Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UQ03 (COR2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coronin-2B
Alternative name(s):
Coronin-like protein C
Short name=Clipin-C
Protein FC96
Gene names
Name:CORO2B
Synonyms:KIAA0925
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the reorganization of neuronal actin structure.

Subunit structure

Binds to F-actin and to vinculin.

Subcellular location

Cytoplasmcytoskeleton Probable.

Tissue specificity

Expressed predominantly in brain.

Sequence similarities

Belongs to the WD repeat coronin family.

Contains 5 WD repeats.

Sequence caution

The sequence AAH26335.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA36341.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
WD repeat
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentactin cytoskeleton

Non-traceable author statement Ref.1. Source: UniProtKB

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionactin binding

Non-traceable author statement Ref.1. Source: UniProtKB

actin filament binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UQ03-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UQ03-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MTVTKM → M

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480Coronin-2B
PRO_0000050930

Regions

Repeat85 – 12541WD 1
Repeat135 – 17743WD 2
Repeat179 – 21739WD 3
Repeat220 – 26344WD 4
Repeat265 – 30844WD 5
Coiled coil436 – 47944 Potential

Natural variations

Alternative sequence1 – 66MTVTKM → M in isoform 2.
VSP_037706
Natural variant2381L → V. Ref.4
Corresponds to variant rs17852400 [ dbSNP | Ensembl ].
VAR_058323
Natural variant3181P → L in a colorectal cancer sample; somatic mutation. Ref.6
VAR_035878

Experimental info

Sequence conflict1281E → A in BAA36341. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 28, 2009. Version 4.
Checksum: CE91834164A23D79

FASTA48054,953
        10         20         30         40         50         60 
MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT RFLAIVTESA 

        70         80         90        100        110        120 
GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID NIIASCSEDT SVRIWEIPEG 

       130        140        150        160        170        180 
GLKRNMTEAL LELHGHSRRV GLVEWHPTTN NILFSAGYDY KVLIWNLDVG EPVKMIDCHT 

       190        200        210        220        230        240 
DVILCMSFNT DGSLLTTTCK DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT 

       250        260        270        280        290        300 
GVSRWNTRQI ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI 

       310        320        330        340        350        360 
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI EPISMIVPRR 

       370        380        390        400        410        420 
SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG YKKSSKMVFK APIKEKKSVV 

       430        440        450        460        470        480 
VNGIDLLENV PPRTENELLR MFFRQQDEIR RLKEELAQKD IRIRQLQLEL KNLRNSPKNC 

« Hide

Isoform 2 [UniParc].

Checksum: 5C85A21F2202A197
Show »

FASTA47554,393

References

« Hide 'large scale' references
[1]"A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein."
Nakamura T., Takeuchi K., Muraoka S., Takezoe H., Takahashi N., Mori N.
J. Biol. Chem. 274:13322-13327(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Amygdala.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-238.
Tissue: Brain.
[5]"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-480 (ISOFORM 1).
Tissue: Brain.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-318.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010098 mRNA. Translation: BAA36341.1. Different initiation.
AK289678 mRNA. Translation: BAF82367.1.
AC090734 Genomic DNA. No translation available.
AC105014 Genomic DNA. No translation available.
BC026335 mRNA. Translation: AAH26335.1. Different initiation.
AB023142 mRNA. Translation: BAA76769.1.
RefSeqNP_001177385.1. NM_001190456.1.
NP_001177386.1. NM_001190457.1.
NP_006082.3. NM_006091.4.
XP_005254182.1. XM_005254125.1.
UniGeneHs.551213.

3D structure databases

ProteinModelPortalQ9UQ03.
SMRQ9UQ03. Positions 15-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115663. 2 interactions.
IntActQ9UQ03. 1 interaction.
MINTMINT-1394971.
STRING9606.ENSP00000261861.

PTM databases

PhosphoSiteQ9UQ03.

Polymorphism databases

DMDM254763439.

Proteomic databases

PaxDbQ9UQ03.
PRIDEQ9UQ03.

Protocols and materials databases

DNASU10391.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261861; ENSP00000261861; ENSG00000103647. [Q9UQ03-2]
ENST00000540068; ENSP00000446250; ENSG00000103647. [Q9UQ03-2]
ENST00000543950; ENSP00000443819; ENSG00000103647. [Q9UQ03-2]
ENST00000566799; ENSP00000454783; ENSG00000103647. [Q9UQ03-1]
GeneID10391.
KEGGhsa:10391.
UCSCuc002arj.4. human. [Q9UQ03-1]

Organism-specific databases

CTD10391.
GeneCardsGC15P068871.
HGNCHGNC:2256. CORO2B.
HPAHPA017960.
MIM605002. gene.
neXtProtNX_Q9UQ03.
PharmGKBPA26772.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOGENOMHOG000166356.
HOVERGENHBG059978.
InParanoidQ9UQ03.
OMAREHCFDG.
OrthoDBEOG7J70FB.
PhylomeDBQ9UQ03.
TreeFamTF314280.

Enzyme and pathway databases

SignaLinkQ9UQ03.

Gene expression databases

ArrayExpressQ9UQ03.
BgeeQ9UQ03.
CleanExHS_CORO2B.
GenevestigatorQ9UQ03.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR027339. CORO2B.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF3. PTHR10856:SF3. 1 hit.
PfamPF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCORO2B. human.
GenomeRNAi10391.
NextBio39366.
PROQ9UQ03.
SOURCESearch...

Entry information

Entry nameCOR2B_HUMAN
AccessionPrimary (citable) accession number: Q9UQ03
Secondary accession number(s): A8K0W3, O94767, Q8TAN1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 117 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM