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Protein

Cystine/glutamate transporter

Gene

SLC7A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.1 Publication

GO - Molecular functioni

  • cystine:glutamate antiporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000151012-MONOMER
ReactomeiR-HSA-210991 Basigin interactions
R-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.3.8.18 the amino acid-polyamine-organocation (apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine/glutamate transporter
Alternative name(s):
Amino acid transport system xc-
Calcium channel blocker resistance protein CCBR1
Solute carrier family 7 member 11
xCT
Gene namesi
Name:SLC7A11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151012.13
HGNCiHGNC:11059 SLC7A11
MIMi607933 gene
neXtProtiNX_Q9UPY5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 74ExtracellularSequence analysis10
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 113CytoplasmicSequence analysisAdd BLAST18
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 158ExtracellularSequence analysisAdd BLAST24
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189CytoplasmicSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 234ExtracellularSequence analysisAdd BLAST24
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 265CytoplasmicSequence analysis10
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 317ExtracellularSequence analysisAdd BLAST31
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 364CytoplasmicSequence analysisAdd BLAST26
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 387ExtracellularSequence analysis2
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 422CytoplasmicSequence analysisAdd BLAST14
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 449ExtracellularSequence analysis6
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 501CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23657
OpenTargetsiENSG00000151012
PharmGKBiPA35919

Chemistry databases

ChEMBLiCHEMBL1075149
DrugBankiDB06151 Acetylcysteine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00740 Riluzole
DB01098 Rosuvastatin
DB00795 Sulfasalazine
DB04348 Taurocholic Acid
DB08834 Tauroursodeoxycholic acid
GuidetoPHARMACOLOGYi902

Polymorphism and mutation databases

BioMutaiSLC7A11
DMDMi12585385

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542791 – 501Cystine/glutamate transporterAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UPY5
MaxQBiQ9UPY5
PaxDbiQ9UPY5
PeptideAtlasiQ9UPY5
PRIDEiQ9UPY5

PTM databases

iPTMnetiQ9UPY5
PhosphoSitePlusiQ9UPY5

Expressioni

Gene expression databases

BgeeiENSG00000151012
CleanExiHS_SLC7A11
ExpressionAtlasiQ9UPY5 baseline and differential
GenevisibleiQ9UPY5 HS

Organism-specific databases

HPAiHPA064215

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD44P160704EBI-3843348,EBI-490245

Protein-protein interaction databases

BioGridi117179, 3 interactors
IntActiQ9UPY5, 7 interactors
MINTiQ9UPY5
STRINGi9606.ENSP00000280612

Chemistry databases

BindingDBiQ9UPY5

Structurei

3D structure databases

ProteinModelPortaliQ9UPY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00760000119037
HOGENOMiHOG000098892
HOVERGENiHBG000476
InParanoidiQ9UPY5
KOiK13869
OMAiTGIPAYY
OrthoDBiEOG091G07EM
PhylomeDBiQ9UPY5
TreeFamiTF313355

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR004760 L_AA_transporter
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PIRSFiPIRSF006060 AA_transporter, 1 hit
TIGRFAMsiTIGR00911 2A0308, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UPY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV
60 70 80 90 100
SIIIGTIIGA GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL
110 120 130 140 150
GTTIKKSGGH YTYILEVFGP LPAFVRVWVE LLIIRPAATA VISLAFGRYI
160 170 180 190 200
LEPFFIQCEI PELAIKLITA VGITVVMVLN SMSVSWSARI QIFLTFCKLT
210 220 230 240 250
AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY YGMYAYAGWF
260 270 280 290 300
YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS
310 320 330 340 350
NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH
360 370 380 390 400
LPEILSMIHV RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI
410 420 430 440 450
GLAVAGLIYL RYKCPDMHRP FKVPLFIPAL FSFTCLFMVA LSLYSDPFST
460 470 480 490 500
GIGFVITLTG VPAYYLFIIW DKKPRWFRIM SEKITRTLQI ILEVVPEEDK

L
Length:501
Mass (Da):55,423
Last modified:May 1, 2000 - v1
Checksum:i3EF2648B94A9F59E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026891 mRNA Translation: BAA82628.1
AF200708 mRNA Translation: AAG35592.1
AF252872 mRNA Translation: AAK49111.1
AJ277882 mRNA Translation: CAC81905.1
AK290359 mRNA Translation: BAF83048.1
AK314855 mRNA Translation: BAG37372.1
CH471056 Genomic DNA Translation: EAX05135.1
BC012087 mRNA Translation: AAH12087.1
CCDSiCCDS3742.1
RefSeqiNP_055146.1, NM_014331.3
UniGeneiHs.390594

Genome annotation databases

EnsembliENST00000280612; ENSP00000280612; ENSG00000151012
GeneIDi23657
KEGGihsa:23657
UCSCiuc062zqn.1 human

Similar proteinsi

Entry informationi

Entry nameiXCT_HUMAN
AccessioniPrimary (citable) accession number: Q9UPY5
Secondary accession number(s): A8K2U4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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