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Protein

PHD finger protein 24

Gene

PHF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 19062PHD-typeAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 24Imported
Gene namesi
Name:PHF24Imported
Synonyms:KIAA1045Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:29180. PHF24.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993280.

Polymorphism and mutation databases

BioMutaiKIAA1045.
DMDMi73621116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 400399PHD finger protein 24PRO_0000059331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei43 – 431PhosphoserineCombined sources
Modified residuei47 – 471PhosphothreonineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9UPV7.
PaxDbiQ9UPV7.
PeptideAtlasiQ9UPV7.
PRIDEiQ9UPV7.

PTM databases

iPTMnetiQ9UPV7.
PhosphoSiteiQ9UPV7.

Expressioni

Gene expression databases

BgeeiQ9UPV7.
CleanExiHS_KIAA1045.
GenevisibleiQ9UPV7. HS.

Organism-specific databases

HPAiHPA020974.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000242315.

Structurei

Secondary structure

1
400
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni134 – 1363Combined sources
Beta strandi148 – 1525Combined sources
Helixi156 – 1627Combined sources
Beta strandi178 – 1825Combined sources
Turni186 – 1883Combined sources
Beta strandi193 – 1953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WILNMR-A123-198[»]
ProteinModelPortaliQ9UPV7.
SMRiQ9UPV7. Positions 123-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UPV7.

Family & Domainsi

Sequence similaritiesi

Contains 1 PHD-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri129 – 19062PHD-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQZR. Eukaryota.
ENOG4111QYS. LUCA.
GeneTreeiENSGT00390000002865.
HOGENOMiHOG000231402.
HOVERGENiHBG056700.
InParanoidiQ9UPV7.
OMAiSCHYCDN.
OrthoDBiEOG78H3T7.
PhylomeDBiQ9UPV7.
TreeFamiTF333336.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR031946. KIAA1045_Zf_RING.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF16744. Zf_RING. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UPV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLMSKRQT VEQVQKVSLA VSAFKDGLRD RPSIRRTGEL PGSRRGTVEG
60 70 80 90 100
SVQEVQEEKE AEAGTSVVQE ESSAGRAAWE RLRDGRGVEP EEFDRTSRFT
110 120 130 140 150
PPAFIRPTRK LDDDKPPEIC LEPREPVVND EMCDVCEVWT AESLFPCRVC
160 170 180 190 200
TRVFHDGCLR RMGYIQGDSA AEVTEMAHTE TGWSCHYCDN INLLLTEEEM
210 220 230 240 250
YSLTETFQRC KVIPDCSLTL EDFLRYRHQA AKRGDRDRAL SEEQEEQAAR
260 270 280 290 300
QFAALDPEHR GHIEWPDFLS HESLLLLQQL RPQNSLLRLL TVKERERARA
310 320 330 340 350
AFLARGSGST VSEAECRRAQ HSWFCKRFPE APSCSVSISH VGPIADSSPA
360 370 380 390 400
SSSSKSQDKT LLPTEQESRF VDWPTFLQEN VLYILAARPN SAAIHLKPPG
Length:400
Mass (Da):45,192
Last modified:August 16, 2005 - v2
Checksum:i96FE4C51C897888F
GO

Sequence cautioni

The sequence BAA82997.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028968 mRNA. Translation: BAA82997.1. Different initiation.
AK294342 mRNA. Translation: BAH11739.1.
AL355377 Genomic DNA. Translation: CAI13804.1.
CH471071 Genomic DNA. Translation: EAW58408.1.
AY956807 mRNA. Translation: AAX51885.1.
AY956808 mRNA. Translation: AAX51886.1.
CCDSiCCDS43796.1.
RefSeqiNP_001291262.1. NM_001304333.2.
NP_056112.1. NM_015297.2.
UniGeneiHs.7989.

Genome annotation databases

EnsembliENST00000242315; ENSP00000242315; ENSG00000122733.
GeneIDi23349.
KEGGihsa:23349.
UCSCiuc003zvr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028968 mRNA. Translation: BAA82997.1. Different initiation.
AK294342 mRNA. Translation: BAH11739.1.
AL355377 Genomic DNA. Translation: CAI13804.1.
CH471071 Genomic DNA. Translation: EAW58408.1.
AY956807 mRNA. Translation: AAX51885.1.
AY956808 mRNA. Translation: AAX51886.1.
CCDSiCCDS43796.1.
RefSeqiNP_001291262.1. NM_001304333.2.
NP_056112.1. NM_015297.2.
UniGeneiHs.7989.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WILNMR-A123-198[»]
ProteinModelPortaliQ9UPV7.
SMRiQ9UPV7. Positions 123-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000242315.

PTM databases

iPTMnetiQ9UPV7.
PhosphoSiteiQ9UPV7.

Polymorphism and mutation databases

BioMutaiKIAA1045.
DMDMi73621116.

Proteomic databases

EPDiQ9UPV7.
PaxDbiQ9UPV7.
PeptideAtlasiQ9UPV7.
PRIDEiQ9UPV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242315; ENSP00000242315; ENSG00000122733.
GeneIDi23349.
KEGGihsa:23349.
UCSCiuc003zvr.4. human.

Organism-specific databases

CTDi23349.
GeneCardsiKIAA1045.
HGNCiHGNC:29180. PHF24.
HPAiHPA020974.
neXtProtiNX_Q9UPV7.
PharmGKBiPA134993280.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQZR. Eukaryota.
ENOG4111QYS. LUCA.
GeneTreeiENSGT00390000002865.
HOGENOMiHOG000231402.
HOVERGENiHBG056700.
InParanoidiQ9UPV7.
OMAiSCHYCDN.
OrthoDBiEOG78H3T7.
PhylomeDBiQ9UPV7.
TreeFamiTF333336.

Miscellaneous databases

EvolutionaryTraceiQ9UPV7.
GenomeRNAii23349.
PROiQ9UPV7.

Gene expression databases

BgeeiQ9UPV7.
CleanExiHS_KIAA1045.
GenevisibleiQ9UPV7. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR031946. KIAA1045_Zf_RING.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF16744. Zf_RING. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Identification of candidate tumor suppressor genes in nasopharyngeal carcinoma using a combination of digital expression analysis, expression profiling and functional assay."
    Liu D.X., Low J.S.W., Cui Y., Hsieh W.-S., Tao Q.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-74.
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.
  8. "Solution structure of the RING finger domain of the human KIAA1045 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 123-198 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiPHF24_HUMAN
AccessioniPrimary (citable) accession number: Q9UPV7
Secondary accession number(s): B7Z253, Q58FE9, Q5T662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.