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Protein

Cystine/glutamate transporter

Gene

SLC7A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.1 Publication

GO - Molecular functioni

  • cystine:glutamate antiporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000151012-MONOMER.
ZFISH:ENSG00000151012-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.3.8.18. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine/glutamate transporter
Alternative name(s):
Amino acid transport system xc-
Calcium channel blocker resistance protein CCBR1
Solute carrier family 7 member 11
xCT
Gene namesi
Name:SLC7A11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:11059. SLC7A11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 74ExtracellularSequence analysis10
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 113CytoplasmicSequence analysisAdd BLAST18
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 158ExtracellularSequence analysisAdd BLAST24
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 189CytoplasmicSequence analysis10
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 234ExtracellularSequence analysisAdd BLAST24
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 265CytoplasmicSequence analysis10
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Topological domaini287 – 317ExtracellularSequence analysisAdd BLAST31
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 364CytoplasmicSequence analysisAdd BLAST26
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 387ExtracellularSequence analysis2
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 422CytoplasmicSequence analysisAdd BLAST14
Transmembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 449ExtracellularSequence analysis6
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 501CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • cytoskeleton Source: Ensembl
  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
  • rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23657.
OpenTargetsiENSG00000151012.
PharmGKBiPA35919.

Chemistry databases

ChEMBLiCHEMBL1075149.
DrugBankiDB06151. Acetylcysteine.
DB00138. L-Cystine.
DB00740. Riluzole.
DB01098. Rosuvastatin.
DB00795. Sulfasalazine.
DB08834. Tauroursodeoxycholic acid.
GuidetoPHARMACOLOGYi902.

Polymorphism and mutation databases

BioMutaiSLC7A11.
DMDMi12585385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542791 – 501Cystine/glutamate transporterAdd BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UPY5.
MaxQBiQ9UPY5.
PaxDbiQ9UPY5.
PeptideAtlasiQ9UPY5.
PRIDEiQ9UPY5.

PTM databases

iPTMnetiQ9UPY5.
PhosphoSitePlusiQ9UPY5.

Expressioni

Gene expression databases

BgeeiENSG00000151012.
CleanExiHS_SLC7A11.
ExpressionAtlasiQ9UPY5. baseline and differential.
GenevisibleiQ9UPY5. HS.

Interactioni

Subunit structurei

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CD44P160704EBI-3843348,EBI-490245

Protein-protein interaction databases

BioGridi117179. 2 interactors.
IntActiQ9UPY5. 5 interactors.
STRINGi9606.ENSP00000280612.

Chemistry databases

BindingDBiQ9UPY5.

Structurei

3D structure databases

ProteinModelPortaliQ9UPY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9UPY5.
KOiK13869.
OMAiMHRPFKX.
OrthoDBiEOG091G07EM.
PhylomeDBiQ9UPY5.
TreeFamiTF313355.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UPY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV
60 70 80 90 100
SIIIGTIIGA GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL
110 120 130 140 150
GTTIKKSGGH YTYILEVFGP LPAFVRVWVE LLIIRPAATA VISLAFGRYI
160 170 180 190 200
LEPFFIQCEI PELAIKLITA VGITVVMVLN SMSVSWSARI QIFLTFCKLT
210 220 230 240 250
AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY YGMYAYAGWF
260 270 280 290 300
YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS
310 320 330 340 350
NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH
360 370 380 390 400
LPEILSMIHV RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI
410 420 430 440 450
GLAVAGLIYL RYKCPDMHRP FKVPLFIPAL FSFTCLFMVA LSLYSDPFST
460 470 480 490 500
GIGFVITLTG VPAYYLFIIW DKKPRWFRIM SEKITRTLQI ILEVVPEEDK

L
Length:501
Mass (Da):55,423
Last modified:May 1, 2000 - v1
Checksum:i3EF2648B94A9F59E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026891 mRNA. Translation: BAA82628.1.
AF200708 mRNA. Translation: AAG35592.1.
AF252872 mRNA. Translation: AAK49111.1.
AJ277882 mRNA. Translation: CAC81905.1.
AK290359 mRNA. Translation: BAF83048.1.
AK314855 mRNA. Translation: BAG37372.1.
CH471056 Genomic DNA. Translation: EAX05135.1.
BC012087 mRNA. Translation: AAH12087.1.
CCDSiCCDS3742.1.
RefSeqiNP_055146.1. NM_014331.3.
UniGeneiHs.390594.

Genome annotation databases

EnsembliENST00000280612; ENSP00000280612; ENSG00000151012.
GeneIDi23657.
KEGGihsa:23657.
UCSCiuc062zqn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026891 mRNA. Translation: BAA82628.1.
AF200708 mRNA. Translation: AAG35592.1.
AF252872 mRNA. Translation: AAK49111.1.
AJ277882 mRNA. Translation: CAC81905.1.
AK290359 mRNA. Translation: BAF83048.1.
AK314855 mRNA. Translation: BAG37372.1.
CH471056 Genomic DNA. Translation: EAX05135.1.
BC012087 mRNA. Translation: AAH12087.1.
CCDSiCCDS3742.1.
RefSeqiNP_055146.1. NM_014331.3.
UniGeneiHs.390594.

3D structure databases

ProteinModelPortaliQ9UPY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117179. 2 interactors.
IntActiQ9UPY5. 5 interactors.
STRINGi9606.ENSP00000280612.

Chemistry databases

BindingDBiQ9UPY5.
ChEMBLiCHEMBL1075149.
DrugBankiDB06151. Acetylcysteine.
DB00138. L-Cystine.
DB00740. Riluzole.
DB01098. Rosuvastatin.
DB00795. Sulfasalazine.
DB08834. Tauroursodeoxycholic acid.
GuidetoPHARMACOLOGYi902.

Protein family/group databases

TCDBi2.A.3.8.18. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ9UPY5.
PhosphoSitePlusiQ9UPY5.

Polymorphism and mutation databases

BioMutaiSLC7A11.
DMDMi12585385.

Proteomic databases

EPDiQ9UPY5.
MaxQBiQ9UPY5.
PaxDbiQ9UPY5.
PeptideAtlasiQ9UPY5.
PRIDEiQ9UPY5.

Protocols and materials databases

DNASUi23657.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280612; ENSP00000280612; ENSG00000151012.
GeneIDi23657.
KEGGihsa:23657.
UCSCiuc062zqn.1. human.

Organism-specific databases

CTDi23657.
DisGeNETi23657.
GeneCardsiSLC7A11.
HGNCiHGNC:11059. SLC7A11.
MIMi607933. gene.
neXtProtiNX_Q9UPY5.
OpenTargetsiENSG00000151012.
PharmGKBiPA35919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1287. Eukaryota.
COG0531. LUCA.
GeneTreeiENSGT00760000119037.
HOGENOMiHOG000098892.
HOVERGENiHBG000476.
InParanoidiQ9UPY5.
KOiK13869.
OMAiMHRPFKX.
OrthoDBiEOG091G07EM.
PhylomeDBiQ9UPY5.
TreeFamiTF313355.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000151012-MONOMER.
ZFISH:ENSG00000151012-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

GeneWikiiSLC7A11.
GenomeRNAii23657.
PROiQ9UPY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151012.
CleanExiHS_SLC7A11.
ExpressionAtlasiQ9UPY5. baseline and differential.
GenevisibleiQ9UPY5. HS.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004760. L_AA_transporter.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00911. 2A0308. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXCT_HUMAN
AccessioniPrimary (citable) accession number: Q9UPY5
Secondary accession number(s): A8K2U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.