Q9UPZ3 (HPS5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hermansky-Pudlak syndrome 5 protein

Alternative name(s):
Alpha-integrin-binding protein 63
Ruby-eye protein 2 homolog
Short name=Ru2

Gene names

Name:	HPS5
Synonyms:	AIBP63, KIAA1017

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1129 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. Ref.9 Ref.15
Subunit structure	Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6. Directly interacts with HPS6. May interact with all alpha-integrin chains that have an aromatic residue before the first lysine of the conserved KXGFFKR motif, including ITGA2, ITGA3, ITGA5 and ITGA6. Ref.7 Ref.8
Subcellular location	Cytoplasm › cytosol Ref.8.
Tissue specificity	Widely expressed. Isoform 1:Highly expressed in lungs and testis. Isoform 2:Highly expressed in placenta, kidney, testis ovary, lung and thymus. Ref.15
Involvement in disease	Hermansky-Pudlak syndrome 5 (HPS5) [MIM:614074]: A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.15
Sequence similarities	Belongs to the HPS5 family.
Sequence caution	The sequence BAA76861.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Albinism Disease mutation Hermansky-Pudlak syndrome
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Inferred from electronic annotation. Source: Compara organelle organization Inferred from electronic annotation. Source: Compara pigmentation Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UPZ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UPZ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1129	1129	Hermansky-Pudlak syndrome 5 protein		PRO_0000084054
Regions
	Compositional bias	158 – 163	6	Poly-Ala
Amino acid modifications
	Modified residue	532	1	Phosphoserine Ref.14
Natural variations
	Alternative sequence	1 – 114	114	Missing in isoform 2.		VSP_007035
	Natural variant	417	1	L → M. Ref.1 Ref.2 Corresponds to variant rs7128017 [ dbSNP | Ensembl ].		VAR_015513
	Natural variant	624	1	L → R in HPS5. Ref.15		VAR_062285
	Natural variant	1098	1	T → I in HPS5. Ref.15		VAR_062286
Experimental info
	Sequence conflict	70	1	L → P in BAF84352. Ref.4
	Sequence conflict	588	1	C → R in BAF85125. Ref.4
	Sequence conflict	1016	1	E → K in AAH33640. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 28, 2003. Version 2. Checksum: C4FBF4EC90D1B8ED	FASTA	1,129	127,449
	10 20 30 40 50 60 MAFVPVIPES YSHVLAEFES LDPLLSALRL DSSRLKCTSI AVSRKWLALG SSGGGLHLIQ 70 80 90 100 110 120 KEGWKHRLFL SHREGAISQV ACCLHDDDYV AVATSQGLVV VWELNQERRG KPEQMYVSSE 130 140 150 160 170 180 HKGRRVTALC WDTAILRVFV GDHAGKVSAI KLNTSKQAKA AAAFVMFPVQ TITTVDSCVV 190 200 210 220 230 240 QLDYLDGRLL ISSLTRSFLC DTEREKFWKI GNKERDGEYG ACFFPGRCSG GQQPLIYCAR 250 260 270 280 290 300 PGSRMWEVNF DGEVISTHQF KKLLSLPPLP VITLRSEPQY DHTAGSSQSL SFPKLLHLSE 310 320 330 340 350 360 HCVLTWTERG IYIFIPQNVQ VLLWSEVKDI QDVAVCRNEL FCLHLNGKVS HLSLISVERC 370 380 390 400 410 420 VERLLRRGLW NLAARTCCLF QNSVIASRAR KTLTADKLEH LKSQLDHGTY NDLISQLEEL 430 440 450 460 470 480 ILKFEPLDSA CSSRRSSISS HESFSILDSG IYRIISSRRG SQSDEDSCSL HSQTLSEDER 490 500 510 520 530 540 FKEFTSQQEE DLPDQCCGSH GNEDNVSHAP VMFETDKNET FLPFGIPLPF RSPSPLVSLQ 550 560 570 580 590 600 AVKESVSSFV RKTTEKIGTL HTSPDLKVRP ELRGDEQSCE EDVSSDTCPK EEDTEEEKEV 610 620 630 640 650 660 TSPPPEEDRF QELKVATAEA MTKLQDPLVL FESESLRMVL QEWLSHLEKT FAMKDFSGVS 670 680 690 700 710 720 DTDNSSMKLN QDVLLVNESK KGILDEDNEK EKRDSLGNEE SVDKTACECV RSPRESLDDL 730 740 750 760 770 780 FQICSPCAIA SGLRNDLAEL TTLCLELNVL NSKIKSTSGH VDHTLQQYSP EILACQFLKK 790 800 810 820 830 840 YFFLLNLKRA KESIKLSYSN SPSVWDTFIE GLKEMASSNP VYMEMEKGDL PTRLKLLDDE 850 860 870 880 890 900 VPFDSPLLVV YATRLYEKFG ESALRSLIKF FPSILPSDII QLCHHHPAEF LAYLDSLVKS 910 920 930 940 950 960 RPEDQRSSFL ESLLQPESLR LDWLLLAVSL DAPPSTSTMD DEGYPRPHSH LLSWGYSQLI 970 980 990 1000 1010 1020 LHLIKLPADF ITKEKMTDIC RSCGFWPGYL ILCLELERRR EAFTNIVYLN DMSLMEGDNG 1030 1040 1050 1060 1070 1080 WIPETVEEWK LLLHLIQSKS TRPAPQESLN GSLSDGPSPI NVENVALLLA KAMGPDRAWS 1090 1100 1110 1120 LLQECGLALE LSEKFTRTCD ILRIAEKRQR ALIQSMLEKC DRFLWSQQA
	Isoform 2 [UniParc]. Checksum: F6A30F048F6519A5	FASTA	1,015	114,826
	10 20 30 40 50 60 MYVSSEHKGR RVTALCWDTA ILRVFVGDHA GKVSAIKLNT SKQAKAAAAF VMFPVQTITT 70 80 90 100 110 120 VDSCVVQLDY LDGRLLISSL TRSFLCDTER EKFWKIGNKE RDGEYGACFF PGRCSGGQQP 130 140 150 160 170 180 LIYCARPGSR MWEVNFDGEV ISTHQFKKLL SLPPLPVITL RSEPQYDHTA GSSQSLSFPK 190 200 210 220 230 240 LLHLSEHCVL TWTERGIYIF IPQNVQVLLW SEVKDIQDVA VCRNELFCLH LNGKVSHLSL 250 260 270 280 290 300 ISVERCVERL LRRGLWNLAA RTCCLFQNSV IASRARKTLT ADKLEHLKSQ LDHGTYNDLI 310 320 330 340 350 360 SQLEELILKF EPLDSACSSR RSSISSHESF SILDSGIYRI ISSRRGSQSD EDSCSLHSQT 370 380 390 400 410 420 LSEDERFKEF TSQQEEDLPD QCCGSHGNED NVSHAPVMFE TDKNETFLPF GIPLPFRSPS 430 440 450 460 470 480 PLVSLQAVKE SVSSFVRKTT EKIGTLHTSP DLKVRPELRG DEQSCEEDVS SDTCPKEEDT 490 500 510 520 530 540 EEEKEVTSPP PEEDRFQELK VATAEAMTKL QDPLVLFESE SLRMVLQEWL SHLEKTFAMK 550 560 570 580 590 600 DFSGVSDTDN SSMKLNQDVL LVNESKKGIL DEDNEKEKRD SLGNEESVDK TACECVRSPR 610 620 630 640 650 660 ESLDDLFQIC SPCAIASGLR NDLAELTTLC LELNVLNSKI KSTSGHVDHT LQQYSPEILA 670 680 690 700 710 720 CQFLKKYFFL LNLKRAKESI KLSYSNSPSV WDTFIEGLKE MASSNPVYME MEKGDLPTRL 730 740 750 760 770 780 KLLDDEVPFD SPLLVVYATR LYEKFGESAL RSLIKFFPSI LPSDIIQLCH HHPAEFLAYL 790 800 810 820 830 840 DSLVKSRPED QRSSFLESLL QPESLRLDWL LLAVSLDAPP STSTMDDEGY PRPHSHLLSW 850 860 870 880 890 900 GYSQLILHLI KLPADFITKE KMTDICRSCG FWPGYLILCL ELERRREAFT NIVYLNDMSL 910 920 930 940 950 960 MEGDNGWIPE TVEEWKLLLH LIQSKSTRPA PQESLNGSLS DGPSPINVEN VALLLAKAMG 970 980 990 1000 1010 PDRAWSLLQE CGLALELSEK FTRTCDILRI AEKRQRALIQ SMLEKCDRFL WSQQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6." Zhang Q., Zhao B., Li W., Oiso N., Novak E.K., Rusiniak M.E., Gautam R., Chintala S., O'Brien E.P., Zhang Y., Roe B.A., Elliott R.W., Eicher E.M., Liang P., Kratz C., Legius E., Spritz R.A., O'Sullivan T.N. , Copeland N.G., Jenkins N.A., Swank R.T. Nat. Genet. 33:145-153(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT MET-417, DISEASE. Tissue: Placenta.
[2]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT MET-417. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Eye.
[7]	"Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains." Wixler V., Laplantine E., Geerts D., Sonnenberg A., Petersohn D., Eckes B., Paulsson M., Aumailley M. FEBS Lett. 445:351-355(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 517-1129, INTERACTION WITH ALPHA-INTEGRIN CHAINS. Tissue: Placenta.
[8]	"Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6." Di Pietro S.M., Falcon-Perez J.M., Dell'Angelica E.C. Traffic 5:276-283(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HPS6, SUBCELLULAR LOCATION.
[9]	"Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5." Helip-Wooley A., Westbroek W., Dorward H.M., Koshoffer A., Huizing M., Boissy R.E., Gahl W.A. J. Invest. Dermatol. 127:1471-1478(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[10]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Embryonic kidney.
[11]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Cellular, molecular and clinical characterization of patients with Hermansky-Pudlak syndrome type 5." Huizing M., Hess R., Dorward H., Claassen D.A., Helip-Wooley A., Kleta R., Kaiser-Kupfer M.I., White J.G., Gahl W.A. Traffic 5:711-722(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HPS5 ARG-624 AND ILE-1098, FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF534400 mRNA. Translation: AAO25962.1. AF534401 mRNA. Translation: AAO25963.1. AF534402 mRNA. Translation: AAO25964.1. AB023234 mRNA. Translation: BAA76861.2. Different initiation. AK291663 mRNA. Translation: BAF84352.1. AK292436 mRNA. Translation: BAF85125.1. CH471064 Genomic DNA. Translation: EAW68402.1. CH471064 Genomic DNA. Translation: EAW68404.1. CH471064 Genomic DNA. Translation: EAW68405.1. CH471064 Genomic DNA. Translation: EAW68406.1. CH471064 Genomic DNA. Translation: EAW68407.1. BC033640 mRNA. Translation: AAH33640.1. AJ131721 mRNA. Translation: CAB38232.1.
IPI	IPI00010486. IPI00219602.
RefSeq	NP_009147.3. NM_007216.3. NP_852608.1. NM_181507.1. NP_852609.1. NM_181508.1.
UniGene	Hs.437599.
3D structure databases
ProteinModelPortal	Q9UPZ3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000312758.
PTM databases
PhosphoSite	Q9UPZ3.
Polymorphism databases
DMDM	29429222.
Proteomic databases
PaxDb	Q9UPZ3.
PRIDE	Q9UPZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349215; ENSP00000265967; ENSG00000110756. ENST00000396253; ENSP00000379552; ENSG00000110756. ENST00000438420; ENSP00000399590; ENSG00000110756.
GeneID	11234.
KEGG	hsa:11234.
UCSC	uc001mod.1. human.
Organism-specific databases
CTD	11234.
GeneCards	GC11M018300.
HGNC	HGNC:17022. HPS5.
HPA	HPA037910.
MIM	607521. gene. 614074. phenotype.
neXtProt	NX_Q9UPZ3.
Orphanet	231512. Hermansky-Pudlak syndrome without pulmonary fibrosis.
PharmGKB	PA38432.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253874.
HOVERGEN	HBG039495.
InParanoid	Q9UPZ3.
OMA	IQDVAVC.
OrthoDB	EOG4K0QMQ.
PhylomeDB	Q9UPZ3.
Gene expression databases
ArrayExpress	Q9UPZ3.
Bgee	Q9UPZ3.
CleanEx	HS_HPS5.
Genevestigator	Q9UPZ3.
GermOnline	ENSG00000110756. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR017217. BLOC-2_complex_Hps5_subunit. IPR015943. WD40/YVTN_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
PIRSF	PIRSF037475. BLOC-2_complex_Hps5. 1 hit.
SUPFAM	SSF50978. WD40_like. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	HPS5. human.
GenomeRNAi	11234.
NextBio	42750.
SOURCE	Search...

Entry information

Entry name

HPS5_HUMAN

Accession

Primary (citable) accession number: Q9UPZ3
Secondary accession number(s): A8K6J8 , A8K8S1, D3DQX9, D3DQY0, O95942, Q8N4U0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	March 28, 2003
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.