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Q9UPW0

- FOXJ3_HUMAN

UniProt

Q9UPW0 - FOXJ3_HUMAN

Protein

Forkhead box protein J3

Gene

FOXJ3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi77 – 16892Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein J3
    Gene namesi
    Name:FOXJ3
    Synonyms:KIAA1041
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:29178. FOXJ3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134945417.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Forkhead box protein J3PRO_0000091855Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei223 – 2231Phosphoserine4 Publications
    Modified residuei295 – 2951Phosphoserine1 Publication
    Modified residuei489 – 4891Phosphoserine1 Publication
    Modified residuei606 – 6061Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPW0.
    PaxDbiQ9UPW0.
    PRIDEiQ9UPW0.

    PTM databases

    PhosphoSiteiQ9UPW0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UPW0.
    BgeeiQ9UPW0.
    CleanExiHS_FOXJ3.
    GenevestigatoriQ9UPW0.

    Interactioni

    Protein-protein interaction databases

    BioGridi116553. 8 interactions.
    IntActiQ9UPW0. 1 interaction.
    STRINGi9606.ENSP00000354620.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPW0.
    SMRiQ9UPW0. Positions 77-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000231184.
    HOVERGENiHBG051648.
    InParanoidiQ9UPW0.
    KOiK09403.
    OMAiVTSLRMT.
    OrthoDBiEOG7RZ5RQ.
    PhylomeDBiQ9UPW0.
    TreeFamiTF333250.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UPW0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG    50
    TGISKKNALL DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT 100
    LSEIYQWICD NFPYYREAGS GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS 150
    YWAIDTNPKE DVLPTRPKKR ARSVERASTP YSIDSDSLGM ECIISGSASP 200
    TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV NLNSVGSVHS 250
    YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY 300
    KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS 350
    NSHGSGLNTT GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP 400
    APHPQQHSQL QSPHPQHPSP HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS 450
    GVSNDWYATL DMLKESCRIA SSVNWSDVDL SQFQGLMESM RQADLKNWSL 500
    DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT KPSQHIGTGN 550
    LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA 600
    FQMRRSLPPD DIQDDFDWDS IV 622
    Length:622
    Mass (Da):68,960
    Last modified:May 18, 2010 - v2
    Checksum:i2C53E63C76AF057B
    GO
    Isoform 2 (identifier: Q9UPW0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         177-210: Missing.

    Show »
    Length:588
    Mass (Da):65,533
    Checksum:i73DC52B528BC4CDC
    GO

    Sequence cautioni

    The sequence BAA82993.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti485 – 4851G → GG in CAB75651. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti162 – 1621V → A.2 Publications
    Corresponds to variant rs343376 [ dbSNP | Ensembl ].
    VAR_039104
    Natural varianti377 – 3771T → P.2 Publications
    Corresponds to variant rs1139978 [ dbSNP | Ensembl ].
    VAR_039105

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei177 – 21034Missing in isoform 2. 1 PublicationVSP_010367Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028964 mRNA. Translation: BAA82993.2. Different initiation.
    AC096540 Genomic DNA. No translation available.
    AC114492 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07162.1.
    CH471059 Genomic DNA. Translation: EAX07163.1.
    CH471059 Genomic DNA. Translation: EAX07164.1.
    CH471059 Genomic DNA. Translation: EAX07165.1.
    BC014182 mRNA. Translation: AAH14182.1.
    BC151828 mRNA. Translation: AAI51829.1.
    BC152441 mRNA. Translation: AAI52442.1.
    AL157422 mRNA. Translation: CAB75651.2.
    CCDSiCCDS30689.1. [Q9UPW0-1]
    CCDS55594.1. [Q9UPW0-2]
    PIRiT46900.
    RefSeqiNP_001185779.1. NM_001198850.1. [Q9UPW0-1]
    NP_001185780.1. NM_001198851.1. [Q9UPW0-1]
    NP_001185781.1. NM_001198852.1. [Q9UPW0-2]
    NP_055762.3. NM_014947.4. [Q9UPW0-1]
    UniGeneiHs.26023.

    Genome annotation databases

    EnsembliENST00000361346; ENSP00000354620; ENSG00000198815. [Q9UPW0-1]
    ENST00000361776; ENSP00000354449; ENSG00000198815. [Q9UPW0-2]
    ENST00000372572; ENSP00000361653; ENSG00000198815. [Q9UPW0-1]
    ENST00000372573; ENSP00000361654; ENSG00000198815. [Q9UPW0-1]
    ENST00000545068; ENSP00000439044; ENSG00000198815. [Q9UPW0-1]
    GeneIDi22887.
    KEGGihsa:22887.
    UCSCiuc001che.3. human. [Q9UPW0-1]
    uc001chh.2. human. [Q9UPW0-2]

    Polymorphism databases

    DMDMi296434510.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028964 mRNA. Translation: BAA82993.2 . Different initiation.
    AC096540 Genomic DNA. No translation available.
    AC114492 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07162.1 .
    CH471059 Genomic DNA. Translation: EAX07163.1 .
    CH471059 Genomic DNA. Translation: EAX07164.1 .
    CH471059 Genomic DNA. Translation: EAX07165.1 .
    BC014182 mRNA. Translation: AAH14182.1 .
    BC151828 mRNA. Translation: AAI51829.1 .
    BC152441 mRNA. Translation: AAI52442.1 .
    AL157422 mRNA. Translation: CAB75651.2 .
    CCDSi CCDS30689.1. [Q9UPW0-1 ]
    CCDS55594.1. [Q9UPW0-2 ]
    PIRi T46900.
    RefSeqi NP_001185779.1. NM_001198850.1. [Q9UPW0-1 ]
    NP_001185780.1. NM_001198851.1. [Q9UPW0-1 ]
    NP_001185781.1. NM_001198852.1. [Q9UPW0-2 ]
    NP_055762.3. NM_014947.4. [Q9UPW0-1 ]
    UniGenei Hs.26023.

    3D structure databases

    ProteinModelPortali Q9UPW0.
    SMRi Q9UPW0. Positions 77-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116553. 8 interactions.
    IntActi Q9UPW0. 1 interaction.
    STRINGi 9606.ENSP00000354620.

    PTM databases

    PhosphoSitei Q9UPW0.

    Polymorphism databases

    DMDMi 296434510.

    Proteomic databases

    MaxQBi Q9UPW0.
    PaxDbi Q9UPW0.
    PRIDEi Q9UPW0.

    Protocols and materials databases

    DNASUi 22887.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361346 ; ENSP00000354620 ; ENSG00000198815 . [Q9UPW0-1 ]
    ENST00000361776 ; ENSP00000354449 ; ENSG00000198815 . [Q9UPW0-2 ]
    ENST00000372572 ; ENSP00000361653 ; ENSG00000198815 . [Q9UPW0-1 ]
    ENST00000372573 ; ENSP00000361654 ; ENSG00000198815 . [Q9UPW0-1 ]
    ENST00000545068 ; ENSP00000439044 ; ENSG00000198815 . [Q9UPW0-1 ]
    GeneIDi 22887.
    KEGGi hsa:22887.
    UCSCi uc001che.3. human. [Q9UPW0-1 ]
    uc001chh.2. human. [Q9UPW0-2 ]

    Organism-specific databases

    CTDi 22887.
    GeneCardsi GC01M042642.
    HGNCi HGNC:29178. FOXJ3.
    neXtProti NX_Q9UPW0.
    PharmGKBi PA134945417.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000231184.
    HOVERGENi HBG051648.
    InParanoidi Q9UPW0.
    KOi K09403.
    OMAi VTSLRMT.
    OrthoDBi EOG7RZ5RQ.
    PhylomeDBi Q9UPW0.
    TreeFami TF333250.

    Miscellaneous databases

    ChiTaRSi FOXJ3. human.
    GenomeRNAii 22887.
    NextBioi 43479.
    PROi Q9UPW0.

    Gene expression databases

    ArrayExpressi Q9UPW0.
    Bgeei Q9UPW0.
    CleanExi HS_FOXJ3.
    Genevestigatori Q9UPW0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-162 AND PRO-377.
      Tissue: Brain.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-416 (ISOFORM 2), VARIANTS ALA-162 AND PRO-377.
      Tissue: Lung.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 451-622.
      Tissue: Amygdala.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-295 AND SER-489, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND SER-606, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFOXJ3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPW0
    Secondary accession number(s): A7MBL7
    , A7MD18, D3DPW2, Q9NSS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3