ID   COR2B_HUMAN             Reviewed;         480 AA.
AC   Q9UQ03; A8K0W3; O94767; Q8TAN1;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 4.
DT   27-MAR-2024, entry version 182.
DE   RecName: Full=Coronin-2B;
DE   AltName: Full=Coronin-like protein C;
DE            Short=Clipin-C;
DE   AltName: Full=Protein FC96;
GN   Name=CORO2B; Synonyms=KIAA0925;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=10224093; DOI=10.1074/jbc.274.19.13322;
RA   Nakamura T., Takeuchi K., Muraoka S., Takezoe H., Takahashi N., Mori N.;
RT   "A neurally enriched coronin-like protein, ClipinC, is a novel candidate
RT   for an actin cytoskeleton-cortical membrane-linking protein.";
RL   J. Biol. Chem. 274:13322-13327(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-238.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-480 (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA   Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 6:63-70(1999).
RN   [6]
RP   VARIANT [LARGE SCALE ANALYSIS] LEU-318.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May play a role in the reorganization of neuronal actin
CC       structure.
CC   -!- SUBUNIT: Binds to F-actin and to vinculin.
CC   -!- INTERACTION:
CC       Q9UQ03; Q92624: APPBP2; NbExp=6; IntAct=EBI-723376, EBI-743771;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UQ03-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UQ03-2; Sequence=VSP_037706;
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in brain.
CC   -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH26335.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAA36341.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB010098; BAA36341.1; ALT_INIT; mRNA.
DR   EMBL; AK289678; BAF82367.1; -; mRNA.
DR   EMBL; AC090734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC026335; AAH26335.1; ALT_INIT; mRNA.
DR   EMBL; AB023142; BAA76769.1; -; mRNA.
DR   CCDS; CCDS10229.2; -. [Q9UQ03-1]
DR   CCDS; CCDS53952.1; -. [Q9UQ03-2]
DR   RefSeq; NP_001177385.1; NM_001190456.1. [Q9UQ03-2]
DR   RefSeq; NP_001177386.1; NM_001190457.1. [Q9UQ03-2]
DR   RefSeq; NP_001310943.1; NM_001324014.1. [Q9UQ03-2]
DR   RefSeq; NP_001310944.1; NM_001324015.1. [Q9UQ03-2]
DR   RefSeq; NP_006082.3; NM_006091.4. [Q9UQ03-1]
DR   AlphaFoldDB; Q9UQ03; -.
DR   SMR; Q9UQ03; -.
DR   BioGRID; 115663; 22.
DR   IntAct; Q9UQ03; 14.
DR   STRING; 9606.ENSP00000261861; -.
DR   iPTMnet; Q9UQ03; -.
DR   PhosphoSitePlus; Q9UQ03; -.
DR   BioMuta; CORO2B; -.
DR   DMDM; 254763439; -.
DR   EPD; Q9UQ03; -.
DR   jPOST; Q9UQ03; -.
DR   MassIVE; Q9UQ03; -.
DR   MaxQB; Q9UQ03; -.
DR   PaxDb; 9606-ENSP00000454783; -.
DR   PeptideAtlas; Q9UQ03; -.
DR   ProteomicsDB; 85482; -. [Q9UQ03-1]
DR   ProteomicsDB; 85483; -. [Q9UQ03-2]
DR   Pumba; Q9UQ03; -.
DR   Antibodypedia; 2828; 204 antibodies from 24 providers.
DR   DNASU; 10391; -.
DR   Ensembl; ENST00000261861.10; ENSP00000261861.6; ENSG00000103647.13. [Q9UQ03-1]
DR   Ensembl; ENST00000540068.6; ENSP00000446250.1; ENSG00000103647.13. [Q9UQ03-2]
DR   Ensembl; ENST00000543950.3; ENSP00000443819.1; ENSG00000103647.13. [Q9UQ03-2]
DR   GeneID; 10391; -.
DR   KEGG; hsa:10391; -.
DR   MANE-Select; ENST00000261861.10; ENSP00000261861.6; NM_006091.5; NP_006082.3.
DR   UCSC; uc002arj.5; human. [Q9UQ03-1]
DR   AGR; HGNC:2256; -.
DR   CTD; 10391; -.
DR   DisGeNET; 10391; -.
DR   GeneCards; CORO2B; -.
DR   HGNC; HGNC:2256; CORO2B.
DR   HPA; ENSG00000103647; Tissue enhanced (brain, retina).
DR   MIM; 605002; gene.
DR   neXtProt; NX_Q9UQ03; -.
DR   OpenTargets; ENSG00000103647; -.
DR   PharmGKB; PA26772; -.
DR   VEuPathDB; HostDB:ENSG00000103647; -.
DR   eggNOG; KOG0303; Eukaryota.
DR   GeneTree; ENSGT00940000158689; -.
DR   HOGENOM; CLU_026859_4_0_1; -.
DR   InParanoid; Q9UQ03; -.
DR   OMA; DGNFCAV; -.
DR   OrthoDB; 5474889at2759; -.
DR   PhylomeDB; Q9UQ03; -.
DR   TreeFam; TF314280; -.
DR   PathwayCommons; Q9UQ03; -.
DR   SignaLink; Q9UQ03; -.
DR   BioGRID-ORCS; 10391; 8 hits in 1147 CRISPR screens.
DR   ChiTaRS; CORO2B; human.
DR   GenomeRNAi; 10391; -.
DR   Pharos; Q9UQ03; Tdark.
DR   PRO; PR:Q9UQ03; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; Q9UQ03; Protein.
DR   Bgee; ENSG00000103647; Expressed in ganglionic eminence and 142 other cell types or tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; NAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005925; C:focal adhesion; IDA:MGI.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; NAS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:1990147; F:talin binding; IDA:MGI.
DR   GO; GO:0017166; F:vinculin binding; IPI:MGI.
DR   GO; GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.
DR   GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
DR   GO; GO:0010812; P:negative regulation of cell-substrate adhesion; IDA:MGI.
DR   GO; GO:1904950; P:negative regulation of establishment of protein localization; IDA:MGI.
DR   GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR   GO; GO:1904951; P:positive regulation of establishment of protein localization; IDA:MGI.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IDA:MGI.
DR   GO; GO:0080135; P:regulation of cellular response to stress; IDA:MGI.
DR   GO; GO:0003093; P:regulation of glomerular filtration; IEA:Ensembl.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR015505; Coronin.
DR   InterPro; IPR015048; DUF1899.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10856; CORONIN; 1.
DR   PANTHER; PTHR10856:SF17; CORONIN-2B; 1.
DR   Pfam; PF08953; DUF1899; 1.
DR   Pfam; PF00400; WD40; 3.
DR   Pfam; PF16300; WD40_4; 1.
DR   SMART; SM01166; DUF1899; 1.
DR   SMART; SM01167; DUF1900; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR   Genevisible; Q9UQ03; HS.
PE   1: Evidence at protein level;
KW   Actin-binding; Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..480
FT                   /note="Coronin-2B"
FT                   /id="PRO_0000050930"
FT   REPEAT          29..77
FT                   /note="WD 1"
FT   REPEAT          78..127
FT                   /note="WD 2"
FT   REPEAT          128..170
FT                   /note="WD 3"
FT   REPEAT          171..212
FT                   /note="WD 4"
FT   REPEAT          213..259
FT                   /note="WD 5"
FT   REPEAT          260..305
FT                   /note="WD 6"
FT   REPEAT          306..345
FT                   /note="WD 7"
FT   COILED          436..479
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..6
FT                   /note="MTVTKM -> M (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_037706"
FT   VARIANT         238
FT                   /note="L -> V (in dbSNP:rs17852400)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_058323"
FT   VARIANT         318
FT                   /note="P -> L (in a colorectal cancer sample; somatic
FT                   mutation; dbSNP:rs1314209013)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_035878"
FT   CONFLICT        128
FT                   /note="E -> A (in Ref. 1; BAA36341)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   480 AA;  54953 MW;  CE91834164A23D79 CRC64;
     MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT RFLAIVTESA
     GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID NIIASCSEDT SVRIWEIPEG
     GLKRNMTEAL LELHGHSRRV GLVEWHPTTN NILFSAGYDY KVLIWNLDVG EPVKMIDCHT
     DVILCMSFNT DGSLLTTTCK DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT
     GVSRWNTRQI ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
     STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI EPISMIVPRR
     SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG YKKSSKMVFK APIKEKKSVV
     VNGIDLLENV PPRTENELLR MFFRQQDEIR RLKEELAQKD IRIRQLQLEL KNLRNSPKNC
//