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Q9UPY3

- DICER_HUMAN

UniProt

Q9UPY3 - DICER_HUMAN

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Protein

Endoribonuclease Dicer

Gene

DICER1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.10 Publications

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.2 Publications

Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium or manganese ions per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1316 – 13161Magnesium or manganese 1By similarity
Metal bindingi1395 – 13951Magnesium or manganese 1By similarity
Metal bindingi1398 – 13981Magnesium or manganese 1By similarity
Metal bindingi1705 – 17051Magnesium or manganese 2
Sitei1806 – 18061Important for activityBy similarity
Metal bindingi1810 – 18101Magnesium or manganese 2
Metal bindingi1813 – 18131Magnesium or manganese 2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. double-stranded RNA binding Source: UniProtKB
  3. helicase activity Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. miRNA binding Source: Ensembl
  6. ribonuclease III activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. branching morphogenesis of an epithelial tube Source: Ensembl
  3. cardiac muscle cell development Source: Ensembl
  4. cerebral cortex development Source: Ensembl
  5. defense response to virus Source: Ensembl
  6. embryonic hindlimb morphogenesis Source: Ensembl
  7. gene expression Source: Reactome
  8. hair follicle cell proliferation Source: Ensembl
  9. hair follicle morphogenesis Source: Ensembl
  10. inner ear receptor cell development Source: Ensembl
  11. intestinal epithelial cell development Source: Ensembl
  12. lung development Source: Ensembl
  13. mRNA stabilization Source: Ensembl
  14. multicellular organism growth Source: Ensembl
  15. negative regulation of Schwann cell proliferation Source: BHF-UCL
  16. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  17. nerve development Source: BHF-UCL
  18. neuron projection morphogenesis Source: BHF-UCL
  19. olfactory bulb interneuron differentiation Source: Ensembl
  20. peripheral nervous system myelin formation Source: BHF-UCL
  21. positive regulation of gene expression Source: Ensembl
  22. positive regulation of miRNA metabolic process Source: Ensembl
  23. positive regulation of myelination Source: BHF-UCL
  24. positive regulation of Schwann cell differentiation Source: BHF-UCL
  25. post-embryonic development Source: Ensembl
  26. pre-miRNA processing Source: UniProtKB
  27. production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
  28. production of siRNA involved in RNA interference Source: UniProtKB
  29. regulation of cell cycle Source: Ensembl
  30. regulation of enamel mineralization Source: Ensembl
  31. regulation of neuron differentiation Source: Ensembl
  32. regulation of oligodendrocyte differentiation Source: Ensembl
  33. regulation of viral genome replication Source: Ensembl
  34. reproductive structure development Source: Ensembl
  35. RNA phosphodiester bond hydrolysis Source: GOC
  36. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  37. spinal cord motor neuron differentiation Source: Ensembl
  38. spindle assembly Source: Ensembl
  39. spleen development Source: Ensembl
  40. stem cell maintenance Source: Ensembl
  41. targeting of mRNA for destruction involved in RNA interference Source: UniProtKB
  42. zygote asymmetric cell division Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Helicase, Hydrolase, Nuclease

Keywords - Biological processi

RNA-mediated gene silencing

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BRENDAi3.1.26.3. 2681.
ReactomeiREACT_118560. Small interfering RNA (siRNA) biogenesis.
REACT_12417. MicroRNA (miRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoribonuclease Dicer (EC:3.1.26.3)
Alternative name(s):
Helicase with RNase motif
Short name:
Helicase MOI
Gene namesi
Name:DICER1
Synonyms:DICER, HERNA, KIAA0928
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:17098. DICER1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytosol Source: Reactome
  3. dendrite Source: Ensembl
  4. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  5. growth cone Source: Ensembl
  6. RISC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Pleuropulmonary blastoma (PPB) [MIM:601200]: A rare pediatric intrathoracic neoplasm. The tumor arises from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial elements, a feature that distinguishes it from the classic adult-type pulmonary blastoma. It arises during fetal lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have multilocular cystic nephroma, a benign kidney tumor.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1583 – 15831L → R in PPB. 1 Publication
VAR_063150
Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1) [MIM:138800]: A common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti839 – 8391S → F in MNG1. 1 Publication
VAR_065301
Rhabdomyosarcoma, embryonal, 2 (RMSE2) [MIM:180295]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Note: The disease is caused by mutations affecting the gene represented in this entry.
DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293). Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors. These mutations do not abolish DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic (PubMed:22187960).2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi960 – 9601F → A: 2-fold decrease in activity.
Mutagenesisi971 – 9711Y → A: 10-fold decrease in activity; when associated with Y-972.
Mutagenesisi972 – 9721Y → A: 10-fold decrease in activity; when associated with Y-971.
Mutagenesisi1036 – 10361E → A: 5-fold decrease in activity.
Mutagenesisi1313 – 13131E → A: No effect on activity. 1 Publication
Mutagenesisi1320 – 13201D → A: Decreased activity. Loss of activity; when associated with D-1709. 1 Publication
Mutagenesisi1340 – 13401E → A: No effect on activity. 1 Publication
Mutagenesisi1444 – 14441E → A: Decreased activity. Loss of activity; when associated with E-1813. 1 Publication
Mutagenesisi1702 – 17021Q → A: No effect on activity. 1 Publication
Mutagenesisi1709 – 17091D → A: Decreased activity. Loss of activity; when associated with D-1320. 1 Publication
Mutagenesisi1729 – 17291P → E: No effect on activity. 1 Publication
Mutagenesisi1813 – 18131E → A: Decreased activity. Loss of activity; when associated with E-1444. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi138800. phenotype.
180295. phenotype.
601200. phenotype.
Orphaneti276399. Familial multinodular goiter.
404476. Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome.
99916. Ovarian malignant Sertoli-Leydig cell tumor.
284343. Pleuropulmonary blastoma family tumor susceptibility syndrome.
PharmGKBiPA38437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19221922Endoribonuclease DicerPRO_0000180470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei413 – 4131Phosphoserine1 Publication
Modified residuei415 – 4151Phosphoserine1 Publication
Modified residuei1016 – 10161Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UPY3.
PaxDbiQ9UPY3.
PRIDEiQ9UPY3.

PTM databases

PhosphoSiteiQ9UPY3.

Expressioni

Gene expression databases

BgeeiQ9UPY3.
CleanExiHS_DICER1.
ExpressionAtlasiQ9UPY3. baseline and differential.
GenevestigatoriQ9UPY3.

Organism-specific databases

HPAiHPA000694.

Interactioni

Subunit structurei

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D.14 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P0C2057EBI-395506,EBI-8332963From a different organism.
ADARP55265-14EBI-395506,EBI-6913056
ADARP55265-58EBI-395506,EBI-6913210
AGO1Q9UL185EBI-395506,EBI-527363
AGO2Q9UKV813EBI-395506,EBI-528269
Ago2Q8CJG02EBI-395506,EBI-528299From a different organism.
DHX58Q96C102EBI-395506,EBI-744193
EIF2AK2P195252EBI-395506,EBI-640775
PIWIL1Q96J942EBI-395506,EBI-527417
PRKRAO755692EBI-395506,EBI-713955
TARBP2Q1563315EBI-395506,EBI-978581

Protein-protein interaction databases

BioGridi116978. 52 interactions.
DIPiDIP-29664N.
IntActiQ9UPY3. 21 interactions.
MINTiMINT-1957525.
STRINGi9606.ENSP00000343745.

Structurei

Secondary structure

1
1922
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi768 – 78013Combined sources
Helixi783 – 7853Combined sources
Helixi795 – 7973Combined sources
Beta strandi801 – 8088Combined sources
Beta strandi816 – 8205Combined sources
Beta strandi823 – 83614Combined sources
Helixi840 – 85516Combined sources
Beta strandi877 – 8837Combined sources
Beta strandi890 – 8923Combined sources
Helixi894 – 9029Combined sources
Beta strandi906 – 9083Combined sources
Beta strandi916 – 9183Combined sources
Helixi924 – 9274Combined sources
Beta strandi931 – 9377Combined sources
Beta strandi939 – 9413Combined sources
Beta strandi945 – 9517Combined sources
Helixi968 – 9769Combined sources
Beta strandi987 – 9926Combined sources
Helixi1016 – 103015Combined sources
Helixi1035 – 10373Combined sources
Beta strandi1038 – 10403Combined sources
Helixi1045 – 10517Combined sources
Helixi1054 – 10618Combined sources
Turni1662 – 16654Combined sources
Helixi1666 – 16738Combined sources
Helixi1680 – 16878Combined sources
Helixi1702 – 172221Combined sources
Helixi1729 – 173911Combined sources
Helixi1742 – 175110Combined sources
Helixi1754 – 17563Combined sources
Helixi1763 – 177816Combined sources
Helixi1806 – 182217Combined sources
Helixi1827 – 184721Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EB1X-ray2.00A/B/C1660-1852[»]
4NGBX-ray2.25A765-1065[»]
4NGCX-ray2.10A765-1065[»]
4NGDX-ray1.96A765-1065[»]
4NGFX-ray3.10A/B/C/D765-1065[»]
4NGGX-ray2.60A765-1065[»]
4NH3X-ray2.62A765-1065[»]
4NH5X-ray2.55A765-1065[»]
4NH6X-ray2.55A765-1065[»]
4NHAX-ray3.40A765-1065[»]
ProteinModelPortaliQ9UPY3.
SMRiQ9UPY3. Positions 45-208, 444-582, 766-1063, 1654-1916.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UPY3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 227177Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini433 – 602170Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini630 – 72293Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd
BLAST
Domaini891 – 1042152PAZPROSITE-ProRule annotationAdd
BLAST
Domaini1276 – 1403128RNase III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1666 – 1824159RNase III 2PROSITE-ProRule annotationAdd
BLAST
Domaini1849 – 191466DRBMPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 595340Required for interaction with PRKRA and TARBP2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1784DECH box

Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation
Contains 1 Dicer dsRNA-binding fold domain.PROSITE-ProRule annotation
Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 PAZ domain.PROSITE-ProRule annotation
Contains 2 RNase III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1111.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000001567.
HOVERGENiHBG107811.
InParanoidiQ9UPY3.
KOiK11592.
OMAiMKLCENC.
OrthoDBiEOG78PV82.
PhylomeDBiQ9UPY3.
TreeFamiTF330258.

Family and domain databases

Gene3Di1.10.1520.10. 4 hits.
3.30.160.20. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR005034. Dicer_dimerisation_dom.
IPR014720. dsRNA-bd_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR003100. PAZ_dom.
IPR000999. RNase_III_dom.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF02170. PAZ. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00358. DSRM. 1 hit.
SM00490. HELICc. 1 hit.
SM00949. PAZ. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMiSSF101690. SSF101690. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 4 hits.
PROSITEiPS51327. DICER_DSRBF. 1 hit.
PS50137. DS_RBD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50821. PAZ. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPY3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE
60 70 80 90 100
LLEAALDHNT IVCLNTGSGK TFIAVLLTKE LSYQIRGDFS RNGKRTVFLV
110 120 130 140 150
NSANQVAQQV SAVRTHSDLK VGEYSNLEVN ASWTKERWNQ EFTKHQVLIM
160 170 180 190 200
TCYVALNVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM KLCENCPSCP
210 220 230 240 250
RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL VVLDRYTSQP
260 270 280 290 300
CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK
310 320 330 340 350
QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT
360 370 380 390 400
FLRKIHALCE EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW
410 420 430 440 450
YNNRNQDNYV SWSDSEDDDE DEEIEEKEKP ETNFPSPFTN ILCGIIFVER
460 470 480 490 500
RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR NKQMEAEFRK
510 520 530 540 550
QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP TEYRSYVQSK
560 570 580 590 600
GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGETD
610 620 630 640 650
IDPVMDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA
660 670 680 690 700
PKCRTRELPD GTFYSTLYLP INSPLRASIV GPPMSCVRLA ERVVALICCE
710 720 730 740 750
KLHKIGELDD HLMPVGKETV KYEEELDLHD EEETSVPGRP GSTKRRQCYP
760 770 780 790 800
KAIPECLRDS YPRPDQPCYL YVIGMVLTTP LPDELNFRRR KLYPPEDTTR
810 820 830 840 850
CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFMLSL QMLELITRLH
860 870 880 890 900
QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI
910 920 930 940 950
EKSEARIGIP STKYTKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV
960 970 980 990 1000
YTDLTPLSKF PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL
1010 1020 1030 1040 1050
TPRHLNQKGK ALPLSSAEKR KAKWESLQNK QILVPELCAI HPIPASLWRK
1060 1070 1080 1090 1100
AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPADFR YPNLDFGWKK
1110 1120 1130 1140 1150
SIDSKSFISI SNSSSAENDN YCKHSTIVPE NAAHQGANRT SSLENHDQMS
1160 1170 1180 1190 1200
VNCRTLLSES PGKLHVEVSA DLTAINGLSY NQNLANGSYD LANRDFCQGN
1210 1220 1230 1240 1250
QLNYYKQEIP VQPTTSYSIQ NLYSYENQPQ PSDECTLLSN KYLDGNANKS
1260 1270 1280 1290 1300
TSDGSPVMAV MPGTTDTIQV LKGRMDSEQS PSIGYSSRTL GPNPGLILQA
1310 1320 1330 1340 1350
LTLSNASDGF NLERLEMLGD SFLKHAITTY LFCTYPDAHE GRLSYMRSKK
1360 1370 1380 1390 1400
VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD KSNTDKWEKD
1410 1420 1430 1440 1450
EMTKDCMLAN GKLDEDYEEE DEEEESLMWR APKEEADYED DFLEYDQEHI
1460 1470 1480 1490 1500
RFIDNMLMGS GAFVKKISLS PFSTTDSAYE WKMPKKSSLG SMPFSSDFED
1510 1520 1530 1540 1550
FDYSSWDAMC YLDPSKAVEE DDFVVGFWNP SEENCGVDTG KQSISYDLHT
1560 1570 1580 1590 1600
EQCIADKSIA DCVEALLGCY LTSCGERAAQ LFLCSLGLKV LPVIKRTDRE
1610 1620 1630 1640 1650
KALCPTRENF NSQQKNLSVS CAAASVASSR SSVLKDSEYG CLKIPPRCMF
1660 1670 1680 1690 1700
DHPDADKTLN HLISGFENFE KKINYRFKNK AYLLQAFTHA SYHYNTITDC
1710 1720 1730 1740 1750
YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV NNTIFASLAV
1760 1770 1780 1790 1800
KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE
1810 1820 1830 1840 1850
DIEVPKAMGD IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP
1860 1870 1880 1890 1900
RSPVRELLEM EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA
1910 1920
KSAAARRALR SLKANQPQVP NS
Length:1,922
Mass (Da):218,682
Last modified:September 1, 2009 - v3
Checksum:i9452B96A601D4551
GO
Isoform 2 (identifier: Q9UPY3-2) [UniParc]FASTAAdd to Basket

Also known as: t-Dicer

The sequence of this isoform differs from the canonical sequence as follows:
     1789-1922: LRRSEEDEEK...KANQPQVPNS → KSFLQMYPVP...TTGRSESLWK

Show »
Length:1,829
Mass (Da):208,448
Checksum:i8F52FAB99C876358
GO
Isoform 3 (identifier: Q9UPY3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MKSPALQPLSMAG → MLAWESDHFLRIL
     14-1115: Missing.

Note: No experimental confirmation available.

Show »
Length:820
Mass (Da):92,726
Checksum:i006901B4B9E96382
GO

Sequence cautioni

The sequence CAB38857.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 9016VLLTK…RGDFS → STTLLKSCLYLDLGETSA in BAA78691. (PubMed:10786632)CuratedAdd
BLAST
Sequence conflicti189 – 1891I → F in BAA78691. (PubMed:10786632)Curated
Sequence conflicti195 – 1951N → I in BAA78691. (PubMed:10786632)Curated
Sequence conflicti214 – 2141C → W in BAA78691. (PubMed:10786632)Curated
Sequence conflicti218 – 2181E → D in BAA78691. (PubMed:10786632)Curated
Sequence conflicti223 – 2231I → F in BAA78691. (PubMed:10786632)Curated
Sequence conflicti393 – 3942QQ → HS in BAA78691. (PubMed:10786632)Curated
Sequence conflicti492 – 4932KQ → NT in BAA78691. (PubMed:10786632)Curated
Sequence conflicti609 – 6091D → H in BAA78691. (PubMed:10786632)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti839 – 8391S → F in MNG1. 1 Publication
VAR_065301
Natural varianti1583 – 15831L → R in PPB. 1 Publication
VAR_063150
Natural varianti1705 – 17051E → K in non-epithelial ovarian tumor; somatic mutation; results in reduced RNase IIIb activity but retention of RNase IIIa activity. 1 Publication
VAR_067091
Natural varianti1709 – 17091D → E in non-epithelial ovarian tumor; somatic mutation; results in reduced RNase IIIb activity but retention of RNase IIIa activity. 1 Publication
VAR_067092
Natural varianti1709 – 17091D → G in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067093
Natural varianti1709 – 17091D → N in non-epithelial ovarian tumor; somatic mutation; results in reduced RNase IIIb activity but retention of RNase IIIa activity. 1 Publication
VAR_067094
Natural varianti1810 – 18101D → H in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067095
Natural varianti1810 – 18101D → N in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067096
Natural varianti1810 – 18101D → Y in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067097
Natural varianti1813 – 18131E → G in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067098
Natural varianti1813 – 18131E → K in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067099
Natural varianti1813 – 18131E → Q in non-epithelial ovarian tumor; somatic mutation. 1 Publication
VAR_067100

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MKSPA…LSMAG → MLAWESDHFLRIL in isoform 3. 1 PublicationVSP_055341Add
BLAST
Alternative sequencei14 – 11151102Missing in isoform 3. 1 PublicationVSP_055342Add
BLAST
Alternative sequencei1789 – 1922134LRRSE…QVPNS → KSFLQMYPVPLCENCLKWNQ KLPNLARLRELTTGRSESLW K in isoform 2. 1 PublicationVSP_042832Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028449 mRNA. Translation: BAA78691.1.
HM595745 mRNA. Translation: ADK25182.1.
AJ132261 mRNA. Translation: CAB38857.2. Different initiation.
AB023145 mRNA. Translation: BAA76772.2.
AK091513 mRNA. Translation: BAG52376.1.
AL356017 Genomic DNA. No translation available.
AL390254 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81596.1.
BC150287 mRNA. Translation: AAI50288.1.
CCDSiCCDS55941.1. [Q9UPY3-2]
CCDS9931.1. [Q9UPY3-1]
RefSeqiNP_001182502.1. NM_001195573.1. [Q9UPY3-2]
NP_001258211.1. NM_001271282.2. [Q9UPY3-1]
NP_001278557.1. NM_001291628.1. [Q9UPY3-1]
NP_085124.2. NM_030621.4. [Q9UPY3-1]
NP_803187.1. NM_177438.2. [Q9UPY3-1]
UniGeneiHs.738957.
Hs.87889.

Genome annotation databases

EnsembliENST00000343455; ENSP00000343745; ENSG00000100697. [Q9UPY3-1]
ENST00000393063; ENSP00000376783; ENSG00000100697. [Q9UPY3-1]
ENST00000526495; ENSP00000437256; ENSG00000100697. [Q9UPY3-1]
ENST00000527414; ENSP00000435681; ENSG00000100697. [Q9UPY3-1]
ENST00000541352; ENSP00000444719; ENSG00000100697. [Q9UPY3-2]
ENST00000556045; ENSP00000451041; ENSG00000100697. [Q9UPY3-3]
GeneIDi23405.
KEGGihsa:23405.
UCSCiuc001ydv.3. human. [Q9UPY3-1]
uc001ydy.1. human.
uc021sbc.1. human. [Q9UPY3-2]

Polymorphism databases

DMDMi257051056.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

The dark side of RNA - Issue 87 of October 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028449 mRNA. Translation: BAA78691.1 .
HM595745 mRNA. Translation: ADK25182.1 .
AJ132261 mRNA. Translation: CAB38857.2 . Different initiation.
AB023145 mRNA. Translation: BAA76772.2 .
AK091513 mRNA. Translation: BAG52376.1 .
AL356017 Genomic DNA. No translation available.
AL390254 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81596.1 .
BC150287 mRNA. Translation: AAI50288.1 .
CCDSi CCDS55941.1. [Q9UPY3-2 ]
CCDS9931.1. [Q9UPY3-1 ]
RefSeqi NP_001182502.1. NM_001195573.1. [Q9UPY3-2 ]
NP_001258211.1. NM_001271282.2. [Q9UPY3-1 ]
NP_001278557.1. NM_001291628.1. [Q9UPY3-1 ]
NP_085124.2. NM_030621.4. [Q9UPY3-1 ]
NP_803187.1. NM_177438.2. [Q9UPY3-1 ]
UniGenei Hs.738957.
Hs.87889.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EB1 X-ray 2.00 A/B/C 1660-1852 [» ]
4NGB X-ray 2.25 A 765-1065 [» ]
4NGC X-ray 2.10 A 765-1065 [» ]
4NGD X-ray 1.96 A 765-1065 [» ]
4NGF X-ray 3.10 A/B/C/D 765-1065 [» ]
4NGG X-ray 2.60 A 765-1065 [» ]
4NH3 X-ray 2.62 A 765-1065 [» ]
4NH5 X-ray 2.55 A 765-1065 [» ]
4NH6 X-ray 2.55 A 765-1065 [» ]
4NHA X-ray 3.40 A 765-1065 [» ]
ProteinModelPortali Q9UPY3.
SMRi Q9UPY3. Positions 45-208, 444-582, 766-1063, 1654-1916.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116978. 52 interactions.
DIPi DIP-29664N.
IntActi Q9UPY3. 21 interactions.
MINTi MINT-1957525.
STRINGi 9606.ENSP00000343745.

Chemistry

ChEMBLi CHEMBL2311232.

PTM databases

PhosphoSitei Q9UPY3.

Polymorphism databases

DMDMi 257051056.

Proteomic databases

MaxQBi Q9UPY3.
PaxDbi Q9UPY3.
PRIDEi Q9UPY3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343455 ; ENSP00000343745 ; ENSG00000100697 . [Q9UPY3-1 ]
ENST00000393063 ; ENSP00000376783 ; ENSG00000100697 . [Q9UPY3-1 ]
ENST00000526495 ; ENSP00000437256 ; ENSG00000100697 . [Q9UPY3-1 ]
ENST00000527414 ; ENSP00000435681 ; ENSG00000100697 . [Q9UPY3-1 ]
ENST00000541352 ; ENSP00000444719 ; ENSG00000100697 . [Q9UPY3-2 ]
ENST00000556045 ; ENSP00000451041 ; ENSG00000100697 . [Q9UPY3-3 ]
GeneIDi 23405.
KEGGi hsa:23405.
UCSCi uc001ydv.3. human. [Q9UPY3-1 ]
uc001ydy.1. human.
uc021sbc.1. human. [Q9UPY3-2 ]

Organism-specific databases

CTDi 23405.
GeneCardsi GC14M095552.
HGNCi HGNC:17098. DICER1.
HPAi HPA000694.
MIMi 138800. phenotype.
180295. phenotype.
601200. phenotype.
606241. gene.
neXtProti NX_Q9UPY3.
Orphaneti 276399. Familial multinodular goiter.
404476. Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome.
99916. Ovarian malignant Sertoli-Leydig cell tumor.
284343. Pleuropulmonary blastoma family tumor susceptibility syndrome.
PharmGKBi PA38437.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1111.
GeneTreei ENSGT00510000046789.
HOGENOMi HOG000001567.
HOVERGENi HBG107811.
InParanoidi Q9UPY3.
KOi K11592.
OMAi MKLCENC.
OrthoDBi EOG78PV82.
PhylomeDBi Q9UPY3.
TreeFami TF330258.

Enzyme and pathway databases

BRENDAi 3.1.26.3. 2681.
Reactomei REACT_118560. Small interfering RNA (siRNA) biogenesis.
REACT_12417. MicroRNA (miRNA) biogenesis.

Miscellaneous databases

ChiTaRSi DICER1. human.
EvolutionaryTracei Q9UPY3.
GeneWikii DICER1.
GenomeRNAii 23405.
NextBioi 35469529.
PROi Q9UPY3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UPY3.
CleanExi HS_DICER1.
ExpressionAtlasi Q9UPY3. baseline and differential.
Genevestigatori Q9UPY3.

Family and domain databases

Gene3Di 1.10.1520.10. 4 hits.
3.30.160.20. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR005034. Dicer_dimerisation_dom.
IPR014720. dsRNA-bd_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR003100. PAZ_dom.
IPR000999. RNase_III_dom.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF03368. Dicer_dimer. 1 hit.
PF00271. Helicase_C. 1 hit.
PF02170. PAZ. 1 hit.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00358. DSRM. 1 hit.
SM00490. HELICc. 1 hit.
SM00949. PAZ. 1 hit.
SM00535. RIBOc. 2 hits.
[Graphical view ]
SUPFAMi SSF101690. SSF101690. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF69065. SSF69065. 4 hits.
PROSITEi PS51327. DICER_DSRBF. 1 hit.
PS50137. DS_RBD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50821. PAZ. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase."
    Matsuda S., Ichigotani Y., Okuda T., Irimura T., Nakatsugawa S., Hamaguchi M.
    Biochim. Biophys. Acta 1490:163-169(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "A novel splice variant of the human dicer gene is expressed in neuroblastoma cells."
    Potenza N., Papa U., Scaruffi P., Mosca N., Tonini G.P., Russo A.
    FEBS Lett. 584:3452-3457(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Neuroblastoma.
  3. "RNA binding and processing by recombinant human Dicer."
    Provost P., Dishart D., Doucet D., Hermansson A., Frendewey D., Samuelsson B., Radmark O.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  7. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  10. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1922 (ISOFORM 1).
    Tissue: Lung.
  11. "Single processing center models for human Dicer and bacterial RNase III."
    Zhang H., Kolb F.A., Jaskiewicz L., Westhof E., Filipowicz W.
    Cell 118:57-68(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF GLU-1313; ASP-1320; GLU-1340; GLU-1444; GLN-1702; ASP-1709; PRO-1729 AND GLU-1813.
  12. "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer."
    Tahbaz N., Kolb F.A., Zhang H., Jaronczyk K., Filipowicz W., Hobman T.C.
    EMBO Rep. 5:189-194(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PIWIL1.
  13. "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing."
    Gregory R.I., Chendrimada T.P., Cooch N., Shiekhattar R.
    Cell 123:631-640(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AGO2 AND TARBP2.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH AGO1 AND AGO2.
  15. "TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing."
    Haase A.D., Jaskiewicz L., Zhang H., Laine S., Sack R., Gatignol A., Filipowicz W.
    EMBO Rep. 6:961-967(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TARBP2.
  16. "A human, ATP-independent, RISC assembly machine fueled by pre-miRNA."
    Maniataki E., Mourelatos Z.
    Genes Dev. 19:2979-2990(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AGO2.
  17. "TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing."
    Chendrimada T.P., Gregory R.I., Kumaraswamy E., Norman J., Cooch N., Nishikura K., Shiekhattar R.
    Nature 436:740-744(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH AGO2 AND TARBP2.
  18. "The role of PACT in the RNA silencing pathway."
    Lee Y., Hur I., Park S.-Y., Kim Y.-K., Suh M.R., Kim V.N.
    EMBO J. 25:522-532(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PRKRA AND TARBP2, SUBCELLULAR LOCATION.
  19. "Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."
    Kok K.H., Ng M.-H., Ching Y.-P., Jin D.-Y.
    J. Biol. Chem. 282:17649-17657(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PRKRA AND TARBP2.
  20. "RNA helicase A interacts with RISC in human cells and functions in RISC loading."
    Robb G.B., Rana T.M.
    Mol. Cell 26:523-537(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DHX9.
  21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH AGO2; EIF6; MOV10 AND TARBP2, ASSOCIATION WITH THE 60S RIBOSOME.
  22. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH AGO2.
  23. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1016, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH AGO2 AND TARBP2.
  25. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  26. Cited for: FUNCTION.
  27. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  28. Cited for: INVOLVEMET IN RMSE2.
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413 AND SER-415, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  30. "Human RNA methyltransferase BCDIN3D regulates microRNA processing."
    Xhemalce B., Robson S.C., Kouzarides T.
    Cell 151:278-288(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCDIN3D.
  31. Cited for: INVOLVEMENT IN NON-EPITHELIAL OVARIAN TUMORS, VARIANTS LYS-1705; ASN-1709; GLU-1709; GLY-1709; HIS-1810; TYR-1810; ASN-1810; GLN-1813; GLY-1813 AND LYS-1813, CHARACTERIZATION OF VARIANTS LYS-1705; ASN-1709 AND GLU-1709.
  32. "Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer."
    Takeshita D., Zenno S., Lee W.C., Nagata K., Saigo K., Tanokura M.
    J. Mol. Biol. 374:106-120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1660-1852, CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
  33. Cited for: VARIANT PPB ARG-1583.
  34. Cited for: VARIANT MNG1 PHE-839.

Entry informationi

Entry nameiDICER_HUMAN
AccessioniPrimary (citable) accession number: Q9UPY3
Secondary accession number(s): A7E2D3
, B3KRG4, E0AD28, O95943, Q9UQ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3