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Protein

Zinc finger CCCH domain-containing protein 4

Gene

ZC3H4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri390 – 417C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri419 – 446C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri447 – 470C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 4
Gene namesi
Name:ZC3H4
Synonyms:C19orf7, KIAA1064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17808. ZC3H4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130749.
PharmGKBiPA162409534.

Polymorphism and mutation databases

BioMutaiZC3H4.
DMDMi94707996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340681 – 1303Zinc finger CCCH domain-containing protein 4Add BLAST1303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphothreonineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei155PhosphotyrosineCombined sources1
Modified residuei601Asymmetric dimethylarginineBy similarity1
Modified residuei807PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Modified residuei1106PhosphothreonineCombined sources1
Modified residuei1108PhosphoserineCombined sources1
Modified residuei1110PhosphoserineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1118PhosphothreonineBy similarity1
Modified residuei1269PhosphoserineCombined sources1
Modified residuei1275PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9UPT8.
MaxQBiQ9UPT8.
PaxDbiQ9UPT8.
PeptideAtlasiQ9UPT8.
PRIDEiQ9UPT8.

PTM databases

iPTMnetiQ9UPT8.
PhosphoSitePlusiQ9UPT8.
SwissPalmiQ9UPT8.

Miscellaneous databases

PMAP-CutDBQ9UPT8.

Expressioni

Gene expression databases

BgeeiENSG00000130749.
CleanExiHS_ZC3H4.
ExpressionAtlasiQ9UPT8. baseline and differential.
GenevisibleiQ9UPT8. HS.

Organism-specific databases

HPAiHPA040934.
HPA041068.

Interactioni

Protein-protein interaction databases

BioGridi116818. 27 interactors.
IntActiQ9UPT8. 5 interactors.
STRINGi9606.ENSP00000253048.

Structurei

Secondary structure

11303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni426 – 430Combined sources5
Beta strandi440 – 447Combined sources8
Helixi450 – 453Combined sources4
Beta strandi464 – 466Combined sources3
Helixi472 – 487Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQENMR-A417-501[»]
ProteinModelPortaliQ9UPT8.
SMRiQ9UPT8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UPT8.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili95 – 128Sequence analysisAdd BLAST34
Coiled coili767 – 800Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 51Pro-richAdd BLAST47
Compositional biasi233 – 374Gly-richAdd BLAST142
Compositional biasi506 – 690Pro-richAdd BLAST185
Compositional biasi1129 – 1138Poly-Gly10

Sequence similaritiesi

Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri390 – 417C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri419 – 446C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri447 – 470C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
ENOG410Y9BS. LUCA.
GeneTreeiENSGT00530000063288.
HOGENOMiHOG000231733.
HOVERGENiHBG108366.
InParanoidiQ9UPT8.
OMAiGPPQMPM.
OrthoDBiEOG091G02BE.
PhylomeDBiQ9UPT8.
TreeFamiTF321641.

Family and domain databases

Gene3Di4.10.1000.10. 3 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UPT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL
60 70 80 90 100
PDDREDGELE EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH
110 120 130 140 150
RRLKRKRKKE REKEKRRSKK RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK
160 170 180 190 200
GHRKYREYSP PYAPSHQQYP PSHATPLPKK AYSKMDSKSY GMYEDYENEQ
210 220 230 240 250
YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS RGRGRGYRGR
260 270 280 290 300
GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD
310 320 330 340 350
DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG
360 370 380 390 400
GMNKGGMNDD EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV
410 420 430 440 450
EGRCTWGDHC NFSHDIELPK KRELCKFYIT GFCARAENCP YMHGDFPCKL
460 470 480 490 500
YHTTGNCING DDCMFSHDPL TEETRELLDK MLADDAEAGA EDEKEVEELK
510 520 530 540 550
KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG PPPPPPPPPP
560 570 580 590 600
PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV
610 620 630 640 650
RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA
660 670 680 690 700
DMPMGPGMNP GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ
710 720 730 740 750
QQEGMEMEPG LLGDAEDYGH YEELPGEPGE HLFPEHPLEP DSFSEGGPPG
760 770 780 790 800
RPKPGAGVPD FLPSAQRALY LRIQQKQQEE EERARRLAES SKQDRENEEG
810 820 830 840 850
DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS SSGLGDPRLQ
860 870 880 890 900
KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK
910 920 930 940 950
PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR
960 970 980 990 1000
DPRSQLQQFS HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA
1010 1020 1030 1040 1050
ALQSMPTLDP RLHRAATAGP PNARQRPGAS TDSSTQGANL PDFELLSRIL
1060 1070 1080 1090 1100
KTVNATGSSA APGSSDKPSD PRVRKAPTDP RLQKPTDSTA SSRAAKPGPA
1110 1120 1130 1140 1150
EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS SVLSGISLYD
1160 1170 1180 1190 1200
PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE
1210 1220 1230 1240 1250
TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL
1260 1270 1280 1290 1300
PVPTLFGTVK QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP

FCQ
Length:1,303
Mass (Da):140,257
Last modified:May 2, 2006 - v3
Checksum:iA6DAE368F543FF4D
GO

Sequence cautioni

The sequence BAA83016 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052964287E → K.Corresponds to variant rs192824dbSNPEnsembl.1
Natural variantiVAR_052965464M → V.Corresponds to variant rs402833dbSNPEnsembl.1
Natural variantiVAR_0529661228A → G.Corresponds to variant rs309195dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028987 mRNA. Translation: BAA83016.2. Different initiation.
AL050155 mRNA. Translation: CAB43296.1.
CCDSiCCDS42582.1.
PIRiT08781.
RefSeqiNP_055983.1. NM_015168.1.
XP_006723176.1. XM_006723113.3.
UniGeneiHs.104661.

Genome annotation databases

EnsembliENST00000253048; ENSP00000253048; ENSG00000130749.
GeneIDi23211.
KEGGihsa:23211.
UCSCiuc002pga.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028987 mRNA. Translation: BAA83016.2. Different initiation.
AL050155 mRNA. Translation: CAB43296.1.
CCDSiCCDS42582.1.
PIRiT08781.
RefSeqiNP_055983.1. NM_015168.1.
XP_006723176.1. XM_006723113.3.
UniGeneiHs.104661.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQENMR-A417-501[»]
ProteinModelPortaliQ9UPT8.
SMRiQ9UPT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116818. 27 interactors.
IntActiQ9UPT8. 5 interactors.
STRINGi9606.ENSP00000253048.

PTM databases

iPTMnetiQ9UPT8.
PhosphoSitePlusiQ9UPT8.
SwissPalmiQ9UPT8.

Polymorphism and mutation databases

BioMutaiZC3H4.
DMDMi94707996.

Proteomic databases

EPDiQ9UPT8.
MaxQBiQ9UPT8.
PaxDbiQ9UPT8.
PeptideAtlasiQ9UPT8.
PRIDEiQ9UPT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253048; ENSP00000253048; ENSG00000130749.
GeneIDi23211.
KEGGihsa:23211.
UCSCiuc002pga.5. human.

Organism-specific databases

CTDi23211.
GeneCardsiZC3H4.
HGNCiHGNC:17808. ZC3H4.
HPAiHPA040934.
HPA041068.
neXtProtiNX_Q9UPT8.
OpenTargetsiENSG00000130749.
PharmGKBiPA162409534.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1040. Eukaryota.
ENOG410Y9BS. LUCA.
GeneTreeiENSGT00530000063288.
HOGENOMiHOG000231733.
HOVERGENiHBG108366.
InParanoidiQ9UPT8.
OMAiGPPQMPM.
OrthoDBiEOG091G02BE.
PhylomeDBiQ9UPT8.
TreeFamiTF321641.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130749-MONOMER.

Miscellaneous databases

ChiTaRSiZC3H4. human.
EvolutionaryTraceiQ9UPT8.
GenomeRNAii23211.
PMAP-CutDBQ9UPT8.
PROiQ9UPT8.

Gene expression databases

BgeeiENSG00000130749.
CleanExiHS_ZC3H4.
ExpressionAtlasiQ9UPT8. baseline and differential.
GenevisibleiQ9UPT8. HS.

Family and domain databases

Gene3Di4.10.1000.10. 3 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 3 hits.
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3H4_HUMAN
AccessioniPrimary (citable) accession number: Q9UPT8
Secondary accession number(s): Q9Y420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: November 30, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.