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Q9UQ03

- COR2B_HUMAN

UniProt

Q9UQ03 - COR2B_HUMAN

Protein

Coronin-2B

Gene

CORO2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 4 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    May play a role in the reorganization of neuronal actin structure.

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. actin filament binding Source: RefGenome

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiQ9UQ03.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coronin-2B
    Alternative name(s):
    Coronin-like protein C
    Short name:
    Clipin-C
    Protein FC96
    Gene namesi
    Name:CORO2B
    Synonyms:KIAA0925
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:2256. CORO2B.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26772.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Coronin-2BPRO_0000050930Add
    BLAST

    Proteomic databases

    MaxQBiQ9UQ03.
    PaxDbiQ9UQ03.
    PRIDEiQ9UQ03.

    PTM databases

    PhosphoSiteiQ9UQ03.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain.

    Gene expression databases

    ArrayExpressiQ9UQ03.
    BgeeiQ9UQ03.
    CleanExiHS_CORO2B.
    GenevestigatoriQ9UQ03.

    Organism-specific databases

    HPAiHPA017960.

    Interactioni

    Subunit structurei

    Binds to F-actin and to vinculin.

    Protein-protein interaction databases

    BioGridi115663. 2 interactions.
    IntActiQ9UQ03. 3 interactions.
    MINTiMINT-1394971.
    STRINGi9606.ENSP00000261861.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UQ03.
    SMRiQ9UQ03. Positions 15-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati85 – 12541WD 1Add
    BLAST
    Repeati135 – 17743WD 2Add
    BLAST
    Repeati179 – 21739WD 3Add
    BLAST
    Repeati220 – 26344WD 4Add
    BLAST
    Repeati265 – 30844WD 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili436 – 47944Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat coronin family.Curated
    Contains 5 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOGENOMiHOG000166356.
    HOVERGENiHBG059978.
    InParanoidiQ9UQ03.
    OMAiREHCFDG.
    OrthoDBiEOG7J70FB.
    PhylomeDBiQ9UQ03.
    TreeFamiTF314280.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR027339. CORO2B.
    IPR015505. Coronin.
    IPR015048. DUF1899.
    IPR015049. DUF1900.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PANTHERiPTHR10856. PTHR10856. 1 hit.
    PTHR10856:SF17. PTHR10856:SF17. 1 hit.
    PfamiPF08953. DUF1899. 1 hit.
    PF08954. DUF1900. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UQ03-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT    50
    RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID 100
    NIIASCSEDT SVRIWEIPEG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN 150
    NILFSAGYDY KVLIWNLDVG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK 200
    DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI 250
    ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI 300
    STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI 350
    EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG 400
    YKKSSKMVFK APIKEKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR 450
    RLKEELAQKD IRIRQLQLEL KNLRNSPKNC 480
    Length:480
    Mass (Da):54,953
    Last modified:July 28, 2009 - v4
    Checksum:iCE91834164A23D79
    GO
    Isoform 2 (identifier: Q9UQ03-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MTVTKM → M

    Show »
    Length:475
    Mass (Da):54,393
    Checksum:i5C85A21F2202A197
    GO

    Sequence cautioni

    The sequence AAH26335.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA36341.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281E → A in BAA36341. (PubMed:10224093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti238 – 2381L → V.1 Publication
    Corresponds to variant rs17852400 [ dbSNP | Ensembl ].
    VAR_058323
    Natural varianti318 – 3181P → L in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035878

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66MTVTKM → M in isoform 2. 1 PublicationVSP_037706

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010098 mRNA. Translation: BAA36341.1. Different initiation.
    AK289678 mRNA. Translation: BAF82367.1.
    AC090734 Genomic DNA. No translation available.
    AC105014 Genomic DNA. No translation available.
    BC026335 mRNA. Translation: AAH26335.1. Different initiation.
    AB023142 mRNA. Translation: BAA76769.1.
    CCDSiCCDS10229.2. [Q9UQ03-1]
    CCDS53952.1. [Q9UQ03-2]
    RefSeqiNP_001177385.1. NM_001190456.1. [Q9UQ03-2]
    NP_001177386.1. NM_001190457.1. [Q9UQ03-2]
    NP_006082.3. NM_006091.4. [Q9UQ03-1]
    XP_005254182.1. XM_005254125.1. [Q9UQ03-2]
    UniGeneiHs.551213.

    Genome annotation databases

    EnsembliENST00000261861; ENSP00000261861; ENSG00000103647. [Q9UQ03-2]
    ENST00000540068; ENSP00000446250; ENSG00000103647. [Q9UQ03-2]
    ENST00000543950; ENSP00000443819; ENSG00000103647. [Q9UQ03-2]
    ENST00000566799; ENSP00000454783; ENSG00000103647. [Q9UQ03-1]
    GeneIDi10391.
    KEGGihsa:10391.
    UCSCiuc002arj.4. human. [Q9UQ03-1]

    Polymorphism databases

    DMDMi254763439.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010098 mRNA. Translation: BAA36341.1 . Different initiation.
    AK289678 mRNA. Translation: BAF82367.1 .
    AC090734 Genomic DNA. No translation available.
    AC105014 Genomic DNA. No translation available.
    BC026335 mRNA. Translation: AAH26335.1 . Different initiation.
    AB023142 mRNA. Translation: BAA76769.1 .
    CCDSi CCDS10229.2. [Q9UQ03-1 ]
    CCDS53952.1. [Q9UQ03-2 ]
    RefSeqi NP_001177385.1. NM_001190456.1. [Q9UQ03-2 ]
    NP_001177386.1. NM_001190457.1. [Q9UQ03-2 ]
    NP_006082.3. NM_006091.4. [Q9UQ03-1 ]
    XP_005254182.1. XM_005254125.1. [Q9UQ03-2 ]
    UniGenei Hs.551213.

    3D structure databases

    ProteinModelPortali Q9UQ03.
    SMRi Q9UQ03. Positions 15-399.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115663. 2 interactions.
    IntActi Q9UQ03. 3 interactions.
    MINTi MINT-1394971.
    STRINGi 9606.ENSP00000261861.

    PTM databases

    PhosphoSitei Q9UQ03.

    Polymorphism databases

    DMDMi 254763439.

    Proteomic databases

    MaxQBi Q9UQ03.
    PaxDbi Q9UQ03.
    PRIDEi Q9UQ03.

    Protocols and materials databases

    DNASUi 10391.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261861 ; ENSP00000261861 ; ENSG00000103647 . [Q9UQ03-2 ]
    ENST00000540068 ; ENSP00000446250 ; ENSG00000103647 . [Q9UQ03-2 ]
    ENST00000543950 ; ENSP00000443819 ; ENSG00000103647 . [Q9UQ03-2 ]
    ENST00000566799 ; ENSP00000454783 ; ENSG00000103647 . [Q9UQ03-1 ]
    GeneIDi 10391.
    KEGGi hsa:10391.
    UCSCi uc002arj.4. human. [Q9UQ03-1 ]

    Organism-specific databases

    CTDi 10391.
    GeneCardsi GC15P068871.
    HGNCi HGNC:2256. CORO2B.
    HPAi HPA017960.
    MIMi 605002. gene.
    neXtProti NX_Q9UQ03.
    PharmGKBi PA26772.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOGENOMi HOG000166356.
    HOVERGENi HBG059978.
    InParanoidi Q9UQ03.
    OMAi REHCFDG.
    OrthoDBi EOG7J70FB.
    PhylomeDBi Q9UQ03.
    TreeFami TF314280.

    Enzyme and pathway databases

    SignaLinki Q9UQ03.

    Miscellaneous databases

    ChiTaRSi CORO2B. human.
    GenomeRNAii 10391.
    NextBioi 39366.
    PROi Q9UQ03.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UQ03.
    Bgeei Q9UQ03.
    CleanExi HS_CORO2B.
    Genevestigatori Q9UQ03.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR027339. CORO2B.
    IPR015505. Coronin.
    IPR015048. DUF1899.
    IPR015049. DUF1900.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    PANTHERi PTHR10856. PTHR10856. 1 hit.
    PTHR10856:SF17. PTHR10856:SF17. 1 hit.
    Pfami PF08953. DUF1899. 1 hit.
    PF08954. DUF1900. 1 hit.
    PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein."
      Nakamura T., Takeuchi K., Muraoka S., Takezoe H., Takahashi N., Mori N.
      J. Biol. Chem. 274:13322-13327(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Amygdala.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-238.
      Tissue: Brain.
    5. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-480 (ISOFORM 1).
      Tissue: Brain.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-318.

    Entry informationi

    Entry nameiCOR2B_HUMAN
    AccessioniPrimary (citable) accession number: Q9UQ03
    Secondary accession number(s): A8K0W3, O94767, Q8TAN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 121 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3