Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exocyst complex component 7

Gene

EXOC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 7
Alternative name(s):
Exocyst complex component Exo70
Gene namesi
Name:EXOC7
Synonyms:EXO70, KIAA1067
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:23214. EXOC7.

Subcellular locationi

GO - Cellular componenti

  • centriolar satellite Source: BHF-UCL
  • cytosol Source: Reactome
  • exocyst Source: InterPro
  • growth cone membrane Source: Ensembl
  • membrane Source: UniProtKB
  • microtubule organizing center Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988420.

Polymorphism and mutation databases

BioMutaiEXOC7.
DMDMi38372889.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Exocyst complex component 7PRO_0000118960Add
BLAST

Proteomic databases

MaxQBiQ9UPT5.
PaxDbiQ9UPT5.
PRIDEiQ9UPT5.

PTM databases

PhosphoSiteiQ9UPT5.

Expressioni

Gene expression databases

BgeeiQ9UPT5.
CleanExiHS_EXOC7.
ExpressionAtlasiQ9UPT5. baseline and differential.
GenevisibleiQ9UPT5. HS.

Organism-specific databases

HPAiHPA022840.
HPA022842.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ARFGEF2Q9Y6D54EBI-6251402,EBI-2837511
HGSO149644EBI-720048,EBI-740220
IFT20Q8IY314EBI-720048,EBI-744203
SMARCE1Q969G35EBI-720048,EBI-455078
SSC5DA1L4H13EBI-720048,EBI-10172867

Protein-protein interaction databases

BioGridi116867. 40 interactions.
IntActiQ9UPT5. 23 interactions.
MINTiMINT-3083437.
STRINGi9606.ENSP00000334100.

Structurei

3D structure databases

ProteinModelPortaliQ9UPT5.
SMRiQ9UPT5. Positions 85-241, 357-734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 4238Sequence AnalysisAdd
BLAST
Coiled coili63 – 8523Sequence AnalysisAdd
BLAST

Domaini

The N-terminus is involved in SEC8 and ARHQ binding.By similarity
The C-terminus is required for translocation to the plasma membrane.By similarity

Sequence similaritiesi

Belongs to the EXO70 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG245075.
GeneTreeiENSGT00390000003595.
HOVERGENiHBG051515.
InParanoidiQ9UPT5.
KOiK07195.
OMAiADIIPEH.
OrthoDBiEOG7S4X64.
PhylomeDBiQ9UPT5.
TreeFamiTF324243.

Family and domain databases

InterProiIPR016159. Cullin_repeat-like_dom.
IPR004140. Exo70.
[Graphical view]
PANTHERiPTHR12542. PTHR12542. 1 hit.
PfamiPF03081. Exo70. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 2 hits.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q9UPT5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE
60 70 80 90 100
SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI
110 120 130 140 150
IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKEAL
160 170 180 190 200
ESEFRSLMTR HSKVVSPVLI LDLISGDDDL EAQEDVTLEH LPESVLQDVI
210 220 230 240 250
RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK SSSSSGVPYS
260 270 280 290 300
PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE
310 320 330 340 350
GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL
360 370 380 390 400
AGRDDMLDVE TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ
410 420 430 440 450
DALDGLMLEG ENIVSAARKA IVRHDFSTVL TVFPILRHLK QTKPEFDQVL
460 470 480 490 500
QGTAASTKNK LPGLITSMET IGAKALEDFA DNIKNDPDKE YNMPKDGTVH
510 520 530 540 550
ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF SKRLLSTYIC
560 570 580 590 600
KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT
610 620 630 640 650
QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ
660 670 680 690 700
IIKERFKGFN DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL
710 720 730
QKFGSVPFTK NPEKYIKYGV EQVGDMIDRL FDTSA
Note: No experimental confirmation available.
Length:735
Mass (Da):83,382
Last modified:November 14, 2003 - v3
Checksum:i6B929762542854B6
GO
Isoform 1 (identifier: Q9UPT5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-352: Missing.

Show »
Length:684
Mass (Da):78,060
Checksum:i6E25C7BAB9017D9E
GO
Isoform 2 (identifier: Q9UPT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-352: Missing.

Show »
Length:653
Mass (Da):74,713
Checksum:iD70DC752161DDE68
GO
Isoform 4 (identifier: Q9UPT5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-283: TIRKAQNLLKQYS → EPPSWPISATARG
     284-735: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:283
Mass (Da):32,451
Checksum:i93885953F51F60E1
GO
Isoform 5 (identifier: Q9UPT5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-327: Missing.

Show »
Length:676
Mass (Da):77,303
Checksum:i2CBC61E2A6578A8A
GO
Isoform 6 (identifier: Q9UPT5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-328: Missing.

Show »
Length:707
Mass (Da):80,650
Checksum:i3EF94FEE3F52C8E9
GO

Sequence cautioni

The sequence BAA83019.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14095.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341L → Q in BAB14694 (PubMed:14702039).Curated
Sequence conflicti362 – 3621D → N in BAB14694 (PubMed:14702039).Curated
Sequence conflicti459 – 4591N → I in AAH18466 (PubMed:15489334).Curated
Sequence conflicti646 – 6461D → G in BAB14694 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei269 – 32759Missing in isoform 5. 1 PublicationVSP_041098Add
BLAST
Alternative sequencei271 – 35282Missing in isoform 2. 1 PublicationVSP_001483Add
BLAST
Alternative sequencei271 – 28313TIRKA…LKQYS → EPPSWPISATARG in isoform 4. 1 PublicationVSP_008876Add
BLAST
Alternative sequencei284 – 735452Missing in isoform 4. 1 PublicationVSP_008877Add
BLAST
Alternative sequencei301 – 32828Missing in isoform 6. 1 PublicationVSP_041099Add
BLAST
Alternative sequencei302 – 35251Missing in isoform 1. 3 PublicationsVSP_008878Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ457119 mRNA. Translation: ACK36853.1.
FJ457120 mRNA. Translation: ACK36854.1.
AB028990 mRNA. Translation: BAA83019.1. Different initiation.
AK022397 mRNA. Translation: BAB14026.1.
AK022552 mRNA. Translation: BAB14095.1. Different initiation.
AK023832 mRNA. Translation: BAB14694.1.
AL834324 mRNA. Translation: CAD38992.2.
AC018665 Genomic DNA. No translation available.
BC011045 mRNA. Translation: AAH11045.1.
BC018466 mRNA. Translation: AAH18466.1.
CCDSiCCDS11741.1. [Q9UPT5-2]
CCDS32738.1. [Q9UPT5-1]
CCDS45781.1. [Q9UPT5-5]
CCDS45782.1. [Q9UPT5-3]
RefSeqiNP_001013861.1. NM_001013839.3. [Q9UPT5-1]
NP_001138769.1. NM_001145297.3. [Q9UPT5-3]
NP_001138770.1. NM_001145298.3. [Q9UPT5-5]
NP_001138771.1. NM_001145299.3. [Q9UPT5-6]
NP_001269242.1. NM_001282313.1.
NP_056034.2. NM_015219.4. [Q9UPT5-2]
UniGeneiHs.514496.

Genome annotation databases

EnsembliENST00000332065; ENSP00000333806; ENSG00000182473. [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473.
ENST00000411744; ENSP00000404322; ENSG00000182473. [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473. [Q9UPT5-1]
GeneIDi23265.
KEGGihsa:23265.
UCSCiuc002jqq.3. human. [Q9UPT5-1]
uc002jqr.3. human. [Q9UPT5-2]
uc002jqs.3. human. [Q9UPT5-3]
uc002jqu.2. human. [Q9UPT5-4]
uc010wsw.2. human. [Q9UPT5-6]
uc010wsx.2. human. [Q9UPT5-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ457119 mRNA. Translation: ACK36853.1.
FJ457120 mRNA. Translation: ACK36854.1.
AB028990 mRNA. Translation: BAA83019.1. Different initiation.
AK022397 mRNA. Translation: BAB14026.1.
AK022552 mRNA. Translation: BAB14095.1. Different initiation.
AK023832 mRNA. Translation: BAB14694.1.
AL834324 mRNA. Translation: CAD38992.2.
AC018665 Genomic DNA. No translation available.
BC011045 mRNA. Translation: AAH11045.1.
BC018466 mRNA. Translation: AAH18466.1.
CCDSiCCDS11741.1. [Q9UPT5-2]
CCDS32738.1. [Q9UPT5-1]
CCDS45781.1. [Q9UPT5-5]
CCDS45782.1. [Q9UPT5-3]
RefSeqiNP_001013861.1. NM_001013839.3. [Q9UPT5-1]
NP_001138769.1. NM_001145297.3. [Q9UPT5-3]
NP_001138770.1. NM_001145298.3. [Q9UPT5-5]
NP_001138771.1. NM_001145299.3. [Q9UPT5-6]
NP_001269242.1. NM_001282313.1.
NP_056034.2. NM_015219.4. [Q9UPT5-2]
UniGeneiHs.514496.

3D structure databases

ProteinModelPortaliQ9UPT5.
SMRiQ9UPT5. Positions 85-241, 357-734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116867. 40 interactions.
IntActiQ9UPT5. 23 interactions.
MINTiMINT-3083437.
STRINGi9606.ENSP00000334100.

PTM databases

PhosphoSiteiQ9UPT5.

Polymorphism and mutation databases

BioMutaiEXOC7.
DMDMi38372889.

Proteomic databases

MaxQBiQ9UPT5.
PaxDbiQ9UPT5.
PRIDEiQ9UPT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332065; ENSP00000333806; ENSG00000182473. [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473.
ENST00000411744; ENSP00000404322; ENSG00000182473. [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473. [Q9UPT5-1]
GeneIDi23265.
KEGGihsa:23265.
UCSCiuc002jqq.3. human. [Q9UPT5-1]
uc002jqr.3. human. [Q9UPT5-2]
uc002jqs.3. human. [Q9UPT5-3]
uc002jqu.2. human. [Q9UPT5-4]
uc010wsw.2. human. [Q9UPT5-6]
uc010wsx.2. human. [Q9UPT5-5]

Organism-specific databases

CTDi23265.
GeneCardsiGC17M074077.
HGNCiHGNC:23214. EXOC7.
HPAiHPA022840.
HPA022842.
MIMi608163. gene.
neXtProtiNX_Q9UPT5.
PharmGKBiPA134988420.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245075.
GeneTreeiENSGT00390000003595.
HOVERGENiHBG051515.
InParanoidiQ9UPT5.
KOiK07195.
OMAiADIIPEH.
OrthoDBiEOG7S4X64.
PhylomeDBiQ9UPT5.
TreeFamiTF324243.

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_15550. Insulin processing.
REACT_268299. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiEXOC7. human.
GeneWikiiEXOC7.
GenomeRNAii23265.
NextBioi45012.
PROiQ9UPT5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UPT5.
CleanExiHS_EXOC7.
ExpressionAtlasiQ9UPT5. baseline and differential.
GenevisibleiQ9UPT5. HS.

Family and domain databases

InterProiIPR016159. Cullin_repeat-like_dom.
IPR004140. Exo70.
[Graphical view]
PANTHERiPTHR12542. PTHR12542. 1 hit.
PfamiPF03081. Exo70. 1 hit.
[Graphical view]
SUPFAMiSSF74788. SSF74788. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "EXOC7 is alternatively spliced in cellular senescence."
    Dellago H., Loescher M., Ajuh P., Voglauer R., Fortschegger K., Eisenhaber F., Lamond A.I., Grillari J.
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Mammary gland, Placenta and Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain and Eye.
  7. "Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis."
    Fielding A.B., Schonteich E., Matheson J., Wilson G., Yu X., Hickson G.R., Srivastava S., Baldwin S.A., Prekeris R., Gould G.W.
    EMBO J. 24:3389-3399(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB11FIP3.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXOC7_HUMAN
AccessioniPrimary (citable) accession number: Q9UPT5
Secondary accession number(s): B5MC69
, B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 14, 2003
Last modified: July 22, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.