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Protein

Wiskott-Aldrich syndrome protein family member 3

Gene

WASF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.2 Publications

GO - Molecular functioni

GO - Biological processi

  • actin filament polymerization Source: ProtInc
  • cytoskeleton organization Source: UniProtKB
  • lamellipodium assembly Source: Ensembl
  • oligodendrocyte development Source: Ensembl
  • positive regulation of myelination Source: Ensembl
  • protein-containing complex assembly Source: ProtInc
  • regulation of cell shape Source: UniProtKB

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Wiskott-Aldrich syndrome protein family member 3
Short name:
WASP family protein member 3
Alternative name(s):
Protein WAVE-3
Verprolin homology domain-containing protein 3
Gene namesi
Name:WASF3
Synonyms:KIAA0900, SCAR3, WAVE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000132970.12
HGNCiHGNC:12734 WASF3
MIMi605068 gene
neXtProtiNX_Q9UPY6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi10810
OpenTargetsiENSG00000132970
PharmGKBiPA37345

Polymorphism and mutation databases

BioMutaiWASF3
DMDMi59800455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001889961 – 502Wiskott-Aldrich syndrome protein family member 3Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Phosphotyrosine; by ABL11 Publication1
Modified residuei248Phosphotyrosine; by ABL11 Publication1
Modified residuei337Phosphotyrosine; by ABL11 Publication1
Modified residuei486Phosphotyrosine; by ABL11 Publication1

Post-translational modificationi

Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPY6
PaxDbiQ9UPY6
PeptideAtlasiQ9UPY6
PRIDEiQ9UPY6
ProteomicsDBi85474

PTM databases

iPTMnetiQ9UPY6
PhosphoSitePlusiQ9UPY6

Miscellaneous databases

PMAP-CutDBiQ9UPY6

Expressioni

Tissue specificityi

Expressed in ovary and brain.

Gene expression databases

BgeeiENSG00000132970
CleanExiHS_WASF3
ExpressionAtlasiQ9UPY6 baseline and differential
GenevisibleiQ9UPY6 HS

Organism-specific databases

HPAiCAB037086

Interactioni

Subunit structurei

Binds actin and the Arp2/3 complex.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116024, 26 interactors
DIPiDIP-61425N
IntActiQ9UPY6, 10 interactors
STRINGi9606.ENSP00000335055

Structurei

3D structure databases

ProteinModelPortaliQ9UPY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini440 – 457WH2PROSITE-ProRule annotationAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili57 – 93Sequence analysisAdd BLAST37
Coiled coili162 – 206Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi304 – 310Poly-Pro7
Compositional biasi343 – 350Poly-Pro8
Compositional biasi395 – 410Poly-ProAdd BLAST16

Domaini

Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.

Sequence similaritiesi

Belongs to the SCAR/WAVE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1830 Eukaryota
ENOG410XRBQ LUCA
GeneTreeiENSGT00730000110593
HOGENOMiHOG000021456
HOVERGENiHBG058482
InParanoidiQ9UPY6
KOiK06083
OMAiQPHNTRE
OrthoDBiEOG091G08O1
PhylomeDBiQ9UPY6
TreeFamiTF315031

Family and domain databases

InterProiView protein in InterPro
IPR028288 SCAR/WAVE_fam
IPR003124 WH2_dom
PANTHERiPTHR12902 PTHR12902, 1 hit
PfamiView protein in Pfam
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00246 WH2, 1 hit
PROSITEiView protein in PROSITE
PS51082 WH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLVKRNIEP RHLCRGALPE GITSELECVT NSTLAAIIRQ LSSLSKHAED
60 70 80 90 100
IFGELFNEAN NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA
110 120 130 140 150
FKSSTVQDQQ VVSKNSIPNP VADIYNQSDK PPPLNILTPY RDDKKDGLKF
160 170 180 190 200
YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK EQKRIDGTTR EVKKVRKARN
210 220 230 240 250
RRQEWNMMAY DKELRPDNRL SQSVYHGASS EGSLSPDTRS HASDVTDYSY
260 270 280 290 300
PATPNHSLHP QPVTPSYAAG DVPPHGPASQ AAEHEYRPPS ASARHMALNR
310 320 330 340 350
PQQPPPPPPP QAPEGSQASA PMAPADYGML PAQIIEYYNP SGPPPPPPPP
360 370 380 390 400
VIPSAQTAFV SPLQMPMQPP FPASASSTHA APPHPPSTGL LVTAPPPPGP
410 420 430 440 450
PPPPPGPPGP GSSLSSSPMH GPPVAEAKRQ EPAQPPISDA RSDLLAAIRM
460 470 480 490 500
GIQLKKVQEQ REQEAKREPV GNDVATILSR RIAVEYSDSD DDSEFDENDW

SD
Length:502
Mass (Da):55,293
Last modified:February 1, 2005 - v2
Checksum:iC0655CE181BD3C57
GO
Isoform 2 (identifier: Q9UPY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     181-239: EQKRIDGTTR...SEGSLSPDTR → REKHKLNPNR...SAKEDRVPSG

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):55,007
Checksum:iD32CA1466AF9B1CE
GO

Sequence cautioni

The sequence BAA74923 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307 – 308PP → RR (PubMed:10381382).Curated2
Sequence conflicti307 – 308PP → RR (PubMed:12856283).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052953415S → L. Corresponds to variant dbSNP:rs17084492Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054517181 – 239EQKRI…SPDTR → REKHKLNPNRNQQVNVRKVR TRKEEWERRKMGIEFMSDAK KLEQAGSAKEDRVPSG in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026543 mRNA Translation: BAA81796.1
AF454702 mRNA Translation: AAL51032.1
AB020707 mRNA Translation: BAA74923.2 Different initiation.
AL159978 Genomic DNA No translation available.
AL163538 Genomic DNA No translation available.
AL353789 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08388.1
BC050283 mRNA Translation: AAH50283.1
AF134305 mRNA Translation: AAD33054.1
CCDSiCCDS76626.1 [Q9UPY6-2]
CCDS9318.1 [Q9UPY6-1]
RefSeqiNP_001278894.1, NM_001291965.1 [Q9UPY6-2]
NP_006637.2, NM_006646.5 [Q9UPY6-1]
XP_011533191.1, XM_011534889.1 [Q9UPY6-1]
XP_011533192.1, XM_011534890.1 [Q9UPY6-1]
UniGeneiHs.618732

Genome annotation databases

EnsembliENST00000335327; ENSP00000335055; ENSG00000132970 [Q9UPY6-1]
ENST00000361042; ENSP00000354325; ENSG00000132970 [Q9UPY6-2]
GeneIDi10810
KEGGihsa:10810
UCSCiuc001uqv.5 human [Q9UPY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWASF3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPY6
Secondary accession number(s): O94974, Q86VQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 2005
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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