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Protein

Cystine/glutamate transporter

Gene

SLC7A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.1 Publication

GO - Molecular functioni

  1. cystine:glutamate antiporter activity Source: ProtInc

GO - Biological processi

  1. amino acid transport Source: Reactome
  2. blood coagulation Source: Reactome
  3. brain development Source: Ensembl
  4. ion transport Source: Reactome
  5. lens fiber cell differentiation Source: Ensembl
  6. leukocyte migration Source: Reactome
  7. L-glutamate transmembrane transport Source: GOC
  8. platelet aggregation Source: Ensembl
  9. response to nicotine Source: Ensembl
  10. response to oxidative stress Source: Ensembl
  11. response to toxic substance Source: UniProtKB
  12. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000151012-MONOMER.
ReactomeiREACT_12560. Basigin interactions.
REACT_13796. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.8.18. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine/glutamate transporter
Alternative name(s):
Amino acid transport system xc-
Calcium channel blocker resistance protein CCBR1
Solute carrier family 7 member 11
xCT
Gene namesi
Name:SLC7A11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11059. SLC7A11.

Subcellular locationi

Membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Topological domaini65 – 7410ExtracellularSequence Analysis
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 11318CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Topological domaini135 – 15824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Topological domaini180 – 18910CytoplasmicSequence Analysis
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 23424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei235 – 25521HelicalSequence AnalysisAdd
BLAST
Topological domaini256 – 26510CytoplasmicSequence Analysis
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Topological domaini287 – 31731ExtracellularSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Topological domaini339 – 36426CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence AnalysisAdd
BLAST
Topological domaini386 – 3872ExtracellularSequence Analysis
Transmembranei388 – 40821HelicalSequence AnalysisAdd
BLAST
Topological domaini409 – 42214CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei423 – 44321HelicalSequence AnalysisAdd
BLAST
Topological domaini444 – 4496ExtracellularSequence Analysis
Transmembranei450 – 47021HelicalSequence AnalysisAdd
BLAST
Topological domaini471 – 50131CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoskeleton Source: Ensembl
  3. integral component of membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35919.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cystine/glutamate transporterPRO_0000054279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Phosphoserine2 Publications
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UPY5.
PaxDbiQ9UPY5.
PRIDEiQ9UPY5.

PTM databases

PhosphoSiteiQ9UPY5.

Expressioni

Gene expression databases

BgeeiQ9UPY5.
CleanExiHS_SLC7A11.
ExpressionAtlasiQ9UPY5. baseline and differential.
GenevestigatoriQ9UPY5.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD44P160704EBI-3843348,EBI-490245

Protein-protein interaction databases

BioGridi117179. 2 interactions.
IntActiQ9UPY5. 1 interaction.
STRINGi9606.ENSP00000280612.

Structurei

3D structure databases

ProteinModelPortaliQ9UPY5.
SMRiQ9UPY5. Positions 52-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9UPY5.
KOiK13869.
OMAiNIPLAIC.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9UPY5.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UPY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV
60 70 80 90 100
SIIIGTIIGA GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL
110 120 130 140 150
GTTIKKSGGH YTYILEVFGP LPAFVRVWVE LLIIRPAATA VISLAFGRYI
160 170 180 190 200
LEPFFIQCEI PELAIKLITA VGITVVMVLN SMSVSWSARI QIFLTFCKLT
210 220 230 240 250
AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY YGMYAYAGWF
260 270 280 290 300
YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS
310 320 330 340 350
NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH
360 370 380 390 400
LPEILSMIHV RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI
410 420 430 440 450
GLAVAGLIYL RYKCPDMHRP FKVPLFIPAL FSFTCLFMVA LSLYSDPFST
460 470 480 490 500
GIGFVITLTG VPAYYLFIIW DKKPRWFRIM SEKITRTLQI ILEVVPEEDK

L
Length:501
Mass (Da):55,423
Last modified:May 1, 2000 - v1
Checksum:i3EF2648B94A9F59E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026891 mRNA. Translation: BAA82628.1.
AF200708 mRNA. Translation: AAG35592.1.
AF252872 mRNA. Translation: AAK49111.1.
AJ277882 mRNA. Translation: CAC81905.1.
AK290359 mRNA. Translation: BAF83048.1.
AK314855 mRNA. Translation: BAG37372.1.
CH471056 Genomic DNA. Translation: EAX05135.1.
BC012087 mRNA. Translation: AAH12087.1.
CCDSiCCDS3742.1.
RefSeqiNP_055146.1. NM_014331.3.
UniGeneiHs.390594.

Genome annotation databases

EnsembliENST00000280612; ENSP00000280612; ENSG00000151012.
GeneIDi23657.
KEGGihsa:23657.
UCSCiuc021xrw.1. human.

Polymorphism databases

DMDMi12585385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026891 mRNA. Translation: BAA82628.1.
AF200708 mRNA. Translation: AAG35592.1.
AF252872 mRNA. Translation: AAK49111.1.
AJ277882 mRNA. Translation: CAC81905.1.
AK290359 mRNA. Translation: BAF83048.1.
AK314855 mRNA. Translation: BAG37372.1.
CH471056 Genomic DNA. Translation: EAX05135.1.
BC012087 mRNA. Translation: AAH12087.1.
CCDSiCCDS3742.1.
RefSeqiNP_055146.1. NM_014331.3.
UniGeneiHs.390594.

3D structure databases

ProteinModelPortaliQ9UPY5.
SMRiQ9UPY5. Positions 52-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117179. 2 interactions.
IntActiQ9UPY5. 1 interaction.
STRINGi9606.ENSP00000280612.

Chemistry

BindingDBiQ9UPY5.
ChEMBLiCHEMBL1075149.
DrugBankiDB06151. Acetylcysteine.
DB00138. L-Cystine.
DB00740. Riluzole.
DB01098. Rosuvastatin.
DB00795. Sulfasalazine.
DB08834. Tauroursodeoxycholic acid.

Protein family/group databases

TCDBi2.A.3.8.18. the amino acid-polyamine-organocation (apc) family.

PTM databases

PhosphoSiteiQ9UPY5.

Polymorphism databases

DMDMi12585385.

Proteomic databases

MaxQBiQ9UPY5.
PaxDbiQ9UPY5.
PRIDEiQ9UPY5.

Protocols and materials databases

DNASUi23657.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280612; ENSP00000280612; ENSG00000151012.
GeneIDi23657.
KEGGihsa:23657.
UCSCiuc021xrw.1. human.

Organism-specific databases

CTDi23657.
GeneCardsiGC04M139085.
HGNCiHGNC:11059. SLC7A11.
MIMi607933. gene.
neXtProtiNX_Q9UPY5.
PharmGKBiPA35919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0531.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9UPY5.
KOiK13869.
OMAiNIPLAIC.
OrthoDBiEOG73BVCR.
PhylomeDBiQ9UPY5.
TreeFamiTF313355.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000151012-MONOMER.
ReactomeiREACT_12560. Basigin interactions.
REACT_13796. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikiiSLC7A11.
GenomeRNAii23657.
NextBioi46497.
PROiQ9UPY5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UPY5.
CleanExiHS_SLC7A11.
ExpressionAtlasiQ9UPY5. baseline and differential.
GenevestigatoriQ9UPY5.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-."
    Sato H., Tamba M., Kuriyama-Matsumura K., Okuno S., Bannai S.
    Antioxid. Redox Signal. 2:665-671(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "CCBR1, novel CD98 light chain implicated in redox control and calcium signaling."
    Conklin D.S., Beach D.H.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells."
    Bridges C.C., Kekuda R., Wang H., Prasad P.D., Mehta P., Huang W., Smith S.B., Ganapathy V.
    Invest. Ophthalmol. Vis. Sci. 42:47-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. Borsani G., Manzoni M., Palacin M., Pineda M., Gasol E.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  8. "Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility."
    Gasol E., Jimenez-Vidal M., Chillaron J., Zorzano A., Palacin M.
    J. Biol. Chem. 279:31228-31236(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MEMBRANE TOPOLOGY, SUBCELLULAR LOCATION.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXCT_HUMAN
AccessioniPrimary (citable) accession number: Q9UPY5
Secondary accession number(s): A8K2U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.