Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UPT8 (ZC3H4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger CCCH domain-containing protein 4
Gene names
Name:ZC3H4
Synonyms:C19orf7, KIAA1064
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1303 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 3 C3H1-type zinc fingers.

Sequence caution

The sequence BAA83016.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13031303Zinc finger CCCH domain-containing protein 4
PRO_0000234068

Regions

Zinc finger390 – 41728C3H1-type 1
Zinc finger419 – 44628C3H1-type 2
Zinc finger447 – 47024C3H1-type 3
Coiled coil95 – 12834 Potential
Coiled coil767 – 80034 Potential
Compositional bias5 – 5147Pro-rich
Compositional bias233 – 374142Gly-rich
Compositional bias506 – 690185Pro-rich
Compositional bias1129 – 113810Poly-Gly

Amino acid modifications

Modified residue721Phosphothreonine Ref.6
Modified residue751Phosphothreonine Ref.8
Modified residue761Phosphoserine Ref.8
Modified residue921Phosphoserine Ref.11
Modified residue941Phosphoserine Ref.11
Modified residue1551Phosphotyrosine Ref.8
Modified residue8071Phosphoserine Ref.8 Ref.10
Modified residue8081Phosphoserine Ref.10
Modified residue9041Phosphoserine Ref.8 Ref.11
Modified residue9081Phosphoserine Ref.8
Modified residue11041Phosphoserine Ref.10
Modified residue11061Phosphothreonine Ref.8
Modified residue11081Phosphoserine Ref.8
Modified residue11141Phosphoserine Ref.8 Ref.10 Ref.11
Modified residue12691Phosphoserine Ref.5 Ref.10
Modified residue12751Phosphoserine Ref.5 Ref.7 Ref.8 Ref.13

Natural variations

Natural variant2871E → K.
Corresponds to variant rs192824 [ dbSNP | Ensembl ].
VAR_052964
Natural variant4641M → V.
Corresponds to variant rs402833 [ dbSNP | Ensembl ].
VAR_052965
Natural variant12281A → G.
Corresponds to variant rs309195 [ dbSNP | Ensembl ].
VAR_052966

Secondary structure

........... 1303
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9UPT8 [UniParc].

Last modified May 2, 2006. Version 3.
Checksum: A6DAE368F543FF4D

FASTA1,303140,257
        10         20         30         40         50         60 
MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL PDDREDGELE 

        70         80         90        100        110        120 
EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH RRLKRKRKKE REKEKRRSKK 

       130        140        150        160        170        180 
RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK GHRKYREYSP PYAPSHQQYP PSHATPLPKK 

       190        200        210        220        230        240 
AYSKMDSKSY GMYEDYENEQ YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS 

       250        260        270        280        290        300 
RGRGRGYRGR GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD 

       310        320        330        340        350        360 
DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG GMNKGGMNDD 

       370        380        390        400        410        420 
EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV EGRCTWGDHC NFSHDIELPK 

       430        440        450        460        470        480 
KRELCKFYIT GFCARAENCP YMHGDFPCKL YHTTGNCING DDCMFSHDPL TEETRELLDK 

       490        500        510        520        530        540 
MLADDAEAGA EDEKEVEELK KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG 

       550        560        570        580        590        600 
PPPPPPPPPP PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV 

       610        620        630        640        650        660 
RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA DMPMGPGMNP 

       670        680        690        700        710        720 
GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ QQEGMEMEPG LLGDAEDYGH 

       730        740        750        760        770        780 
YEELPGEPGE HLFPEHPLEP DSFSEGGPPG RPKPGAGVPD FLPSAQRALY LRIQQKQQEE 

       790        800        810        820        830        840 
EERARRLAES SKQDRENEEG DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS 

       850        860        870        880        890        900 
SSGLGDPRLQ KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK 

       910        920        930        940        950        960 
PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR DPRSQLQQFS 

       970        980        990       1000       1010       1020 
HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA ALQSMPTLDP RLHRAATAGP 

      1030       1040       1050       1060       1070       1080 
PNARQRPGAS TDSSTQGANL PDFELLSRIL KTVNATGSSA APGSSDKPSD PRVRKAPTDP 

      1090       1100       1110       1120       1130       1140 
RLQKPTDSTA SSRAAKPGPA EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS 

      1150       1160       1170       1180       1190       1200 
SVLSGISLYD PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE 

      1210       1220       1230       1240       1250       1260 
TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL PVPTLFGTVK 

      1270       1280       1290       1300 
QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP FCQ 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 993-1303.
Tissue: Uterus.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1269 AND SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-75; SER-76; TYR-155; SER-807; SER-904; SER-908; THR-1106; SER-1108; SER-1114 AND SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-807; SER-808; SER-1104; SER-1114 AND SER-1269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[11]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-94; SER-904 AND SER-1114, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1275, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Solution structure of the zinc-finger domain in KIAA1064 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: STRUCTURE BY NMR OF 417-501 IN COMPLEX WITH ZINC.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028987 mRNA. Translation: BAA83016.2. Different initiation.
AL050155 mRNA. Translation: CAB43296.1.
CCDSCCDS42582.1.
PIRT08781.
RefSeqNP_055983.1. NM_015168.1.
XP_006723176.1. XM_006723113.1.
UniGeneHs.104661.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQENMR-A417-501[»]
ProteinModelPortalQ9UPT8.
SMRQ9UPT8. Positions 417-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116818. 16 interactions.
IntActQ9UPT8. 2 interactions.
STRING9606.ENSP00000253048.

PTM databases

PhosphoSiteQ9UPT8.

Polymorphism databases

DMDM94707996.

Proteomic databases

MaxQBQ9UPT8.
PaxDbQ9UPT8.
PRIDEQ9UPT8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253048; ENSP00000253048; ENSG00000130749.
GeneID23211.
KEGGhsa:23211.
UCSCuc002pga.4. human.

Organism-specific databases

CTD23211.
GeneCardsGC19M047569.
HGNCHGNC:17808. ZC3H4.
HPAHPA040934.
HPA041068.
neXtProtNX_Q9UPT8.
PharmGKBPA162409534.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245027.
HOGENOMHOG000231733.
HOVERGENHBG108366.
InParanoidQ9UPT8.
OMAEGDTGNW.
OrthoDBEOG7ZWD14.
PhylomeDBQ9UPT8.
TreeFamTF321641.

Gene expression databases

BgeeQ9UPT8.
CleanExHS_ZC3H4.
GenevestigatorQ9UPT8.

Family and domain databases

Gene3D4.10.1000.10. 1 hit.
InterProIPR000571. Znf_CCCH.
[Graphical view]
PfamPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZC3H4. human.
EvolutionaryTraceQ9UPT8.
GenomeRNAi23211.
NextBio44759.
PMAP-CutDBQ9UPT8.
PROQ9UPT8.

Entry information

Entry nameZC3H4_HUMAN
AccessionPrimary (citable) accession number: Q9UPT8
Secondary accession number(s): Q9Y420
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: July 9, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM