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Q9UPU3

- SORC3_HUMAN

UniProt

Q9UPU3 - SORC3_HUMAN

Protein

VPS10 domain-containing receptor SorCS3

Gene

SORCS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. neuropeptide receptor activity Source: UniProtKB

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    VPS10 domain-containing receptor SorCS3
    Gene namesi
    Name:SORCS3
    Synonyms:KIAA1059
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:16699. SORCS3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134949387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Chaini34 – 12221189VPS10 domain-containing receptor SorCS3PRO_0000033174Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi840 – 8401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi932 – 9321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi953 – 9531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1065 – 10651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9UPU3.
    PRIDEiQ9UPU3.

    PTM databases

    PhosphoSiteiQ9UPU3.

    Expressioni

    Tissue specificityi

    Highly expressed in brain.

    Gene expression databases

    ArrayExpressiQ9UPU3.
    BgeeiQ9UPU3.
    CleanExiHS_SORCS3.
    GenevestigatoriQ9UPU3.

    Organism-specific databases

    HPAiHPA049097.

    Interactioni

    Protein-protein interaction databases

    BioGridi116635. 3 interactions.
    MINTiMINT-1326895.
    STRINGi9606.ENSP00000358715.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPU3.
    SMRiQ9UPU3. Positions 193-805, 816-913.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini34 – 11251092LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1147 – 122276CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1126 – 114621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati231 – 24212BNR 1Add
    BLAST
    Repeati279 – 29012BNR 2Add
    BLAST
    Repeati320 – 33112BNR 3Add
    BLAST
    Repeati515 – 52612BNR 4Add
    BLAST
    Repeati592 – 60312BNR 5Add
    BLAST
    Repeati634 – 64512BNR 6Add
    BLAST
    Domaini827 – 91791PKDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 6 BNR repeats.Curated
    Contains 1 PKD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281049.
    HOGENOMiHOG000236260.
    HOVERGENiHBG059252.
    InParanoidiQ9UPU3.
    OMAiLDQKLYS.
    OrthoDBiEOG7GJ6C3.
    PhylomeDBiQ9UPU3.
    TreeFamiTF324918.

    Family and domain databases

    Gene3Di2.60.40.670. 1 hit.
    InterProiIPR000601. PKD_dom.
    IPR006581. VPS10.
    [Graphical view]
    PfamiPF00801. PKD. 1 hit.
    [Graphical view]
    SMARTiSM00602. VPS10. 1 hit.
    [Graphical view]
    SUPFAMiSSF49299. SSF49299. 2 hits.
    PROSITEiPS50093. PKD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UPU3-1 [UniParc]FASTAAdd to Basket

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    MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA     50
    SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE 100
    MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP 150
    ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM 200
    VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK 250
    TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL 300
    LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK 350
    EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY 400
    IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV 450
    QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG 500
    IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL 550
    HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT 600
    WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS 650
    VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED 700
    YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW 750
    DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN 800
    CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG 850
    DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG 900
    SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW 950
    FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF 1000
    QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP 1050
    GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG 1100
    VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI 1150
    PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV 1200
    IGGIATIANS ESTKEIPNCT SV 1222
    Length:1,222
    Mass (Da):135,755
    Last modified:March 1, 2002 - v2
    Checksum:i57671F993B09D597
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028982 mRNA. Translation: BAA83011.2.
    AL161646
    , AL353900, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH70335.1.
    AL353900
    , AL161646, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAI64579.1.
    AL358949
    , AL161646, AL353900, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH72221.1.
    AL365449
    , AL161646, AL353900, AL358949, AL445492, AL596118 Genomic DNA. Translation: CAH70813.1.
    AL445492
    , AL161646, AL353900, AL358949, AL365449, AL596118 Genomic DNA. Translation: CAH70477.1.
    AL596118
    , AL161646, AL353900, AL358949, AL365449, AL445492 Genomic DNA. Translation: CAH70023.1.
    CCDSiCCDS7558.1.
    RefSeqiNP_055793.1. NM_014978.1.
    UniGeneiHs.671950.

    Genome annotation databases

    EnsembliENST00000369701; ENSP00000358715; ENSG00000156395.
    GeneIDi22986.
    KEGGihsa:22986.
    UCSCiuc001kyi.1. human.

    Polymorphism databases

    DMDMi27151703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028982 mRNA. Translation: BAA83011.2 .
    AL161646
    , AL353900 , AL358949 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAH70335.1 .
    AL353900
    , AL161646 , AL358949 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAI64579.1 .
    AL358949
    , AL161646 , AL353900 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAH72221.1 .
    AL365449
    , AL161646 , AL353900 , AL358949 , AL445492 , AL596118 Genomic DNA. Translation: CAH70813.1 .
    AL445492
    , AL161646 , AL353900 , AL358949 , AL365449 , AL596118 Genomic DNA. Translation: CAH70477.1 .
    AL596118
    , AL161646 , AL353900 , AL358949 , AL365449 , AL445492 Genomic DNA. Translation: CAH70023.1 .
    CCDSi CCDS7558.1.
    RefSeqi NP_055793.1. NM_014978.1.
    UniGenei Hs.671950.

    3D structure databases

    ProteinModelPortali Q9UPU3.
    SMRi Q9UPU3. Positions 193-805, 816-913.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116635. 3 interactions.
    MINTi MINT-1326895.
    STRINGi 9606.ENSP00000358715.

    PTM databases

    PhosphoSitei Q9UPU3.

    Polymorphism databases

    DMDMi 27151703.

    Proteomic databases

    PaxDbi Q9UPU3.
    PRIDEi Q9UPU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369701 ; ENSP00000358715 ; ENSG00000156395 .
    GeneIDi 22986.
    KEGGi hsa:22986.
    UCSCi uc001kyi.1. human.

    Organism-specific databases

    CTDi 22986.
    GeneCardsi GC10P106390.
    HGNCi HGNC:16699. SORCS3.
    HPAi HPA049097.
    MIMi 606285. gene.
    neXtProti NX_Q9UPU3.
    PharmGKBi PA134949387.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281049.
    HOGENOMi HOG000236260.
    HOVERGENi HBG059252.
    InParanoidi Q9UPU3.
    OMAi LDQKLYS.
    OrthoDBi EOG7GJ6C3.
    PhylomeDBi Q9UPU3.
    TreeFami TF324918.

    Miscellaneous databases

    GenomeRNAii 22986.
    NextBioi 43827.
    PROi Q9UPU3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPU3.
    Bgeei Q9UPU3.
    CleanExi HS_SORCS3.
    Genevestigatori Q9UPU3.

    Family and domain databases

    Gene3Di 2.60.40.670. 1 hit.
    InterProi IPR000601. PKD_dom.
    IPR006581. VPS10.
    [Graphical view ]
    Pfami PF00801. PKD. 1 hit.
    [Graphical view ]
    SMARTi SM00602. VPS10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49299. SSF49299. 2 hits.
    PROSITEi PS50093. PKD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genes for the human VPS10 domain-containing receptors are large and contain many small exons."
      Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C.
      Hum. Genet. 108:529-536(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSORC3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPU3
    Secondary accession number(s): Q5VXF9, Q9NQJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 13, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3