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Protein

Forkhead box protein J3

Gene

FOXJ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi77 – 168Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30902-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J3
Gene namesi
Name:FOXJ3
Synonyms:KIAA1041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29178. FOXJ3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22887.
OpenTargetsiENSG00000198815.
PharmGKBiPA134945417.

Polymorphism and mutation databases

BioMutaiFOXJ3.
DMDMi296434510.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918551 – 622Forkhead box protein J3Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPW0.
PaxDbiQ9UPW0.
PeptideAtlasiQ9UPW0.
PRIDEiQ9UPW0.

PTM databases

iPTMnetiQ9UPW0.
PhosphoSitePlusiQ9UPW0.

Expressioni

Gene expression databases

BgeeiENSG00000198815.
CleanExiHS_FOXJ3.
ExpressionAtlasiQ9UPW0. baseline and differential.
GenevisibleiQ9UPW0. HS.

Organism-specific databases

HPAiHPA067284.

Interactioni

Protein-protein interaction databases

BioGridi116553. 16 interactors.
IntActiQ9UPW0. 13 interactors.
STRINGi9606.ENSP00000354620.

Structurei

3D structure databases

ProteinModelPortaliQ9UPW0.
SMRiQ9UPW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000231184.
HOVERGENiHBG051648.
InParanoidiQ9UPW0.
KOiK09403.
OMAiTTIAGHH.
OrthoDBiEOG091G0U7S.
PhylomeDBiQ9UPW0.
TreeFamiTF333250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG
60 70 80 90 100
TGISKKNALL DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT
110 120 130 140 150
LSEIYQWICD NFPYYREAGS GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS
160 170 180 190 200
YWAIDTNPKE DVLPTRPKKR ARSVERASTP YSIDSDSLGM ECIISGSASP
210 220 230 240 250
TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV NLNSVGSVHS
260 270 280 290 300
YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY
310 320 330 340 350
KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS
360 370 380 390 400
NSHGSGLNTT GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP
410 420 430 440 450
APHPQQHSQL QSPHPQHPSP HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS
460 470 480 490 500
GVSNDWYATL DMLKESCRIA SSVNWSDVDL SQFQGLMESM RQADLKNWSL
510 520 530 540 550
DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT KPSQHIGTGN
560 570 580 590 600
LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA
610 620
FQMRRSLPPD DIQDDFDWDS IV
Length:622
Mass (Da):68,960
Last modified:May 18, 2010 - v2
Checksum:i2C53E63C76AF057B
GO
Isoform 2 (identifier: Q9UPW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-210: Missing.

Show »
Length:588
Mass (Da):65,533
Checksum:i73DC52B528BC4CDC
GO

Sequence cautioni

The sequence BAA82993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti485G → GG in CAB75651 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039104162V → A.2 PublicationsCorresponds to variant rs343376dbSNPEnsembl.1
Natural variantiVAR_039105377T → P.2 PublicationsCorresponds to variant rs1139978dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010367177 – 210Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028964 mRNA. Translation: BAA82993.2. Different initiation.
AC096540 Genomic DNA. No translation available.
AC114492 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07162.1.
CH471059 Genomic DNA. Translation: EAX07163.1.
CH471059 Genomic DNA. Translation: EAX07164.1.
CH471059 Genomic DNA. Translation: EAX07165.1.
BC014182 mRNA. Translation: AAH14182.1.
BC151828 mRNA. Translation: AAI51829.1.
BC152441 mRNA. Translation: AAI52442.1.
AL157422 mRNA. Translation: CAB75651.2.
CCDSiCCDS30689.1. [Q9UPW0-1]
CCDS55594.1. [Q9UPW0-2]
PIRiT46900.
RefSeqiNP_001185779.1. NM_001198850.1. [Q9UPW0-1]
NP_001185780.1. NM_001198851.1. [Q9UPW0-1]
NP_001185781.1. NM_001198852.1. [Q9UPW0-2]
NP_055762.3. NM_014947.4. [Q9UPW0-1]
XP_011539328.1. XM_011541026.2. [Q9UPW0-1]
UniGeneiHs.26023.

Genome annotation databases

EnsembliENST00000361346; ENSP00000354620; ENSG00000198815. [Q9UPW0-1]
ENST00000361776; ENSP00000354449; ENSG00000198815. [Q9UPW0-2]
ENST00000372572; ENSP00000361653; ENSG00000198815. [Q9UPW0-1]
ENST00000372573; ENSP00000361654; ENSG00000198815. [Q9UPW0-1]
ENST00000545068; ENSP00000439044; ENSG00000198815. [Q9UPW0-1]
GeneIDi22887.
KEGGihsa:22887.
UCSCiuc001che.3. human. [Q9UPW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028964 mRNA. Translation: BAA82993.2. Different initiation.
AC096540 Genomic DNA. No translation available.
AC114492 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07162.1.
CH471059 Genomic DNA. Translation: EAX07163.1.
CH471059 Genomic DNA. Translation: EAX07164.1.
CH471059 Genomic DNA. Translation: EAX07165.1.
BC014182 mRNA. Translation: AAH14182.1.
BC151828 mRNA. Translation: AAI51829.1.
BC152441 mRNA. Translation: AAI52442.1.
AL157422 mRNA. Translation: CAB75651.2.
CCDSiCCDS30689.1. [Q9UPW0-1]
CCDS55594.1. [Q9UPW0-2]
PIRiT46900.
RefSeqiNP_001185779.1. NM_001198850.1. [Q9UPW0-1]
NP_001185780.1. NM_001198851.1. [Q9UPW0-1]
NP_001185781.1. NM_001198852.1. [Q9UPW0-2]
NP_055762.3. NM_014947.4. [Q9UPW0-1]
XP_011539328.1. XM_011541026.2. [Q9UPW0-1]
UniGeneiHs.26023.

3D structure databases

ProteinModelPortaliQ9UPW0.
SMRiQ9UPW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116553. 16 interactors.
IntActiQ9UPW0. 13 interactors.
STRINGi9606.ENSP00000354620.

PTM databases

iPTMnetiQ9UPW0.
PhosphoSitePlusiQ9UPW0.

Polymorphism and mutation databases

BioMutaiFOXJ3.
DMDMi296434510.

Proteomic databases

EPDiQ9UPW0.
PaxDbiQ9UPW0.
PeptideAtlasiQ9UPW0.
PRIDEiQ9UPW0.

Protocols and materials databases

DNASUi22887.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361346; ENSP00000354620; ENSG00000198815. [Q9UPW0-1]
ENST00000361776; ENSP00000354449; ENSG00000198815. [Q9UPW0-2]
ENST00000372572; ENSP00000361653; ENSG00000198815. [Q9UPW0-1]
ENST00000372573; ENSP00000361654; ENSG00000198815. [Q9UPW0-1]
ENST00000545068; ENSP00000439044; ENSG00000198815. [Q9UPW0-1]
GeneIDi22887.
KEGGihsa:22887.
UCSCiuc001che.3. human. [Q9UPW0-1]

Organism-specific databases

CTDi22887.
DisGeNETi22887.
GeneCardsiFOXJ3.
HGNCiHGNC:29178. FOXJ3.
HPAiHPA067284.
MIMi616035. gene.
neXtProtiNX_Q9UPW0.
OpenTargetsiENSG00000198815.
PharmGKBiPA134945417.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
HOGENOMiHOG000231184.
HOVERGENiHBG051648.
InParanoidiQ9UPW0.
KOiK09403.
OMAiTTIAGHH.
OrthoDBiEOG091G0U7S.
PhylomeDBiQ9UPW0.
TreeFamiTF333250.

Enzyme and pathway databases

BioCyciZFISH:G66-30902-MONOMER.

Miscellaneous databases

ChiTaRSiFOXJ3. human.
GenomeRNAii22887.
PROiQ9UPW0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198815.
CleanExiHS_FOXJ3.
ExpressionAtlasiQ9UPW0. baseline and differential.
GenevisibleiQ9UPW0. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXJ3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPW0
Secondary accession number(s): A7MBL7
, A7MD18, D3DPW2, Q9NSS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.