Q9UPY3 (DICER_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 109.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Endoribonuclease Dicer EC=3.1.26.- Alternative name(s): Helicase with RNase motif Short name=Helicase MOI | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1922 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. Ref.9 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18 Ref.22 Ref.24 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit Probable. Ref.27 |
| Subunit structure | Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.27 |
| Subcellular location | |
| Involvement in disease | Defects in DICER1 are a cause of pleuropulmonary blastoma (PPB) [MIM:601200]. PPB is a rare pediatric tumor of the lung that arises during fetal lung development and is often part of an inherited cancer syndrome. PPBs contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense 'cambium' layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Ref.26 Ref.28 Defects in DICER1 are the cause of goiter multinodular type 1 with or without Sertoli-Leydig cell tumors (MNG1) [MIM:138800]. A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary. Ref.26 Ref.29 Note=DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (Ref.26). Ref.26 |
| Sequence similarities | Belongs to the helicase family. Dicer subfamily. Contains 1 Dicer dsRNA-binding fold domain. Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 PAZ domain. Contains 2 RNase III domains. |
| Caution | It is uncertain whether Met-1 or Met-11 is the initiator. |
| Sequence caution | The sequence CAB38857.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| EIF2C1 | Q9UL18 | 2 | EBI-395506,EBI-527363 | |
| EIF2C2 | Q9UKV8 | 6 | EBI-395506,EBI-528269 | |
| Eif2c2 | Q8CJG0 | 2 | EBI-395506,EBI-528299 | From a different organism. |
| PIWIL1 | Q96J94 | 2 | EBI-395506,EBI-527417 | |
| TARBP2 | Q15633 | 8 | EBI-395506,EBI-978581 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1922 | 1922 | Endoribonuclease Dicer | PRO_0000180470 | ||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||
| Domain | 51 – 227 | 177 | Helicase ATP-binding | |||||||||||||||||||||||||
| Domain | 433 – 602 | 170 | Helicase C-terminal | |||||||||||||||||||||||||
| Domain | 630 – 722 | 93 | Dicer dsRNA-binding fold | |||||||||||||||||||||||||
| Domain | 891 – 1042 | 152 | PAZ | |||||||||||||||||||||||||
| Domain | 1276 – 1403 | 128 | RNase III 1 | |||||||||||||||||||||||||
| Domain | 1666 – 1824 | 159 | RNase III 2 | |||||||||||||||||||||||||
| Domain | 1849 – 1914 | 66 | DRBM | |||||||||||||||||||||||||
| Nucleotide binding | 64 – 71 | 8 | ATP By similarity | |||||||||||||||||||||||||
| Region | 256 – 595 | 340 | Required for interaction with PRKRA and TARBP2 | |||||||||||||||||||||||||
| Motif | 175 – 178 | 4 | DECH box | |||||||||||||||||||||||||
Sites | ||||||||||||||||||||||||||||
| Metal binding | 1316 | 1 | Magnesium or manganese 1 By similarity | |||||||||||||||||||||||||
| Metal binding | 1395 | 1 | Magnesium or manganese 1 By similarity | |||||||||||||||||||||||||
| Metal binding | 1398 | 1 | Magnesium or manganese 1 By similarity | |||||||||||||||||||||||||
| Metal binding | 1705 | 1 | Magnesium or manganese 2 | |||||||||||||||||||||||||
| Metal binding | 1810 | 1 | Magnesium or manganese 2 | |||||||||||||||||||||||||
| Metal binding | 1813 | 1 | Magnesium or manganese 2 | |||||||||||||||||||||||||
| Site | 1806 | 1 | Important for activity By similarity | |||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||
| Modified residue | 664 | 1 | Phosphotyrosine Ref.16 | |||||||||||||||||||||||||
| Modified residue | 1016 | 1 | Phosphoserine Ref.23 | |||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||
| Natural variant | 839 | 1 | S → F in MNG1. Ref.29 | VAR_065301 | ||||||||||||||||||||||||
| Natural variant | 1583 | 1 | L → R in PPB. Ref.28 | VAR_063150 | ||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||
| Mutagenesis | 960 | 1 | F → A: 2-fold decrease in activity. | |||||||||||||||||||||||||
| Mutagenesis | 971 | 1 | Y → A: 10-fold decrease in activity; when associated with Y-972. | |||||||||||||||||||||||||
| Mutagenesis | 972 | 1 | Y → A: 10-fold decrease in activity; when associated with Y-971. | |||||||||||||||||||||||||
| Mutagenesis | 1036 | 1 | E → A: 5-fold decrease in activity. | |||||||||||||||||||||||||
| Mutagenesis | 1313 | 1 | E → A: No effect on activity. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1320 | 1 | D → A: Decreased activity. Loss of activity; when associated with D-1709. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1340 | 1 | E → A: No effect on activity. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1444 | 1 | E → A: Decreased activity. Loss of activity; when associated with E-1813. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1702 | 1 | Q → A: No effect on activity. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1709 | 1 | D → A: Decreased activity. Loss of activity; when associated with D-1320. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1729 | 1 | P → E: No effect on activity. Ref.9 | |||||||||||||||||||||||||
| Mutagenesis | 1813 | 1 | E → A: Decreased activity. Loss of activity; when associated with E-1444. Ref.9 | |||||||||||||||||||||||||
| Sequence conflict | 75 – 90 | 16 | VLLTK…RGDFS → STTLLKSCLYLDLGETSA in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 189 | 1 | I → F in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 195 | 1 | N → I in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 214 | 1 | C → W in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 218 | 1 | E → D in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 223 | 1 | I → F in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 393 – 394 | 2 | QQ → HS in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 492 – 493 | 2 | KQ → NT in BAA78691. Ref.1 | |||||||||||||||||||||||||
| Sequence conflict | 609 | 1 | D → H in BAA78691. Ref.1 | |||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||
| Turn | 1662 – 1665 | 4 | ||||||||||||||||||||||||||
| Helix | 1666 – 1673 | 8 | ||||||||||||||||||||||||||
| Helix | 1680 – 1687 | 8 | ||||||||||||||||||||||||||
| Helix | 1702 – 1722 | 21 | ||||||||||||||||||||||||||
| Helix | 1729 – 1739 | 11 | ||||||||||||||||||||||||||
| Helix | 1742 – 1751 | 10 | ||||||||||||||||||||||||||
| Helix | 1754 – 1756 | 3 | ||||||||||||||||||||||||||
| Helix | 1763 – 1778 | 16 | ||||||||||||||||||||||||||
| Helix | 1806 – 1822 | 17 | ||||||||||||||||||||||||||
| Helix | 1827 – 1847 | 21 | ||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase." Matsuda S., Ichigotani Y., Okuda T., Irimura T., Nakatsugawa S., Hamaguchi M. Biochim. Biophys. Acta 1490:163-169(2000) [PubMed: 10786632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "RNA binding and processing by recombinant human Dicer." Provost P., Dishart D., Doucet D., Hermansson A., Frendewey D., Samuelsson B., Radmark O. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. |
| [3] | "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [4] | "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION. |
| [5] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [8] | "Interaction of 5-lipoxygenase with cellular proteins." Provost P., Samuelsson B., Radmark O. Proc. Natl. Acad. Sci. U.S.A. 96:1881-1885(1999) [PubMed: 10051563] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1922. Tissue: Lung. |
| [9] | "Single processing center models for human Dicer and bacterial RNase III." Zhang H., Kolb F.A., Jaskiewicz L., Westhof E., Filipowicz W. Cell 118:57-68(2004) [PubMed: 15242644] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF GLU-1313; ASP-1320; GLU-1340; GLU-1444; GLN-1702; ASP-1709; PRO-1729 AND GLU-1813. |
| [10] | "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer." Tahbaz N., Kolb F.A., Zhang H., Jaronczyk K., Filipowicz W., Hobman T.C. EMBO Rep. 5:189-194(2004) [PubMed: 14749716] [Abstract] Cited for: INTERACTION WITH PIWIL1. |
| [11] | "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing." Gregory R.I., Chendrimada T.P., Cooch N., Shiekhattar R. Cell 123:631-640(2005) [PubMed: 16271387] [Abstract] Cited for: FUNCTION, INTERACTION WITH EIF2C2 AND TARBP2. |
| [12] | "Identification of novel argonaute-associated proteins." Meister G., Landthaler M., Peters L., Chen P.Y., Urlaub H., Luehrmann R., Tuschl T. Curr. Biol. 15:2149-2155(2005) [PubMed: 16289642] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH EIF2C1 AND EIF2C2. |
| [13] | "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing." Haase A.D., Jaskiewicz L., Zhang H., Laine S., Sack R., Gatignol A., Filipowicz W. EMBO Rep. 6:961-967(2005) [PubMed: 16142218] [Abstract] Cited for: FUNCTION, INTERACTION WITH TARBP2. |
| [14] | "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA." Maniataki E., Mourelatos Z. Genes Dev. 19:2979-2990(2005) [PubMed: 16357216] [Abstract] Cited for: FUNCTION, INTERACTION WITH EIF2C2. |
| [15] | "TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing." Chendrimada T.P., Gregory R.I., Kumaraswamy E., Norman J., Cooch N., Nishikura K., Shiekhattar R. Nature 436:740-744(2005) [PubMed: 15973356] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH EIF2C2 AND TARBP2. |
| [16] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-664, MASS SPECTROMETRY. |
| [17] | "The role of PACT in the RNA silencing pathway." Lee Y., Hur I., Park S.-Y., Kim Y.-K., Suh M.R., Kim V.N. EMBO J. 25:522-532(2006) [PubMed: 16424907] [Abstract] Cited for: FUNCTION, INTERACTION WITH PRKRA AND TARBP2, SUBCELLULAR LOCATION. |
| [18] | "Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA." Kok K.H., Ng M.-H., Ching Y.-P., Jin D.-Y. J. Biol. Chem. 282:17649-17657(2007) [PubMed: 17452327] [Abstract] Cited for: FUNCTION, INTERACTION WITH PRKRA AND TARBP2. |
| [19] | "RNA helicase A interacts with RISC in human cells and functions in RISC loading." Robb G.B., Rana T.M. Mol. Cell 26:523-537(2007) [PubMed: 17531811] [Abstract] Cited for: INTERACTION WITH DHX9. |
| [20] | "MicroRNA silencing through RISC recruitment of eIF6." Chendrimada T.P., Finn K.J., Ji X., Baillat D., Gregory R.I., Liebhaber S.A., Pasquinelli A.E., Shiekhattar R. Nature 447:823-828(2007) [PubMed: 17507929] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EIF2C2; EIF6; MOV10 AND TARBP2, ASSOCIATION WITH THE 60S RIBOSOME. |
| [21] | "Prolyl 4-hydroxylation regulates Argonaute 2 stability." Qi H.H., Ongusaha P.P., Myllyharju J., Cheng D., Pakkanen O., Shi Y., Lee S.W., Peng J., Shi Y. Nature 455:421-424(2008) [PubMed: 18690212] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EIF2C2. |
| [22] | "In vitro reconstitution of the human RISC-loading complex." MacRae I.J., Ma E., Zhou M., Robinson C.V., Doudna J.A. Proc. Natl. Acad. Sci. U.S.A. 105:512-517(2008) [PubMed: 18178619] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH EIF2C2 AND TARBP2. |
| [23] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [24] | "A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function." Melo S.A., Ropero S., Moutinho C., Aaltonen L.A., Yamamoto H., Calin G.A., Rossi S., Fernandez A.F., Carneiro F., Oliveira C., Ferreira B., Liu C.-G., Villanueva A., Capella G., Schwartz S. Jr., Shiekhattar R., Esteller M. Nat. Genet. 41:365-370(2009) [PubMed: 19219043] [Abstract] Cited for: FUNCTION. |
| [25] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [26] | "Extending the phenotypes associated with DICER1 mutations." Foulkes W.D., Bahubeshi A., Hamel N., Pasini B., Asioli S., Baynam G., Choong C.S., Charles A., Frieder R.P., Dishop M.K., Graf N., Ekim M., Bouron-Dal Soglio D., Arseneau J., Young R.H., Sabbaghian N., Srivastava A., Tischkowitz M.D., Priest J.R. Hum. Mutat. 32:1381-1384(2011) [PubMed: 21882293] [Abstract] Cited for: DISEASE. |
| [27] | "Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer." Takeshita D., Zenno S., Lee W.C., Nagata K., Saigo K., Tanokura M. J. Mol. Biol. 374:106-120(2007) [PubMed: 17920623] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1660-1852, COFACTOR, SUBUNIT. |
| [28] | "DICER1 mutations in familial pleuropulmonary blastoma." Hill D.A., Ivanovich J., Priest J.R., Gurnett C.A., Dehner L.P., Desruisseau D., Jarzembowski J.A., Wikenheiser-Brokamp K.A., Suarez B.K., Whelan A.J., Williams G., Bracamontes D., Messinger Y., Goodfellow P.J. Science 325:965-965(2009) [PubMed: 19556464] [Abstract] Cited for: VARIANT PPB ARG-1583. |
| [29] | "DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors." Rio Frio T., Bahubeshi A., Kanellopoulou C., Hamel N., Niedziela M., Sabbaghian N., Pouchet C., Gilbert L., O'Brien P.K., Serfas K., Broderick P., Houlston R.S., Lesueur F., Bonora E., Muljo S., Schimke R.N., Bouron-Dal Soglio D., Arseneau J. Tischkowitz M.JAMA 305:68-77(2011) [PubMed: 21205968] [Abstract] Cited for: VARIANT MNG1 PHE-839. |
| + | Additional computationally mapped references. |
Web resources
| Protein Spotlight The dark side of RNA - Issue 87 of October 2007 |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AB028449 mRNA. Translation: BAA78691.1. AJ132261 mRNA. Translation: CAB38857.2. Different initiation. AB023145 mRNA. Translation: BAA76772.2. AL356017 Genomic DNA. No translation available. AL390254 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81596.1. BC150287 mRNA. Translation: AAI50288.1. | ||||||||||||
| IPI | IPI00219036. | ||||||||||||
| RefSeq | NP_085124.2. NM_030621.3. NP_803187.1. NM_177438.2. | ||||||||||||
| UniGene | Hs.87889. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q9UPY3. | ||||||||||||
| SMR | Q9UPY3. Positions 38-208, 440-568, 625-722, 925-1046, 1293-1370, 1654-1916. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP-29664N. | ||||||||||||
| IntAct | Q9UPY3. 11 interactions. | ||||||||||||
| MINT | MINT-1957525. | ||||||||||||
| STRING | Q9UPY3. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q9UPY3. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 257051056. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q9UPY3. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000343455; ENSP00000343745; ENSG00000100697. ENST00000393063; ENSP00000376783; ENSG00000100697. | ||||||||||||
| GeneID | 23405. | ||||||||||||
| KEGG | hsa:23405. | ||||||||||||
| UCSC | uc001ydv.2. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 23405. | ||||||||||||
| GeneCards | GC14M095552. | ||||||||||||
| H-InvDB | HIX0011933. | ||||||||||||
| HGNC | HGNC:17098. DICER1. | ||||||||||||
| HPA | HPA000694. | ||||||||||||
| MIM | 138800. phenotype. 601200. phenotype. 606241. gene. | ||||||||||||
| neXtProt | NX_Q9UPY3. | ||||||||||||
| Orphanet | 64742. Pleuro-pulmonary blastoma. | ||||||||||||
| PharmGKB | PA38437. | ||||||||||||
| HUGE | Search... | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG08464. | ||||||||||||
| GeneTree | ENSGT00510000046789. | ||||||||||||
| HOGENOM | HBG358142. | ||||||||||||
| HOVERGEN | HBG107811. | ||||||||||||
| InParanoid | Q9UPY3. | ||||||||||||
| OMA | VNQDKSN. | ||||||||||||
| OrthoDB | EOG4JDH5W. | ||||||||||||
| PhylomeDB | Q9UPY3. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 3.1.26.3. 2681. | ||||||||||||
| Reactome | REACT_12472. Regulatory RNA pathways. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q9UPY3. | ||||||||||||
| Bgee | Q9UPY3. | ||||||||||||
| CleanEx | HS_DICER1. | ||||||||||||
| Genevestigator | Q9UPY3. | ||||||||||||
| GermOnline | ENSG00000100697. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR014001. DEAD-like_helicase. IPR005034. Dicer_dsRNA_binding_fold. IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR001650. Helicase_C. IPR003100. PAZ. IPR000999. RNase_III. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 4 hits. | ||||||||||||
| KO | K11592. | ||||||||||||
| Pfam | PF00270. DEAD. 1 hit. PF03368. dsRNA_bind. 1 hit. PF00271. Helicase_C. 1 hit. PF02170. PAZ. 1 hit. PF00636. Ribonuclease_3. 2 hits. [Graphical view] | ||||||||||||
| SMART | SM00487. DEXDc. 1 hit. SM00358. DSRM. 1 hit. SM00490. HELICc. 1 hit. SM00949. PAZ. 1 hit. SM00535. RIBOc. 2 hits. [Graphical view] | ||||||||||||
| SUPFAM | SSF101690. PAZ. 1 hit. SSF69065. RNase_III. 2 hits. | ||||||||||||
| PROSITE | PS51327. DICER_DSRBF. 1 hit. PS50137. DS_RBD. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50821. PAZ. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| NextBio | 45577. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | DICER_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UPY3 Secondary accession number(s): A7E2D3, O95943, Q9UQ02 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |

Clusters with