Reviewed, UniProtKB/Swiss-Prot Q9UPU6 (ZN409_HUMAN)

Names and origin

Protein names

Recommended name:
Zinc finger protein 409

Gene names

Name:	ZNF409
Synonyms:	KIAA1056

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	862 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular transcription Inferred from electronic annotation. Source: UniProtKB-KW regulation of cellular transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 862	862	Zinc finger protein 409		PRO_0000047570
Regions
	Zinc finger	237 – 259	23	C2H2-type 1
	Zinc finger	453 – 476	24	C2H2-type 2
	Zinc finger	508 – 532	25	C2H2-type 3
	Zinc finger	569 – 593	25	C2H2-type 4
	Zinc finger	758 – 782	25	C2H2-type 5
	Zinc finger	821 – 845	25	C2H2-type 6
	Compositional bias	605 – 710	106	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9UPU6-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: EB6BFF9A0B939217	FASTA	862	91,802
	10 20 30 40 50 60 MATLNSASTT GTTPSPGHNA PSLPSDTFSS STPSDPVTKD PPAASSTSEN MRSSEPGGQL 70 80 90 100 110 120 LESGCGLVPP KEIGEPQEGP DCGHFPPNDP GVEKDKEQEE EEEGLPPMDL SNHLFFTAGG 130 140 150 160 170 180 EAYLVAKLSL PGGSELLLPK GFPWGEAGIK EEPSLPFLAY PPPSHLTALH IQHGFDPIQG 190 200 210 220 230 240 FSSSDQILSH DTSAPSPAAC EERHGAFWSY QLAPNPPGDP KDGPMGNSGG NHVAVFWLCL 250 260 270 280 290 300 LCRLGFSKPQ AFMDHTQSHG VKLTPAQYQG LSGSPAVLQE GDEGCKALIS FLEPKLPARP 310 320 330 340 350 360 SSDIPLDNSS TVNMEANVAQ TEDGPPEAEV QALILLDEEV MALSPPSPPT ATWDPSPTQA 370 380 390 400 410 420 KESPVAAGEA GPDWFPEGQE EDGGLCPPLN QSSPTSKEGG TLPAPVGSPE DPSDPPQPYR 430 440 450 460 470 480 LADDYTPAPA AFQGLSLSSH MSLLHSRNSC KTLKCPKCNW HYKYQQTLDV HMQEKHPESN 490 500 510 520 530 540 SHCSYCSAGG AHPRLARGES YNCGYKPYRC DVCNYSTTTK GNLSIHMQSD KHLANLQGFQ 550 560 570 580 590 600 AGPGGQGSPT EASLPPSAGD KEPKTKSSWQ CKVCSYETNI SRNLRIHMTS EKHMQNVLML 610 620 630 640 650 660 HQGLPLGLPP GLMGPGPPPP PGATPTSPPE LFQYFGPQAL GQPQTPLAGP GLRPDKPLEA 670 680 690 700 710 720 QLLLNGFHHV GAPARKFPTS APGSLSPDAH LPPSQLLGSS SDSLPTSPPP DDSLSLKVFR 730 740 750 760 770 780 CLVCQAFSTD SLELLLYHCS IGRSLPEAEW KEVAGDTHRC KLCCYGTQLK ANFQLHLKTD 790 800 810 820 830 840 KHAQKYQLAA HLREGGGAMG TPSPASLGDG APYGSVSPLH LRCNICDFES NSKEKMQLHA 850 860 RGAAHEENSQ IYKRTETGLL IK

References

[1]

"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028979 mRNA. Translation: BAA83008.2. Different initiation.
IPI	IPI00007109.
UniGene	Hs.508937 Hs.525247
3D structure databases
SMR	Q9UPU6. Positions 449-542, 451-589, 504-602.
ModBase	Search...
PTM databases
PhosphoSite	Q9UPU6.
Proteomic databases
PRIDE	Q9UPU6.
Genome annotation databases
Ensembl	ENST00000382785; ENSP00000372235; ENSG00000136367; Homo sapiens. [Genome view]
UCSC	uc001wkf.1. human.
Organism-specific databases
GeneCards	GC14M023069. GC14U900909.
HGNC	HGNC:20042. ZNF409.
HPA	HPA005146.
PharmGKB	PA142670520.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
InParanoid	Q9UPU6.
Gene expression databases
ArrayExpress	Q9UPU6.
Bgee	Q9UPU6.
CleanEx	HS_ZNF409.
Genevestigator	Q9UPU6.
GermOnline	ENSG00000206083. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 2 hits. PS50157. ZINC_FINGER_C2H2_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZN409_HUMAN

Accession

Primary (citable) accession number: Q9UPU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.