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Q9UPV9

- TRAK1_HUMAN

UniProt

Q9UPV9 - TRAK1_HUMAN

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Protein
Trafficking kinesin-binding protein 1
Gene
TRAK1, KIAA1042, OIP106
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. endosome to lysosome transport Source: UniProtKB
  2. protein O-linked glycosylation Source: UniProtKB
  3. protein targeting Source: UniProtKB
  4. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking kinesin-binding protein 1
Alternative name(s):
106 kDa O-GlcNAc transferase-interacting protein
Gene namesi
Name:TRAK1
Synonyms:KIAA1042, OIP106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29947. TRAK1.

Subcellular locationi

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome
Note: Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.6 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. mitochondrion Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Trafficking kinesin-binding protein 1
PRO_0000058037Add
BLAST

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9UPV9.
PaxDbiQ9UPV9.
PRIDEiQ9UPV9.

PTM databases

PhosphoSiteiQ9UPV9.

Expressioni

Tissue specificityi

High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.1 Publication

Gene expression databases

ArrayExpressiQ9UPV9.
BgeeiQ9UPV9.
CleanExiHS_TRAK1.
GenevestigatoriQ9UPV9.

Organism-specific databases

HPAiHPA005853.

Interactioni

Subunit structurei

Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS. Interacts with GABRA1 By similarity. Interacts with KIF5C.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RHOT1Q8IXI23EBI-1105048,EBI-1396430

Protein-protein interaction databases

BioGridi116570. 7 interactions.
IntActiQ9UPV9. 8 interactions.
MINTiMINT-1195439.
STRINGi9606.ENSP00000328998.

Structurei

3D structure databases

ProteinModelPortaliQ9UPV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 354308HAP1 N-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni359 – 509151Interaction with HGS
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 356253 Reviewed prediction
Add
BLAST
Coiled coili492 – 53241 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi200 – 2034Poly-Ser

Domaini

The C-terminal region is required for the early endosomal and mitochondrial localization.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG246318.
HOGENOMiHOG000143414.
HOVERGENiHBG069248.
InParanoidiQ9UPV9.
KOiK15369.
OMAiNSCDVCN.
OrthoDBiEOG7CRTSM.
PhylomeDBiQ9UPV9.
TreeFamiTF323495.

Family and domain databases

InterProiIPR006933. HAP1_N.
IPR022154. Traffickng_kinesin-bd_prot_dom.
[Graphical view]
PfamiPF04849. HAP1_N. 1 hit.
PF12448. Milton. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPV9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALVFQFGQP VRAQPLPGLC HGKLIRTNAC DVCNSTDLPE VEIISLLEEQ    50
LPHYKLRADT IYGYDHDDWL HTPLISPDAN IDLTTEQIEE TLKYFLLCAE 100
RVGQMTKTYN DIDAVTRLLE EKERDLELAA RIGQSLLKKN KTLTERNELL 150
EEQVEHIREE VSQLRHELSM KDELLQFYTS AAEESEPESV CSTPLKRNES 200
SSSVQNYFHL DSLQKKLKDL EEENVVLRSE ASQLKTETIT YEEKEQQLVN 250
DCVKELRDAN VQIASISEEL AKKTEDAARQ QEEITHLLSQ IVDLQKKAKA 300
CAVENEELVQ HLGAAKDAQR QLTAELRELE DKYAECMEML HEAQEELKNL 350
RNKTMPNTTS RRYHSLGLFP MDSLAAEIEG TMRKELQLEE AESPDITHQK 400
RVFETVRNIN QVVKQRSLTP SPMNIPGSNQ SSAMNSLLSS CVSTPRSSFY 450
GSDIGNVVLD NKTNSIILET EAADLGNDER SKKPGTPGTP GSHDLETALR 500
RLSLRRENYL SERRFFEEEQ ERKLQELAEK GELRSGSLTP TESIMSLGTH 550
SRFSEFTGFS GMSFSSRSYL PEKLQIVKPL EGSATLHHWQ QLAQPHLGGI 600
LDPRPGVVTK GFRTLDVDLD EVYCLNDFEE DDTGDHISLP RLATSTPVQH 650
PETSAHHPGK CMSQTNSTFT FTTCRILHPS DELTRVTPSL NSAPTPACGS 700
TSHLKSTPVA TPCTPRRLSL AESFTNTRES TTTMSTSLGL VWLLKERGIS 750
AAVYDPQSWD RAGRGSLLHS YTPKMAVIPS TPPNSPMQTP TSSPPSFEFK 800
CTSPPYDNFL ASKPASSILR EVREKNVRSS ESQTDVSVSN LNLVDKVRRF 850
GVAKVVNSGR AHVPTLTEEQ GPLLCGPPGP APALVPRGLV PEGLPLRCPT 900
VTSAIGGLQL NSGIRRNRSF PTMVGSSMQM KAPVTLTSGI LMGAKLSKQT 950
SLR 953
Length:953
Mass (Da):106,040
Last modified:May 1, 2000 - v1
Checksum:iE834BE07CF41D9A4
GO
Isoform 2 (identifier: Q9UPV9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MALVFQFGQP...QIEETLKYFL → MSLRDKGGEE...HDTQDLLEEV
     655-744: AHHPGKCMSQ...STSLGLVWLL → GERSQARVTV...LSVASARLCG
     745-953: Missing.

Note: 4 (AAH15922) sequence is in conflict in position: 631:E->EEE.

Show »
Length:686
Mass (Da):77,256
Checksum:iE14EC7B6B460E042
GO
Isoform 3 (identifier: Q9UPV9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MALVFQFGQP...IEETLKYFLL → MQKFIEADYYELDWYYEECSDVL
     583-630: SATLHHWQQL...EVYCLNDFEE → DHAGPRPLSV...SHPRCWFEFL
     631-953: Missing.

Note: No experimental confirmation available.

Show »
Length:556
Mass (Da):63,642
Checksum:i9837FDB279C91758
GO

Sequence cautioni

The sequence BAA82994.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797MALVF…KYFLL → MQKFIEADYYELDWYYEECS DVL in isoform 3.
VSP_045558Add
BLAST
Alternative sequencei1 – 9696MALVF…LKYFL → MSLRDKGGEEECFEYDCQDE ERKPTHRQHDTQDLLEEV in isoform 2.
VSP_010839Add
BLAST
Alternative sequencei583 – 63048SATLH…NDFEE → DHAGPRPLSVLLGDSLWSLI HLRKAGHLCHAYSFFFRDSH PRCWFEFL in isoform 3.
VSP_045559Add
BLAST
Alternative sequencei631 – 953323Missing in isoform 3.
VSP_045560Add
BLAST
Alternative sequencei655 – 74490AHHPG…LVWLL → GERSQARVTVSGSRSYPSRP QASPEEMQEPPAATEEEEEE EEEEGSGEGTTISPVNLAPF PEAEFWAILTSVPGTIRSGS LSVASARLCG in isoform 2.
VSP_010840Add
BLAST
Alternative sequencei745 – 953209Missing in isoform 2.
VSP_010841Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti503 – 5031S → P in CAH56169. 1 Publication
Sequence conflicti638 – 6381S → F in CAH56169. 1 Publication
Isoform 2 (identifier: Q9UPV9-2)
Sequence conflicti631 – 6311E → EE in CAH56169. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028965 mRNA. Translation: BAA82994.2. Different initiation.
BX647199 mRNA. Translation: CAH56169.1.
AL713787 mRNA. Translation: CAH56394.1.
AC018358 Genomic DNA. No translation available.
AC093414 Genomic DNA. No translation available.
AC137935 Genomic DNA. No translation available.
BC015922 mRNA. Translation: AAH15922.1.
CCDSiCCDS2695.1. [Q9UPV9-2]
CCDS43072.1. [Q9UPV9-1]
CCDS58826.1. [Q9UPV9-3]
RefSeqiNP_001036111.1. NM_001042646.2. [Q9UPV9-1]
NP_001252537.1. NM_001265608.1.
NP_001252539.1. NM_001265610.1. [Q9UPV9-3]
NP_055780.2. NM_014965.4. [Q9UPV9-2]
UniGeneiHs.535711.

Genome annotation databases

EnsembliENST00000327628; ENSP00000328998; ENSG00000182606. [Q9UPV9-1]
ENST00000341421; ENSP00000340702; ENSG00000182606.
ENST00000449246; ENSP00000410717; ENSG00000182606. [Q9UPV9-3]
GeneIDi22906.
KEGGihsa:22906.
UCSCiuc003cky.4. human. [Q9UPV9-1]

Polymorphism databases

DMDMi13124654.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028965 mRNA. Translation: BAA82994.2 . Different initiation.
BX647199 mRNA. Translation: CAH56169.1 .
AL713787 mRNA. Translation: CAH56394.1 .
AC018358 Genomic DNA. No translation available.
AC093414 Genomic DNA. No translation available.
AC137935 Genomic DNA. No translation available.
BC015922 mRNA. Translation: AAH15922.1 .
CCDSi CCDS2695.1. [Q9UPV9-2 ]
CCDS43072.1. [Q9UPV9-1 ]
CCDS58826.1. [Q9UPV9-3 ]
RefSeqi NP_001036111.1. NM_001042646.2. [Q9UPV9-1 ]
NP_001252537.1. NM_001265608.1.
NP_001252539.1. NM_001265610.1. [Q9UPV9-3 ]
NP_055780.2. NM_014965.4. [Q9UPV9-2 ]
UniGenei Hs.535711.

3D structure databases

ProteinModelPortali Q9UPV9.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116570. 7 interactions.
IntActi Q9UPV9. 8 interactions.
MINTi MINT-1195439.
STRINGi 9606.ENSP00000328998.

PTM databases

PhosphoSitei Q9UPV9.

Polymorphism databases

DMDMi 13124654.

Proteomic databases

MaxQBi Q9UPV9.
PaxDbi Q9UPV9.
PRIDEi Q9UPV9.

Protocols and materials databases

DNASUi 22906.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327628 ; ENSP00000328998 ; ENSG00000182606 . [Q9UPV9-1 ]
ENST00000341421 ; ENSP00000340702 ; ENSG00000182606 .
ENST00000449246 ; ENSP00000410717 ; ENSG00000182606 . [Q9UPV9-3 ]
GeneIDi 22906.
KEGGi hsa:22906.
UCSCi uc003cky.4. human. [Q9UPV9-1 ]

Organism-specific databases

CTDi 22906.
GeneCardsi GC03P042108.
HGNCi HGNC:29947. TRAK1.
HPAi HPA005853.
MIMi 608112. gene.
neXtProti NX_Q9UPV9.
PharmGKBi PA128394593.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246318.
HOGENOMi HOG000143414.
HOVERGENi HBG069248.
InParanoidi Q9UPV9.
KOi K15369.
OMAi NSCDVCN.
OrthoDBi EOG7CRTSM.
PhylomeDBi Q9UPV9.
TreeFami TF323495.

Miscellaneous databases

ChiTaRSi TRAK1. human.
GeneWikii TRAK1.
GenomeRNAii 22906.
NextBioi 35534989.
PROi Q9UPV9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UPV9.
Bgeei Q9UPV9.
CleanExi HS_TRAK1.
Genevestigatori Q9UPV9.

Family and domain databases

InterProi IPR006933. HAP1_N.
IPR022154. Traffickng_kinesin-bd_prot_dom.
[Graphical view ]
Pfami PF04849. HAP1_N. 1 hit.
PF12448. Milton. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-508 (ISOFORM 3).
    Tissue: Kidney and Salivary gland.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  5. "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase."
    Iyer S.P.N., Akimoto Y., Hart G.W.
    J. Biol. Chem. 278:5399-5409(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH O-GLCNAC TRANSFERASE, GLYCOSYLATION.
  6. "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin."
    Brickley K., Smith M.J., Beck M., Stephenson F.A.
    J. Biol. Chem. 280:14723-14732(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIF5C, SUBCELLULAR LOCATION.
  7. "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking."
    Fransson S., Ruusala A., Aspenstroem P.
    Biochem. Biophys. Res. Commun. 344:500-510(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH RHOT1 AND RHOT2.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker."
    Zhang F., Ren G., Lu Y., Jin B., Wang J., Chen X., Liu Z., Li K., Nie Y., Wang X., Fan D.
    Cancer Lett. 274:250-258(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, MARKER FOR GASTRIC CANCER.
  10. "Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking."
    Webber E., Li L., Chin L.S.
    J. Mol. Biol. 382:638-651(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HGS.
  11. "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."
    Li Y., Lim S., Hoffman D., Aspenstrom P., Federoff H.J., Rempe D.A.
    J. Cell Biol. 185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTRAK1_HUMAN
AccessioniPrimary (citable) accession number: Q9UPV9
Secondary accession number(s): E9PDS2
, J3KNT7, Q63HR0, Q659B5, Q96B69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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