Q9UPW5 (CBPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytosolic carboxypeptidase 1
EC=3.4.17.-

Alternative name(s):
ATP/GTP-binding protein 1
Nervous system nuclear protein induced by axotomy protein 1 homolog

Gene names

Name:	AGTPBP1
Synonyms:	CCP1, KIAA1035, NNA1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1226 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Interacts with MYLK By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Nucleus By similarity. Mitochondrion By similarity.
Sequence similarities	Belongs to the peptidase M14 family.
Sequence caution	The sequence BAA82987.2 differs from that shown. Reason: Frameshift at position 10. The sequence BAB14100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14505.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAG61460.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH56222.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAW62697.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	C-terminal protein deglutamylation Inferred from sequence or structural similarity. Source: UniProtKB adult walking behavior Inferred from electronic annotation. Source: Compara cerebellar Purkinje cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB eye photoreceptor cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion organization Inferred from sequence or structural similarity. Source: UniProtKB neuromuscular process Inferred from sequence or structural similarity. Source: UniProtKB neurotransmitter metabolic process Inferred from electronic annotation. Source: Compara olfactory bulb development Inferred from sequence or structural similarity. Source: UniProtKB protein side chain deglutamylation Inferred from sequence or structural similarity. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: UniProtKB-KW retina development in camera-type eye Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metallocarboxypeptidase activity Inferred from sequence or structural similarity. Source: UniProtKB tubulin binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UPW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UPW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     304-343: Missing.

Isoform 3 (identifier: Q9UPW5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MSKLKVIPEKS → MRTGSAASSAAAAAAAAAASASPATGVCMKTPGGGRRGIRRDPGAEPGAAALRGPRQRPILSR
     304-343: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1226	1226	Cytosolic carboxypeptidase 1		PRO_0000308690
Sites
	Active site	970	1	Nucleophile By similarity
	Metal binding	920	1	Zinc By similarity
	Metal binding	923	1	Zinc By similarity
	Metal binding	1017	1	Zinc By similarity
Natural variations
	Alternative sequence	1 – 11	11	MSKLKVIPEKS → MRTGSAASSAAAAAAAAAAS ASPATGVCMKTPGGGRRGIR RDPGAEPGAAALRGPRQRPI LSR in isoform 3.		VSP_040422
	Alternative sequence	304 – 343	40	Missing in isoform 2 and isoform 3.		VSP_029044
	Natural variant	423	1	E → K in a colorectal cancer sample; somatic mutation. Ref.11		VAR_036884
Experimental info
	Sequence conflict	274	1	Q → R in BAA91749. Ref.3
	Sequence conflict	398 – 399	2	DI → KK in CAH56222. Ref.7
	Sequence conflict	464	1	E → G in BAA91749. Ref.3
	Sequence conflict	495	1	M → V in BAB14505. Ref.3
	Sequence conflict	574	1	M → V in BAB14100. Ref.3
	Sequence conflict	598	1	E → G in BAA91749. Ref.3
	Sequence conflict	712	1	F → I in CAH56222. Ref.7
	Sequence conflict	756	1	M → T in BAB14100. Ref.3
	Sequence conflict	812	1	S → P in BAB14505. Ref.3
	Sequence conflict	830	1	T → A in CAH56158. Ref.7
	Sequence conflict	909	1	N → D in BAB14505. Ref.3
	Sequence conflict	975	1	G → R in BAG58598. Ref.3
	Sequence conflict	1054	1	Y → F in BAB14505. Ref.3
	Sequence conflict	1153	1	L → P in CAH56158. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 3. Checksum: A6D598D11D2BD1F8	FASTA	1,226	138,448
	10 20 30 40 50 60 MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT 70 80 90 100 110 120 AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN 130 140 150 160 170 180 ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL 190 200 210 220 230 240 QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA 250 260 270 280 290 300 VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN 310 320 330 340 350 360 TSQECLAVRT LDPLVNTSSL IMRKCFPKNR LPLPTIKSSF HFQLPVIPVT GPVAQLYSLP 370 380 390 400 410 420 PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE TDINKLKPQQ EPGRTIEDLK 430 440 450 460 470 480 MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT AGEETSGNSG NLRKVVMKEN 490 500 510 520 530 540 ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI SSVHGLNNDI VKALDRITLQ 550 560 570 580 590 600 NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV LFEGRTVQLG KLCCTGVETE 610 620 630 640 650 660 DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV PEYSEVAYPD YFGHIPPPFK 670 680 690 700 710 720 EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN YTIPEEGDIL KFNSKFESGN 730 740 750 760 770 780 LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV AYRFNIINCE KSNSQFNYGM 790 800 810 820 830 840 QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG QKGKSYYTIT FTVNFPHKDD 850 860 870 880 890 900 VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE TLSGNSCPLV TITAMPESNY 910 920 930 940 950 960 YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN NPTAQSLRES YIFKIVPMLN 970 980 990 1000 1010 1020 PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL QYLAAVKRLP LVYCDYHGHS 1030 1040 1050 1060 1070 1080 RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI LSHIAPAFCM SSCSFVVEKS 1090 1100 1110 1120 1130 1140 KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT RELEEMGAKF CVGLLRLKRL 1150 1160 1170 1180 1190 1200 TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR FLEEVDYSAE SNDELDIELA 1210 1220 ENVGDYEPSA QEEVLSDSEL SRTYLP
	Isoform 2 [UniParc]. Checksum: D5361B66224C04BE	FASTA	1,186	133,864
	10 20 30 40 50 60 MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT 70 80 90 100 110 120 AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN 130 140 150 160 170 180 ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL 190 200 210 220 230 240 QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA 250 260 270 280 290 300 VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN 310 320 330 340 350 360 TSQLPVIPVT GPVAQLYSLP PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE 370 380 390 400 410 420 TDINKLKPQQ EPGRTIEDLK MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT 430 440 450 460 470 480 AGEETSGNSG NLRKVVMKEN ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI 490 500 510 520 530 540 SSVHGLNNDI VKALDRITLQ NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV 550 560 570 580 590 600 LFEGRTVQLG KLCCTGVETE DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV 610 620 630 640 650 660 PEYSEVAYPD YFGHIPPPFK EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN 670 680 690 700 710 720 YTIPEEGDIL KFNSKFESGN LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV 730 740 750 760 770 780 AYRFNIINCE KSNSQFNYGM QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG 790 800 810 820 830 840 QKGKSYYTIT FTVNFPHKDD VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE 850 860 870 880 890 900 TLSGNSCPLV TITAMPESNY YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN 910 920 930 940 950 960 NPTAQSLRES YIFKIVPMLN PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL 970 980 990 1000 1010 1020 QYLAAVKRLP LVYCDYHGHS RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI 1030 1040 1050 1060 1070 1080 LSHIAPAFCM SSCSFVVEKS KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT 1090 1100 1110 1120 1130 1140 RELEEMGAKF CVGLLRLKRL TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR 1150 1160 1170 1180 FLEEVDYSAE SNDELDIELA ENVGDYEPSA QEEVLSDSEL SRTYLP
	Isoform 3 [UniParc]. Checksum: 8119980498634DDF	FASTA	1,238	138,647
	10 20 30 40 50 60 MRTGSAASSA AAAAAAAAAS ASPATGVCMK TPGGGRRGIR RDPGAEPGAA ALRGPRQRPI 70 80 90 100 110 120 LSRLTNNSRI VGLLAQLEKI NAEPSESDTA RYVTSKILHL AQSQEKTRRE MTAKGSTGME 130 140 150 160 170 180 ILLSTLENTK DLQTTLNILS ILVELVSAGG GRRVSFLVTK GGSQILLQLL MNASKESPPH 190 200 210 220 230 240 EDLMVQIHSI LAKIGPKDKK FGVKARINGA LNITLNLVKQ NLQNHRLVLP CLQLLRVYSA 250 260 270 280 290 300 NSVNSVSLGK NGVVELMFKI IGPFSKKNSS LIKVALDTLA ALLKSKTNAR RAVDRGYVQV 310 320 330 340 350 360 LLTIYVDWHR HDNRHRNMLI RKGILQSLKS VTNIKLGRKA FIDANGMKIL YNTSQLPVIP 370 380 390 400 410 420 VTGPVAQLYS LPPEVDDVVD ESDDNDDIDV EAENETENED DLDQNFKNDD IETDINKLKP 430 440 450 460 470 480 QQEPGRTIED LKMYEHLFPE LVDDFQDYDL ISKEPKPFVF EGKVRGPIVV PTAGEETSGN 490 500 510 520 530 540 SGNLRKVVMK ENISSKGDEG EKKSTFMDLA KEDIKDNDRT LQQQPGDQNR TISSVHGLNN 550 560 570 580 590 600 DIVKALDRIT LQNIPSQTAP GFTAEMKKDC SLPLTVLTCA KACPHMATCG NVLFEGRTVQ 610 620 630 640 650 660 LGKLCCTGVE TEDDEDTESN SSVEQASVEV PDGPTLHDPD LYIEIVKNTK SVPEYSEVAY 670 680 690 700 710 720 PDYFGHIPPP FKEPILERPY GVQRTKIAQD IERLIHQSDI IDRVVYDLDN PNYTIPEEGD 730 740 750 760 770 780 ILKFNSKFES GNLRKVIQIR KNEYDLILNS DINSNHYHQW FYFEVSGMRP GVAYRFNIIN 790 800 810 820 830 840 CEKSNSQFNY GMQPLMYSVQ EALNARPWWI RMGTDICYYK NHFSRSSVAA GGQKGKSYYT 850 860 870 880 890 900 ITFTVNFPHK DDVCYFAYHY PYTYSTLQMH LQKLESAHNP QQIYFRKDVL CETLSGNSCP 910 920 930 940 950 960 LVTITAMPES NYYEHICHFR NRPYVFLSAR VHPGETNASW VMKGTLEYLM SNNPTAQSLR 970 980 990 1000 1010 1020 ESYIFKIVPM LNPDGVINGN HRCSLSGEDL NRQWQSPSPD LHPTIYHAKG LLQYLAAVKR 1030 1040 1050 1060 1070 1080 LPLVYCDYHG HSRKKNVFMY GCSIKETVWH TNDNATSCDV VEDTGYRTLP KILSHIAPAF 1090 1100 1110 1120 1130 1140 CMSSCSFVVE KSKESTARVV VWREIGVQRS YTMESTLCGC DQGKYKGLQI GTRELEEMGA 1150 1160 1170 1180 1190 1200 KFCVGLLRLK RLTSPLEYNL PSSLLDFEND LIESSCKVTS PTTYVLDEDE PRFLEEVDYS 1210 1220 1230 AESNDELDIE LAENVGDYEP SAQEEVLSDS ELSRTYLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Hippocampus.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-1226. Tissue: Esophageal carcinoma and Lymph node.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-423.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028958 mRNA. Translation: BAA82987.2. Frameshift. AK001544 mRNA. Translation: BAA91749.1. AK022562 mRNA. Translation: BAB14100.1. Different initiation. AK023280 mRNA. Translation: BAB14505.1. Different initiation. AK295774 mRNA. Translation: BAG58598.1. AK299506 mRNA. Translation: BAG61460.1. Different initiation. AL157882, AL451131 Genomic DNA. Translation: CAH71213.1. AL157882, AL451131 Genomic DNA. Translation: CAH71214.1. AL451131, AL157882 Genomic DNA. Translation: CAH72317.1. AL451131, AL157882 Genomic DNA. Translation: CAH72318.1. CH471089 Genomic DNA. Translation: EAW62694.1. CH471089 Genomic DNA. Translation: EAW62698.1. CH471089 Genomic DNA. Translation: EAW62697.1. Sequence problems. BC060815 mRNA. Translation: AAH60815.1. BX648366 mRNA. Translation: CAH56158.1. AL833359 mRNA. Translation: CAH56222.1. Different initiation.
IPI	IPI00167865. IPI00418530. IPI00942428.
RefSeq	NP_056054.2. NM_015239.2.
UniGene	Hs.719980.
3D structure databases
ProteinModelPortal	Q9UPW5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UPW5. 9 interactions.
MINT	MINT-2858492.
STRING	9606.ENSP00000338512.
Protein family/group databases
MEROPS	M14.028.
PTM databases
PhosphoSite	Q9UPW5.
Polymorphism databases
DMDM	160019039.
Proteomic databases
PaxDb	Q9UPW5.
PRIDE	Q9UPW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357081; ENSP00000349592; ENSG00000135049. ENST00000376083; ENSP00000365251; ENSG00000135049. ENST00000376109; ENSP00000365277; ENSG00000135049.
GeneID	23287.
KEGG	hsa:23287.
UCSC	uc004aod.4. human. uc010mqc.3. human. uc011lte.2. human.
Organism-specific databases
CTD	23287.
GeneCards	GC09M088161.
HGNC	HGNC:17258. AGTPBP1.
MIM	606830. gene.
neXtProt	NX_Q9UPW5.
PharmGKB	PA24630.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2866.
HOVERGEN	HBG107587.
InParanoid	Q9UPW5.
OMA	VSGMRPG.
OrthoDB	EOG4TMR17.
Gene expression databases
ArrayExpress	Q9UPW5.
Bgee	Q9UPW5.
CleanEx	HS_AGTPBP1.
Genevestigator	Q9UPW5.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000834. Peptidase_M14. [Graphical view]
Pfam	PF00246. Peptidase_M14. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS00132. CARBOXYPEPT_ZN_1. False negative. PS00133. CARBOXYPEPT_ZN_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23287.
NextBio	45098.
SOURCE	Search...

Entry information

Entry name

CBPC1_HUMAN

Accession

Primary (citable) accession number: Q9UPW5
Secondary accession number(s): B4DIT6 , B4DRZ8, Q5VV80, Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	April 3, 2013
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.