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Protein

Coronin-2B

Gene

CORO2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the reorganization of neuronal actin structure.

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiQ9UQ03

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2B
Alternative name(s):
Coronin-like protein C
Short name:
Clipin-C
Protein FC96
Gene namesi
Name:CORO2B
Synonyms:KIAA0925
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000103647.12
HGNCiHGNC:2256 CORO2B
MIMi605002 gene
neXtProtiNX_Q9UQ03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10391
OpenTargetsiENSG00000103647
PharmGKBiPA26772

Polymorphism and mutation databases

BioMutaiCORO2B
DMDMi254763439

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509301 – 480Coronin-2BAdd BLAST480

Proteomic databases

EPDiQ9UQ03
PaxDbiQ9UQ03
PeptideAtlasiQ9UQ03
PRIDEiQ9UQ03

PTM databases

iPTMnetiQ9UQ03
PhosphoSitePlusiQ9UQ03

Expressioni

Tissue specificityi

Expressed predominantly in brain.

Gene expression databases

BgeeiENSG00000103647
CleanExiHS_CORO2B
GenevisibleiQ9UQ03 HS

Organism-specific databases

HPAiHPA017960

Interactioni

Subunit structurei

Binds to F-actin and to vinculin.

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-723376,EBI-743771

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: GO_Central

Protein-protein interaction databases

BioGridi1156637 interactors.
IntActiQ9UQ03 4 interactors.
STRINGi9606.ENSP00000454783

Structurei

3D structure databases

ProteinModelPortaliQ9UQ03
SMRiQ9UQ03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 77WD 1Add BLAST49
Repeati78 – 127WD 2Add BLAST50
Repeati128 – 170WD 3Add BLAST43
Repeati171 – 212WD 4Add BLAST42
Repeati213 – 259WD 5Add BLAST47
Repeati260 – 305WD 6Add BLAST46
Repeati306 – 345WD 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili436 – 479Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ9UQ03
KOiK13887
OMAiREHCFDG
OrthoDBiEOG091G03H5
PhylomeDBiQ9UQ03
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.101 hit
InterProiView protein in InterPro
IPR027339 CORO2B
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF17 PTHR10856:SF17, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UQ03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPEG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDVG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKMVFK APIKEKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRIRQLQLEL KNLRNSPKNC
Length:480
Mass (Da):54,953
Last modified:July 28, 2009 - v4
Checksum:iCE91834164A23D79
GO
Isoform 2 (identifier: Q9UQ03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MTVTKM → M

Show »
Length:475
Mass (Da):54,393
Checksum:i5C85A21F2202A197
GO

Sequence cautioni

The sequence AAH26335 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA36341 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128E → A in BAA36341 (PubMed:10224093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058323238L → V1 PublicationCorresponds to variant dbSNP:rs17852400Ensembl.1
Natural variantiVAR_035878318P → L in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377061 – 6MTVTKM → M in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010098 mRNA Translation: BAA36341.1 Different initiation.
AK289678 mRNA Translation: BAF82367.1
AC090734 Genomic DNA No translation available.
AC105014 Genomic DNA No translation available.
BC026335 mRNA Translation: AAH26335.1 Different initiation.
AB023142 mRNA Translation: BAA76769.1
CCDSiCCDS10229.2 [Q9UQ03-1]
CCDS53952.1 [Q9UQ03-2]
RefSeqiNP_001177385.1, NM_001190456.1 [Q9UQ03-2]
NP_001177386.1, NM_001190457.1 [Q9UQ03-2]
NP_001310943.1, NM_001324014.1 [Q9UQ03-2]
NP_001310944.1, NM_001324015.1 [Q9UQ03-2]
NP_006082.3, NM_006091.4 [Q9UQ03-1]
UniGeneiHs.551213

Genome annotation databases

EnsembliENST00000261861; ENSP00000261861; ENSG00000103647 [Q9UQ03-2]
ENST00000540068; ENSP00000446250; ENSG00000103647 [Q9UQ03-2]
ENST00000543950; ENSP00000443819; ENSG00000103647 [Q9UQ03-2]
ENST00000566799; ENSP00000454783; ENSG00000103647 [Q9UQ03-1]
GeneIDi10391
KEGGihsa:10391
UCSCiuc002arj.5 human [Q9UQ03-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOR2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ03
Secondary accession number(s): A8K0W3, O94767, Q8TAN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 150 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome