Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UPY5

- XCT_HUMAN

UniProt

Q9UPY5 - XCT_HUMAN

Protein

Cystine/glutamate transporter

Gene

SLC7A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.1 Publication

    GO - Molecular functioni

    1. cystine:glutamate antiporter activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. amino acid transport Source: Reactome
    2. blood coagulation Source: Reactome
    3. brain development Source: Ensembl
    4. ion transport Source: Reactome
    5. lens fiber cell differentiation Source: Ensembl
    6. leukocyte migration Source: Reactome
    7. L-glutamate transport Source: GOC
    8. platelet aggregation Source: Ensembl
    9. response to nicotine Source: Ensembl
    10. response to oxidative stress Source: Ensembl
    11. response to toxic substance Source: UniProtKB
    12. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Amino-acid transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000151012-MONOMER.
    ReactomeiREACT_12560. Basigin interactions.
    REACT_13796. Amino acid transport across the plasma membrane.

    Protein family/group databases

    TCDBi2.A.3.8.18. the amino acid-polyamine-organocation (apc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cystine/glutamate transporter
    Alternative name(s):
    Amino acid transport system xc-
    Calcium channel blocker resistance protein CCBR1
    Solute carrier family 7 member 11
    xCT
    Gene namesi
    Name:SLC7A11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11059. SLC7A11.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoskeleton Source: Ensembl
    2. integral component of membrane Source: ProtInc
    3. plasma membrane Source: Reactome
    4. rough endoplasmic reticulum Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35919.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cystine/glutamate transporterPRO_0000054279Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261Phosphoserine2 Publications
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPY5.
    PaxDbiQ9UPY5.
    PRIDEiQ9UPY5.

    PTM databases

    PhosphoSiteiQ9UPY5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UPY5.
    BgeeiQ9UPY5.
    CleanExiHS_SLC7A11.
    GenevestigatoriQ9UPY5.

    Interactioni

    Subunit structurei

    Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CD44P160704EBI-3843348,EBI-490245

    Protein-protein interaction databases

    BioGridi117179. 2 interactions.
    IntActiQ9UPY5. 1 interaction.
    STRINGi9606.ENSP00000280612.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPY5.
    SMRiQ9UPY5. Positions 52-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 7410ExtracellularSequence Analysis
    Topological domaini96 – 11318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini180 – 18910CytoplasmicSequence Analysis
    Topological domaini211 – 23424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini256 – 26510CytoplasmicSequence Analysis
    Topological domaini287 – 31731ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini339 – 36426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini386 – 3872ExtracellularSequence Analysis
    Topological domaini409 – 42214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini444 – 4496ExtracellularSequence Analysis
    Topological domaini471 – 50131CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei365 – 38521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000098892.
    HOVERGENiHBG000476.
    InParanoidiQ9UPY5.
    KOiK13869.
    OMAiMYAYAGX.
    OrthoDBiEOG73BVCR.
    PhylomeDBiQ9UPY5.
    TreeFamiTF313355.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR004760. L_AA_transporter.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00911. 2A0308. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UPY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV    50
    SIIIGTIIGA GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL 100
    GTTIKKSGGH YTYILEVFGP LPAFVRVWVE LLIIRPAATA VISLAFGRYI 150
    LEPFFIQCEI PELAIKLITA VGITVVMVLN SMSVSWSARI QIFLTFCKLT 200
    AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY YGMYAYAGWF 250
    YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS 300
    NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH 350
    LPEILSMIHV RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI 400
    GLAVAGLIYL RYKCPDMHRP FKVPLFIPAL FSFTCLFMVA LSLYSDPFST 450
    GIGFVITLTG VPAYYLFIIW DKKPRWFRIM SEKITRTLQI ILEVVPEEDK 500
    L 501
    Length:501
    Mass (Da):55,423
    Last modified:May 1, 2000 - v1
    Checksum:i3EF2648B94A9F59E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026891 mRNA. Translation: BAA82628.1.
    AF200708 mRNA. Translation: AAG35592.1.
    AF252872 mRNA. Translation: AAK49111.1.
    AJ277882 mRNA. Translation: CAC81905.1.
    AK290359 mRNA. Translation: BAF83048.1.
    AK314855 mRNA. Translation: BAG37372.1.
    CH471056 Genomic DNA. Translation: EAX05135.1.
    BC012087 mRNA. Translation: AAH12087.1.
    CCDSiCCDS3742.1.
    RefSeqiNP_055146.1. NM_014331.3.
    UniGeneiHs.390594.

    Genome annotation databases

    EnsembliENST00000280612; ENSP00000280612; ENSG00000151012.
    GeneIDi23657.
    KEGGihsa:23657.
    UCSCiuc021xrw.1. human.

    Polymorphism databases

    DMDMi12585385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026891 mRNA. Translation: BAA82628.1 .
    AF200708 mRNA. Translation: AAG35592.1 .
    AF252872 mRNA. Translation: AAK49111.1 .
    AJ277882 mRNA. Translation: CAC81905.1 .
    AK290359 mRNA. Translation: BAF83048.1 .
    AK314855 mRNA. Translation: BAG37372.1 .
    CH471056 Genomic DNA. Translation: EAX05135.1 .
    BC012087 mRNA. Translation: AAH12087.1 .
    CCDSi CCDS3742.1.
    RefSeqi NP_055146.1. NM_014331.3.
    UniGenei Hs.390594.

    3D structure databases

    ProteinModelPortali Q9UPY5.
    SMRi Q9UPY5. Positions 52-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117179. 2 interactions.
    IntActi Q9UPY5. 1 interaction.
    STRINGi 9606.ENSP00000280612.

    Chemistry

    BindingDBi Q9UPY5.
    ChEMBLi CHEMBL1075149.
    DrugBanki DB06151. Acetylcysteine.
    DB00138. L-Cystine.
    DB00740. Riluzole.
    DB01098. Rosuvastatin.
    DB00795. Sulfasalazine.
    DB08834. Tauroursodeoxycholic acid.

    Protein family/group databases

    TCDBi 2.A.3.8.18. the amino acid-polyamine-organocation (apc) family.

    PTM databases

    PhosphoSitei Q9UPY5.

    Polymorphism databases

    DMDMi 12585385.

    Proteomic databases

    MaxQBi Q9UPY5.
    PaxDbi Q9UPY5.
    PRIDEi Q9UPY5.

    Protocols and materials databases

    DNASUi 23657.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280612 ; ENSP00000280612 ; ENSG00000151012 .
    GeneIDi 23657.
    KEGGi hsa:23657.
    UCSCi uc021xrw.1. human.

    Organism-specific databases

    CTDi 23657.
    GeneCardsi GC04M139085.
    HGNCi HGNC:11059. SLC7A11.
    MIMi 607933. gene.
    neXtProti NX_Q9UPY5.
    PharmGKBi PA35919.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000098892.
    HOVERGENi HBG000476.
    InParanoidi Q9UPY5.
    KOi K13869.
    OMAi MYAYAGX.
    OrthoDBi EOG73BVCR.
    PhylomeDBi Q9UPY5.
    TreeFami TF313355.

    Enzyme and pathway databases

    BioCyci MetaCyc:ENSG00000151012-MONOMER.
    Reactomei REACT_12560. Basigin interactions.
    REACT_13796. Amino acid transport across the plasma membrane.

    Miscellaneous databases

    GeneWikii SLC7A11.
    GenomeRNAii 23657.
    NextBioi 46497.
    PROi Q9UPY5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPY5.
    Bgeei Q9UPY5.
    CleanExi HS_SLC7A11.
    Genevestigatori Q9UPY5.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR004760. L_AA_transporter.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00911. 2A0308. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-."
      Sato H., Tamba M., Kuriyama-Matsumura K., Okuno S., Bannai S.
      Antioxid. Redox Signal. 2:665-671(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "CCBR1, novel CD98 light chain implicated in redox control and calcium signaling."
      Conklin D.S., Beach D.H.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells."
      Bridges C.C., Kekuda R., Wang H., Prasad P.D., Mehta P., Huang W., Smith S.B., Ganapathy V.
      Invest. Ophthalmol. Vis. Sci. 42:47-54(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    4. Borsani G., Manzoni M., Palacin M., Pineda M., Gasol E.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    8. "Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility."
      Gasol E., Jimenez-Vidal M., Chillaron J., Zorzano A., Palacin M.
      J. Biol. Chem. 279:31228-31236(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MEMBRANE TOPOLOGY, SUBCELLULAR LOCATION.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiXCT_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPY5
    Secondary accession number(s): A8K2U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3