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Protein

Protein turtle homolog B

Gene

IGSF9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein turtle homolog B
Alternative name(s):
Immunoglobulin superfamily member 9B
Short name:
IgSF9B
Gene namesi
Name:IGSF9B
Synonyms:KIAA1030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:32326. IGSF9B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 722702ExtracellularSequence analysisAdd
BLAST
Transmembranei723 – 74321HelicalSequence analysisAdd
BLAST
Topological domaini744 – 1349606CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671660.

Polymorphism and mutation databases

DMDMi158706512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 13491329Protein turtle homolog BPRO_0000306110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 113PROSITE-ProRule annotation
Disulfide bondi161 ↔ 208PROSITE-ProRule annotation
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi250 ↔ 303PROSITE-ProRule annotation
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
Disulfide bondi442 ↔ 488PROSITE-ProRule annotation
Glycosylationi624 – 6241N-linked (GlcNAc...)Sequence analysis
Modified residuei775 – 7751PhosphoserineBy similarity
Modified residuei783 – 7831PhosphoserineBy similarity
Modified residuei794 – 7941PhosphoserineBy similarity
Modified residuei1207 – 12071PhosphoserineBy similarity
Modified residuei1215 – 12151PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated and sialylated. Not significantly O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9UPX0.
PaxDbiQ9UPX0.
PeptideAtlasiQ9UPX0.
PRIDEiQ9UPX0.

PTM databases

iPTMnetiQ9UPX0.
PhosphoSiteiQ9UPX0.

Expressioni

Gene expression databases

BgeeiQ9UPX0.
CleanExiHS_IGSF9B.
ExpressionAtlasiQ9UPX0. baseline and differential.

Organism-specific databases

HPAiHPA010802.

Interactioni

Subunit structurei

Found in a complex with MAGI2 and NLGN2, where it interacts with MAGI2 (via PDZ 5 and PDZ 6 domains).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000317980.

Structurei

3D structure databases

ProteinModelPortaliQ9UPX0.
SMRiQ9UPX0. Positions 28-708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 129106Ig-like 1Add
BLAST
Domaini139 – 22688Ig-like 2Add
BLAST
Domaini228 – 32093Ig-like 3Add
BLAST
Domaini324 – 41592Ig-like 4Add
BLAST
Domaini420 – 50485Ig-like 5Add
BLAST
Domaini512 – 60493Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini614 – 70895Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi924 – 1342419Pro-richAdd
BLAST

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
KOG4222. Eukaryota.
ENOG410XNZS. LUCA.
GeneTreeiENSGT00530000063887.
HOGENOMiHOG000154717.
HOVERGENiHBG088669.
InParanoidiQ9UPX0.
OMAiITMTCTA.
OrthoDBiEOG7M98FF.
PhylomeDBiQ9UPX0.
TreeFamiTF326128.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWYVATFIA SVIGTRGLAA EGAHGLREEP EFVTARAGES VVLRCDVIHP
60 70 80 90 100
VTGQPPPYVV EWFKFGVPIP IFIKFGYYPP HVDPEYAGRA SLHDKASLRL
110 120 130 140 150
EQVRSEDQGW YECKVLMLDQ QYDTFHNGSW VHLTINAPPT FTETPPQYIE
160 170 180 190 200
AKEGGSITMT CTAFGNPKPI VTWLKEGTLL GASGKYQVSD GSLTVTSVSR
210 220 230 240 250
EDRGAYTCRA YSIQGEAVHT THLLVQGPPF IVSPPENITV NISQDALLTC
260 270 280 290 300
RAEAYPGNLT YTWYWQDENV YFQNDLKLRV RILIDGTLII FRVKPEDSGK
310 320 330 340 350
YTCVPSNSLG RSPSASAYLT VQYPARVLNM PPVIYVPVGI HGYIRCPVDA
360 370 380 390 400
EPPATVVKWN KDGRPLQVEK NLGWTLMEDG SIRIEEATEE ALGTYTCVPY
410 420 430 440 450
NTLGTMGQSA PARLVLKDPP YFTVLPGWEY RQEAGRELLI PCAAAGDPFP
460 470 480 490 500
VITWRKVGKP SRSKHSALPS GSLQFRALSK EDHGEWECVA TNVVTSITAS
510 520 530 540 550
THLTVIGTSP HAPGSVRVQV SMTTANVSWE PGYDGGYEQT FSVWMKRAQF
560 570 580 590 600
GPHDWLSLPV PPGPSWLLVD TLEPETAYQF SVLAQNKLGT SAFSEVVTVN
610 620 630 640 650
TLAFPITTPE PLVLVTPPRC LIANRTQQGV LLSWLPPANH SFPIDRYIME
660 670 680 690 700
FRVAERWELL DDGIPGTEGE FFAKDLSQDT WYEFRVLAVM QDLISEPSNI
710 720 730 740 750
AGVSSTDIFP QPDLTEDGLA RPVLAGIVAT ICFLAAAILF STLAACFVNK
760 770 780 790 800
QRKRKLKRKK DPPLSITHCR KSLESPLSSG KVSPESIRTL RAPSESSDDQ
810 820 830 840 850
GQPAAKRMLS PTREKELSLY KKTKRAISSK KYSVAKAEAE AEATTPIELI
860 870 880 890 900
SRGPDGRFVM DPAEMEPSLK SRRIEGFPFA EETDMYPEFR QSDEENEDPL
910 920 930 940 950
VPTSVAALKS QLTPLSSSQE SYLPPPAYSP RFQPRGLEGP GGLEGRLQAT
960 970 980 990 1000
GQARPPAPRP FHHGQYYGYL SSSSPGEVEP PPFYVPEVGS PLSSVMSSPP
1010 1020 1030 1040 1050
LPTEGPFGHP TIPEENGENA SNSTLPLTQT PTGGRSPEPW GRPEFPFGGL
1060 1070 1080 1090 1100
ETPAMMFPHQ LPPCDVPESL QPKAGLPRGL PPTSLQVPAA YPGILSLEAP
1110 1120 1130 1140 1150
KGWAGKSPGR GPVPAPPAAK WQDRPMQPLV SQGQLRHTSQ GMGIPVLPYP
1160 1170 1180 1190 1200
EPAEPGAHGG PSTFGLDTRW YEPQPRPRPS PRQARRAEPS LHQVVLQPSR
1210 1220 1230 1240 1250
LSPLTQSPLS SRTGSPELAA RARPRPGLLQ QAEMSEITLQ PPAAVSFSRK
1260 1270 1280 1290 1300
STPSTGSPSQ SSRSGSPSYR PAMGFTTLAT GYPSPPPGPA PAGPGDSLDV
1310 1320 1330 1340
FGQTPSPRRT GEELLRPETP PPTLPTSGKL QRDRPAPATS PPERALSKL
Length:1,349
Mass (Da):147,089
Last modified:October 2, 2007 - v2
Checksum:iC8A15ED782EB3893
GO
Isoform 2 (identifier: Q9UPX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1329-1349: KLQRDRPAPATSPPERALSKL → TLPPAPGNAA...HDDPGHATLL

Note: Gene prediction based on EST data.
Show »
Length:1,437
Mass (Da):156,887
Checksum:i11BBEEFCCCE12A62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1331 – 13311Q → R in BAA82982 (PubMed:10470851).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1329 – 134921KLQRD…ALSKL → TLPPAPGNAAAPERLEALKY QRIKKPKKSSKGSSKSKKRS DDSASQTQQLPNSQVLWPDE AVCLRKKKRHSRPDPFARLS DLCHRQLPEDQTAILNSVDH DDPGHATLL in isoform 2. CuratedVSP_054730Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000911 Genomic DNA. No translation available.
AP001979 Genomic DNA. No translation available.
AB028953 mRNA. Translation: BAA82982.1.
CCDSiCCDS61010.1. [Q9UPX0-2]
RefSeqiNP_001264214.1. NM_001277285.1. [Q9UPX0-2]
UniGeneiHs.204121.
Hs.440476.

Genome annotation databases

EnsembliENST00000321016; ENSP00000317980; ENSG00000080854. [Q9UPX0-1]
ENST00000533871; ENSP00000436552; ENSG00000080854. [Q9UPX0-2]
GeneIDi22997.
KEGGihsa:22997.
UCSCiuc031qfh.2. human. [Q9UPX0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000911 Genomic DNA. No translation available.
AP001979 Genomic DNA. No translation available.
AB028953 mRNA. Translation: BAA82982.1.
CCDSiCCDS61010.1. [Q9UPX0-2]
RefSeqiNP_001264214.1. NM_001277285.1. [Q9UPX0-2]
UniGeneiHs.204121.
Hs.440476.

3D structure databases

ProteinModelPortaliQ9UPX0.
SMRiQ9UPX0. Positions 28-708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317980.

PTM databases

iPTMnetiQ9UPX0.
PhosphoSiteiQ9UPX0.

Polymorphism and mutation databases

DMDMi158706512.

Proteomic databases

EPDiQ9UPX0.
PaxDbiQ9UPX0.
PeptideAtlasiQ9UPX0.
PRIDEiQ9UPX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321016; ENSP00000317980; ENSG00000080854. [Q9UPX0-1]
ENST00000533871; ENSP00000436552; ENSG00000080854. [Q9UPX0-2]
GeneIDi22997.
KEGGihsa:22997.
UCSCiuc031qfh.2. human. [Q9UPX0-1]

Organism-specific databases

CTDi22997.
GeneCardsiIGSF9B.
H-InvDBHIX0010294.
HGNCiHGNC:32326. IGSF9B.
HPAiHPA010802.
MIMi613773. gene.
neXtProtiNX_Q9UPX0.
PharmGKBiPA142671660.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
KOG4222. Eukaryota.
ENOG410XNZS. LUCA.
GeneTreeiENSGT00530000063887.
HOGENOMiHOG000154717.
HOVERGENiHBG088669.
InParanoidiQ9UPX0.
OMAiITMTCTA.
OrthoDBiEOG7M98FF.
PhylomeDBiQ9UPX0.
TreeFamiTF326128.

Miscellaneous databases

ChiTaRSiIGSF9B. human.
GenomeRNAii22997.
PROiQ9UPX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UPX0.
CleanExiHS_IGSF9B.
ExpressionAtlasiQ9UPX0. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
SM00406. IGv. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 585-1349 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiTUTLB_HUMAN
AccessioniPrimary (citable) accession number: Q9UPX0
Secondary accession number(s): G5EA26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.