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Protein

VPS10 domain-containing receptor SorCS3

Gene

SORCS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • neuropeptide receptor activity Source: UniProtKB

GO - Biological processi

  • learning Source: Ensembl
  • memory Source: Ensembl
  • neuropeptide signaling pathway Source: UniProtKB
  • regulation of long term synaptic depression Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS3
Gene namesi
Name:SORCS3
Synonyms:KIAA1059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:16699. SORCS3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 1125LumenalSequence analysisAdd BLAST1092
Transmembranei1126 – 1146HelicalSequence analysisAdd BLAST21
Topological domaini1147 – 1222CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22986.
OpenTargetsiENSG00000156395.
PharmGKBiPA134949387.

Polymorphism and mutation databases

BioMutaiSORCS3.
DMDMi27151703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000003317434 – 1222VPS10 domain-containing receptor SorCS3Add BLAST1189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi789N-linked (GlcNAc...)Sequence analysis1
Glycosylationi800N-linked (GlcNAc...)Sequence analysis1
Glycosylationi840N-linked (GlcNAc...)Sequence analysis1
Glycosylationi932N-linked (GlcNAc...)Sequence analysis1
Glycosylationi953N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1065N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UPU3.
PaxDbiQ9UPU3.
PeptideAtlasiQ9UPU3.
PRIDEiQ9UPU3.

PTM databases

iPTMnetiQ9UPU3.
PhosphoSitePlusiQ9UPU3.

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

BgeeiENSG00000156395.
CleanExiHS_SORCS3.
ExpressionAtlasiQ9UPU3. baseline and differential.
GenevisibleiQ9UPU3. HS.

Interactioni

Protein-protein interaction databases

BioGridi116635. 2 interactors.
IntActiQ9UPU3. 1 interactor.
MINTiMINT-1326895.
STRINGi9606.ENSP00000358715.

Structurei

3D structure databases

ProteinModelPortaliQ9UPU3.
SMRiQ9UPU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati231 – 242BNR 1Add BLAST12
Repeati279 – 290BNR 2Add BLAST12
Repeati320 – 331BNR 3Add BLAST12
Repeati515 – 526BNR 4Add BLAST12
Repeati592 – 603BNR 5Add BLAST12
Repeati634 – 645BNR 6Add BLAST12
Domaini827 – 917PKDPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 6 BNR repeats.Curated
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISX9. Eukaryota.
ENOG410XNN6. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ9UPU3.
OMAiLDQKLYS.
OrthoDBiEOG091G00JR.
PhylomeDBiQ9UPU3.
TreeFamiTF324918.

Family and domain databases

Gene3Di2.60.40.670. 2 hits.
InterProiIPR000601. PKD_dom.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 2 hits.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UPU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA
60 70 80 90 100
SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE
110 120 130 140 150
MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP
160 170 180 190 200
ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM
210 220 230 240 250
VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK
260 270 280 290 300
TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL
310 320 330 340 350
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK
360 370 380 390 400
EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY
410 420 430 440 450
IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV
460 470 480 490 500
QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG
510 520 530 540 550
IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL
560 570 580 590 600
HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT
610 620 630 640 650
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS
660 670 680 690 700
VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED
710 720 730 740 750
YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW
760 770 780 790 800
DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN
810 820 830 840 850
CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG
860 870 880 890 900
DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG
910 920 930 940 950
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW
960 970 980 990 1000
FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF
1010 1020 1030 1040 1050
QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP
1060 1070 1080 1090 1100
GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG
1110 1120 1130 1140 1150
VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI
1160 1170 1180 1190 1200
PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV
1210 1220
IGGIATIANS ESTKEIPNCT SV
Length:1,222
Mass (Da):135,755
Last modified:March 1, 2002 - v2
Checksum:i57671F993B09D597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028982 mRNA. Translation: BAA83011.2.
AL161646
, AL353900, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH70335.1.
AL353900
, AL161646, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAI64579.1.
AL358949
, AL161646, AL353900, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH72221.1.
AL365449
, AL161646, AL353900, AL358949, AL445492, AL596118 Genomic DNA. Translation: CAH70813.1.
AL445492
, AL161646, AL353900, AL358949, AL365449, AL596118 Genomic DNA. Translation: CAH70477.1.
AL596118
, AL161646, AL353900, AL358949, AL365449, AL445492 Genomic DNA. Translation: CAH70023.1.
CCDSiCCDS7558.1.
RefSeqiNP_055793.1. NM_014978.2.
UniGeneiHs.671950.

Genome annotation databases

EnsembliENST00000369699; ENSP00000358713; ENSG00000156395.
ENST00000369701; ENSP00000358715; ENSG00000156395.
GeneIDi22986.
KEGGihsa:22986.
UCSCiuc001kyi.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028982 mRNA. Translation: BAA83011.2.
AL161646
, AL353900, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH70335.1.
AL353900
, AL161646, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAI64579.1.
AL358949
, AL161646, AL353900, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH72221.1.
AL365449
, AL161646, AL353900, AL358949, AL445492, AL596118 Genomic DNA. Translation: CAH70813.1.
AL445492
, AL161646, AL353900, AL358949, AL365449, AL596118 Genomic DNA. Translation: CAH70477.1.
AL596118
, AL161646, AL353900, AL358949, AL365449, AL445492 Genomic DNA. Translation: CAH70023.1.
CCDSiCCDS7558.1.
RefSeqiNP_055793.1. NM_014978.2.
UniGeneiHs.671950.

3D structure databases

ProteinModelPortaliQ9UPU3.
SMRiQ9UPU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116635. 2 interactors.
IntActiQ9UPU3. 1 interactor.
MINTiMINT-1326895.
STRINGi9606.ENSP00000358715.

PTM databases

iPTMnetiQ9UPU3.
PhosphoSitePlusiQ9UPU3.

Polymorphism and mutation databases

BioMutaiSORCS3.
DMDMi27151703.

Proteomic databases

EPDiQ9UPU3.
PaxDbiQ9UPU3.
PeptideAtlasiQ9UPU3.
PRIDEiQ9UPU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369699; ENSP00000358713; ENSG00000156395.
ENST00000369701; ENSP00000358715; ENSG00000156395.
GeneIDi22986.
KEGGihsa:22986.
UCSCiuc001kyi.1. human.

Organism-specific databases

CTDi22986.
DisGeNETi22986.
GeneCardsiSORCS3.
HGNCiHGNC:16699. SORCS3.
MIMi606285. gene.
neXtProtiNX_Q9UPU3.
OpenTargetsiENSG00000156395.
PharmGKBiPA134949387.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISX9. Eukaryota.
ENOG410XNN6. LUCA.
GeneTreeiENSGT00510000046443.
HOGENOMiHOG000236260.
HOVERGENiHBG059252.
InParanoidiQ9UPU3.
OMAiLDQKLYS.
OrthoDBiEOG091G00JR.
PhylomeDBiQ9UPU3.
TreeFamiTF324918.

Miscellaneous databases

ChiTaRSiSORCS3. human.
GenomeRNAii22986.
PROiQ9UPU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156395.
CleanExiHS_SORCS3.
ExpressionAtlasiQ9UPU3. baseline and differential.
GenevisibleiQ9UPU3. HS.

Family and domain databases

Gene3Di2.60.40.670. 2 hits.
InterProiIPR000601. PKD_dom.
IPR031777. Sortilin_C.
IPR031778. Sortilin_N.
IPR006581. VPS10.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
PF15902. Sortilin-Vps10. 1 hit.
PF15901. Sortilin_C. 1 hit.
[Graphical view]
SMARTiSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 2 hits.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSORC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.