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Q9UPT5 (EXOC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exocyst complex component 7
Alternative name(s):
Exocyst complex component Exo70
Gene names
Name:EXOC7
Synonyms:EXO70, KIAA1067
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length735 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion By similarity.

Subunit structure

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 By similarity. Ref.7

Subcellular location

Cytoplasmcytosol By similarity. Cell membrane; Peripheral membrane protein By similarity. Note: Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ By similarity.

Domain

The N-terminus is involved in SEC8 and ARHQ binding By similarity.

The C-terminus is required for translocation to the plasma membrane By similarity.

Sequence similarities

Belongs to the EXO70 family.

Sequence caution

The sequence BAA83019.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB14095.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ARFGEF2Q9Y6D54EBI-6251402,EBI-2837511

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 3 (identifier: Q9UPT5-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 1 (identifier: Q9UPT5-1)

The sequence of this isoform differs from the canonical sequence as follows:
     302-352: Missing.
Isoform 2 (identifier: Q9UPT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     271-352: Missing.
Isoform 4 (identifier: Q9UPT5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     271-283: TIRKAQNLLKQYS → EPPSWPISATARG
     284-735: Missing.
Note: May be due to intron retention. No experimental confirmation available.
Isoform 5 (identifier: Q9UPT5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     269-327: Missing.
Isoform 6 (identifier: Q9UPT5-6)

The sequence of this isoform differs from the canonical sequence as follows:
     301-328: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 735735Exocyst complex component 7
PRO_0000118960

Regions

Coiled coil5 – 4238 Potential
Coiled coil63 – 8523 Potential

Natural variations

Alternative sequence269 – 32759Missing in isoform 5.
VSP_041098
Alternative sequence271 – 35282Missing in isoform 2.
VSP_001483
Alternative sequence271 – 28313TIRKA…LKQYS → EPPSWPISATARG in isoform 4.
VSP_008876
Alternative sequence284 – 735452Missing in isoform 4.
VSP_008877
Alternative sequence301 – 32828Missing in isoform 6.
VSP_041099
Alternative sequence302 – 35251Missing in isoform 1.
VSP_008878

Experimental info

Sequence conflict2341L → Q in BAB14694. Ref.3
Sequence conflict3621D → N in BAB14694. Ref.3
Sequence conflict4591N → I in AAH18466. Ref.6
Sequence conflict6461D → G in BAB14694. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 3 [UniParc].

Last modified November 14, 2003. Version 3.
Checksum: 6B929762542854B6

FASTA73583,382
        10         20         30         40         50         60 
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE SRLMKLENSI 

        70         80         90        100        110        120 
IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI IREGPTGRLE EYLGSMAKIQ 

       130        140        150        160        170        180 
KAVEYFQDNS PDSPELNKVK LLFERGKEAL ESEFRSLMTR HSKVVSPVLI LDLISGDDDL 

       190        200        210        220        230        240 
EAQEDVTLEH LPESVLQDVI RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK 

       250        260        270        280        290        300 
SSSSSGVPYS PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE 

       310        320        330        340        350        360 
GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL AGRDDMLDVE 

       370        380        390        400        410        420 
TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ DALDGLMLEG ENIVSAARKA 

       430        440        450        460        470        480 
IVRHDFSTVL TVFPILRHLK QTKPEFDQVL QGTAASTKNK LPGLITSMET IGAKALEDFA 

       490        500        510        520        530        540 
DNIKNDPDKE YNMPKDGTVH ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF 

       550        560        570        580        590        600 
SKRLLSTYIC KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT 

       610        620        630        640        650        660 
QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ IIKERFKGFN 

       670        680        690        700        710        720 
DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL QKFGSVPFTK NPEKYIKYGV 

       730 
EQVGDMIDRL FDTSA 

« Hide

Isoform 1 [UniParc].

Checksum: 6E25C7BAB9017D9E
Show »

FASTA68478,060
Isoform 2 [UniParc].

Checksum: D70DC752161DDE68
Show »

FASTA65374,713
Isoform 4 [UniParc].

Checksum: 93885953F51F60E1
Show »

FASTA28332,451
Isoform 5 [UniParc].

Checksum: 2CBC61E2A6578A8A
Show »

FASTA67677,303
Isoform 6 [UniParc].

Checksum: 3EF94FEE3F52C8E9
Show »

FASTA70780,650

References

« Hide 'large scale' references
[1]"EXOC7 is alternatively spliced in cellular senescence."
Dellago H., Loescher M., Ajuh P., Voglauer R., Fortschegger K., Eisenhaber F., Lamond A.I., Grillari J.
Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
[2]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
Tissue: Mammary gland, Placenta and Teratocarcinoma.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Brain and Eye.
[7]"Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis."
Fielding A.B., Schonteich E., Matheson J., Wilson G., Yu X., Hickson G.R., Srivastava S., Baldwin S.A., Prekeris R., Gould G.W.
EMBO J. 24:3389-3399(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAB11FIP3.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FJ457119 mRNA. Translation: ACK36853.1.
FJ457120 mRNA. Translation: ACK36854.1.
AB028990 mRNA. Translation: BAA83019.1. Different initiation.
AK022397 mRNA. Translation: BAB14026.1.
AK022552 mRNA. Translation: BAB14095.1. Different initiation.
AK023832 mRNA. Translation: BAB14694.1.
AL834324 mRNA. Translation: CAD38992.2.
AC018665 Genomic DNA. No translation available.
BC011045 mRNA. Translation: AAH11045.1.
BC018466 mRNA. Translation: AAH18466.1.
RefSeqNP_001013861.1. NM_001013839.3.
NP_001138769.1. NM_001145297.3.
NP_001138770.1. NM_001145298.3.
NP_001138771.1. NM_001145299.3.
NP_001269242.1. NM_001282313.1.
NP_056034.2. NM_015219.4.
UniGeneHs.514496.

3D structure databases

ProteinModelPortalQ9UPT5.
SMRQ9UPT5. Positions 85-734.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116867. 24 interactions.
IntActQ9UPT5. 20 interactions.
MINTMINT-3083437.
STRING9606.ENSP00000334100.

PTM databases

PhosphoSiteQ9UPT5.

Polymorphism databases

DMDM38372889.

Proteomic databases

PaxDbQ9UPT5.
PRIDEQ9UPT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332065; ENSP00000333806; ENSG00000182473. [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473. [Q9UPT5-3]
ENST00000411744; ENSP00000404322; ENSG00000182473. [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473. [Q9UPT5-1]
ENST00000607838; ENSP00000475431; ENSG00000182473. [Q9UPT5-6]
GeneID23265.
KEGGhsa:23265.
UCSCuc002jqq.3. human. [Q9UPT5-1]
uc002jqr.3. human. [Q9UPT5-2]
uc002jqs.3. human. [Q9UPT5-3]
uc002jqu.2. human. [Q9UPT5-4]
uc010wsw.2. human. [Q9UPT5-6]
uc010wsx.2. human. [Q9UPT5-5]

Organism-specific databases

CTD23265.
GeneCardsGC17M074077.
HGNCHGNC:23214. EXOC7.
HPAHPA022840.
HPA022842.
MIM608163. gene.
neXtProtNX_Q9UPT5.
PharmGKBPA134988420.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245075.
HOVERGENHBG051515.
InParanoidQ9UPT5.
KOK07195.
OMAADIIPEH.
OrthoDBEOG7S4X64.
PhylomeDBQ9UPT5.
TreeFamTF324243.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.
REACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ9UPT5.
BgeeQ9UPT5.
CleanExHS_EXOC7.
GenevestigatorQ9UPT5.

Family and domain databases

InterProIPR016159. Cullin_repeat-like_dom.
IPR004140. Exo70.
[Graphical view]
PANTHERPTHR12542. PTHR12542. 1 hit.
PfamPF03081. Exo70. 1 hit.
[Graphical view]
SUPFAMSSF74788. SSF74788. 2 hits.
ProtoNetSearch...

Other

ChiTaRSEXOC7. human.
GeneWikiEXOC7.
GenomeRNAi23265.
NextBio45012.
PROQ9UPT5.
SOURCESearch...

Entry information

Entry nameEXOC7_HUMAN
AccessionPrimary (citable) accession number: Q9UPT5
Secondary accession number(s): B5MC69 expand/collapse secondary AC list , B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 14, 2003
Last modified: April 16, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM