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Q9UPU3 (SORC3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
VPS10 domain-containing receptor SorCS3
Gene names
Name:SORCS3
Synonyms:KIAA1059
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1222 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Highly expressed in brain.

Sequence similarities

Belongs to the VPS10-related sortilin family. SORCS subfamily.

Contains 6 BNR repeats.

Contains 1 PKD domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Non-traceable author statement Ref.1. Source: UniProtKB

   Molecular_functionneuropeptide receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 12221189VPS10 domain-containing receptor SorCS3
PRO_0000033174

Regions

Topological domain34 – 11251092Lumenal Potential
Transmembrane1126 – 114621Helical; Potential
Topological domain1147 – 122276Cytoplasmic Potential
Repeat231 – 24212BNR 1
Repeat279 – 29012BNR 2
Repeat320 – 33112BNR 3
Repeat515 – 52612BNR 4
Repeat592 – 60312BNR 5
Repeat634 – 64512BNR 6
Domain827 – 91791PKD

Amino acid modifications

Glycosylation2071N-linked (GlcNAc...) Potential
Glycosylation4561N-linked (GlcNAc...) Potential
Glycosylation7891N-linked (GlcNAc...) Potential
Glycosylation8001N-linked (GlcNAc...) Potential
Glycosylation8401N-linked (GlcNAc...) Potential
Glycosylation9321N-linked (GlcNAc...) Potential
Glycosylation9531N-linked (GlcNAc...) Potential
Glycosylation10651N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9UPU3 [UniParc].

Last modified March 1, 2002. Version 2.
Checksum: 57671F993B09D597

FASTA1,222135,755
        10         20         30         40         50         60 
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA SRPPALSPLS 

        70         80         90        100        110        120 
PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE MQVEAGGTSP AGERRGRGIP 

       130        140        150        160        170        180 
APAKLGGARR SRRAQPPITQ ERGDAWATAP ADGSRGSRPL AKGSREEVKA PRAGGSAAED 

       190        200        210        220        230        240 
LRLPSTSFAL TGDSAHNQAM VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY 

       250        260        270        280        290        300 
EKLNDKVGLK TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL 

       310        320        330        340        350        360 
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK EADLVHMEVR 

       370        380        390        400        410        420 
TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY IFIQVTTSGR ASYYVSYRRE 

       430        440        450        460        470        480 
AFAQIKLPKY SLPKDMHIIS TDENQVFAAV QEWNQNDTYN LYISDTRGIY FTLAMENIKS 

       490        500        510        520        530        540 
SRGLMGNIII ELYEVAGIKG IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH 

       550        560        570        580        590        600 
CLLPFCSLHL HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT 

       610        620        630        640        650        660 
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS VPLFVDGALV 

       670        680        690        700        710        720 
EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED YQTWHLLNQG EPCVMGERKI 

       730        740        750        760        770        780 
FKKRKPGAQC ALGRDHSGSV VSEPCVCANW DFECDYGYER HGESQCVPAF WYNPASPSKD 

       790        800        810        820        830        840 
CSLGQSYLNS TGYRRIVSNN CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN 

       850        860        870        880        890        900 
ATFIILMEEG DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG 

       910        920        930        940        950        960 
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW FGNSTKPLIT 

       970        980        990       1000       1010       1020 
LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF QSQLLSFSPN LDYHNPDIPE 

      1030       1040       1050       1060       1070       1080 
WRKDIGNVIK RALVKVTSVP EDQILIAVFP GLPTSAELFI LPPKNLTERR KGNEGDLEQI 

      1090       1100       1110       1120       1130       1140 
VETLFNALNQ NLVQFELKPG VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV 

      1150       1160       1170       1180       1190       1200 
FLIYKFKRKI PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV 

      1210       1220 
IGGIATIANS ESTKEIPNCT SV 

« Hide

References

« Hide 'large scale' references
[1]"The genes for the human VPS10 domain-containing receptors are large and contain many small exons."
Hampe W., Rezgaoui M., Hermans-Borgmeyer I., Schaller H.C.
Hum. Genet. 108:529-536(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028982 mRNA. Translation: BAA83011.2.
AL161646 expand/collapse EMBL AC list , AL353900, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH70335.1.
AL353900 expand/collapse EMBL AC list , AL161646, AL358949, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAI64579.1.
AL358949 expand/collapse EMBL AC list , AL161646, AL353900, AL365449, AL445492, AL596118 Genomic DNA. Translation: CAH72221.1.
AL365449 expand/collapse EMBL AC list , AL161646, AL353900, AL358949, AL445492, AL596118 Genomic DNA. Translation: CAH70813.1.
AL445492 expand/collapse EMBL AC list , AL161646, AL353900, AL358949, AL365449, AL596118 Genomic DNA. Translation: CAH70477.1.
AL596118 expand/collapse EMBL AC list , AL161646, AL353900, AL358949, AL365449, AL445492 Genomic DNA. Translation: CAH70023.1.
CCDSCCDS7558.1.
RefSeqNP_055793.1. NM_014978.1.
UniGeneHs.671950.

3D structure databases

ProteinModelPortalQ9UPU3.
SMRQ9UPU3. Positions 193-805, 816-913.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116635. 3 interactions.
MINTMINT-1326895.
STRING9606.ENSP00000358715.

PTM databases

PhosphoSiteQ9UPU3.

Polymorphism databases

DMDM27151703.

Proteomic databases

PaxDbQ9UPU3.
PRIDEQ9UPU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369701; ENSP00000358715; ENSG00000156395.
GeneID22986.
KEGGhsa:22986.
UCSCuc001kyi.1. human.

Organism-specific databases

CTD22986.
GeneCardsGC10P106390.
HGNCHGNC:16699. SORCS3.
HPAHPA049097.
MIM606285. gene.
neXtProtNX_Q9UPU3.
PharmGKBPA134949387.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281049.
HOGENOMHOG000236260.
HOVERGENHBG059252.
InParanoidQ9UPU3.
OMALDQKLYS.
OrthoDBEOG7GJ6C3.
PhylomeDBQ9UPU3.
TreeFamTF324918.

Gene expression databases

ArrayExpressQ9UPU3.
BgeeQ9UPU3.
CleanExHS_SORCS3.
GenevestigatorQ9UPU3.

Family and domain databases

Gene3D2.60.40.670. 1 hit.
InterProIPR000601. PKD_dom.
IPR006581. VPS10.
[Graphical view]
PfamPF00801. PKD. 1 hit.
[Graphical view]
SMARTSM00602. VPS10. 1 hit.
[Graphical view]
SUPFAMSSF49299. SSF49299. 2 hits.
PROSITEPS50093. PKD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi22986.
NextBio43827.
PROQ9UPU3.
SOURCESearch...

Entry information

Entry nameSORC3_HUMAN
AccessionPrimary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM