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Q9UPT8

- ZC3H4_HUMAN

UniProt

Q9UPT8 - ZC3H4_HUMAN

Protein

Zinc finger CCCH domain-containing protein 4

Gene

ZC3H4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 3 (02 May 2006)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri390 – 41728C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44628C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 47024C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCCH domain-containing protein 4
    Gene namesi
    Name:ZC3H4
    Synonyms:C19orf7, KIAA1064
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17808. ZC3H4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409534.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13031303Zinc finger CCCH domain-containing protein 4PRO_0000234068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei72 – 721Phosphothreonine1 Publication
    Modified residuei75 – 751Phosphothreonine1 Publication
    Modified residuei76 – 761Phosphoserine1 Publication
    Modified residuei92 – 921Phosphoserine1 Publication
    Modified residuei94 – 941Phosphoserine1 Publication
    Modified residuei155 – 1551Phosphotyrosine1 Publication
    Modified residuei807 – 8071Phosphoserine2 Publications
    Modified residuei808 – 8081Phosphoserine1 Publication
    Modified residuei904 – 9041Phosphoserine2 Publications
    Modified residuei908 – 9081Phosphoserine1 Publication
    Modified residuei1104 – 11041Phosphoserine1 Publication
    Modified residuei1106 – 11061Phosphothreonine1 Publication
    Modified residuei1108 – 11081Phosphoserine1 Publication
    Modified residuei1114 – 11141Phosphoserine3 Publications
    Modified residuei1269 – 12691Phosphoserine2 Publications
    Modified residuei1275 – 12751Phosphoserine4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPT8.
    PaxDbiQ9UPT8.
    PRIDEiQ9UPT8.

    PTM databases

    PhosphoSiteiQ9UPT8.

    Miscellaneous databases

    PMAP-CutDBQ9UPT8.

    Expressioni

    Gene expression databases

    BgeeiQ9UPT8.
    CleanExiHS_ZC3H4.
    GenevestigatoriQ9UPT8.

    Organism-specific databases

    HPAiHPA040934.
    HPA041068.

    Interactioni

    Protein-protein interaction databases

    BioGridi116818. 17 interactions.
    IntActiQ9UPT8. 2 interactions.
    STRINGi9606.ENSP00000253048.

    Structurei

    Secondary structure

    1
    1303
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni426 – 4305
    Beta strandi440 – 4478
    Helixi450 – 4534
    Beta strandi464 – 4663
    Helixi472 – 48716

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CQENMR-A417-501[»]
    ProteinModelPortaliQ9UPT8.
    SMRiQ9UPT8. Positions 417-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9UPT8.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili95 – 12834Sequence AnalysisAdd
    BLAST
    Coiled coili767 – 80034Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 5147Pro-richAdd
    BLAST
    Compositional biasi233 – 374142Gly-richAdd
    BLAST
    Compositional biasi506 – 690185Pro-richAdd
    BLAST
    Compositional biasi1129 – 113810Poly-Gly

    Sequence similaritiesi

    Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri390 – 41728C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44628C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 47024C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG245027.
    HOGENOMiHOG000231733.
    HOVERGENiHBG108366.
    InParanoidiQ9UPT8.
    OMAiEGDTGNW.
    OrthoDBiEOG7ZWD14.
    PhylomeDBiQ9UPT8.
    TreeFamiTF321641.

    Family and domain databases

    Gene3Di4.10.1000.10. 1 hit.
    InterProiIPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 3 hits.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UPT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL     50
    PDDREDGELE EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH 100
    RRLKRKRKKE REKEKRRSKK RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK 150
    GHRKYREYSP PYAPSHQQYP PSHATPLPKK AYSKMDSKSY GMYEDYENEQ 200
    YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS RGRGRGYRGR 250
    GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD 300
    DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG 350
    GMNKGGMNDD EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV 400
    EGRCTWGDHC NFSHDIELPK KRELCKFYIT GFCARAENCP YMHGDFPCKL 450
    YHTTGNCING DDCMFSHDPL TEETRELLDK MLADDAEAGA EDEKEVEELK 500
    KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG PPPPPPPPPP 550
    PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV 600
    RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA 650
    DMPMGPGMNP GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ 700
    QQEGMEMEPG LLGDAEDYGH YEELPGEPGE HLFPEHPLEP DSFSEGGPPG 750
    RPKPGAGVPD FLPSAQRALY LRIQQKQQEE EERARRLAES SKQDRENEEG 800
    DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS SSGLGDPRLQ 850
    KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK 900
    PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR 950
    DPRSQLQQFS HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA 1000
    ALQSMPTLDP RLHRAATAGP PNARQRPGAS TDSSTQGANL PDFELLSRIL 1050
    KTVNATGSSA APGSSDKPSD PRVRKAPTDP RLQKPTDSTA SSRAAKPGPA 1100
    EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS SVLSGISLYD 1150
    PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE 1200
    TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL 1250
    PVPTLFGTVK QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP 1300
    FCQ 1303
    Length:1,303
    Mass (Da):140,257
    Last modified:May 2, 2006 - v3
    Checksum:iA6DAE368F543FF4D
    GO

    Sequence cautioni

    The sequence BAA83016.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti287 – 2871E → K.
    Corresponds to variant rs192824 [ dbSNP | Ensembl ].
    VAR_052964
    Natural varianti464 – 4641M → V.
    Corresponds to variant rs402833 [ dbSNP | Ensembl ].
    VAR_052965
    Natural varianti1228 – 12281A → G.
    Corresponds to variant rs309195 [ dbSNP | Ensembl ].
    VAR_052966

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028987 mRNA. Translation: BAA83016.2. Different initiation.
    AL050155 mRNA. Translation: CAB43296.1.
    CCDSiCCDS42582.1.
    PIRiT08781.
    RefSeqiNP_055983.1. NM_015168.1.
    XP_006723176.1. XM_006723113.1.
    UniGeneiHs.104661.

    Genome annotation databases

    EnsembliENST00000253048; ENSP00000253048; ENSG00000130749.
    GeneIDi23211.
    KEGGihsa:23211.
    UCSCiuc002pga.4. human.

    Polymorphism databases

    DMDMi94707996.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028987 mRNA. Translation: BAA83016.2 . Different initiation.
    AL050155 mRNA. Translation: CAB43296.1 .
    CCDSi CCDS42582.1.
    PIRi T08781.
    RefSeqi NP_055983.1. NM_015168.1.
    XP_006723176.1. XM_006723113.1.
    UniGenei Hs.104661.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CQE NMR - A 417-501 [» ]
    ProteinModelPortali Q9UPT8.
    SMRi Q9UPT8. Positions 417-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116818. 17 interactions.
    IntActi Q9UPT8. 2 interactions.
    STRINGi 9606.ENSP00000253048.

    PTM databases

    PhosphoSitei Q9UPT8.

    Polymorphism databases

    DMDMi 94707996.

    Proteomic databases

    MaxQBi Q9UPT8.
    PaxDbi Q9UPT8.
    PRIDEi Q9UPT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253048 ; ENSP00000253048 ; ENSG00000130749 .
    GeneIDi 23211.
    KEGGi hsa:23211.
    UCSCi uc002pga.4. human.

    Organism-specific databases

    CTDi 23211.
    GeneCardsi GC19M047569.
    HGNCi HGNC:17808. ZC3H4.
    HPAi HPA040934.
    HPA041068.
    neXtProti NX_Q9UPT8.
    PharmGKBi PA162409534.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245027.
    HOGENOMi HOG000231733.
    HOVERGENi HBG108366.
    InParanoidi Q9UPT8.
    OMAi EGDTGNW.
    OrthoDBi EOG7ZWD14.
    PhylomeDBi Q9UPT8.
    TreeFami TF321641.

    Miscellaneous databases

    ChiTaRSi ZC3H4. human.
    EvolutionaryTracei Q9UPT8.
    GenomeRNAii 23211.
    NextBioi 44759.
    PMAP-CutDB Q9UPT8.
    PROi Q9UPT8.

    Gene expression databases

    Bgeei Q9UPT8.
    CleanExi HS_ZC3H4.
    Genevestigatori Q9UPT8.

    Family and domain databases

    Gene3Di 4.10.1000.10. 1 hit.
    InterProi IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 3 hits.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 993-1303.
      Tissue: Uterus.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1269 AND SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75; SER-76; TYR-155; SER-807; SER-904; SER-908; THR-1106; SER-1108; SER-1114 AND SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-807; SER-808; SER-1104; SER-1114 AND SER-1269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-94; SER-904 AND SER-1114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Solution structure of the zinc-finger domain in KIAA1064 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: STRUCTURE BY NMR OF 417-501 IN COMPLEX WITH ZINC.

    Entry informationi

    Entry nameiZC3H4_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPT8
    Secondary accession number(s): Q9Y420
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 111 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3