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Protein

Ubiquitin carboxyl-terminal hydrolase 24

Gene

USP24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1698NucleophilePROSITE-ProRule annotation1
Active sitei1970Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-5689880. Ub-specific processing proteases.
SIGNORiQ9UPU5.

Protein family/group databases

MEROPSiC19.047.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 24
Ubiquitin thioesterase 24
Ubiquitin-specific-processing protease 24
Gene namesi
Name:USP24
Synonyms:KIAA1057
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12623. USP24.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

DisGeNETi23358.
OpenTargetsiENSG00000162402.
PharmGKBiPA37248.

Polymorphism and mutation databases

BioMutaiUSP24.
DMDMi212276491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806521 – 2620Ubiquitin carboxyl-terminal hydrolase 24Add BLAST2620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei942PhosphotyrosineBy similarity1
Modified residuei1141PhosphoserineCombined sources1
Modified residuei1285PhosphoserineCombined sources1
Modified residuei1943PhosphoserineBy similarity1
Modified residuei2047PhosphoserineCombined sources1
Modified residuei2077PhosphoserineBy similarity1
Modified residuei2561PhosphoserineCombined sources1
Modified residuei2565PhosphothreonineCombined sources1
Modified residuei2604PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPU5.
MaxQBiQ9UPU5.
PaxDbiQ9UPU5.
PeptideAtlasiQ9UPU5.
PRIDEiQ9UPU5.

PTM databases

iPTMnetiQ9UPU5.
PhosphoSitePlusiQ9UPU5.

Expressioni

Gene expression databases

BgeeiENSG00000162402.
CleanExiHS_USP24.
ExpressionAtlasiQ9UPU5. baseline and differential.
GenevisibleiQ9UPU5. HS.

Organism-specific databases

HPAiHPA026723.
HPA028428.
HPA067124.

Interactioni

Protein-protein interaction databases

BioGridi116939. 28 interactors.
IntActiQ9UPU5. 12 interactors.
MINTiMINT-7945132.
STRINGi9606.ENSP00000294383.

Structurei

3D structure databases

ProteinModelPortaliQ9UPU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 44UBAPROSITE-ProRule annotationAdd BLAST42
Domaini1689 – 2042USPAdd BLAST354

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 94Gly-richAdd BLAST48
Compositional biasi1035 – 1062Ser-richAdd BLAST28
Compositional biasi1132 – 1164Ser-richAdd BLAST33

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1866. Eukaryota.
COG5077. LUCA.
GeneTreeiENSGT00760000119158.
HOGENOMiHOG000068011.
HOVERGENiHBG105784.
InParanoidiQ9UPU5.
KOiK11840.
OMAiCMEYFDL.
OrthoDBiEOG090300H8.
PhylomeDBiQ9UPU5.
TreeFamiTF323966.

Family and domain databases

InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR001394. Peptidase_C19_UCH.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR033382. USP24.
IPR018200. USP_CS.
IPR028889. USP_dom.
PANTHERiPTHR24006:SF625. PTHR24006:SF625. 1 hit.
PfamiView protein in Pfam
PF00443. UCH. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50030. UBA. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UPU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY
60 70 80 90 100
GGYEPMDSGG GPSPGPGGGP RGDGGGDGGG GGPSRGGSTG GGGGFDPPPA
110 120 130 140 150
YHEVVDAEKN DENGNCSGEG IEFPTTNLYE LESRVLTDHW SIPYKREESL
160 170 180 190 200
GKCLLASTYL ARLGLSESDE NCRRFMDRCM PEAFKKLLTS SAVHKWGTEI
210 220 230 240 250
HEGIYNMLML LIELVAERIK QDPIPTGLLG VLTMAFNPDN EYHFKNRMKV
260 270 280 290 300
SQRNWAEVFG EGNMFAVSPV STFQKEPHGW VVDLVNKFGE LGGFAAIQAK
310 320 330 340 350
LHSEDIELGA VSALIQPLGV CAEYLNSSVV QPMLDPVILT TIQDVRSVEE
360 370 380 390 400
KDLKDKRLVS IPELLSAVKL LCMRFQPDLV TIVDDLRLDI LLRMLKSPHF
410 420 430 440 450
SAKMNSLKEV TKLIEDSTLS KSVKNAIDTD RLLDWLVENS VLSIALEGNI
460 470 480 490 500
DQAQYCDRIK GIIELLGSKL SLDELTKIWK IQSGQSSTVI ENIHTIIAAA
510 520 530 540 550
AVKFNSDQLN HLFVLIQKSW ETESDRVRQK LLSLIGRIGR EARFETTSGK
560 570 580 590 600
VLDVLWELAH LPTLPSSLIQ QALEEHLTIL SDAYAVKEAI KRSYIIKCIE
610 620 630 640 650
DIKRPGEWSG LEKNKKDGFK SSQLNNPQFV WVVPALRQLH EITRSFIKQT
660 670 680 690 700
YQKQDKSIIQ DLKKNFEIVK LVTGSLIACH RLAAAVAGPG GLSGSTLVDG
710 720 730 740 750
RYTYREYLEA HLKFLAFFLQ EATLYLGWNR AKEIWECLVT GQDVCELDRE
760 770 780 790 800
MCFEWFTKGQ HDLESDVQQQ LFKEKILKLE SYEITMNGFN LFKTFFENVN
810 820 830 840 850
LCDHRLKRQG AQLYVEKLEL IGMDFIWKIA MESPDEEIAN EAIQLIINYS
860 870 880 890 900
YINLNPRLKK DSVSLHKKFI ADCYTRLEAA SSALGGPTLT HAVTRATKML
910 920 930 940 950
TATAMPTVAT SVQSPYRSTK LVIIERLLLL AERYVITIED FYSVPRTILP
960 970 980 990 1000
HGASFHGHLL TLNVTYESTK DTFTVEAHSN ETIGSVRWKI AKQLCSPVDN
1010 1020 1030 1040 1050
IQIFTNDSLL TVNKDQKLLH QLGFSDEQIL TVKTSGSGTP SGSSADSSTS
1060 1070 1080 1090 1100
SSSSSSGVFS SSYAMEQEKS LPGVVMALVC NVFDMLYQLA NLEEPRITLR
1110 1120 1130 1140 1150
VRKLLLLIPT DPAIQEALDQ LDSLGRKKTL LSESSSQSSK SPSLSSKQQH
1160 1170 1180 1190 1200
QPSASSILES LFRSFAPGMS TFRVLYNLEV LSSKLMPTAD DDMARSCAKS
1210 1220 1230 1240 1250
FCENFLKAGG LSLVVNVMQR DSIPSEVDYE TRQGVYSICL QLARFLLVGQ
1260 1270 1280 1290 1300
TMPTLLDEDL TKDGIEALSS RPFRNVSRQT SRQMSLCGTP EKSSYRQLSV
1310 1320 1330 1340 1350
SDRSSIRVEE IIPAARVAIQ TMEVSDFTST VACFMRLSWA AAAGRLDLVG
1360 1370 1380 1390 1400
SSQPIKESNS LCPAGIRNRL SSSGSNCSSG SEGEPVALHA GICVRQQSVS
1410 1420 1430 1440 1450
TKDSLIAGEA LSLLVTCLQL RSQQLASFYN LPCVADFIID ILLGSPSAEI
1460 1470 1480 1490 1500
RRVACDQLYT LSQTDTSAHP DVQKPNQFLL GVILTAQLPL WSPTSIMRGV
1510 1520 1530 1540 1550
NQRLLSQCME YFDLRCQLLD DLTTSEMEQL RISPATMLED EITWLDNFEP
1560 1570 1580 1590 1600
NRTAECETSE ADNILLAGHL RLIKTLLSLC GAEKEMLGSS LIKPLLDDFL
1610 1620 1630 1640 1650
FRASRIILNS HSPAGSAAIS QQDFHPKCST ANSRLAAYEV LVMLADSSPS
1660 1670 1680 1690 1700
NLQIIIKELL SMHHQPDPAL TKEFDYLPPV DSRSSSGFVG LRNGGATCYM
1710 1720 1730 1740 1750
NAVFQQLYMQ PGLPESLLSV DDDTDNPDDS VFYQVQSLFG HLMESKLQYY
1760 1770 1780 1790 1800
VPENFWKIFK MWNKELYVRE QQDAYEFFTS LIDQMDEYLK KMGRDQIFKN
1810 1820 1830 1840 1850
TFQGIYSDQK ICKDCPHRYE REEAFMALNL GVTSCQSLEI SLDQFVRGEV
1860 1870 1880 1890 1900
LEGSNAYYCE KCKEKRITVK RTCIKSLPSV LVIHLMRFGF DWESGRSIKY
1910 1920 1930 1940 1950
DEQIRFPWML NMEPYTVSGM ARQDSSSEVG ENGRSVDQGG GGSPRKKVAL
1960 1970 1980 1990 2000
TENYELVGVI VHSGQAHAGH YYSFIKDRRG CGKGKWYKFN DTVIEEFDLN
2010 2020 2030 2040 2050
DETLEYECFG GEYRPKVYDQ TNPYTDVRRR YWNAYMLFYQ RVSDQNSPVL
2060 2070 2080 2090 2100
PKKSRVSVVR QEAEDLSLSA PSSPEISPQS SPRPHRPNND RLSILTKLVK
2110 2120 2130 2140 2150
KGEKKGLFVE KMPARIYQMV RDENLKFMKN RDVYSSDYFS FVLSLASLNA
2160 2170 2180 2190 2200
TKLKHPYYPC MAKVSLQLAI QFLFQTYLRT KKKLRVDTEE WIATIEALLS
2210 2220 2230 2240 2250
KSFDACQWLV EYFISSEGRE LIKIFLLECN VREVRVAVAT ILEKTLDSAL
2260 2270 2280 2290 2300
FYQDKLKSLH QLLEVLLALL DKDVPENCKN CAQYFFLFNT FVQKQGIRAG
2310 2320 2330 2340 2350
DLLLRHSALR HMISFLLGAS RQNNQIRRWS SAQAREFGNL HNTVALLVLH
2360 2370 2380 2390 2400
SDVSSQRNVA PGIFKQRPPI SIAPSSPLLP LHEEVEALLF MSEGKPYLLE
2410 2420 2430 2440 2450
VMFALRELTG SLLALIEMVV YCCFCNEHFS FTMLHFIKNQ LETAPPHELK
2460 2470 2480 2490 2500
NTFQLLHEIL VIEDPIQVER VKFVFETENG LLALMHHSNH VDSSRCYQCV
2510 2520 2530 2540 2550
KFLVTLAQKC PAAKEYFKEN SHHWSWAVQW LQKKMSEHYW TPQSNVSNET
2560 2570 2580 2590 2600
STGKTFQRTI SAQDTLAYAT ALLNEKEQSG SSNGSESSPA NENGDRHLQQ
2610 2620
GSESPMMIGE LRSDLDDVDP
Length:2,620
Mass (Da):294,365
Last modified:November 4, 2008 - v3
Checksum:i2773B7857A8B6633
GO

Sequence cautioni

The sequence AAH29660 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91084 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti840N → S in BAC86814 (PubMed:14702039).Curated1
Sequence conflicti990I → L in BAC86814 (PubMed:14702039).Curated1
Sequence conflicti1253P → S in BAC86814 (PubMed:14702039).Curated1
Sequence conflicti1776E → G in BAC86814 (PubMed:14702039).Curated1
Sequence conflicti2576K → R in BAA91084 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047154226T → I. Corresponds to variant dbSNP:rs1165222Ensembl.1
Natural variantiVAR_0471551940G → S. Corresponds to variant dbSNP:rs2274540Ensembl.1
Natural variantiVAR_0471562134Y → S. Corresponds to variant dbSNP:rs12753590Ensembl.1
Natural variantiVAR_0471572468V → A2 PublicationsCorresponds to variant dbSNP:rs487230Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091609 Genomic DNA. No translation available.
AK000321 mRNA. Translation: BAA91084.1. Different initiation.
AK127075 mRNA. Translation: BAC86814.1.
AB028980 mRNA. Translation: BAA83009.1.
BC029660 mRNA. Translation: AAH29660.1. Different initiation.
CCDSiCCDS44154.2.
RefSeqiNP_056121.2. NM_015306.2.
UniGeneiHs.477009.

Genome annotation databases

EnsembliENST00000294383; ENSP00000294383; ENSG00000162402.
GeneIDi23358.
KEGGihsa:23358.
UCSCiuc021onw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091609 Genomic DNA. No translation available.
AK000321 mRNA. Translation: BAA91084.1. Different initiation.
AK127075 mRNA. Translation: BAC86814.1.
AB028980 mRNA. Translation: BAA83009.1.
BC029660 mRNA. Translation: AAH29660.1. Different initiation.
CCDSiCCDS44154.2.
RefSeqiNP_056121.2. NM_015306.2.
UniGeneiHs.477009.

3D structure databases

ProteinModelPortaliQ9UPU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116939. 28 interactors.
IntActiQ9UPU5. 12 interactors.
MINTiMINT-7945132.
STRINGi9606.ENSP00000294383.

Protein family/group databases

MEROPSiC19.047.

PTM databases

iPTMnetiQ9UPU5.
PhosphoSitePlusiQ9UPU5.

Polymorphism and mutation databases

BioMutaiUSP24.
DMDMi212276491.

Proteomic databases

EPDiQ9UPU5.
MaxQBiQ9UPU5.
PaxDbiQ9UPU5.
PeptideAtlasiQ9UPU5.
PRIDEiQ9UPU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294383; ENSP00000294383; ENSG00000162402.
GeneIDi23358.
KEGGihsa:23358.
UCSCiuc021onw.2. human.

Organism-specific databases

CTDi23358.
DisGeNETi23358.
GeneCardsiUSP24.
H-InvDBHIX0000626.
HGNCiHGNC:12623. USP24.
HPAiHPA026723.
HPA028428.
HPA067124.
MIMi610569. gene.
neXtProtiNX_Q9UPU5.
OpenTargetsiENSG00000162402.
PharmGKBiPA37248.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1866. Eukaryota.
COG5077. LUCA.
GeneTreeiENSGT00760000119158.
HOGENOMiHOG000068011.
HOVERGENiHBG105784.
InParanoidiQ9UPU5.
KOiK11840.
OMAiCMEYFDL.
OrthoDBiEOG090300H8.
PhylomeDBiQ9UPU5.
TreeFamiTF323966.

Enzyme and pathway databases

ReactomeiR-HSA-5689880. Ub-specific processing proteases.
SIGNORiQ9UPU5.

Miscellaneous databases

ChiTaRSiUSP24. human.
GeneWikiiUSP24.
GenomeRNAii23358.
PROiQ9UPU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162402.
CleanExiHS_USP24.
ExpressionAtlasiQ9UPU5. baseline and differential.
GenevisibleiQ9UPU5. HS.

Family and domain databases

InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR001394. Peptidase_C19_UCH.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
IPR033382. USP24.
IPR018200. USP_CS.
IPR028889. USP_dom.
PANTHERiPTHR24006:SF625. PTHR24006:SF625. 1 hit.
PfamiView protein in Pfam
PF00443. UCH. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50030. UBA. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBP24_HUMAN
AccessioniPrimary (citable) accession number: Q9UPU5
Secondary accession number(s): Q6ZSY2, Q8N2Y4, Q9NXD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 4, 2008
Last modified: February 15, 2017
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.