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Q9UPU3

- SORC3_HUMAN

UniProt

Q9UPU3 - SORC3_HUMAN

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Protein
VPS10 domain-containing receptor SorCS3
Gene
SORCS3, KIAA1059
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. neuropeptide receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS3
Gene namesi
Name:SORCS3
Synonyms:KIAA1059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:16699. SORCS3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 11251092Lumenal Reviewed prediction
Add
BLAST
Transmembranei1126 – 114621Helical; Reviewed prediction
Add
BLAST
Topological domaini1147 – 122276Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333 Reviewed prediction
Add
BLAST
Chaini34 – 12221189VPS10 domain-containing receptor SorCS3
PRO_0000033174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi789 – 7891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi800 – 8001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi840 – 8401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi932 – 9321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi953 – 9531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1065 – 10651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UPU3.
PRIDEiQ9UPU3.

PTM databases

PhosphoSiteiQ9UPU3.

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

ArrayExpressiQ9UPU3.
BgeeiQ9UPU3.
CleanExiHS_SORCS3.
GenevestigatoriQ9UPU3.

Organism-specific databases

HPAiHPA049097.

Interactioni

Protein-protein interaction databases

BioGridi116635. 3 interactions.
MINTiMINT-1326895.
STRINGi9606.ENSP00000358715.

Structurei

3D structure databases

ProteinModelPortaliQ9UPU3.
SMRiQ9UPU3. Positions 193-805, 816-913.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati231 – 24212BNR 1
Add
BLAST
Repeati279 – 29012BNR 2
Add
BLAST
Repeati320 – 33112BNR 3
Add
BLAST
Repeati515 – 52612BNR 4
Add
BLAST
Repeati592 – 60312BNR 5
Add
BLAST
Repeati634 – 64512BNR 6
Add
BLAST
Domaini827 – 91791PKD
Add
BLAST

Sequence similaritiesi

Contains 6 BNR repeats.
Contains 1 PKD domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281049.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ9UPU3.
OMAiLDQKLYS.
OrthoDBiEOG7GJ6C3.
PhylomeDBiQ9UPU3.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR000601. PKD_dom.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 2 hits.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UPU3-1 [UniParc]FASTAAdd to Basket

« Hide

MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA     50
SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE 100
MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP 150
ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM 200
VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK 250
TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL 300
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK 350
EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY 400
IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV 450
QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG 500
IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL 550
HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT 600
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS 650
VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED 700
YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW 750
DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN 800
CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG 850
DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG 900
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW 950
FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF 1000
QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP 1050
GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG 1100
VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI 1150
PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV 1200
IGGIATIANS ESTKEIPNCT SV 1222
Length:1,222
Mass (Da):135,755
Last modified:March 1, 2002 - v2
Checksum:i57671F993B09D597
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028982 mRNA. Translation: BAA83011.2.
AL161646
, AL353900, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH70335.1.
AL353900
, AL161646, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAI64579.1.
AL358949
, AL161646, AL353900, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH72221.1.
AL365449
, AL161646, AL353900, AL358949, AL445492, AL596118 Genomic DNA. Translation: CAH70813.1.
AL445492
, AL161646, AL353900, AL358949, AL365449, AL596118 Genomic DNA. Translation: CAH70477.1.
AL596118
, AL161646, AL353900, AL358949, AL365449, AL445492 Genomic DNA. Translation: CAH70023.1.
CCDSiCCDS7558.1.
RefSeqiNP_055793.1. NM_014978.1.
UniGeneiHs.671950.

Genome annotation databases

EnsembliENST00000369701; ENSP00000358715; ENSG00000156395.
GeneIDi22986.
KEGGihsa:22986.
UCSCiuc001kyi.1. human.

Polymorphism databases

DMDMi27151703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028982 mRNA. Translation: BAA83011.2 .
AL161646
, AL353900 , AL358949 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAH70335.1 .
AL353900
, AL161646 , AL358949 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAI64579.1 .
AL358949
, AL161646 , AL353900 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAH72221.1 .
AL365449
, AL161646 , AL353900 , AL358949 , AL445492 , AL596118 Genomic DNA. Translation: CAH70813.1 .
AL445492
, AL161646 , AL353900 , AL358949 , AL365449 , AL596118 Genomic DNA. Translation: CAH70477.1 .
AL596118
, AL161646 , AL353900 , AL358949 , AL365449 , AL445492 Genomic DNA. Translation: CAH70023.1 .
CCDSi CCDS7558.1.
RefSeqi NP_055793.1. NM_014978.1.
UniGenei Hs.671950.

3D structure databases

ProteinModelPortali Q9UPU3.
SMRi Q9UPU3. Positions 193-805, 816-913.
ModBasei Search...

Protein-protein interaction databases

BioGridi 116635. 3 interactions.
MINTi MINT-1326895.
STRINGi 9606.ENSP00000358715.

PTM databases

PhosphoSitei Q9UPU3.

Polymorphism databases

DMDMi 27151703.

Proteomic databases

PaxDbi Q9UPU3.
PRIDEi Q9UPU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369701 ; ENSP00000358715 ; ENSG00000156395 .
GeneIDi 22986.
KEGGi hsa:22986.
UCSCi uc001kyi.1. human.

Organism-specific databases

CTDi 22986.
GeneCardsi GC10P106390.
HGNCi HGNC:16699. SORCS3.
HPAi HPA049097.
MIMi 606285. gene.
neXtProti NX_Q9UPU3.
PharmGKBi PA134949387.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281049.
HOGENOMi HOG000236260.
HOVERGENi HBG059252.
InParanoidi Q9UPU3.
OMAi LDQKLYS.
OrthoDBi EOG7GJ6C3.
PhylomeDBi Q9UPU3.
TreeFami TF324918.

Miscellaneous databases

GenomeRNAii 22986.
NextBioi 43827.
PROi Q9UPU3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UPU3.
Bgeei Q9UPU3.
CleanExi HS_SORCS3.
Genevestigatori Q9UPU3.

Family and domain databases

Gene3Di 2.60.40.670. 1 hit.
InterProi IPR000601. PKD_dom.
IPR006581. VPS10.
[Graphical view ]
Pfami PF00801. PKD. 1 hit.
[Graphical view ]
SMARTi SM00602. VPS10. 1 hit.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 2 hits.
PROSITEi PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genes for the human VPS10 domain-containing receptors are large and contain many small exons."
    Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C.
    Hum. Genet. 108:529-536(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSORC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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