Q9UPT5 (EXOC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exocyst complex component 7

Alternative name(s):
Exocyst complex component Exo70

Gene names

Name:	EXOC7
Synonyms:	EXO70, KIAA1067

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	735 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion By similarity.
Subunit structure	The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 By similarity. Ref.7
Subcellular location	Cytoplasm › cytosol By similarity. Cell membrane; Peripheral membrane protein By similarity. Note: Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ By similarity.
Domain	The N-terminus is involved in SEC8 and ARHQ binding By similarity. The C-terminus is required for translocation to the plasma membrane By similarity.
Sequence similarities	Belongs to the EXO70 family.
Sequence caution	The sequence BAA83019.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB14095.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Exocytosis Protein transport Transport
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Traceable author statement. Source: Reactome cellular protein metabolic process Traceable author statement. Source: Reactome exocytosis Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	centriolar satellite Inferred from direct assay PubMed 18000879. Source: BHF-UCL cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell exocyst Inferred from electronic annotation. Source: InterPro growth cone membrane Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARFGEF2	Q9Y6D5	4	EBI-6251402,EBI-2837511

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 3 (identifier: Q9UPT5-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 1 (identifier: Q9UPT5-1)

The sequence of this isoform differs from the canonical sequence as follows:
     302-352: Missing.

Isoform 2 (identifier: Q9UPT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     271-352: Missing.

Isoform 4 (identifier: Q9UPT5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     271-283: TIRKAQNLLKQYS → EPPSWPISATARG
     284-735: Missing.

Note: May be due to intron retention. No experimental confirmation available.

Isoform 5 (identifier: Q9UPT5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     269-327: Missing.

Isoform 6 (identifier: Q9UPT5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     301-328: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 735	735	Exocyst complex component 7		PRO_0000118960
Regions
	Coiled coil	5 – 42	38	Potential
	Coiled coil	63 – 85	23	Potential
Natural variations
	Alternative sequence	269 – 327	59	Missing in isoform 5.		VSP_041098
	Alternative sequence	271 – 352	82	Missing in isoform 2.		VSP_001483
	Alternative sequence	271 – 283	13	TIRKA…LKQYS → EPPSWPISATARG in isoform 4.		VSP_008876
	Alternative sequence	284 – 735	452	Missing in isoform 4.		VSP_008877
	Alternative sequence	301 – 328	28	Missing in isoform 6.		VSP_041099
	Alternative sequence	302 – 352	51	Missing in isoform 1.		VSP_008878
Experimental info
	Sequence conflict	234	1	L → Q in BAB14694. Ref.3
	Sequence conflict	362	1	D → N in BAB14694. Ref.3
	Sequence conflict	459	1	N → I in AAH18466. Ref.6
	Sequence conflict	646	1	D → G in BAB14694. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 3 [UniParc]. Last modified November 14, 2003. Version 3. Checksum: 6B929762542854B6	FASTA	735	83,382
	10 20 30 40 50 60 MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 70 80 90 100 110 120 IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 130 140 150 160 170 180 KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 190 200 210 220 230 240 EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 250 260 270 280 290 300 SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE 310 320 330 340 350 360 GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL AGRDDMLDVE 370 380 390 400 410 420 TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ DALDGLMLEG ENIVSAARKA 430 440 450 460 470 480 IVRHDFSTVL TVFPILRHLK QTKPEFDQVL QGTAASTKNK LPGLITSMET IGAKALEDFA 490 500 510 520 530 540 DNIKNDPDKE YNMPKDGTVH ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF 550 560 570 580 590 600 SKRLLSTYIC KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT 610 620 630 640 650 660 QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ IIKERFKGFN 670 680 690 700 710 720 DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL QKFGSVPFTK NPEKYIKYGV 730 EQVGDMIDRL FDTSA
	Isoform 1 [UniParc]. Checksum: 6E25C7BAB9017D9E	FASTA	684	78,060
	10 20 30 40 50 60 MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 70 80 90 100 110 120 IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 130 140 150 160 170 180 KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 190 200 210 220 230 240 EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 250 260 270 280 290 300 SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE 310 320 330 340 350 360 GRDDMLDVET DAYIHCVSAF VKLAQSEYQL LADIIPEHHQ KKTFDSLIQD ALDGLMLEGE 370 380 390 400 410 420 NIVSAARKAI VRHDFSTVLT VFPILRHLKQ TKPEFDQVLQ GTAASTKNKL PGLITSMETI 430 440 450 460 470 480 GAKALEDFAD NIKNDPDKEY NMPKDGTVHE LTSNAILFLQ QLLDFQETAG AMLASQETSS 490 500 510 520 530 540 SATSYSSEFS KRLLSTYICK VLGNLQLNLL SKSKVYEDPA LSAIFLHNNY NYILKSLEKS 550 560 570 580 590 600 ELIQLVAVTQ KTAERSYREH IEQQIQTYQR SWLKVTDYIA EKNLPVFQPG VKLRDKERQI 610 620 630 640 650 660 IKERFKGFND GLEELCKIQK AWAIPDTEQR DRIRQAQKTI VKETYGAFLQ KFGSVPFTKN 670 680 PEKYIKYGVE QVGDMIDRLF DTSA
	Isoform 2 [UniParc]. Checksum: D70DC752161DDE68	FASTA	653	74,713
	10 20 30 40 50 60 MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 70 80 90 100 110 120 IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 130 140 150 160 170 180 KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 190 200 210 220 230 240 EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 250 260 270 280 290 300 SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG RDDMLDVETD AYIHCVSAFV KLAQSEYQLL 310 320 330 340 350 360 ADIIPEHHQK KTFDSLIQDA LDGLMLEGEN IVSAARKAIV RHDFSTVLTV FPILRHLKQT 370 380 390 400 410 420 KPEFDQVLQG TAASTKNKLP GLITSMETIG AKALEDFADN IKNDPDKEYN MPKDGTVHEL 430 440 450 460 470 480 TSNAILFLQQ LLDFQETAGA MLASQETSSS ATSYSSEFSK RLLSTYICKV LGNLQLNLLS 490 500 510 520 530 540 KSKVYEDPAL SAIFLHNNYN YILKSLEKSE LIQLVAVTQK TAERSYREHI EQQIQTYQRS 550 560 570 580 590 600 WLKVTDYIAE KNLPVFQPGV KLRDKERQII KERFKGFNDG LEELCKIQKA WAIPDTEQRD 610 620 630 640 650 RIRQAQKTIV KETYGAFLQK FGSVPFTKNP EKYIKYGVEQ VGDMIDRLFD TSA
	Isoform 4 [UniParc]. Checksum: 93885953F51F60E1	FASTA	283	32,451
	10 20 30 40 50 60 MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 70 80 90 100 110 120 IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 130 140 150 160 170 180 KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 190 200 210 220 230 240 EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 250 260 270 280 SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG EPPSWPISAT ARG
	Isoform 5 [UniParc]. Checksum: 2CBC61E2A6578A8A	FASTA	676	77,303
	10 20 30 40 50 60 MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 70 80 90 100 110 120 IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 130 140 150 160 170 180 KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 190 200 210 220 230 240 EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 250 260 270 280 290 300 SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG HEHDFRVKHL SEALNDKHGP LAGRDDMLDV 310 320 330 340 350 360 ETDAYIHCVS AFVKLAQSEY QLLADIIPEH HQKKTFDSLI QDALDGLMLE GENIVSAARK 370 380 390 400 410 420 AIVRHDFSTV LTVFPILRHL KQTKPEFDQV LQGTAASTKN KLPGLITSME TIGAKALEDF 430 440 450 460 470 480 ADNIKNDPDK EYNMPKDGTV HELTSNAILF LQQLLDFQET AGAMLASQET SSSATSYSSE 490 500 510 520 530 540 FSKRLLSTYI CKVLGNLQLN LLSKSKVYED PALSAIFLHN NYNYILKSLE KSELIQLVAV 550 560 570 580 590 600 TQKTAERSYR EHIEQQIQTY QRSWLKVTDY IAEKNLPVFQ PGVKLRDKER QIIKERFKGF 610 620 630 640 650 660 NDGLEELCKI QKAWAIPDTE QRDRIRQAQK TIVKETYGAF LQKFGSVPFT KNPEKYIKYG 670 VEQVGDMIDR LFDTSA
	Isoform 6 [UniParc]. Checksum: 3EF94FEE3F52C8E9	FASTA	707	80,650
	10 20 30 40 50 60 MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 70 80 90 100 110 120 IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 130 140 150 160 170 180 KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 190 200 210 220 230 240 EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 250 260 270 280 290 300 SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE 310 320 330 340 350 360 GHEHDFRVKH LSEALNDKHG PLAGRDDMLD VETDAYIHCV SAFVKLAQSE YQLLADIIPE 370 380 390 400 410 420 HHQKKTFDSL IQDALDGLML EGENIVSAAR KAIVRHDFST VLTVFPILRH LKQTKPEFDQ 430 440 450 460 470 480 VLQGTAASTK NKLPGLITSM ETIGAKALED FADNIKNDPD KEYNMPKDGT VHELTSNAIL 490 500 510 520 530 540 FLQQLLDFQE TAGAMLASQE TSSSATSYSS EFSKRLLSTY ICKVLGNLQL NLLSKSKVYE 550 560 570 580 590 600 DPALSAIFLH NNYNYILKSL EKSELIQLVA VTQKTAERSY REHIEQQIQT YQRSWLKVTD 610 620 630 640 650 660 YIAEKNLPVF QPGVKLRDKE RQIIKERFKG FNDGLEELCK IQKAWAIPDT EQRDRIRQAQ 670 680 690 700 KTIVKETYGA FLQKFGSVPF TKNPEKYIKY GVEQVGDMID RLFDTSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"EXOC7 is alternatively spliced in cellular senescence." Dellago H., Loescher M., Ajuh P., Voglauer R., Fortschegger K., Eisenhaber F., Lamond A.I., Grillari J. Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
[2]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Mammary gland, Placenta and Teratocarcinoma.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain and Eye.
[7]	"Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis." Fielding A.B., Schonteich E., Matheson J., Wilson G., Yu X., Hickson G.R., Srivastava S., Baldwin S.A., Prekeris R., Gould G.W. EMBO J. 24:3389-3399(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RAB11FIP3.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FJ457119 mRNA. Translation: ACK36853.1. FJ457120 mRNA. Translation: ACK36854.1. AB028990 mRNA. Translation: BAA83019.1. Different initiation. AK022397 mRNA. Translation: BAB14026.1. AK022552 mRNA. Translation: BAB14095.1. Different initiation. AK023832 mRNA. Translation: BAB14694.1. AL834324 mRNA. Translation: CAD38992.2. AC018665 Genomic DNA. No translation available. BC011045 mRNA. Translation: AAH11045.1. BC018466 mRNA. Translation: AAH18466.1.
IPI	IPI00103064. IPI00172532. IPI00394717. IPI00641168. IPI00877965. IPI00879399.
RefSeq	NP_001013861.1. NM_001013839.2. NP_001138769.1. NM_001145297.2. NP_001138770.1. NM_001145298.2. NP_001138771.1. NM_001145299.2. NP_056034.2. NM_015219.3.
UniGene	Hs.514496.
3D structure databases
ProteinModelPortal	Q9UPT5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UPT5. 18 interactions.
MINT	MINT-3083437.
STRING	9606.ENSP00000334100.
PTM databases
PhosphoSite	Q9UPT5.
Polymorphism databases
DMDM	38372889.
Proteomic databases
PaxDb	Q9UPT5.
PRIDE	Q9UPT5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332065; ENSP00000333806; ENSG00000182473. ENST00000335146; ENSP00000334100; ENSG00000182473. ENST00000405575; ENSP00000384368; ENSG00000182473. ENST00000411744; ENSP00000404322; ENSG00000182473. ENST00000589210; ENSP00000468404; ENSG00000182473.
GeneID	23265.
KEGG	hsa:23265.
UCSC	uc002jqq.3. human. uc002jqr.3. human. uc002jqs.3. human. uc002jqu.2. human. uc010wsw.2. human. uc010wsx.2. human.
Organism-specific databases
CTD	23265.
GeneCards	GC17M074077.
HGNC	HGNC:23214. EXOC7.
HPA	HPA022840. HPA022842.
MIM	608163. gene.
neXtProt	NX_Q9UPT5.
PharmGKB	PA134988420.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245075.
HOVERGEN	HBG051515.
InParanoid	Q9UPT5.
KO	K07195.
OMA	KPIKRPG.
PhylomeDB	Q9UPT5.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events. insulin_pathway. Insulin Pathway.
Reactome	REACT_11123. Membrane Trafficking. REACT_116125. Disease.
Gene expression databases
ArrayExpress	Q9UPT5.
Bgee	Q9UPT5.
CleanEx	HS_EXOC7.
Genevestigator	Q9UPT5.
GermOnline	ENSG00000182473. Homo sapiens.
Family and domain databases
InterPro	IPR016159. Cullin_repeat-like_dom. IPR004140. Exo70. [Graphical view]
PANTHER	PTHR12542. PTHR12542. 1 hit.
Pfam	PF03081. Exo70. 1 hit. [Graphical view]
SUPFAM	SSF74788. Cullin_repeat-like. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	EXOC7. human.
GenomeRNAi	23265.
NextBio	45012.
SOURCE	Search...

Entry information

Entry name

EXOC7_HUMAN

Accession

Primary (citable) accession number: Q9UPT5
Secondary accession number(s): B5MC69 , B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	November 14, 2003
Last modified:	May 29, 2013
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.