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Protein

TBC1 domain family member 2B

Gene

TBC1D2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 2B
Gene namesi
Name:TBC1D2B
Synonyms:KIAA1055
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29183. TBC1D2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670832.

Polymorphism and mutation databases

BioMutaiTBC1D2B.
DMDMi166227884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963TBC1 domain family member 2BPRO_0000315713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei957 – 9571PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPU7.
MaxQBiQ9UPU7.
PaxDbiQ9UPU7.
PRIDEiQ9UPU7.

PTM databases

iPTMnetiQ9UPU7.
PhosphoSiteiQ9UPU7.

Expressioni

Gene expression databases

BgeeiQ9UPU7.
CleanExiHS_TBC1D2B.
ExpressionAtlasiQ9UPU7. baseline and differential.
GenevisibleiQ9UPU7. HS.

Organism-specific databases

HPAiHPA048174.
HPA052663.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-2947180,EBI-712001
GABARAPL1Q9H0R85EBI-2947180,EBI-746969
GABARAPL2P605203EBI-2947180,EBI-720116
MAP1LC3BQ9GZQ83EBI-2947180,EBI-373144
MAP1LC3CQ9BXW42EBI-2947180,EBI-2603996

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116729. 21 interactions.
IntActiQ9UPU7. 11 interactions.
MINTiMINT-2822641.
STRINGi9606.ENSP00000300584.

Structurei

3D structure databases

ProteinModelPortaliQ9UPU7.
SMRiQ9UPU7. Positions 36-143, 594-906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 139106PHPROSITE-ProRule annotationAdd
BLAST
Domaini662 – 856195Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili337 – 535199Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000049204.
HOVERGENiHBG059233.
InParanoidiQ9UPU7.
OMAiNSLDMVK.
OrthoDBiEOG7PK8XW.
PhylomeDBiQ9UPU7.
TreeFamiTF317336.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGAGARAEE GGGGGEGAAQ GAAAEPGAGP AREPARLCGY LQKLSGKGPL
60 70 80 90 100
RGYRSRWFVF DARRCYLYYF KSPQDALPLG HLDIADACFS YQGPDEAAEP
110 120 130 140 150
GTEPPAHFQV HSAGAVTVLK APNRQLMTYW LQELQQKRWE YCNSLDMVKW
160 170 180 190 200
DSRTSPTPGD FPKGLVARDN TDLIYPHPNA SAEKARNVLA VETVPGELVG
210 220 230 240 250
EQAANQPAPG HPNSINFYSL KQWGNELKNS MSSFRPGRGH NDSRRTVFYT
260 270 280 290 300
NEEWELLDPT PKDLEESIVQ EEKKKLTPEG NKGVTGSGFP FDFGRNPYKG
310 320 330 340 350
KRPLKDIIGS YKNRHSSGDP SSEGTSGSGS VSIRKPASEM QLQVQSQQEE
360 370 380 390 400
LEQLKKDLSS QKELVRLLQQ TVRSSQYDKY FTSSRLCEGV PKDTLELLHQ
410 420 430 440 450
KDDQILGLTS QLERFSLEKE SLQQEVRTLK SKVGELNEQL GMLMETIQAK
460 470 480 490 500
DEVIIKLSEG EGNGPPPTVA PSSPSVVPVA RDQLELDRLK DNLQGYKTQN
510 520 530 540 550
KFLNKEILEL SALRRNAERR ERDLMAKYSS LEAKLCQIES KYLILLQEMK
560 570 580 590 600
TPVCSEDQGP TREVIAQLLE DALQVESQEQ PEQAFVKPHL VSEYDIYGFR
610 620 630 640 650
TVPEDDEEEK LVAKVRALDL KTLYLTENQE VSTGVKWENY FASTVNREMM
660 670 680 690 700
CSPELKNLIR AGIPHEHRSK VWKWCVDRHT RKFKDNTEPG HFQTLLQKAL
710 720 730 740 750
EKQNPASKQI ELDLLRTLPN NKHYSCPTSE GIQKLRNVLL AFSWRNPDIG
760 770 780 790 800
YCQGLNRLVA VALLYLEQED AFWCLVTIVE VFMPRDYYTK TLLGSQVDQR
810 820 830 840 850
VFRDLMSEKL PRLHGHFEQY KVDYTLITFN WFLVVFVDSV VSDILFKIWD
860 870 880 890 900
SFLYEGPKVI FRFALALFKY KEEEILKLQD SMSIFKYLRY FTRTILDARK
910 920 930 940 950
LISISFGDLN PFPLRQIRNR RAYHLEKVRL ELTELEAIRE DFLRERDTSP
960
DKGELVSDEE EDT
Length:963
Mass (Da):109,880
Last modified:January 15, 2008 - v2
Checksum:i1BC9B8FCA5BC2EEF
GO
Isoform 2 (identifier: Q9UPU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     900-963: KLISISFGDL...ELVSDEEEDT → SGTDAPTTWRKSGWS

Show »
Length:914
Mass (Da):103,917
Checksum:iCCA1D0A2D006D6BF
GO
Isoform 3 (identifier: Q9UPU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.
     860-860: I → S
     861-963: Missing.

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):36,457
Checksum:i5873220F1C0E82A6
GO

Sequence cautioni

The sequence AAH33712.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI52466.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW99190.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 548548Missing in isoform 3. 1 PublicationVSP_030666Add
BLAST
Alternative sequencei860 – 8601I → S in isoform 3. 1 PublicationVSP_030667
Alternative sequencei861 – 963103Missing in isoform 3. 1 PublicationVSP_030668Add
BLAST
Alternative sequencei900 – 96364KLISI…EEEDT → SGTDAPTTWRKSGWS in isoform 2. 2 PublicationsVSP_030669Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000173 mRNA. Translation: BAA90990.1.
AC104758 Genomic DNA. No translation available.
AC090260 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99188.1.
CH471136 Genomic DNA. Translation: EAW99190.1. Sequence problems.
AB028978 mRNA. Translation: BAA83007.1.
BC033712 mRNA. Translation: AAH33712.1. Different initiation.
BC152465 mRNA. Translation: AAI52466.1. Different initiation.
CCDSiCCDS32301.2. [Q9UPU7-2]
CCDS45314.1. [Q9UPU7-1]
RefSeqiNP_055894.6. NM_015079.5. [Q9UPU7-2]
NP_653173.1. NM_144572.1. [Q9UPU7-1]
UniGeneiHs.567426.

Genome annotation databases

EnsembliENST00000300584; ENSP00000300584; ENSG00000167202. [Q9UPU7-1]
ENST00000409931; ENSP00000387165; ENSG00000167202. [Q9UPU7-2]
GeneIDi23102.
KEGGihsa:23102.
UCSCiuc002bcy.4. human. [Q9UPU7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000173 mRNA. Translation: BAA90990.1.
AC104758 Genomic DNA. No translation available.
AC090260 Genomic DNA. No translation available.
CH471136 Genomic DNA. Translation: EAW99188.1.
CH471136 Genomic DNA. Translation: EAW99190.1. Sequence problems.
AB028978 mRNA. Translation: BAA83007.1.
BC033712 mRNA. Translation: AAH33712.1. Different initiation.
BC152465 mRNA. Translation: AAI52466.1. Different initiation.
CCDSiCCDS32301.2. [Q9UPU7-2]
CCDS45314.1. [Q9UPU7-1]
RefSeqiNP_055894.6. NM_015079.5. [Q9UPU7-2]
NP_653173.1. NM_144572.1. [Q9UPU7-1]
UniGeneiHs.567426.

3D structure databases

ProteinModelPortaliQ9UPU7.
SMRiQ9UPU7. Positions 36-143, 594-906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116729. 21 interactions.
IntActiQ9UPU7. 11 interactions.
MINTiMINT-2822641.
STRINGi9606.ENSP00000300584.

PTM databases

iPTMnetiQ9UPU7.
PhosphoSiteiQ9UPU7.

Polymorphism and mutation databases

BioMutaiTBC1D2B.
DMDMi166227884.

Proteomic databases

EPDiQ9UPU7.
MaxQBiQ9UPU7.
PaxDbiQ9UPU7.
PRIDEiQ9UPU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300584; ENSP00000300584; ENSG00000167202. [Q9UPU7-1]
ENST00000409931; ENSP00000387165; ENSG00000167202. [Q9UPU7-2]
GeneIDi23102.
KEGGihsa:23102.
UCSCiuc002bcy.4. human. [Q9UPU7-1]

Organism-specific databases

CTDi23102.
GeneCardsiTBC1D2B.
H-InvDBHIX0012469.
HIX0059533.
HGNCiHGNC:29183. TBC1D2B.
HPAiHPA048174.
HPA052663.
neXtProtiNX_Q9UPU7.
PharmGKBiPA142670832.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000049204.
HOVERGENiHBG059233.
InParanoidiQ9UPU7.
OMAiNSLDMVK.
OrthoDBiEOG7PK8XW.
PhylomeDBiQ9UPU7.
TreeFamiTF317336.

Miscellaneous databases

ChiTaRSiTBC1D2B. human.
GenomeRNAii23102.
PROiQ9UPU7.

Gene expression databases

BgeeiQ9UPU7.
CleanExiHS_TBC1D2B.
ExpressionAtlasiQ9UPU7. baseline and differential.
GenevisibleiQ9UPU7. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-914 (ISOFORM 2).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-924 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 411-963 (ISOFORM 1).
    Tissue: Duodenum.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-957, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
    Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
    Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-957, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-957, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-957, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-957, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTBD2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UPU7
Secondary accession number(s): A7MD42, Q8N1F9, Q9NXM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 8, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.