; ENSG00000080823. [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823. [Q9UQ07-6]
ENST00000524214; ENSP00000428942; ENSG00000080823. [Q9UQ07-5]
GeneIDi5891.
KEGGihsa:5891.
UCSCiuc001ylm.4. human. [Q9UQ07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022694 mRNA. Translation: BAA81688.1.
U46191 mRNA. Translation: AAB38079.1.
U46192 mRNA. Translation: AAB38082.1.
U46193 mRNA. Translation: AAB38085.1.
U46194 mRNA. Translation: AAB38087.1. Frameshift.
AK302349 mRNA. Translation: BAH13682.1.
AK312778 mRNA. Translation: BAG35641.1.
AL352978 Genomic DNA. No translation available.
AL359402 Genomic DNA. No translation available.
BC053536 mRNA. Translation: AAH53536.1.
CCDSiCCDS61552.1. [Q9UQ07-5]
CCDS9971.1. [Q9UQ07-1]
RefSeqiNP_001258940.1. NM_001272011.1. [Q9UQ07-5]
NP_055041.1. NM_014226.2. [Q9UQ07-1]
UniGeneiHs.104119.

3D structure databases

ProteinModelPortaliQ9UQ07.
SMRiQ9UQ07. Positions 1-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111828. 13 interactions.
IntActiQ9UQ07. 4 interactions.
MINTiMINT-4777240.
STRINGi9606.ENSP00000355304.

PTM databases

PhosphoSiteiQ9UQ07.

Polymorphism and mutation databases

BioMutaiMOK.

Proteomic databases

PaxDbiQ9UQ07.
PRIDEiQ9UQ07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361847; ENSP00000355304; ENSG00000080823. [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823. [Q9UQ07-6]
ENST00000524214; ENSP00000428942; ENSG00000080823. [Q9UQ07-5]
GeneIDi5891.
KEGGihsa:5891.
UCSCiuc001ylm.4. human. [Q9UQ07-1]

Organism-specific databases

CTDi5891.
GeneCardsiGC14M102690.
H-InvDBHIX0011985.
HGNCiHGNC:9833. MOK.
HPAiHPA027282.
HPA027292.
MIMi605762. gene.
neXtProtiNX_Q9UQ07.
PharmGKBiPA34187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00650000093283.
HOGENOMiHOG000233024.
HOVERGENiHBG106271.
InParanoidiQ9UQ07.
KOiK08830.
OMAiILMLHEV.
PhylomeDBiQ9UQ07.
TreeFamiTF328769.

Enzyme and pathway databases

SignaLinkiQ9UQ07.

Miscellaneous databases

ChiTaRSiMOK. human.
GeneWikiiRAGE_(gene).
GenomeRNAii5891.
NextBioi22916.
PROiQ9UQ07.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UQ07.
CleanExiHS_RAGE.
ExpressionAtlasiQ9UQ07. baseline and differential.
GenevisibleiQ9UQ07. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel member of the MAP kinase superfamily."
    Miyata Y., Akashi M., Nishida E.
    Genes Cells 4:299-309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma."
    Gaugler B., Brouwenstijn N., Vantomme V., Szikora J.-P., Van der Spek C.W., Patard J.-J., Boon T., Schrier P., Van den Eynde B.J.
    Immunogenetics 44:323-330(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    Tissue: Renal cell carcinoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), VARIANT ILE-217.
    Tissue: Testis.
  4. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain, Lung and Testis.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-38; ASN-86; ARG-230; SER-248; ASP-272 AND ARG-398.

Entry informationi

Entry nameiMOK_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ07
Secondary accession number(s): B2R6Z4
, B7Z7P6, E7ER76, E7ERR8, Q92790, Q93067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.