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Q9UPU3

- SORC3_HUMAN

UniProt

Q9UPU3 - SORC3_HUMAN

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Protein

VPS10 domain-containing receptor SorCS3

Gene

SORCS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. neuropeptide receptor activity Source: UniProtKB

GO - Biological processi

  1. learning Source: Ensembl
  2. memory Source: Ensembl
  3. neuropeptide signaling pathway Source: UniProtKB
  4. regulation of long term synaptic depression Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS3
Gene namesi
Name:SORCS3
Synonyms:KIAA1059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:16699. SORCS3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. neuronal postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Chaini34 – 12221189VPS10 domain-containing receptor SorCS3PRO_0000033174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi840 – 8401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi932 – 9321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi953 – 9531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1065 – 10651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UPU3.
PRIDEiQ9UPU3.

PTM databases

PhosphoSiteiQ9UPU3.

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

BgeeiQ9UPU3.
CleanExiHS_SORCS3.
ExpressionAtlasiQ9UPU3. baseline.
GenevestigatoriQ9UPU3.

Organism-specific databases

HPAiHPA049097.

Interactioni

Protein-protein interaction databases

BioGridi116635. 3 interactions.
MINTiMINT-1326895.
STRINGi9606.ENSP00000358715.

Structurei

3D structure databases

ProteinModelPortaliQ9UPU3.
SMRiQ9UPU3. Positions 193-805, 816-913.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini34 – 11251092LumenalSequence AnalysisAdd
BLAST
Topological domaini1147 – 122276CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1126 – 114621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati231 – 24212BNR 1Add
BLAST
Repeati279 – 29012BNR 2Add
BLAST
Repeati320 – 33112BNR 3Add
BLAST
Repeati515 – 52612BNR 4Add
BLAST
Repeati592 – 60312BNR 5Add
BLAST
Repeati634 – 64512BNR 6Add
BLAST
Domaini827 – 91791PKDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 6 BNR repeats.Curated
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281049.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ9UPU3.
OMAiLDQKLYS.
OrthoDBiEOG7GJ6C3.
PhylomeDBiQ9UPU3.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR000601. PKD_dom.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 2 hits.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UPU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA
60 70 80 90 100
SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE
110 120 130 140 150
MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP
160 170 180 190 200
ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM
210 220 230 240 250
VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK
260 270 280 290 300
TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL
310 320 330 340 350
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK
360 370 380 390 400
EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY
410 420 430 440 450
IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV
460 470 480 490 500
QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG
510 520 530 540 550
IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL
560 570 580 590 600
HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT
610 620 630 640 650
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS
660 670 680 690 700
VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED
710 720 730 740 750
YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW
760 770 780 790 800
DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN
810 820 830 840 850
CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG
860 870 880 890 900
DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG
910 920 930 940 950
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW
960 970 980 990 1000
FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF
1010 1020 1030 1040 1050
QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP
1060 1070 1080 1090 1100
GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG
1110 1120 1130 1140 1150
VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI
1160 1170 1180 1190 1200
PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV
1210 1220
IGGIATIANS ESTKEIPNCT SV
Length:1,222
Mass (Da):135,755
Last modified:March 1, 2002 - v2
Checksum:i57671F993B09D597
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028982 mRNA. Translation: BAA83011.2.
AL161646
, AL353900, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH70335.1.
AL353900
, AL161646, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAI64579.1.
AL358949
, AL161646, AL353900, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH72221.1.
AL365449
, AL161646, AL353900, AL358949, AL445492, AL596118 Genomic DNA. Translation: CAH70813.1.
AL445492
, AL161646, AL353900, AL358949, AL365449, AL596118 Genomic DNA. Translation: CAH70477.1.
AL596118
, AL161646, AL353900, AL358949, AL365449, AL445492 Genomic DNA. Translation: CAH70023.1.
CCDSiCCDS7558.1.
RefSeqiNP_055793.1. NM_014978.1.
UniGeneiHs.671950.

Genome annotation databases

EnsembliENST00000369699; ENSP00000358713; ENSG00000156395.
ENST00000369701; ENSP00000358715; ENSG00000156395.
GeneIDi22986.
KEGGihsa:22986.
UCSCiuc001kyi.1. human.

Polymorphism databases

DMDMi27151703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028982 mRNA. Translation: BAA83011.2 .
AL161646
, AL353900 , AL358949 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAH70335.1 .
AL353900
, AL161646 , AL358949 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAI64579.1 .
AL358949
, AL161646 , AL353900 , AL365449 , AL445492 , AL596118 Genomic DNA. Translation: CAH72221.1 .
AL365449
, AL161646 , AL353900 , AL358949 , AL445492 , AL596118 Genomic DNA. Translation: CAH70813.1 .
AL445492
, AL161646 , AL353900 , AL358949 , AL365449 , AL596118 Genomic DNA. Translation: CAH70477.1 .
AL596118
, AL161646 , AL353900 , AL358949 , AL365449 , AL445492 Genomic DNA. Translation: CAH70023.1 .
CCDSi CCDS7558.1.
RefSeqi NP_055793.1. NM_014978.1.
UniGenei Hs.671950.

3D structure databases

ProteinModelPortali Q9UPU3.
SMRi Q9UPU3. Positions 193-805, 816-913.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116635. 3 interactions.
MINTi MINT-1326895.
STRINGi 9606.ENSP00000358715.

PTM databases

PhosphoSitei Q9UPU3.

Polymorphism databases

DMDMi 27151703.

Proteomic databases

PaxDbi Q9UPU3.
PRIDEi Q9UPU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369699 ; ENSP00000358713 ; ENSG00000156395 .
ENST00000369701 ; ENSP00000358715 ; ENSG00000156395 .
GeneIDi 22986.
KEGGi hsa:22986.
UCSCi uc001kyi.1. human.

Organism-specific databases

CTDi 22986.
GeneCardsi GC10P106390.
HGNCi HGNC:16699. SORCS3.
HPAi HPA049097.
MIMi 606285. gene.
neXtProti NX_Q9UPU3.
PharmGKBi PA134949387.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281049.
GeneTreei ENSGT00510000046443.
HOGENOMi HOG000236260.
HOVERGENi HBG059252.
InParanoidi Q9UPU3.
OMAi LDQKLYS.
OrthoDBi EOG7GJ6C3.
PhylomeDBi Q9UPU3.
TreeFami TF324918.

Miscellaneous databases

GenomeRNAii 22986.
NextBioi 43827.
PROi Q9UPU3.
SOURCEi Search...

Gene expression databases

Bgeei Q9UPU3.
CleanExi HS_SORCS3.
ExpressionAtlasi Q9UPU3. baseline.
Genevestigatori Q9UPU3.

Family and domain databases

Gene3Di 2.60.40.670. 1 hit.
InterProi IPR000601. PKD_dom.
IPR006581. VPS10.
[Graphical view ]
Pfami PF00801. PKD. 1 hit.
[Graphical view ]
SMARTi SM00602. VPS10. 1 hit.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 2 hits.
PROSITEi PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genes for the human VPS10 domain-containing receptors are large and contain many small exons."
    Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C.
    Hum. Genet. 108:529-536(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSORC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3