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Protein

Coronin-2B

Gene

CORO2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the reorganization of neuronal actin structure.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiQ9UQ03.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2B
Alternative name(s):
Coronin-like protein C
Short name:
Clipin-C
Protein FC96
Gene namesi
Name:CORO2B
Synonyms:KIAA0925
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103647.12.
HGNCiHGNC:2256. CORO2B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10391.
OpenTargetsiENSG00000103647.
PharmGKBiPA26772.

Polymorphism and mutation databases

BioMutaiCORO2B.
DMDMi254763439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509301 – 480Coronin-2BAdd BLAST480

Proteomic databases

EPDiQ9UQ03.
PaxDbiQ9UQ03.
PeptideAtlasiQ9UQ03.
PRIDEiQ9UQ03.

PTM databases

iPTMnetiQ9UQ03.
PhosphoSitePlusiQ9UQ03.

Expressioni

Tissue specificityi

Expressed predominantly in brain.

Gene expression databases

BgeeiENSG00000103647.
CleanExiHS_CORO2B.
GenevisibleiQ9UQ03. HS.

Organism-specific databases

HPAiHPA017960.

Interactioni

Subunit structurei

Binds to F-actin and to vinculin.

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-723376,EBI-743771

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central

Protein-protein interaction databases

BioGridi115663. 7 interactors.
IntActiQ9UQ03. 4 interactors.
MINTiMINT-1394971.
STRINGi9606.ENSP00000454783.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ03.
SMRiQ9UQ03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 77WD 1Add BLAST49
Repeati78 – 127WD 2Add BLAST50
Repeati128 – 170WD 3Add BLAST43
Repeati171 – 212WD 4Add BLAST42
Repeati213 – 259WD 5Add BLAST47
Repeati260 – 305WD 6Add BLAST46
Repeati306 – 345WD 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili436 – 479Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9UQ03.
KOiK13887.
OMAiKNVHDNH.
OrthoDBiEOG091G03H5.
PhylomeDBiQ9UQ03.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR027339. CORO2B.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF17. PTHR10856:SF17. 1 hit.
PfamiView protein in Pfam
PF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
SMARTiView protein in SMART
SM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPEG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDVG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKMVFK APIKEKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRIRQLQLEL KNLRNSPKNC
Length:480
Mass (Da):54,953
Last modified:July 28, 2009 - v4
Checksum:iCE91834164A23D79
GO
Isoform 2 (identifier: Q9UQ03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MTVTKM → M

Show »
Length:475
Mass (Da):54,393
Checksum:i5C85A21F2202A197
GO

Sequence cautioni

Q9UQ03: The sequence AAH26335 differs from that shown. Reason: Erroneous initiation.Curated
Q9UQ03: The sequence BAA36341 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128E → A in BAA36341 (PubMed:10224093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058323238L → V1 PublicationCorresponds to variant dbSNP:rs17852400Ensembl.1
Natural variantiVAR_035878318P → L in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377061 – 6MTVTKM → M in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010098 mRNA. Translation: BAA36341.1. Different initiation.
AK289678 mRNA. Translation: BAF82367.1.
AC090734 Genomic DNA. No translation available.
AC105014 Genomic DNA. No translation available.
BC026335 mRNA. Translation: AAH26335.1. Different initiation.
AB023142 mRNA. Translation: BAA76769.1.
CCDSiCCDS10229.2. [Q9UQ03-1]
CCDS53952.1. [Q9UQ03-2]
RefSeqiNP_001177385.1. NM_001190456.1. [Q9UQ03-2]
NP_001177386.1. NM_001190457.1. [Q9UQ03-2]
NP_001310943.1. NM_001324014.1. [Q9UQ03-2]
NP_001310944.1. NM_001324015.1. [Q9UQ03-2]
NP_006082.3. NM_006091.4. [Q9UQ03-1]
UniGeneiHs.551213.

Genome annotation databases

EnsembliENST00000261861; ENSP00000261861; ENSG00000103647. [Q9UQ03-2]
ENST00000540068; ENSP00000446250; ENSG00000103647. [Q9UQ03-2]
ENST00000543950; ENSP00000443819; ENSG00000103647. [Q9UQ03-2]
ENST00000566799; ENSP00000454783; ENSG00000103647. [Q9UQ03-1]
GeneIDi10391.
KEGGihsa:10391.
UCSCiuc002arj.5. human. [Q9UQ03-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOR2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ03
Secondary accession number(s): A8K0W3, O94767, Q8TAN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 28, 2009
Last modified: October 25, 2017
This is version 147 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families