Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9UPX8

- SHAN2_HUMAN

UniProt

Q9UPX8 - SHAN2_HUMAN

Protein

SH3 and multiple ankyrin repeat domains protein 2

Gene

SHANK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (28 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

    GO - Molecular functioni

    1. GKAP/Homer scaffold activity Source: UniProtKB
    2. ionotropic glutamate receptor binding Source: BHF-UCL
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. adult behavior Source: BHF-UCL
    2. learning Source: BHF-UCL
    3. long term synaptic depression Source: BHF-UCL
    4. long-term synaptic potentiation Source: BHF-UCL
    5. social behavior Source: BHF-UCL
    6. synapse assembly Source: BHF-UCL
    7. vocalization behavior Source: BHF-UCL

    Enzyme and pathway databases

    SignaLinkiQ9UPX8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 and multiple ankyrin repeat domains protein 2
    Short name:
    Shank2
    Alternative name(s):
    Cortactin-binding protein 1
    Short name:
    CortBP1
    Proline-rich synapse-associated protein 1
    Gene namesi
    Name:SHANK2
    Synonyms:CORTBP1, KIAA1022, PROSAP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14295. SHANK2.

    Subcellular locationi

    Apical cell membrane By similarity. Cytoplasm By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell projectiongrowth cone By similarity. Cell projectiondendritic spine By similarity
    Note: Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: BHF-UCL
    2. brush border membrane Source: BHF-UCL
    3. cell junction Source: UniProtKB-KW
    4. ciliary membrane Source: BHF-UCL
    5. cytoplasm Source: UniProtKB-SubCell
    6. dendritic spine Source: BHF-UCL
    7. growth cone Source: BHF-UCL
    8. neuronal cell body Source: BHF-UCL
    9. neuron projection Source: BHF-UCL
    10. photoreceptor inner segment Source: BHF-UCL
    11. photoreceptor outer segment Source: BHF-UCL
    12. plasma membrane Source: BHF-UCL
    13. postsynaptic density Source: BHF-UCL
    14. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Autism 17 (AUTS17) [MIM:613436]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi613436. phenotype.
    Orphaneti106. Autism.
    PharmGKBiPA37867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14701470SH3 and multiple ankyrin repeat domains protein 2PRO_0000174673Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei581 – 5811PhosphoserineBy similarity
    Modified residuei899 – 8991PhosphothreonineBy similarity
    Glycosylationi1288 – 12881O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPX8.
    PaxDbiQ9UPX8.
    PRIDEiQ9UPX8.

    Expressioni

    Tissue specificityi

    Isoform 3 is present in epithelial colonic cells (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ9UPX8.
    BgeeiQ9UPX8.
    CleanExiHS_SHANK2.
    GenevestigatoriQ9UPX8.

    Organism-specific databases

    HPAiHPA008174.

    Interactioni

    Subunit structurei

    Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with CTTN/cortactin SH3 domain, DLGAP1/GKAP and alpha-latrotoxin receptor 1. Interacts with DNM2, DBNL, GRID2, BAIAP2, SLC9A3, PLCB3 and CFTR. Interacts (via proline-rich region) with PDE4D. Interacts with ABI1 (via SH3 domain).3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRKP461082EBI-1570571,EBI-886
    GRB2P629932EBI-1570571,EBI-401755
    NCK1P163336EBI-1570571,EBI-389883
    PIK3R1P279862EBI-1570571,EBI-79464
    PLCG1P191744EBI-1570571,EBI-79387

    Protein-protein interaction databases

    BioGridi116598. 15 interactions.
    DIPiDIP-52255N.
    IntActiQ9UPX8. 10 interactions.
    MINTiMINT-2822695.
    STRINGi9606.ENSP00000345193.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPX8.
    SMRiQ9UPX8. Positions 148-205, 240-343, 1404-1467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini147 – 20660SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 34195PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini1407 – 147064SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi948 – 9547SH3-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi509 – 53527Pro-richAdd
    BLAST

    Domaini

    The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3.By similarity

    Sequence similaritiesi

    Belongs to the SHANK family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3-binding

    Phylogenomic databases

    eggNOGiNOG265246.
    HOGENOMiHOG000293276.
    HOVERGENiHBG054027.
    KOiK15009.
    PhylomeDBiQ9UPX8.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q9UPX8-1) [UniParc]FASTAAdd to Basket

    Also known as: A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSLLNAFTK KEVPFREAPA YSNRRRRPPN TLAAPRVLLR SNSDNNLNAS     50
    APDWAVCSTA TSHRSLSPQL LQQMPSKPEG AAKTIGSYVP GPRSRSPSLN 100
    RLGGAGEDGK RPQPLWHVGS PFALGANKDS LSAFEYPGPK RKLYSAVPGR 150
    LFVAVKPYQP QVDGEIPLHR GDRVKVLSIG EGGFWEGSAR GHIGWFPAEC 200
    VEEVQCKPRD SQAETRADRS KKLFRHYTVG SYDSFDTSSD CIIEEKTVVL 250
    QKKDNEGFGF VLRGAKADTP IEEFTPTPAF PALQYLESVD EGGVAWQAGL 300
    RTGDFLIEVN NENVVKVGHR QVVNMIRQGG NHLVLKVVTV TRNLDPDDTA 350
    RKKAPPPPKR APTTALTLRS KSMTSELEEL VDKASVRKKK DKPEEIVPAS 400
    KPSRAAENMA VEPRVATIKQ RPSSRCFPAG SDMNSVYERQ GIAVMTPTVP 450
    GSPKAPFLGI PRGTMRRQKS IDSRIFLSGI TEEERQFLAP PMLKFTRSLS 500
    MPDTSEDIPP PPQSVPPSPP PPSPTTYNCP KSPTPRVYGT IKPAFNQNSA 550
    AKVSPATRSD TVATMMREKG MYFRRELDRY SLDSEDLYSR NAGPQANFRN 600
    KRGQMPENPY SEVGKIASKA VYVPAKPARR KGMLVKQSNV EDSPEKTCSI 650
    PIPTIIVKEP STSSSGKSSQ GSSMEIDPQA PEPPSQLRPD ESLTVSSPFA 700
    AAIAGAVRDR EKRLEARRNS PAFLSTDLGD EDVGLGPPAP RTRPSMFPEE 750
    GDFADEDSAE QLSSPMPSAT PREPENHFVG GAEASAPGEA GRPLNSTSKA 800
    QGPESSPAVP SASSGTAGPG NYVHPLTGRL LDPSSPLALA LSARDRAMKE 850
    SQQGPKGEAP KADLNKPLYI DTKMRPSLDA GFPTVTRQNT RGPLRRQETE 900
    NKYETDLGRD RKGDDKKNML IDIMDTSQQK SAGLLMVHTV DATKLDNALQ 950
    EEDEKAEVEM KPDSSPSEVP EGVSETEGAL QISAAPEPTT VPGRTIVAVG 1000
    SMEEAVILPF RIPPPPLASV DLDEDFIFTE PLPPPLEFAN SFDIPDDRAA 1050
    SVPALSDLVK QKKSDTPQSP SLNSSQPTNS ADSKKPASLS NCLPASFLPP 1100
    PESFDAVADS GIEEVDSRSS SDHHLETTST ISTVSSISTL SSEGGENVDT 1150
    CTVYADGQAF MVDKPPVPPK PKMKPIIHKS NALYQDALVE EDVDSFVIPP 1200
    PAPPPPPGSA QPGMAKVLQP RTSKLWGDVT EIKSPILSGP KANVISELNS 1250
    ILQQMNREKL AKPGEGLDSP MGAKSASLAP RSPEIMSTIS GTRSTTVTFT 1300
    VRPGTSQPIT LQSRPPDYES RTSGTRRAPS PVVSPTEMNK ETLPAPLSAA 1350
    TASPSPALSD VFSLPSQPPS GDLFGLNPAG RSRSPSPSIL QQPISNKPFT 1400
    TKPVHLWTKP DVADWLESLN LGEHKEAFMD NEIDGSHLPN LQKEDLIDLG 1450
    VTRVGHRMNI ERALKQLLDR 1470
    Length:1,470
    Mass (Da):158,822
    Last modified:July 28, 2009 - v3
    Checksum:i7322993CB9FE0929
    GO
    Isoform 2 (identifier: Q9UPX8-2) [UniParc]FASTAAdd to Basket

    Also known as: C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-237: Missing.
         238-238: S → MMMNVPGGGAAAVMMTGYNNGRCPRNSLY
         472-490: DSRIFLSGITEEERQFLAP → GKKCGTPPQKLPLGFQTQP
         491-1470: Missing.

    Show »
    Length:281
    Mass (Da):30,564
    Checksum:iBD2ECD1A98B92FF4
    GO
    Isoform 3 (identifier: Q9UPX8-3) [UniParc]FASTAAdd to Basket

    Also known as: E

    The sequence of this isoform differs from the canonical sequence as follows:
         1-12: MKSLLNAFTKKE → MPRSPTSSED...YIKNHKETDI

    Note: Contains 6 ANK repeats at positions 196-226, 230-259, 263-293, 297-326, 330-359, 363-393.

    Show »
    Length:1,849
    Mass (Da):201,261
    Checksum:i45550DC5D5701399
    GO
    Isoform 4 (identifier: Q9UPX8-4) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-237: Missing.
         238-238: S → MMMNVPGGGAAAVMMTGYNNGRCPRNSLY
         383-389: Missing.

    Show »
    Length:1,254
    Mass (Da):134,931
    Checksum:iF9D53FB165A65E0A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 237237Missing in isoform 2 and isoform 4. 1 PublicationVSP_037793Add
    BLAST
    Alternative sequencei1 – 1212MKSLL…FTKKE → MPRSPTSSEDEMAQSFSDYS VGSESDSSKEETIYDTIRAT AEKPGGARTEESQGNTLVIR VVIHDLQQTKCIRFNPDATV WVAKQRILCTLTQSLKDVLN YGLFQPASNGRDGKFLDEER LLREYPQPVGEGVPSLEFRY KKRVYKQASLDEKQLAKLHT KTNLKKCMDHIQHRLVEKIT KMLDRGLDPNFHDPETGETP LTLAAQLDDSVEVIKALKNG GAHLDFRAKDGMTALHKAAR ARNQVALKTLLELGASPDYK DSYGLTPLYHTAIVGGDPYC CELLLHEHATVCCKDENGWH EIHQACRYGHVQHLEHLLFY GADMSAQNASGNTALHICAL YNQDSCARVLLFRGGNKELK NYNSQTPFQVAIIAGNFELA EYIKNHKETDI in isoform 3. 2 PublicationsVSP_037794Add
    BLAST
    Alternative sequencei238 – 2381S → MMMNVPGGGAAAVMMTGYNN GRCPRNSLY in isoform 2 and isoform 4. 1 PublicationVSP_037795
    Alternative sequencei383 – 3897Missing in isoform 4. CuratedVSP_037796
    Alternative sequencei472 – 49019DSRIF…QFLAP → GKKCGTPPQKLPLGFQTQP in isoform 2. 1 PublicationVSP_037797Add
    BLAST
    Alternative sequencei491 – 1470980Missing in isoform 2. 1 PublicationVSP_037798Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB208025 mRNA. Translation: BAH37016.1.
    AB208026 mRNA. Translation: BAH37017.1.
    AP000590 Genomic DNA. No translation available.
    AP001271 Genomic DNA. No translation available.
    AP003783 Genomic DNA. No translation available.
    AP005401 Genomic DNA. No translation available.
    BC093885 mRNA. Translation: AAH93885.1.
    BC112097 mRNA. Translation: AAI12098.1.
    DQ152234 mRNA. Translation: AAZ77790.1.
    AB028945 mRNA. Translation: BAA82974.1.
    AF141901 mRNA. Translation: AAF02496.1.
    RefSeqiNP_036441.2. NM_012309.4. [Q9UPX8-3]
    NP_573573.2. NM_133266.4.
    XP_005277987.1. XM_005277930.1. [Q9UPX8-3]
    XP_005277989.1. XM_005277932.1. [Q9UPX8-1]
    UniGeneiHs.268726.

    Genome annotation databases

    EnsembliENST00000423696; ENSP00000394536; ENSG00000162105. [Q9UPX8-1]
    ENST00000449833; ENSP00000399423; ENSG00000162105. [Q9UPX8-4]
    GeneIDi22941.
    KEGGihsa:22941.
    UCSCiuc001opz.3. human. [Q9UPX8-4]
    uc001oqc.3. human. [Q9UPX8-3]

    Polymorphism databases

    DMDMi254763402.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB208025 mRNA. Translation: BAH37016.1 .
    AB208026 mRNA. Translation: BAH37017.1 .
    AP000590 Genomic DNA. No translation available.
    AP001271 Genomic DNA. No translation available.
    AP003783 Genomic DNA. No translation available.
    AP005401 Genomic DNA. No translation available.
    BC093885 mRNA. Translation: AAH93885.1 .
    BC112097 mRNA. Translation: AAI12098.1 .
    DQ152234 mRNA. Translation: AAZ77790.1 .
    AB028945 mRNA. Translation: BAA82974.1 .
    AF141901 mRNA. Translation: AAF02496.1 .
    RefSeqi NP_036441.2. NM_012309.4. [Q9UPX8-3 ]
    NP_573573.2. NM_133266.4.
    XP_005277987.1. XM_005277930.1. [Q9UPX8-3 ]
    XP_005277989.1. XM_005277932.1. [Q9UPX8-1 ]
    UniGenei Hs.268726.

    3D structure databases

    ProteinModelPortali Q9UPX8.
    SMRi Q9UPX8. Positions 148-205, 240-343, 1404-1467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116598. 15 interactions.
    DIPi DIP-52255N.
    IntActi Q9UPX8. 10 interactions.
    MINTi MINT-2822695.
    STRINGi 9606.ENSP00000345193.

    Polymorphism databases

    DMDMi 254763402.

    Proteomic databases

    MaxQBi Q9UPX8.
    PaxDbi Q9UPX8.
    PRIDEi Q9UPX8.

    Protocols and materials databases

    DNASUi 22941.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000423696 ; ENSP00000394536 ; ENSG00000162105 . [Q9UPX8-1 ]
    ENST00000449833 ; ENSP00000399423 ; ENSG00000162105 . [Q9UPX8-4 ]
    GeneIDi 22941.
    KEGGi hsa:22941.
    UCSCi uc001opz.3. human. [Q9UPX8-4 ]
    uc001oqc.3. human. [Q9UPX8-3 ]

    Organism-specific databases

    CTDi 22941.
    GeneCardsi GC11M070313.
    GeneReviewsi SHANK2.
    H-InvDB HIX0171293.
    HGNCi HGNC:14295. SHANK2.
    HPAi HPA008174.
    MIMi 603290. gene.
    613436. phenotype.
    neXtProti NX_Q9UPX8.
    Orphaneti 106. Autism.
    PharmGKBi PA37867.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265246.
    HOGENOMi HOG000293276.
    HOVERGENi HBG054027.
    KOi K15009.
    PhylomeDBi Q9UPX8.

    Enzyme and pathway databases

    SignaLinki Q9UPX8.

    Miscellaneous databases

    GeneWikii SHANK2.
    GenomeRNAii 22941.
    NextBioi 43691.
    PROi Q9UPX8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPX8.
    Bgeei Q9UPX8.
    CleanExi HS_SHANK2.
    Genevestigatori Q9UPX8.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00595. PDZ. 1 hit.
    PF00536. SAM_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00454. SAM. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A molecular scaffolding protein, Shank2, is a potent tumor suppressor in esophageal squamous cell carcinoma."
      Akahane T., Hosoda F., Arai Y., Fujisawa N., Kitabayashi I., Ohta T., Aoyagi K., Sasaki H., Nakanishi Y., Hirohashi S., Ohki M.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-328 (ISOFORM 3), TISSUE SPECIFICITY.
    5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Brain.
    6. "Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development."
      Lim S., Naisbitt S., Yoon J., Hwang J.-I., Suh P.-G., Sheng M., Kim E.
      J. Biol. Chem. 274:29510-29518(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    7. "The Shank family of scaffold proteins."
      Sheng M., Kim E.
      J. Cell Sci. 113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton."
      Okamoto P.M., Gamby C., Wells D., Fallon J., Vallee R.B.
      J. Biol. Chem. 276:48458-48465(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DNM2.
    9. "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42."
      Soltau M., Richter D., Kreienkamp H.-J.
      Mol. Cell. Neurosci. 21:575-583(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BAIAP2.
    10. "Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors."
      Lee J.H., Richter W., Namkung W., Kim K.H., Kim E., Conti M., Lee M.G.
      J. Biol. Chem. 282:10414-10422(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDE4D, TISSUE SPECIFICITY.
    11. "Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation."
      Berkel S., Marshall C.R., Weiss B., Howe J., Roeth R., Moog U., Endris V., Roberts W., Szatmari P., Pinto D., Bonin M., Riess A., Engels H., Sprengel R., Scherer S.W., Rappold G.A.
      Nat. Genet. 42:489-491(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN AUTS17.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSHAN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPX8
    Secondary accession number(s): C0SPG8
    , C0SPG9, Q3Y8G9, Q52LK2, Q9UKP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3