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Q9UPX8

- SHAN2_HUMAN

UniProt

Q9UPX8 - SHAN2_HUMAN

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Protein

SH3 and multiple ankyrin repeat domains protein 2

Gene

SHANK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

GO - Molecular functioni

  1. GKAP/Homer scaffold activity Source: UniProtKB
  2. ionotropic glutamate receptor binding Source: BHF-UCL

GO - Biological processi

  1. adult behavior Source: BHF-UCL
  2. learning Source: BHF-UCL
  3. long term synaptic depression Source: BHF-UCL
  4. long-term synaptic potentiation Source: BHF-UCL
  5. social behavior Source: BHF-UCL
  6. synapse assembly Source: BHF-UCL
  7. vocalization behavior Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9UPX8.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and multiple ankyrin repeat domains protein 2
Short name:
Shank2
Alternative name(s):
Cortactin-binding protein 1
Short name:
CortBP1
Proline-rich synapse-associated protein 1
Gene namesi
Name:SHANK2
Synonyms:CORTBP1, KIAA1022, PROSAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14295. SHANK2.

Subcellular locationi

Apical cell membrane By similarity. Cytoplasm By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell projectiongrowth cone By similarity. Cell projectiondendritic spine By similarity
Note: Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: BHF-UCL
  2. brush border membrane Source: BHF-UCL
  3. cell junction Source: UniProtKB-KW
  4. ciliary membrane Source: BHF-UCL
  5. cytoplasm Source: UniProtKB-KW
  6. dendritic spine Source: BHF-UCL
  7. growth cone Source: BHF-UCL
  8. neuronal cell body Source: BHF-UCL
  9. neuron projection Source: BHF-UCL
  10. photoreceptor inner segment Source: BHF-UCL
  11. photoreceptor outer segment Source: BHF-UCL
  12. plasma membrane Source: BHF-UCL
  13. postsynaptic density Source: BHF-UCL
  14. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Autism 17 (AUTS17) [MIM:613436]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi613436. phenotype.
Orphaneti106. Autism.
PharmGKBiPA37867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14701470SH3 and multiple ankyrin repeat domains protein 2PRO_0000174673Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei581 – 5811PhosphoserineBy similarity
Modified residuei899 – 8991PhosphothreonineBy similarity
Glycosylationi1288 – 12881O-linked (GlcNAc)By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UPX8.
PaxDbiQ9UPX8.
PRIDEiQ9UPX8.

Expressioni

Tissue specificityi

Isoform 3 is present in epithelial colonic cells (at protein level).2 Publications

Gene expression databases

BgeeiQ9UPX8.
CleanExiHS_SHANK2.
ExpressionAtlasiQ9UPX8. baseline and differential.
GenevestigatoriQ9UPX8.

Organism-specific databases

HPAiHPA008174.

Interactioni

Subunit structurei

Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with CTTN/cortactin SH3 domain, DLGAP1/GKAP and alpha-latrotoxin receptor 1. Interacts with DNM2, DBNL, GRID2, BAIAP2, SLC9A3, PLCB3 and CFTR. Interacts (via proline-rich region) with PDE4D. Interacts with ABI1 (via SH3 domain).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKP461082EBI-1570571,EBI-886
GRB2P629932EBI-1570571,EBI-401755
NCK1P163336EBI-1570571,EBI-389883
PIK3R1P279862EBI-1570571,EBI-79464
PLCG1P191744EBI-1570571,EBI-79387

Protein-protein interaction databases

BioGridi116598. 15 interactions.
DIPiDIP-52255N.
IntActiQ9UPX8. 10 interactions.
MINTiMINT-2822695.
STRINGi9606.ENSP00000345193.

Structurei

3D structure databases

ProteinModelPortaliQ9UPX8.
SMRiQ9UPX8. Positions 153-205, 240-343, 1404-1467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 20660SH3PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 34195PDZPROSITE-ProRule annotationAdd
BLAST
Domaini1407 – 147064SAMPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi948 – 9547SH3-bindingSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi509 – 53527Pro-richAdd
BLAST

Domaini

The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3.By similarity

Sequence similaritiesi

Belongs to the SHANK family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiNOG265246.
GeneTreeiENSGT00510000046474.
HOGENOMiHOG000293276.
HOVERGENiHBG054027.
InParanoidiQ9UPX8.
KOiK15009.
PhylomeDBiQ9UPX8.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9UPX8-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAS
60 70 80 90 100
APDWAVCSTA TSHRSLSPQL LQQMPSKPEG AAKTIGSYVP GPRSRSPSLN
110 120 130 140 150
RLGGAGEDGK RPQPLWHVGS PFALGANKDS LSAFEYPGPK RKLYSAVPGR
160 170 180 190 200
LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC
210 220 230 240 250
VEEVQCKPRD SQAETRADRS KKLFRHYTVG SYDSFDTSSD CIIEEKTVVL
260 270 280 290 300
QKKDNEGFGF VLRGAKADTP IEEFTPTPAF PALQYLESVD EGGVAWQAGL
310 320 330 340 350
RTGDFLIEVN NENVVKVGHR QVVNMIRQGG NHLVLKVVTV TRNLDPDDTA
360 370 380 390 400
RKKAPPPPKR APTTALTLRS KSMTSELEEL VDKASVRKKK DKPEEIVPAS
410 420 430 440 450
KPSRAAENMA VEPRVATIKQ RPSSRCFPAG SDMNSVYERQ GIAVMTPTVP
460 470 480 490 500
GSPKAPFLGI PRGTMRRQKS IDSRIFLSGI TEEERQFLAP PMLKFTRSLS
510 520 530 540 550
MPDTSEDIPP PPQSVPPSPP PPSPTTYNCP KSPTPRVYGT IKPAFNQNSA
560 570 580 590 600
AKVSPATRSD TVATMMREKG MYFRRELDRY SLDSEDLYSR NAGPQANFRN
610 620 630 640 650
KRGQMPENPY SEVGKIASKA VYVPAKPARR KGMLVKQSNV EDSPEKTCSI
660 670 680 690 700
PIPTIIVKEP STSSSGKSSQ GSSMEIDPQA PEPPSQLRPD ESLTVSSPFA
710 720 730 740 750
AAIAGAVRDR EKRLEARRNS PAFLSTDLGD EDVGLGPPAP RTRPSMFPEE
760 770 780 790 800
GDFADEDSAE QLSSPMPSAT PREPENHFVG GAEASAPGEA GRPLNSTSKA
810 820 830 840 850
QGPESSPAVP SASSGTAGPG NYVHPLTGRL LDPSSPLALA LSARDRAMKE
860 870 880 890 900
SQQGPKGEAP KADLNKPLYI DTKMRPSLDA GFPTVTRQNT RGPLRRQETE
910 920 930 940 950
NKYETDLGRD RKGDDKKNML IDIMDTSQQK SAGLLMVHTV DATKLDNALQ
960 970 980 990 1000
EEDEKAEVEM KPDSSPSEVP EGVSETEGAL QISAAPEPTT VPGRTIVAVG
1010 1020 1030 1040 1050
SMEEAVILPF RIPPPPLASV DLDEDFIFTE PLPPPLEFAN SFDIPDDRAA
1060 1070 1080 1090 1100
SVPALSDLVK QKKSDTPQSP SLNSSQPTNS ADSKKPASLS NCLPASFLPP
1110 1120 1130 1140 1150
PESFDAVADS GIEEVDSRSS SDHHLETTST ISTVSSISTL SSEGGENVDT
1160 1170 1180 1190 1200
CTVYADGQAF MVDKPPVPPK PKMKPIIHKS NALYQDALVE EDVDSFVIPP
1210 1220 1230 1240 1250
PAPPPPPGSA QPGMAKVLQP RTSKLWGDVT EIKSPILSGP KANVISELNS
1260 1270 1280 1290 1300
ILQQMNREKL AKPGEGLDSP MGAKSASLAP RSPEIMSTIS GTRSTTVTFT
1310 1320 1330 1340 1350
VRPGTSQPIT LQSRPPDYES RTSGTRRAPS PVVSPTEMNK ETLPAPLSAA
1360 1370 1380 1390 1400
TASPSPALSD VFSLPSQPPS GDLFGLNPAG RSRSPSPSIL QQPISNKPFT
1410 1420 1430 1440 1450
TKPVHLWTKP DVADWLESLN LGEHKEAFMD NEIDGSHLPN LQKEDLIDLG
1460 1470
VTRVGHRMNI ERALKQLLDR
Length:1,470
Mass (Da):158,822
Last modified:July 28, 2009 - v3
Checksum:i7322993CB9FE0929
GO
Isoform 2 (identifier: Q9UPX8-2) [UniParc]FASTAAdd to Basket

Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     238-238: S → MMMNVPGGGAAAVMMTGYNNGRCPRNSLY
     472-490: DSRIFLSGITEEERQFLAP → GKKCGTPPQKLPLGFQTQP
     491-1470: Missing.

Show »
Length:281
Mass (Da):30,564
Checksum:iBD2ECD1A98B92FF4
GO
Isoform 3 (identifier: Q9UPX8-3) [UniParc]FASTAAdd to Basket

Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKSLLNAFTKKE → MPRSPTSSED...YIKNHKETDI

Note: Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393.

Show »
Length:1,849
Mass (Da):201,261
Checksum:i45550DC5D5701399
GO
Isoform 4 (identifier: Q9UPX8-4) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     238-238: S → MMMNVPGGGAAAVMMTGYNNGRCPRNSLY
     383-389: Missing.

Show »
Length:1,254
Mass (Da):134,931
Checksum:iF9D53FB165A65E0A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 237237Missing in isoform 2 and isoform 4. 1 PublicationVSP_037793Add
BLAST
Alternative sequencei1 – 1212MKSLL…FTKKE → MPRSPTSSEDEMAQSFSDYS VGSESDSSKEETIYDTIRAT AEKPGGARTEESQGNTLVIR VVIHDLQQTKCIRFNPDATV WVAKQRILCTLTQSLKDVLN YGLFQPASNGRDGKFLDEER LLREYPQPVGEGVPSLEFRY KKRVYKQASLDEKQLAKLHT KTNLKKCMDHIQHRLVEKIT KMLDRGLDPNFHDPETGETP LTLAAQLDDSVEVIKALKNG GAHLDFRAKDGMTALHKAAR ARNQVALKTLLELGASPDYK DSYGLTPLYHTAIVGGDPYC CELLLHEHATVCCKDENGWH EIHQACRYGHVQHLEHLLFY GADMSAQNASGNTALHICAL YNQDSCARVLLFRGGNKELK NYNSQTPFQVAIIAGNFELA EYIKNHKETDI in isoform 3. 2 PublicationsVSP_037794Add
BLAST
Alternative sequencei238 – 2381S → MMMNVPGGGAAAVMMTGYNN GRCPRNSLY in isoform 2 and isoform 4. 1 PublicationVSP_037795
Alternative sequencei383 – 3897Missing in isoform 4. CuratedVSP_037796
Alternative sequencei472 – 49019DSRIF…QFLAP → GKKCGTPPQKLPLGFQTQP in isoform 2. 1 PublicationVSP_037797Add
BLAST
Alternative sequencei491 – 1470980Missing in isoform 2. 1 PublicationVSP_037798Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208025 mRNA. Translation: BAH37016.1.
AB208026 mRNA. Translation: BAH37017.1.
AP000590 Genomic DNA. No translation available.
AP001271 Genomic DNA. No translation available.
AP003783 Genomic DNA. No translation available.
AP005401 Genomic DNA. No translation available.
BC093885 mRNA. Translation: AAH93885.1.
BC112097 mRNA. Translation: AAI12098.1.
DQ152234 mRNA. Translation: AAZ77790.1.
AB028945 mRNA. Translation: BAA82974.1.
AF141901 mRNA. Translation: AAF02496.1.
RefSeqiNP_036441.2. NM_012309.4. [Q9UPX8-3]
NP_573573.2. NM_133266.4.
XP_005277987.1. XM_005277930.1. [Q9UPX8-3]
XP_005277989.1. XM_005277932.1. [Q9UPX8-1]
UniGeneiHs.268726.

Genome annotation databases

EnsembliENST00000409530; ENSP00000387324; ENSG00000162105. [Q9UPX8-2]
ENST00000423696; ENSP00000394536; ENSG00000162105. [Q9UPX8-1]
ENST00000601538; ENSP00000469689; ENSG00000162105. [Q9UPX8-3]
GeneIDi22941.
KEGGihsa:22941.
UCSCiuc001opz.3. human. [Q9UPX8-4]
uc001oqc.3. human. [Q9UPX8-3]

Polymorphism databases

DMDMi254763402.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208025 mRNA. Translation: BAH37016.1 .
AB208026 mRNA. Translation: BAH37017.1 .
AP000590 Genomic DNA. No translation available.
AP001271 Genomic DNA. No translation available.
AP003783 Genomic DNA. No translation available.
AP005401 Genomic DNA. No translation available.
BC093885 mRNA. Translation: AAH93885.1 .
BC112097 mRNA. Translation: AAI12098.1 .
DQ152234 mRNA. Translation: AAZ77790.1 .
AB028945 mRNA. Translation: BAA82974.1 .
AF141901 mRNA. Translation: AAF02496.1 .
RefSeqi NP_036441.2. NM_012309.4. [Q9UPX8-3 ]
NP_573573.2. NM_133266.4.
XP_005277987.1. XM_005277930.1. [Q9UPX8-3 ]
XP_005277989.1. XM_005277932.1. [Q9UPX8-1 ]
UniGenei Hs.268726.

3D structure databases

ProteinModelPortali Q9UPX8.
SMRi Q9UPX8. Positions 153-205, 240-343, 1404-1467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116598. 15 interactions.
DIPi DIP-52255N.
IntActi Q9UPX8. 10 interactions.
MINTi MINT-2822695.
STRINGi 9606.ENSP00000345193.

Polymorphism databases

DMDMi 254763402.

Proteomic databases

MaxQBi Q9UPX8.
PaxDbi Q9UPX8.
PRIDEi Q9UPX8.

Protocols and materials databases

DNASUi 22941.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409530 ; ENSP00000387324 ; ENSG00000162105 . [Q9UPX8-2 ]
ENST00000423696 ; ENSP00000394536 ; ENSG00000162105 . [Q9UPX8-1 ]
ENST00000601538 ; ENSP00000469689 ; ENSG00000162105 . [Q9UPX8-3 ]
GeneIDi 22941.
KEGGi hsa:22941.
UCSCi uc001opz.3. human. [Q9UPX8-4 ]
uc001oqc.3. human. [Q9UPX8-3 ]

Organism-specific databases

CTDi 22941.
GeneCardsi GC11M070313.
GeneReviewsi SHANK2.
H-InvDB HIX0171293.
HGNCi HGNC:14295. SHANK2.
HPAi HPA008174.
MIMi 603290. gene.
613436. phenotype.
neXtProti NX_Q9UPX8.
Orphaneti 106. Autism.
PharmGKBi PA37867.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265246.
GeneTreei ENSGT00510000046474.
HOGENOMi HOG000293276.
HOVERGENi HBG054027.
InParanoidi Q9UPX8.
KOi K15009.
PhylomeDBi Q9UPX8.

Enzyme and pathway databases

SignaLinki Q9UPX8.

Miscellaneous databases

ChiTaRSi SHANK2. human.
GeneWikii SHANK2.
GenomeRNAii 22941.
NextBioi 43691.
PROi Q9UPX8.
SOURCEi Search...

Gene expression databases

Bgeei Q9UPX8.
CleanExi HS_SHANK2.
ExpressionAtlasi Q9UPX8. baseline and differential.
Genevestigatori Q9UPX8.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00595. PDZ. 1 hit.
PF00536. SAM_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00454. SAM. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A molecular scaffolding protein, Shank2, is a potent tumor suppressor in esophageal squamous cell carcinoma."
    Akahane T., Hosoda F., Arai Y., Fujisawa N., Kitabayashi I., Ohta T., Aoyagi K., Sasaki H., Nakanishi Y., Hirohashi S., Ohki M.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-328 (ISOFORM 3), TISSUE SPECIFICITY.
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  6. "Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
    Lim S., Naisbitt S., Yoon J., Hwang J.-I., Suh P.-G., Sheng M., Kim E.
    J. Biol. Chem. 274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  7. "The Shank family of scaffold proteins."
    Sheng M., Kim E.
    J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton."
    Okamoto P.M., Gamby C., Wells D., Fallon J., Vallee R.B.
    J. Biol. Chem. 276:48458-48465(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNM2.
  9. "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
    Soltau M., Richter D., Kreienkamp H.-J.
    Mol. Cell. Neurosci. 21:575-583(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BAIAP2.
  10. "Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors."
    Lee J.H., Richter W., Namkung W., Kim K.H., Kim E., Conti M., Lee M.G.
    J. Biol. Chem. 282:10414-10422(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDE4D, TISSUE SPECIFICITY.
  11. "Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation."
    Berkel S., Marshall C.R., Weiss B., Howe J., Roeth R., Moog U., Endris V., Roberts W., Szatmari P., Pinto D., Bonin M., Riess A., Engels H., Sprengel R., Scherer S.W., Rappold G.A.
    Nat. Genet. 42:489-491(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN AUTS17.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSHAN2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPX8
Secondary accession number(s): C0SPG8
, C0SPG9, Q3Y8G9, Q52LK2, Q9UKP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 28, 2009
Last modified: November 26, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3