VPS10 domain-containing receptor SorCS3 precursor - Homo sapiens (Human)

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Q9UPU3 (SORC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
VPS10 domain-containing receptor SorCS3

Gene names

Name:	SORCS3
Synonyms:	KIAA1059

Organism

Homo sapiens (Human)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Highly expressed in brain.

Sequence similarities

Belongs to the VPS10-related sortilin family. SORCS subfamily.

Contains 6 BNR repeats.

Contains 1 PKD domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	neuropeptide receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

33

Potential

Chain

1189

VPS10 domain-containing receptor SorCS3

PRO_0000033174

Regions

Topological domain

1092

Lumenal Potential

Transmembrane

21

Helical; Potential

Topological domain

76

Cytoplasmic Potential

Repeat

12

BNR 1

Repeat

12

BNR 2

Repeat

12

BNR 3

Repeat

12

BNR 4

Repeat

12

BNR 5

Repeat

12

BNR 6

Domain

91

PKD

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UPU3 [UniParc].

Last modified March 1, 2002. Version 2.
Checksum: 57671F993B09D597
Show »

1,222

135,755

        10         20         30         40         50         60 
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA SRPPALSPLS 

        70         80         90        100        110        120 
PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE MQVEAGGTSP AGERRGRGIP 

       130        140        150        160        170        180 
APAKLGGARR SRRAQPPITQ ERGDAWATAP ADGSRGSRPL AKGSREEVKA PRAGGSAAED 

       190        200        210        220        230        240 
LRLPSTSFAL TGDSAHNQAM VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY 

       250        260        270        280        290        300 
EKLNDKVGLK TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL 

       310        320        330        340        350        360 
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK EADLVHMEVR 

       370        380        390        400        410        420 
TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY IFIQVTTSGR ASYYVSYRRE 

       430        440        450        460        470        480 
AFAQIKLPKY SLPKDMHIIS TDENQVFAAV QEWNQNDTYN LYISDTRGIY FTLAMENIKS 

       490        500        510        520        530        540 
SRGLMGNIII ELYEVAGIKG IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH 

       550        560        570        580        590        600 
CLLPFCSLHL HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT 

       610        620        630        640        650        660 
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS VPLFVDGALV 

       670        680        690        700        710        720 
EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED YQTWHLLNQG EPCVMGERKI 

       730        740        750        760        770        780 
FKKRKPGAQC ALGRDHSGSV VSEPCVCANW DFECDYGYER HGESQCVPAF WYNPASPSKD 

       790        800        810        820        830        840 
CSLGQSYLNS TGYRRIVSNN CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN 

       850        860        870        880        890        900 
ATFIILMEEG DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG 

       910        920        930        940        950        960 
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW FGNSTKPLIT 

       970        980        990       1000       1010       1020 
LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF QSQLLSFSPN LDYHNPDIPE 

      1030       1040       1050       1060       1070       1080 
WRKDIGNVIK RALVKVTSVP EDQILIAVFP GLPTSAELFI LPPKNLTERR KGNEGDLEQI 

      1090       1100       1110       1120       1130       1140 
VETLFNALNQ NLVQFELKPG VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV 

      1150       1160       1170       1180       1190       1200 
FLIYKFKRKI PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV 

      1210       1220 
IGGIATIANS ESTKEIPNCT SV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genes for the human VPS10 domain-containing receptors are large and contain many small exons." Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C. Hum. Genet. 108:529-536(2001) [PubMed: 11499680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028982 mRNA. Translation: BAA83011.2. AL161646 AL596118 Genomic DNA. Translation: CAH70335.1. AL353900 AL596118 Genomic DNA. Translation: CAI64579.1. AL358949 AL596118 Genomic DNA. Translation: CAH72221.1. AL365449 AL596118 Genomic DNA. Translation: CAH70813.1. AL445492 AL596118 Genomic DNA. Translation: CAH70477.1. AL596118 AL445492 Genomic DNA. Translation: CAH70023.1.
IPI	IPI00010381.
RefSeq	NP_055793.1. NM_014978.1.
UniGene	Hs.671950.
3D structure databases
ProteinModelPortal	Q9UPU3.
SMR	Q9UPU3. Positions 295-337, 570-650, 798-915.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1326895.
STRING	Q9UPU3.
PTM databases
PhosphoSite	Q9UPU3.
Polymorphism databases
DMDM	27151703.
Proteomic databases
PRIDE	Q9UPU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369701; ENSP00000358715; ENSG00000156395.
GeneID	22986.
KEGG	hsa:22986.
UCSC	uc001kyi.1. human.
Organism-specific databases
CTD	22986.
GeneCards	GC10P106390.
H-InvDB	HIX0009192.
HGNC	HGNC:16699. SORCS3.
MIM	606285. gene.
neXtProt	NX_Q9UPU3.
PharmGKB	PA134949387.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00510000046443.
HOGENOM	HBG445080.
HOVERGEN	HBG059252.
InParanoid	Q9UPU3.
OMA	FSRRCTK.
OrthoDB	EOG46HG8Z.
PhylomeDB	Q9UPU3.
Gene expression databases
ArrayExpress	Q9UPU3.
Bgee	Q9UPU3.
CleanEx	HS_SORCS3.
Genevestigator	Q9UPU3.
GermOnline	ENSG00000156395. Homo sapiens.
Family and domain databases
InterPro	IPR000601. PKD_dom. IPR006581. VPS10. [Graphical view]
Gene3D	G3DSA:2.60.40.670. PKD. 1 hit.
Pfam	PF00801. PKD. 1 hit. [Graphical view]
SMART	SM00602. VPS10. 1 hit. [Graphical view]
SUPFAM	SSF49299. PKD. 2 hits.
PROSITE	PS50093. PKD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43827.
SOURCE	Search...

Entry information

Entry name

SORC3_HUMAN

Accession

Primary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents