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Protein

Forkhead box protein J3

Gene

FOXJ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi77 – 16892Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J3
Gene namesi
Name:FOXJ3
Synonyms:KIAA1041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29178. FOXJ3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945417.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Forkhead box protein J3PRO_0000091855Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei223 – 2231Phosphoserine4 Publications
Modified residuei295 – 2951Phosphoserine1 Publication
Modified residuei489 – 4891Phosphoserine1 Publication
Modified residuei606 – 6061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UPW0.
PaxDbiQ9UPW0.
PRIDEiQ9UPW0.

PTM databases

PhosphoSiteiQ9UPW0.

Expressioni

Gene expression databases

BgeeiQ9UPW0.
CleanExiHS_FOXJ3.
ExpressionAtlasiQ9UPW0. baseline and differential.
GenevestigatoriQ9UPW0.

Interactioni

Protein-protein interaction databases

BioGridi116553. 8 interactions.
IntActiQ9UPW0. 1 interaction.
STRINGi9606.ENSP00000354620.

Structurei

3D structure databases

ProteinModelPortaliQ9UPW0.
SMRiQ9UPW0. Positions 77-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000231184.
HOVERGENiHBG051648.
InParanoidiQ9UPW0.
KOiK09403.
OMAiVTSLRMT.
OrthoDBiEOG7RZ5RQ.
PhylomeDBiQ9UPW0.
TreeFamiTF333250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPW0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG
60 70 80 90 100
TGISKKNALL DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT
110 120 130 140 150
LSEIYQWICD NFPYYREAGS GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS
160 170 180 190 200
YWAIDTNPKE DVLPTRPKKR ARSVERASTP YSIDSDSLGM ECIISGSASP
210 220 230 240 250
TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV NLNSVGSVHS
260 270 280 290 300
YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY
310 320 330 340 350
KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS
360 370 380 390 400
NSHGSGLNTT GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP
410 420 430 440 450
APHPQQHSQL QSPHPQHPSP HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS
460 470 480 490 500
GVSNDWYATL DMLKESCRIA SSVNWSDVDL SQFQGLMESM RQADLKNWSL
510 520 530 540 550
DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT KPSQHIGTGN
560 570 580 590 600
LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA
610 620
FQMRRSLPPD DIQDDFDWDS IV
Length:622
Mass (Da):68,960
Last modified:May 18, 2010 - v2
Checksum:i2C53E63C76AF057B
GO
Isoform 2 (identifier: Q9UPW0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-210: Missing.

Show »
Length:588
Mass (Da):65,533
Checksum:i73DC52B528BC4CDC
GO

Sequence cautioni

The sequence BAA82993.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti485 – 4851G → GG in CAB75651. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621V → A.2 Publications
Corresponds to variant rs343376 [ dbSNP | Ensembl ].
VAR_039104
Natural varianti377 – 3771T → P.2 Publications
Corresponds to variant rs1139978 [ dbSNP | Ensembl ].
VAR_039105

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei177 – 21034Missing in isoform 2. 1 PublicationVSP_010367Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028964 mRNA. Translation: BAA82993.2. Different initiation.
AC096540 Genomic DNA. No translation available.
AC114492 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07162.1.
CH471059 Genomic DNA. Translation: EAX07163.1.
CH471059 Genomic DNA. Translation: EAX07164.1.
CH471059 Genomic DNA. Translation: EAX07165.1.
BC014182 mRNA. Translation: AAH14182.1.
BC151828 mRNA. Translation: AAI51829.1.
BC152441 mRNA. Translation: AAI52442.1.
AL157422 mRNA. Translation: CAB75651.2.
CCDSiCCDS30689.1. [Q9UPW0-1]
CCDS55594.1. [Q9UPW0-2]
PIRiT46900.
RefSeqiNP_001185779.1. NM_001198850.1. [Q9UPW0-1]
NP_001185780.1. NM_001198851.1. [Q9UPW0-1]
NP_001185781.1. NM_001198852.1. [Q9UPW0-2]
NP_055762.3. NM_014947.4. [Q9UPW0-1]
UniGeneiHs.26023.

Genome annotation databases

EnsembliENST00000361346; ENSP00000354620; ENSG00000198815. [Q9UPW0-1]
ENST00000361776; ENSP00000354449; ENSG00000198815. [Q9UPW0-2]
ENST00000372572; ENSP00000361653; ENSG00000198815. [Q9UPW0-1]
ENST00000372573; ENSP00000361654; ENSG00000198815. [Q9UPW0-1]
ENST00000545068; ENSP00000439044; ENSG00000198815. [Q9UPW0-1]
GeneIDi22887.
KEGGihsa:22887.
UCSCiuc001che.3. human. [Q9UPW0-1]
uc001chh.2. human. [Q9UPW0-2]

Polymorphism databases

DMDMi296434510.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028964 mRNA. Translation: BAA82993.2. Different initiation.
AC096540 Genomic DNA. No translation available.
AC114492 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07162.1.
CH471059 Genomic DNA. Translation: EAX07163.1.
CH471059 Genomic DNA. Translation: EAX07164.1.
CH471059 Genomic DNA. Translation: EAX07165.1.
BC014182 mRNA. Translation: AAH14182.1.
BC151828 mRNA. Translation: AAI51829.1.
BC152441 mRNA. Translation: AAI52442.1.
AL157422 mRNA. Translation: CAB75651.2.
CCDSiCCDS30689.1. [Q9UPW0-1]
CCDS55594.1. [Q9UPW0-2]
PIRiT46900.
RefSeqiNP_001185779.1. NM_001198850.1. [Q9UPW0-1]
NP_001185780.1. NM_001198851.1. [Q9UPW0-1]
NP_001185781.1. NM_001198852.1. [Q9UPW0-2]
NP_055762.3. NM_014947.4. [Q9UPW0-1]
UniGeneiHs.26023.

3D structure databases

ProteinModelPortaliQ9UPW0.
SMRiQ9UPW0. Positions 77-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116553. 8 interactions.
IntActiQ9UPW0. 1 interaction.
STRINGi9606.ENSP00000354620.

PTM databases

PhosphoSiteiQ9UPW0.

Polymorphism databases

DMDMi296434510.

Proteomic databases

MaxQBiQ9UPW0.
PaxDbiQ9UPW0.
PRIDEiQ9UPW0.

Protocols and materials databases

DNASUi22887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361346; ENSP00000354620; ENSG00000198815. [Q9UPW0-1]
ENST00000361776; ENSP00000354449; ENSG00000198815. [Q9UPW0-2]
ENST00000372572; ENSP00000361653; ENSG00000198815. [Q9UPW0-1]
ENST00000372573; ENSP00000361654; ENSG00000198815. [Q9UPW0-1]
ENST00000545068; ENSP00000439044; ENSG00000198815. [Q9UPW0-1]
GeneIDi22887.
KEGGihsa:22887.
UCSCiuc001che.3. human. [Q9UPW0-1]
uc001chh.2. human. [Q9UPW0-2]

Organism-specific databases

CTDi22887.
GeneCardsiGC01M042642.
HGNCiHGNC:29178. FOXJ3.
neXtProtiNX_Q9UPW0.
PharmGKBiPA134945417.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00780000121840.
HOGENOMiHOG000231184.
HOVERGENiHBG051648.
InParanoidiQ9UPW0.
KOiK09403.
OMAiVTSLRMT.
OrthoDBiEOG7RZ5RQ.
PhylomeDBiQ9UPW0.
TreeFamiTF333250.

Miscellaneous databases

ChiTaRSiFOXJ3. human.
GenomeRNAii22887.
NextBioi43479.
PROiQ9UPW0.

Gene expression databases

BgeeiQ9UPW0.
CleanExiHS_FOXJ3.
ExpressionAtlasiQ9UPW0. baseline and differential.
GenevestigatoriQ9UPW0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-162 AND PRO-377.
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-416 (ISOFORM 2), VARIANTS ALA-162 AND PRO-377.
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-622.
    Tissue: Amygdala.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-295 AND SER-489, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND SER-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFOXJ3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPW0
Secondary accession number(s): A7MBL7
, A7MD18, D3DPW2, Q9NSS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.