ID   ANR26_HUMAN             Reviewed;        1710 AA.
AC   Q9UPS8; A6NH29; Q2TAZ3; Q6ZR14; Q9H1Q1; Q9NSK9; Q9NTD5; Q9NW69;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 4.
DT   27-MAR-2024, entry version 171.
DE   RecName: Full=Ankyrin repeat domain-containing protein 26 {ECO:0000305};
GN   Name=ANKRD26 {ECO:0000312|HGNC:HGNC:29186}; Synonyms=KIAA1074;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ARG-20.
RC   TISSUE=Brain;
RX   PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA   Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA   Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIV. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 6:197-205(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1522 (ISOFORM 2), NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 1-546 (ISOFORM 1), AND VARIANTS ARG-20;
RP   SER-606 DEL; ILE-1305 AND LEU-1514.
RC   TISSUE=Embryo, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1338-1710.
RC   TISSUE=Melanoma, and Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1546-1710.
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Lymphoblast;
RX   PubMed=14654843; DOI=10.1038/nature02166;
RA   Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT   "Proteomic characterization of the human centrosome by protein correlation
RT   profiling.";
RL   Nature 426:570-574(2003).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=16364570; DOI=10.1016/j.gene.2005.07.045;
RA   Hahn Y., Bera T.K., Pastan I.H., Lee B.;
RT   "Duplication and extensive remodeling shaped POTE family genes encoding
RT   proteins containing ankyrin repeat and coiled coil domains.";
RL   Gene 366:238-245(2006).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic kidney;
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA   Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA   Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [10]
RP   INVOLVEMENT IN THC2.
RX   PubMed=21211618; DOI=10.1016/j.ajhg.2010.12.006;
RA   Pippucci T., Savoia A., Perrotta S., Pujol-Moix N., Noris P.,
RA   Castegnaro G., Pecci A., Gnan C., Punzo F., Marconi C., Gherardi S.,
RA   Loffredo G., De Rocco D., Scianguetta S., Barozzi S., Magini P., Bozzi V.,
RA   Dezzani L., Di Stazio M., Ferraro M., Perini G., Seri M., Balduini C.L.;
RT   "Mutations in the 5' UTR of ANKRD26, the ankirin repeat domain 26 gene,
RT   cause an autosomal-dominant form of inherited thrombocytopenia, THC2.";
RL   Am. J. Hum. Genet. 88:115-120(2011).
RN   [11]
RP   INTERACTION WITH TRIO; CCDC85B; GPS2 AND HMMR.
RX   PubMed=22666460; DOI=10.1371/journal.pone.0038130;
RA   Liu X.F., Bera T.K., Kahue C., Escobar T., Fei Z., Raciti G.A., Pastan I.;
RT   "ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate
RT   adipogenesis in 3T3-L1 cells.";
RL   PLoS ONE 7:E38130-E38130(2012).
RN   [12]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-15; SER-261; SER-489;
RP   SER-530 AND SER-631, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP   ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Acts as a regulator of adipogenesis. Involved in the
CC       regulation of the feeding behavior. {ECO:0000250|UniProtKB:Q811D2}.
CC   -!- SUBUNIT: Interacts with TRIO (PubMed:22666460). Interacts with GPS2
CC       (PubMed:22666460). Interacts with CCDC85B (PubMed:22666460). Interacts
CC       with HMMR (PubMed:22666460). {ECO:0000269|PubMed:22666460}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UPS8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UPS8-2; Sequence=VSP_019434, VSP_019435;
CC   -!- DISEASE: Thrombocytopenia 2 (THC2) [MIM:188000]: A form of
CC       thrombocytopenia, a hematologic disorder defined by a decrease in the
CC       number of platelets in circulating blood, resulting in the potential
CC       for increased bleeding and decreased ability for clotting.
CC       {ECO:0000269|PubMed:21211618}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA83026.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB028997; BAA83026.2; ALT_INIT; mRNA.
DR   EMBL; AL162272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK001137; BAA91516.1; -; mRNA.
DR   EMBL; AK128577; BAC87508.1; -; mRNA.
DR   EMBL; AL137351; CAB70706.1; -; mRNA.
DR   EMBL; AL162063; CAB82401.1; -; mRNA.
DR   EMBL; BC110646; AAI10647.1; -; mRNA.
DR   CCDS; CCDS41499.1; -. [Q9UPS8-1]
DR   PIR; T46425; T46425.
DR   PIR; T47167; T47167.
DR   RefSeq; NP_001242982.1; NM_001256053.1.
DR   RefSeq; NP_055730.2; NM_014915.2. [Q9UPS8-1]
DR   AlphaFoldDB; Q9UPS8; -.
DR   SMR; Q9UPS8; -.
DR   BioGRID; 116523; 120.
DR   IntAct; Q9UPS8; 38.
DR   MINT; Q9UPS8; -.
DR   STRING; 9606.ENSP00000365255; -.
DR   GlyGen; Q9UPS8; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9UPS8; -.
DR   PhosphoSitePlus; Q9UPS8; -.
DR   BioMuta; ANKRD26; -.
DR   DMDM; 109940217; -.
DR   EPD; Q9UPS8; -.
DR   jPOST; Q9UPS8; -.
DR   MassIVE; Q9UPS8; -.
DR   MaxQB; Q9UPS8; -.
DR   PaxDb; 9606-ENSP00000365255; -.
DR   PeptideAtlas; Q9UPS8; -.
DR   ProteomicsDB; 85431; -. [Q9UPS8-1]
DR   ProteomicsDB; 85432; -. [Q9UPS8-2]
DR   Pumba; Q9UPS8; -.
DR   Antibodypedia; 25959; 146 antibodies from 25 providers.
DR   DNASU; 22852; -.
DR   Ensembl; ENST00000376087.5; ENSP00000365255.4; ENSG00000107890.17. [Q9UPS8-1]
DR   GeneID; 22852; -.
DR   KEGG; hsa:22852; -.
DR   MANE-Select; ENST00000376087.5; ENSP00000365255.4; NM_014915.3; NP_055730.2.
DR   UCSC; uc009xku.2; human. [Q9UPS8-1]
DR   AGR; HGNC:29186; -.
DR   CTD; 22852; -.
DR   DisGeNET; 22852; -.
DR   GeneCards; ANKRD26; -.
DR   GeneReviews; ANKRD26; -.
DR   HGNC; HGNC:29186; ANKRD26.
DR   HPA; ENSG00000107890; Low tissue specificity.
DR   MalaCards; ANKRD26; -.
DR   MIM; 188000; phenotype.
DR   MIM; 610855; gene.
DR   neXtProt; NX_Q9UPS8; -.
DR   OpenTargets; ENSG00000107890; -.
DR   Orphanet; 168629; Autosomal thrombocytopenia with normal platelets.
DR   Orphanet; 71290; Familial platelet disorder with associated myeloid malignancy.
DR   PharmGKB; PA134926710; -.
DR   VEuPathDB; HostDB:ENSG00000107890; -.
DR   eggNOG; ENOG502QR0R; Eukaryota.
DR   GeneTree; ENSGT00940000162459; -.
DR   HOGENOM; CLU_001111_0_0_1; -.
DR   InParanoid; Q9UPS8; -.
DR   OMA; QCQMKEV; -.
DR   OrthoDB; 2385613at2759; -.
DR   PhylomeDB; Q9UPS8; -.
DR   TreeFam; TF333496; -.
DR   PathwayCommons; Q9UPS8; -.
DR   Reactome; R-HSA-9696264; RND3 GTPase cycle.
DR   Reactome; R-HSA-9696270; RND2 GTPase cycle.
DR   Reactome; R-HSA-9696273; RND1 GTPase cycle.
DR   SignaLink; Q9UPS8; -.
DR   SIGNOR; Q9UPS8; -.
DR   BioGRID-ORCS; 22852; 8 hits in 1160 CRISPR screens.
DR   ChiTaRS; ANKRD26; human.
DR   GeneWiki; ANKRD26; -.
DR   GenomeRNAi; 22852; -.
DR   Pharos; Q9UPS8; Tbio.
DR   PRO; PR:Q9UPS8; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9UPS8; Protein.
DR   Bgee; ENSG00000107890; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 126 other cell types or tissues.
DR   ExpressionAtlas; Q9UPS8; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR   GO; GO:0045599; P:negative regulation of fat cell differentiation; ISS:UniProtKB.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR039497; CC144C-like_CC_dom.
DR   InterPro; IPR021885; DUF3496.
DR   PANTHER; PTHR24147; ANKYRIN REPEAT DOMAIN 36-RELATED; 1.
DR   PANTHER; PTHR24147:SF60; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 26-RELATED; 1.
DR   Pfam; PF00023; Ank; 2.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF14915; CCDC144C; 1.
DR   Pfam; PF12001; DUF3496; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF57997; Tropomyosin; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   Genevisible; Q9UPS8; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; ANK repeat; Coiled coil; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1710
FT                   /note="Ankyrin repeat domain-containing protein 26"
FT                   /id="PRO_0000240843"
FT   REPEAT          45..75
FT                   /note="ANK 1"
FT   REPEAT          79..108
FT                   /note="ANK 2"
FT   REPEAT          112..141
FT                   /note="ANK 3"
FT   REPEAT          145..174
FT                   /note="ANK 4"
FT   REPEAT          178..207
FT                   /note="ANK 5"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          892..912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          529..566
FT                   /evidence="ECO:0000255"
FT   COILED          743..873
FT                   /evidence="ECO:0000255"
FT   COILED          905..1472
FT                   /evidence="ECO:0000255"
FT   COILED          1517..1587
FT                   /evidence="ECO:0000255"
FT   COILED          1649..1674
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        230..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..568
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..599
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        657..680
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..698
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         11
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         15
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         241
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q811D2"
FT   MOD_RES         261
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         489
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         530
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   MOD_RES         631
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         1..443
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_019434"
FT   VAR_SEQ         444..545
FT                   /note="KEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLH
FT                   LKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQ -> MNHMF
FT                   HIKRHSISAGTDAYKKTKPIQNLFQKPLYDHCSANNYKSMEPELENVRSSPPRGDRTSK
FT                   VSLKEELQQDMQRFKNEIGMLKVEFQALEKEKVQLQKE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_019435"
FT   VARIANT         20
FT                   /note="Q -> R (in dbSNP:rs7897309)"
FT                   /evidence="ECO:0000269|PubMed:10470851,
FT                   ECO:0000269|PubMed:14702039"
FT                   /id="VAR_026833"
FT   VARIANT         425
FT                   /note="I -> V (in dbSNP:rs12359281)"
FT                   /id="VAR_055513"
FT   VARIANT         606
FT                   /note="Missing (in dbSNP:rs564681878)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_080646"
FT   VARIANT         1220
FT                   /note="V -> L (in dbSNP:rs12572862)"
FT                   /id="VAR_055514"
FT   VARIANT         1305
FT                   /note="V -> I (in dbSNP:rs10829163)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_026834"
FT   VARIANT         1514
FT                   /note="F -> L (in dbSNP:rs2274741)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_026835"
FT   CONFLICT        1347
FT                   /note="D -> G (in Ref. 3; BAC87508)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1517..1523
FT                   /note="NNFASMK -> KQDLPDS (in Ref. 3; BAC87508)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1710 AA;  196411 MW;  01CBF9BADB894872 CRC64;
     MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI HKAASAGNVA
     KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV DRKCQLNVCD NENRTALMKA
     VQCQEEKCAT ILLEHGADPN LADVHGNTAL HYAVYNEDIS VATKLLLYDA NIEAKNKDDL
     TPLLLAVSGK KQQMVEFLIK KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES
     SEDSLSRLSG KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR
     TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK SLANPGLMKE
     EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN RSDMMSALGL GQEEDIESPW
     DSESISENFP QKYVDPLAGA ADGKEKNIGN EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV
     GMPVAHMESP ERYLHLKPTI EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE
     NNQPQVEEER KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN
     KEYASSGPAL QMKEVKSTEK EKRTSKESVN SPVFGKASLL TGGLLQVDDD SSLSEIDEDE
     GRPTKKTSNE KNKVKNQIQS MDDVDDLTQS SETASEDCEL PHSSYKNFML LIEQLGMECK
     DSVSLLKIQD AALSCERLLE LKKNHCELLT VKIKKMEDKV NVLQRELSET KEIKSQLEHQ
     KVEWERELCS LRFSLNQEEE KRRNADTLYE KIREQLRRKE EQYRKEVEVK QQLELSLQTL
     EMELRTVKSN LNQVVQERND AQRQLSREQN ARMLQDGILT NHLSKQKEIE MAQKKMNSEN
     SHSHEEEKDL SHKNSMLQEE IAMLRLEIDT IKNQNQEKEK KCFEDLKIVK EKNEDLQKTI
     KQNEETLTQT ISQYNGRLSV LTAENAMLNS KLENEKQSKE RLEAEVESYH SRLAAAIHDR
     DQSETSKREL ELAFQRARDE CSRLQDKMNF DVSNLKDNNE ILSQQLFKTE SKLNSLEIEF
     HHTRDALREK TLGLERVQKD LSQTQCQMKE MEQKYQNEQV KVNKYIGKQE SVEERLSQLQ
     SENMLLRQQL DDAHNKADNK EKTVINIQDQ FHAIVQKLQA ESEKQSLLLE ERNKELISEC
     NHLKERQYQY ENEKAEREVV VRQLQQELAD TLKKQSMSEA SLEVTSRYRI NLEDETQDLK
     KKLGQIRNQL QEAQDRHTEA VRCAEKMQDH KQKLEKDNAK LKVTVKKQMD KIEELQKNLL
     NANLSEDEKE QLKKLMELKQ SLECNLDQEM KKNVELEREI TGFKNLLKMT RKKLNEYENG
     EFSFHGDLKT SQFEMDIQIN KLKHKIDDLT AELETAGSKC LHLDTKNQIL QEELLSMKTV
     QKKCEKLQKN KKKLEQEVIN LRSHIERNMV ELGQVKQYKQ EIEERARQEI AEKLKEVNLF
     LQAQAASQEN LEQFRENNFA SMKSQMELRI KDLESELSKI KTSQEDFNKT ELEKYKQLYL
     EELKVRKSLS SKLTKTNERL AEVNTKLLVE KQQSRSLFTT LTTRPVMEPP CVGNLNNSLD
     LNRKLIPREN LVISTSNPRA SNNSMENYLS KMQQELEKNI TRELKEAAAE LESGSIASPL
     GSTDESNLNQ DLVWKASREY VQVLKKNYMI
//