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Protein

Thrombospondin type-1 domain-containing protein 7A

Gene

THSD7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Differentiation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000005108-MONOMER.
ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 7A
Gene namesi
Name:THSD7A
Synonyms:KIAA0960
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22207. THSD7A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini48 – 1607ExtracellularSequence analysisAdd BLAST1560
Transmembranei1608 – 1628HelicalSequence analysisAdd BLAST21
Topological domaini1629 – 1657CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi221981.
OpenTargetsiENSG00000005108.
PharmGKBiPA162405715.

Polymorphism and mutation databases

BioMutaiTHSD7A.
DMDMi296453024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 47Sequence analysisAdd BLAST47
ChainiPRO_000025612648 – 1657Thrombospondin type-1 domain-containing protein 7AAdd BLAST1610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi332N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi435 ↔ 505PROSITE-ProRule annotation
Glycosylationi450N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi455 ↔ 509PROSITE-ProRule annotation
Disulfide bondi466 ↔ 494PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi635 ↔ 677PROSITE-ProRule annotation
Disulfide bondi646 ↔ 650PROSITE-ProRule annotation
Glycosylationi679N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi689 ↔ 694PROSITE-ProRule annotation
Disulfide bondi707 ↔ 764PROSITE-ProRule annotation
Glycosylationi717N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi728 ↔ 768PROSITE-ProRule annotation
Disulfide bondi739 ↔ 752PROSITE-ProRule annotation
Disulfide bondi772 ↔ 814PROSITE-ProRule annotation
Disulfide bondi783 ↔ 787PROSITE-ProRule annotation
Disulfide bondi824 ↔ 830PROSITE-ProRule annotation
Glycosylationi968N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi972 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1032PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1018PROSITE-ProRule annotation
Disulfide bondi1036 ↔ 1073PROSITE-ProRule annotation
Glycosylationi1043N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1047 ↔ 1051PROSITE-ProRule annotation
Glycosylationi1182N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1213 ↔ 1219PROSITE-ProRule annotation
Glycosylationi1225N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1276N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1287 ↔ 1325PROSITE-ProRule annotation
Disulfide bondi1298 ↔ 1302PROSITE-ProRule annotation
Disulfide bondi1335 ↔ 1340PROSITE-ProRule annotation
Disulfide bondi1351 ↔ 1407PROSITE-ProRule annotation
Disulfide bondi1358 ↔ 1411PROSITE-ProRule annotation
Glycosylationi1366N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1369 ↔ 1388PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1459PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1430PROSITE-ProRule annotation
Disulfide bondi1469 ↔ 1474PROSITE-ProRule annotation
Glycosylationi1500N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1547N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.1 Publication
Extensively N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UPZ6.
MaxQBiQ9UPZ6.
PaxDbiQ9UPZ6.
PeptideAtlasiQ9UPZ6.
PRIDEiQ9UPZ6.

PTM databases

iPTMnetiQ9UPZ6.
PhosphoSitePlusiQ9UPZ6.

Expressioni

Gene expression databases

BgeeiENSG00000005108.
CleanExiHS_THSD7A.
ExpressionAtlasiQ9UPZ6. baseline and differential.
GenevisibleiQ9UPZ6. HS.

Organism-specific databases

HPAiHPA000923.

Interactioni

Protein-protein interaction databases

BioGridi128774. 3 interactors.
IntActiQ9UPZ6. 2 interactors.
MINTiMINT-1187714.

Structurei

3D structure databases

ProteinModelPortaliQ9UPZ6.
SMRiQ9UPZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 116TSP type-1 1PROSITE-ProRule annotationAdd BLAST60
Domaini194 – 247TSP type-1 2PROSITE-ProRule annotationAdd BLAST54
Domaini360 – 416TSP type-1 3PROSITE-ProRule annotationAdd BLAST57
Domaini423 – 510TSP type-1 4PROSITE-ProRule annotationAdd BLAST88
Domaini512 – 574TSP type-1 5PROSITE-ProRule annotationAdd BLAST63
Domaini634 – 695TSP type-1 6PROSITE-ProRule annotationAdd BLAST62
Domaini696 – 769TSP type-1 7PROSITE-ProRule annotationAdd BLAST74
Domaini771 – 831TSP type-1 8PROSITE-ProRule annotationAdd BLAST61
Domaini906 – 959TSP type-1 9PROSITE-ProRule annotationAdd BLAST54
Domaini960 – 1033TSP type-1 10PROSITE-ProRule annotationAdd BLAST74
Domaini1035 – 1220TSP type-1 11PROSITE-ProRule annotationAdd BLAST186
Domaini1221 – 1284TSP type-1 12PROSITE-ProRule annotationAdd BLAST64
Domaini1286 – 1341TSP type-1 13PROSITE-ProRule annotationAdd BLAST56
Domaini1342 – 1412TSP type-1 14PROSITE-ProRule annotationAdd BLAST71
Domaini1414 – 1475TSP type-1 15PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili267 – 315Sequence analysisAdd BLAST49

Sequence similaritiesi

Contains 15 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INDB. Eukaryota.
ENOG410XR0P. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000154569.
HOVERGENiHBG094038.
InParanoidiQ9UPZ6.
OMAiCNQYLWV.
PhylomeDBiQ9UPZ6.
TreeFamiTF329791.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 11 hits.
[Graphical view]
SMARTiSM00209. TSP1. 16 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 13 hits.
PROSITEiPS50092. TSP1. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UPZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLQARRWAS GSRGAAGPRR GVLQLLPLPL PLPLLLLLLL RPGAGRAAAQ
60 70 80 90 100
GEAEAPTLYL WKTGPWGRCM GDECGPGGIQ TRAVWCAHVE GWTTLHTNCK
110 120 130 140 150
QAERPNNQQN CFKVCDWHKE LYDWRLGPWN QCQPVISKSL EKPLECIKGE
160 170 180 190 200
EGIQVREIAC IQKDKDIPAE DIICEYFEPK PLLEQACLIP CQQDCIVSEF
210 220 230 240 250
SAWSECSKTC GSGLQHRTRH VVAPPQFGGS GCPNLTEFQV CQSSPCEAEE
260 270 280 290 300
LRYSLHVGPW STCSMPHSRQ VRQARRRGKN KEREKDRSKG VKDPEARELI
310 320 330 340 350
KKKRNRNRQN RQENKYWDIQ IGYQTREVMC INKTGKAADL SFCQQEKLPM
360 370 380 390 400
TFQSCVITKE CQVSEWSEWS PCSKTCHDMV SPAGTRVRTR TIRQFPIGSE
410 420 430 440 450
KECPEFEEKE PCLSQGDGVV PCATYGWRTT EWTECRVDPL LSQQDKRRGN
460 470 480 490 500
QTALCGGGIQ TREVYCVQAN ENLLSQLSTH KNKEASKPMD LKLCTGPIPN
510 520 530 540 550
TTQLCHIPCP TECEVSPWSA WGPCTYENCN DQQGKKGFKL RKRRITNEPT
560 570 580 590 600
GGSGVTGNCP HLLEAIPCEE PACYDWKAVR LGNCEPDNGK ECGPGTQVQE
610 620 630 640 650
VVCINSDGEE VDRQLCRDAI FPIPVACDAP CPKDCVLSTW STWSSCSHTC
660 670 680 690 700
SGKTTEGKQI RARSILAYAG EEGGIRCPNS SALQEVRSCN EHPCTVYHWQ
710 720 730 740 750
TGPWGQCIED TSVSSFNTTT TWNGEASCSV GMQTRKVICV RVNVGQVGPK
760 770 780 790 800
KCPESLRPET VRPCLLPCKK DCIVTPYSDW TSCPSSCKEG DSSIRKQSRH
810 820 830 840 850
RVIIQLPANG GRDCTDPLYE EKACEAPQAC QSYRWKTHKW RRCQLVPWSV
860 870 880 890 900
QQDSPGAQEG CGPGRQARAI TCRKQDGGQA GIHECLQYAG PVPALTQACQ
910 920 930 940 950
IPCQDDCQLT SWSKFSSCNG DCGAVRTRKR TLVGKSKKKE KCKNSHLYPL
960 970 980 990 1000
IETQYCPCDK YNAQPVGNWS DCILPEGKVE VLLGMKVQGD IKECGQGYRY
1010 1020 1030 1040 1050
QAMACYDQNG RLVETSRCNS HGYIEEACII PCPSDCKLSE WSNWSRCSKS
1060 1070 1080 1090 1100
CGSGVKVRSK WLREKPYNGG RPCPKLDHVN QAQVYEVVPC HSDCNQYLWV
1110 1120 1130 1140 1150
TEPWSICKVT FVNMRENCGE GVQTRKVRCM QNTADGPSEH VEDYLCDPEE
1160 1170 1180 1190 1200
MPLGSRVCKL PCPEDCVISE WGPWTQCVLP CNQSSFRQRS ADPIRQPADE
1210 1220 1230 1240 1250
GRSCPNAVEK EPCNLNKNCY HYDYNVTDWS TCQLSEKAVC GNGIKTRMLD
1260 1270 1280 1290 1300
CVRSDGKSVD LKYCEALGLE KNWQMNTSCM VECPVNCQLS DWSPWSECSQ
1310 1320 1330 1340 1350
TCGLTGKMIR RRTVTQPFQG DGRPCPSLMD QSKPCPVKPC YRWQYGQWSP
1360 1370 1380 1390 1400
CQVQEAQCGE GTRTRNISCV VSDGSADDFS KVVDEEFCAD IELIIDGNKN
1410 1420 1430 1440 1450
MVLEESCSQP CPGDCYLKDW SSWSLCQLTC VNGEDLGFGG IQVRSRPVII
1460 1470 1480 1490 1500
QELENQHLCP EQMLETKSCY DGQCYEYKWM ASAWKGSSRT VWCQRSDGIN
1510 1520 1530 1540 1550
VTGGCLVMSQ PDADRSCNPP CSQPHSYCSE TKTCHCEEGY TEVMSSNSTL
1560 1570 1580 1590 1600
EQCTLIPVVV LPTMEDKRGD VKTSRAVHPT QPSSNPAGRG RTWFLQPFGP
1610 1620 1630 1640 1650
DGRLKTWVYG VAAGAFVLLI FIVSMIYLAC KKPKKPQRRQ NNRLKPLTLA

YDGDADM
Length:1,657
Mass (Da):185,363
Last modified:May 18, 2010 - v4
Checksum:i4CF0FC4EDA26E516
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131Q → R in AK092252 (PubMed:14702039).Curated1
Sequence conflicti583N → D in BAA76804 (PubMed:10231032).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057366238F → L.Corresponds to variant rs2074599dbSNPEnsembl.1
Natural variantiVAR_068676583N → H.Corresponds to variant rs47dbSNPEnsembl.1
Natural variantiVAR_057367771D → E.Corresponds to variant rs2285744dbSNPEnsembl.1
Natural variantiVAR_068677906D → E.Corresponds to variant rs1432dbSNPEnsembl.1
Natural variantiVAR_0686781652D → E.Corresponds to variant rs56264449dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004141 Genomic DNA. No translation available.
AC004160 Genomic DNA. No translation available.
AC004614 Genomic DNA. No translation available.
AC010908 Genomic DNA. No translation available.
AC073109 Genomic DNA. No translation available.
AK092252 mRNA. No translation available.
AB023177 mRNA. Translation: BAA76804.2.
CCDSiCCDS47543.1.
RefSeqiNP_056019.1. NM_015204.2.
UniGeneiHs.120855.

Genome annotation databases

EnsembliENST00000423059; ENSP00000406482; ENSG00000005108.
GeneIDi221981.
KEGGihsa:221981.
UCSCiuc064bok.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004141 Genomic DNA. No translation available.
AC004160 Genomic DNA. No translation available.
AC004614 Genomic DNA. No translation available.
AC010908 Genomic DNA. No translation available.
AC073109 Genomic DNA. No translation available.
AK092252 mRNA. No translation available.
AB023177 mRNA. Translation: BAA76804.2.
CCDSiCCDS47543.1.
RefSeqiNP_056019.1. NM_015204.2.
UniGeneiHs.120855.

3D structure databases

ProteinModelPortaliQ9UPZ6.
SMRiQ9UPZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128774. 3 interactors.
IntActiQ9UPZ6. 2 interactors.
MINTiMINT-1187714.

PTM databases

iPTMnetiQ9UPZ6.
PhosphoSitePlusiQ9UPZ6.

Polymorphism and mutation databases

BioMutaiTHSD7A.
DMDMi296453024.

Proteomic databases

EPDiQ9UPZ6.
MaxQBiQ9UPZ6.
PaxDbiQ9UPZ6.
PeptideAtlasiQ9UPZ6.
PRIDEiQ9UPZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423059; ENSP00000406482; ENSG00000005108.
GeneIDi221981.
KEGGihsa:221981.
UCSCiuc064bok.1. human.

Organism-specific databases

CTDi221981.
DisGeNETi221981.
GeneCardsiTHSD7A.
H-InvDBHIX0167868.
HGNCiHGNC:22207. THSD7A.
HPAiHPA000923.
MIMi612249. gene.
neXtProtiNX_Q9UPZ6.
OpenTargetsiENSG00000005108.
PharmGKBiPA162405715.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INDB. Eukaryota.
ENOG410XR0P. LUCA.
GeneTreeiENSGT00810000125397.
HOGENOMiHOG000154569.
HOVERGENiHBG094038.
InParanoidiQ9UPZ6.
OMAiCNQYLWV.
PhylomeDBiQ9UPZ6.
TreeFamiTF329791.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000005108-MONOMER.
ReactomeiR-HSA-5083635. Defective B3GALTL causes Peters-plus syndrome (PpS).
R-HSA-5173214. O-glycosylation of TSR domain-containing proteins.

Miscellaneous databases

ChiTaRSiTHSD7A. human.
GenomeRNAii221981.
PROiQ9UPZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000005108.
CleanExiHS_THSD7A.
ExpressionAtlasiQ9UPZ6. baseline and differential.
GenevisibleiQ9UPZ6. HS.

Family and domain databases

InterProiIPR000884. TSP1_rpt.
[Graphical view]
PfamiPF00090. TSP_1. 11 hits.
[Graphical view]
SMARTiSM00209. TSP1. 16 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 13 hits.
PROSITEiPS50092. TSP1. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHS7A_HUMAN
AccessioniPrimary (citable) accession number: Q9UPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.