Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9UQ03

- COR2B_HUMAN

UniProt

Q9UQ03 - COR2B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Coronin-2B

Gene

CORO2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the reorganization of neuronal actin structure.

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. actin filament binding Source: RefGenome

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiQ9UQ03.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2B
Alternative name(s):
Coronin-like protein C
Short name:
Clipin-C
Protein FC96
Gene namesi
Name:CORO2B
Synonyms:KIAA0925
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:2256. CORO2B.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. cytoplasm Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Coronin-2BPRO_0000050930Add
BLAST

Proteomic databases

MaxQBiQ9UQ03.
PaxDbiQ9UQ03.
PRIDEiQ9UQ03.

PTM databases

PhosphoSiteiQ9UQ03.

Expressioni

Tissue specificityi

Expressed predominantly in brain.

Gene expression databases

BgeeiQ9UQ03.
CleanExiHS_CORO2B.
ExpressionAtlasiQ9UQ03. baseline and differential.
GenevestigatoriQ9UQ03.

Organism-specific databases

HPAiHPA017960.

Interactioni

Subunit structurei

Binds to F-actin and to vinculin.

Protein-protein interaction databases

BioGridi115663. 2 interactions.
IntActiQ9UQ03. 3 interactions.
MINTiMINT-1394971.
STRINGi9606.ENSP00000261861.

Structurei

3D structure databases

ProteinModelPortaliQ9UQ03.
SMRiQ9UQ03. Positions 15-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati85 – 12541WD 1Add
BLAST
Repeati135 – 17743WD 2Add
BLAST
Repeati179 – 21739WD 3Add
BLAST
Repeati220 – 26344WD 4Add
BLAST
Repeati265 – 30844WD 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili436 – 47944Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9UQ03.
OMAiREHCFDG.
OrthoDBiEOG7J70FB.
PhylomeDBiQ9UQ03.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027339. CORO2B.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF17. PTHR10856:SF17. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UQ03-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPEG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDVG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKMVFK APIKEKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRIRQLQLEL KNLRNSPKNC
Length:480
Mass (Da):54,953
Last modified:July 28, 2009 - v4
Checksum:iCE91834164A23D79
GO
Isoform 2 (identifier: Q9UQ03-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MTVTKM → M

Show »
Length:475
Mass (Da):54,393
Checksum:i5C85A21F2202A197
GO

Sequence cautioni

The sequence AAH26335.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA36341.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281E → A in BAA36341. (PubMed:10224093)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381L → V.1 Publication
Corresponds to variant rs17852400 [ dbSNP | Ensembl ].
VAR_058323
Natural varianti318 – 3181P → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035878

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MTVTKM → M in isoform 2. 1 PublicationVSP_037706

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010098 mRNA. Translation: BAA36341.1. Different initiation.
AK289678 mRNA. Translation: BAF82367.1.
AC090734 Genomic DNA. No translation available.
AC105014 Genomic DNA. No translation available.
BC026335 mRNA. Translation: AAH26335.1. Different initiation.
AB023142 mRNA. Translation: BAA76769.1.
CCDSiCCDS10229.2. [Q9UQ03-1]
CCDS53952.1. [Q9UQ03-2]
RefSeqiNP_001177385.1. NM_001190456.1. [Q9UQ03-2]
NP_001177386.1. NM_001190457.1. [Q9UQ03-2]
NP_006082.3. NM_006091.4. [Q9UQ03-1]
XP_005254182.1. XM_005254125.1. [Q9UQ03-2]
UniGeneiHs.551213.

Genome annotation databases

EnsembliENST00000261861; ENSP00000261861; ENSG00000103647. [Q9UQ03-2]
ENST00000540068; ENSP00000446250; ENSG00000103647. [Q9UQ03-2]
ENST00000543950; ENSP00000443819; ENSG00000103647. [Q9UQ03-2]
ENST00000566799; ENSP00000454783; ENSG00000103647. [Q9UQ03-1]
GeneIDi10391.
KEGGihsa:10391.
UCSCiuc002arj.4. human. [Q9UQ03-1]

Polymorphism databases

DMDMi254763439.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010098 mRNA. Translation: BAA36341.1 . Different initiation.
AK289678 mRNA. Translation: BAF82367.1 .
AC090734 Genomic DNA. No translation available.
AC105014 Genomic DNA. No translation available.
BC026335 mRNA. Translation: AAH26335.1 . Different initiation.
AB023142 mRNA. Translation: BAA76769.1 .
CCDSi CCDS10229.2. [Q9UQ03-1 ]
CCDS53952.1. [Q9UQ03-2 ]
RefSeqi NP_001177385.1. NM_001190456.1. [Q9UQ03-2 ]
NP_001177386.1. NM_001190457.1. [Q9UQ03-2 ]
NP_006082.3. NM_006091.4. [Q9UQ03-1 ]
XP_005254182.1. XM_005254125.1. [Q9UQ03-2 ]
UniGenei Hs.551213.

3D structure databases

ProteinModelPortali Q9UQ03.
SMRi Q9UQ03. Positions 15-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115663. 2 interactions.
IntActi Q9UQ03. 3 interactions.
MINTi MINT-1394971.
STRINGi 9606.ENSP00000261861.

PTM databases

PhosphoSitei Q9UQ03.

Polymorphism databases

DMDMi 254763439.

Proteomic databases

MaxQBi Q9UQ03.
PaxDbi Q9UQ03.
PRIDEi Q9UQ03.

Protocols and materials databases

DNASUi 10391.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261861 ; ENSP00000261861 ; ENSG00000103647 . [Q9UQ03-2 ]
ENST00000540068 ; ENSP00000446250 ; ENSG00000103647 . [Q9UQ03-2 ]
ENST00000543950 ; ENSP00000443819 ; ENSG00000103647 . [Q9UQ03-2 ]
ENST00000566799 ; ENSP00000454783 ; ENSG00000103647 . [Q9UQ03-1 ]
GeneIDi 10391.
KEGGi hsa:10391.
UCSCi uc002arj.4. human. [Q9UQ03-1 ]

Organism-specific databases

CTDi 10391.
GeneCardsi GC15P068871.
HGNCi HGNC:2256. CORO2B.
HPAi HPA017960.
MIMi 605002. gene.
neXtProti NX_Q9UQ03.
PharmGKBi PA26772.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119195.
HOGENOMi HOG000166356.
HOVERGENi HBG059978.
InParanoidi Q9UQ03.
OMAi REHCFDG.
OrthoDBi EOG7J70FB.
PhylomeDBi Q9UQ03.
TreeFami TF314280.

Enzyme and pathway databases

SignaLinki Q9UQ03.

Miscellaneous databases

ChiTaRSi CORO2B. human.
GenomeRNAii 10391.
NextBioi 39366.
PROi Q9UQ03.
SOURCEi Search...

Gene expression databases

Bgeei Q9UQ03.
CleanExi HS_CORO2B.
ExpressionAtlasi Q9UQ03. baseline and differential.
Genevestigatori Q9UQ03.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR027339. CORO2B.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. DUF1900.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR10856. PTHR10856. 1 hit.
PTHR10856:SF17. PTHR10856:SF17. 1 hit.
Pfami PF08953. DUF1899. 1 hit.
PF08954. DUF1900. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein."
    Nakamura T., Takeuchi K., Muraoka S., Takezoe H., Takahashi N., Mori N.
    J. Biol. Chem. 274:13322-13327(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Amygdala.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-238.
    Tissue: Brain.
  5. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-480 (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-318.

Entry informationi

Entry nameiCOR2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ03
Secondary accession number(s): A8K0W3, O94767, Q8TAN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3