Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ankyrin repeat domain-containing protein 26

Gene

ANKRD26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107890-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 26
Gene namesi
Name:ANKRD26
Synonyms:KIAA1074
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29186. ANKRD26.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi22852.
MalaCardsiANKRD26.
OpenTargetsiENSG00000107890.
Orphaneti168629. Autosomal thrombocytopenia with normal platelets.
PharmGKBiPA134926710.

Polymorphism and mutation databases

BioMutaiANKRD26.
DMDMi109940217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408431 – 1709Ankyrin repeat domain-containing protein 26Add BLAST1709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei241PhosphoserineBy similarity1
Modified residuei261PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPS8.
PaxDbiQ9UPS8.
PeptideAtlasiQ9UPS8.
PRIDEiQ9UPS8.

PTM databases

iPTMnetiQ9UPS8.
PhosphoSitePlusiQ9UPS8.

Expressioni

Gene expression databases

BgeeiENSG00000107890.
CleanExiHS_ANKRD26.
ExpressionAtlasiQ9UPS8. baseline and differential.
GenevisibleiQ9UPS8. HS.

Organism-specific databases

HPAiHPA040654.
HPA041460.

Interactioni

Protein-protein interaction databases

BioGridi116523. 13 interactors.
IntActiQ9UPS8. 8 interactors.
STRINGi9606.ENSP00000365255.

Structurei

3D structure databases

ProteinModelPortaliQ9UPS8.
SMRiQ9UPS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 75ANK 1Add BLAST31
Repeati79 – 108ANK 2Add BLAST30
Repeati112 – 141ANK 3Add BLAST30
Repeati145 – 174ANK 4Add BLAST30
Repeati178 – 207ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili529 – 566Sequence analysisAdd BLAST38
Coiled coili742 – 872Sequence analysisAdd BLAST131
Coiled coili904 – 1471Sequence analysisAdd BLAST568
Coiled coili1516 – 1586Sequence analysisAdd BLAST71
Coiled coili1648 – 1673Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi25 – 28Poly-Gly4
Compositional biasi574 – 579Poly-Asp6

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOVERGENiHBG079895.
InParanoidiQ9UPS8.
PhylomeDBiQ9UPS8.
TreeFamiTF333496.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI
60 70 80 90 100
HKAASAGNVA KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV
110 120 130 140 150
DRKCQLNVCD NENRTALMKA VQCQEEKCAT ILLEHGADPN LADVHGNTAL
160 170 180 190 200
HYAVYNEDIS VATKLLLYDA NIEAKNKDDL TPLLLAVSGK KQQMVEFLIK
210 220 230 240 250
KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES SEDSLSRLSG
260 270 280 290 300
KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR
310 320 330 340 350
TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK
360 370 380 390 400
SLANPGLMKE EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN
410 420 430 440 450
RSDMMSALGL GQEEDIESPW DSESISENFP QKYVDPLAGA ADGKEKNIGN
460 470 480 490 500
EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV GMPVAHMESP ERYLHLKPTI
510 520 530 540 550
EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE NNQPQVEEER
560 570 580 590 600
KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN
610 620 630 640 650
KEYASGPALQ MKEVKSTEKE KRTSKESVNS PVFGKASLLT GGLLQVDDDS
660 670 680 690 700
SLSEIDEDEG RPTKKTSNEK NKVKNQIQSM DDVDDLTQSS ETASEDCELP
710 720 730 740 750
HSSYKNFMLL IEQLGMECKD SVSLLKIQDA ALSCERLLEL KKNHCELLTV
760 770 780 790 800
KIKKMEDKVN VLQRELSETK EIKSQLEHQK VEWERELCSL RFSLNQEEEK
810 820 830 840 850
RRNADTLYEK IREQLRRKEE QYRKEVEVKQ QLELSLQTLE MELRTVKSNL
860 870 880 890 900
NQVVQERNDA QRQLSREQNA RMLQDGILTN HLSKQKEIEM AQKKMNSENS
910 920 930 940 950
HSHEEEKDLS HKNSMLQEEI AMLRLEIDTI KNQNQEKEKK CFEDLKIVKE
960 970 980 990 1000
KNEDLQKTIK QNEETLTQTI SQYNGRLSVL TAENAMLNSK LENEKQSKER
1010 1020 1030 1040 1050
LEAEVESYHS RLAAAIHDRD QSETSKRELE LAFQRARDEC SRLQDKMNFD
1060 1070 1080 1090 1100
VSNLKDNNEI LSQQLFKTES KLNSLEIEFH HTRDALREKT LGLERVQKDL
1110 1120 1130 1140 1150
SQTQCQMKEM EQKYQNEQVK VNKYIGKQES VEERLSQLQS ENMLLRQQLD
1160 1170 1180 1190 1200
DAHNKADNKE KTVINIQDQF HAIVQKLQAE SEKQSLLLEE RNKELISECN
1210 1220 1230 1240 1250
HLKERQYQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVTSRYRIN
1260 1270 1280 1290 1300
LEDETQDLKK KLGQIRNQLQ EAQDRHTEAV RCAEKMQDHK QKLEKDNAKL
1310 1320 1330 1340 1350
KVTVKKQMDK IEELQKNLLN ANLSEDEKEQ LKKLMELKQS LECNLDQEMK
1360 1370 1380 1390 1400
KNVELEREIT GFKNLLKMTR KKLNEYENGE FSFHGDLKTS QFEMDIQINK
1410 1420 1430 1440 1450
LKHKIDDLTA ELETAGSKCL HLDTKNQILQ EELLSMKTVQ KKCEKLQKNK
1460 1470 1480 1490 1500
KKLEQEVINL RSHIERNMVE LGQVKQYKQE IEERARQEIA EKLKEVNLFL
1510 1520 1530 1540 1550
QAQAASQENL EQFRENNFAS MKSQMELRIK DLESELSKIK TSQEDFNKTE
1560 1570 1580 1590 1600
LEKYKQLYLE ELKVRKSLSS KLTKTNERLA EVNTKLLVEK QQSRSLFTTL
1610 1620 1630 1640 1650
TTRPVMEPPC VGNLNNSLDL NRKLIPRENL VISTSNPRAS NNSMENYLSK
1660 1670 1680 1690 1700
MQQELEKNIT RELKEAAAEL ESGSIASPLG STDESNLNQD LVWKASREYV

QVLKKNYMI
Length:1,709
Mass (Da):196,324
Last modified:June 27, 2006 - v3
Checksum:iC01DDA23FA478E2D
GO
Isoform 2 (identifier: Q9UPS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-443: Missing.
     444-545: KEKNIGNEQA...REGSENNQPQ → MNHMFHIKRH...EKEKVQLQKE
     605-605: S → SS

Note: No experimental confirmation available.
Show »
Length:1,267
Mass (Da):148,309
Checksum:i3F635BC067B3CBDE
GO
Isoform 3 (identifier: Q9UPS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     605-605: S → SS

Note: No experimental confirmation available.
Show »
Length:1,710
Mass (Da):196,411
Checksum:i01CBF9BADB894872
GO

Sequence cautioni

The sequence BAA83026 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1346D → G in BAC87508 (PubMed:14702039).Curated1
Sequence conflicti1516 – 1522NNFASMK → KQDLPDS in BAC87508 (PubMed:14702039).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02683320Q → R.2 PublicationsCorresponds to variant rs7897309dbSNPEnsembl.1
Natural variantiVAR_055513425I → V.Corresponds to variant rs12359281dbSNPEnsembl.1
Natural variantiVAR_0555141219V → L.Corresponds to variant rs12572862dbSNPEnsembl.1
Natural variantiVAR_0268341304V → I.1 PublicationCorresponds to variant rs10829163dbSNPEnsembl.1
Natural variantiVAR_0268351513F → L.1 PublicationCorresponds to variant rs2274741dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0194341 – 443Missing in isoform 2. 1 PublicationAdd BLAST443
Alternative sequenceiVSP_019435444 – 545KEKNI…NNQPQ → MNHMFHIKRHSISAGTDAYK KTKPIQNLFQKPLYDHCSAN NYKSMEPELENVRSSPPRGD RTSKVSLKEELQQDMQRFKN EIGMLKVEFQALEKEKVQLQ KE in isoform 2. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_021022605S → SS in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028997 mRNA. Translation: BAA83026.2. Different initiation.
AL162272 Genomic DNA. Translation: CAC19649.1.
AK001137 mRNA. Translation: BAA91516.1.
AK128577 mRNA. Translation: BAC87508.1.
AL137351 mRNA. Translation: CAB70706.1.
AL162063 mRNA. Translation: CAB82401.1.
BC110646 mRNA. Translation: AAI10647.1.
CCDSiCCDS41499.1. [Q9UPS8-3]
PIRiT46425.
T47167.
RefSeqiNP_001242982.1. NM_001256053.1. [Q9UPS8-1]
NP_055730.2. NM_014915.2. [Q9UPS8-3]
UniGeneiHs.361041.

Genome annotation databases

EnsembliENST00000376087; ENSP00000365255; ENSG00000107890. [Q9UPS8-3]
GeneIDi22852.
KEGGihsa:22852.
UCSCiuc009xku.2. human. [Q9UPS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028997 mRNA. Translation: BAA83026.2. Different initiation.
AL162272 Genomic DNA. Translation: CAC19649.1.
AK001137 mRNA. Translation: BAA91516.1.
AK128577 mRNA. Translation: BAC87508.1.
AL137351 mRNA. Translation: CAB70706.1.
AL162063 mRNA. Translation: CAB82401.1.
BC110646 mRNA. Translation: AAI10647.1.
CCDSiCCDS41499.1. [Q9UPS8-3]
PIRiT46425.
T47167.
RefSeqiNP_001242982.1. NM_001256053.1. [Q9UPS8-1]
NP_055730.2. NM_014915.2. [Q9UPS8-3]
UniGeneiHs.361041.

3D structure databases

ProteinModelPortaliQ9UPS8.
SMRiQ9UPS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116523. 13 interactors.
IntActiQ9UPS8. 8 interactors.
STRINGi9606.ENSP00000365255.

PTM databases

iPTMnetiQ9UPS8.
PhosphoSitePlusiQ9UPS8.

Polymorphism and mutation databases

BioMutaiANKRD26.
DMDMi109940217.

Proteomic databases

EPDiQ9UPS8.
PaxDbiQ9UPS8.
PeptideAtlasiQ9UPS8.
PRIDEiQ9UPS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376087; ENSP00000365255; ENSG00000107890. [Q9UPS8-3]
GeneIDi22852.
KEGGihsa:22852.
UCSCiuc009xku.2. human. [Q9UPS8-1]

Organism-specific databases

CTDi22852.
DisGeNETi22852.
GeneCardsiANKRD26.
H-InvDBHIX0008724.
HIX0010691.
HIX0026961.
HIX0037339.
HGNCiHGNC:29186. ANKRD26.
HPAiHPA040654.
HPA041460.
MalaCardsiANKRD26.
MIMi610855. gene.
neXtProtiNX_Q9UPS8.
OpenTargetsiENSG00000107890.
Orphaneti168629. Autosomal thrombocytopenia with normal platelets.
PharmGKBiPA134926710.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00560000076605.
HOVERGENiHBG079895.
InParanoidiQ9UPS8.
PhylomeDBiQ9UPS8.
TreeFamiTF333496.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000107890-MONOMER.

Miscellaneous databases

ChiTaRSiANKRD26. human.
GeneWikiiANKRD26.
GenomeRNAii22852.
PROiQ9UPS8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000107890.
CleanExiHS_ANKRD26.
ExpressionAtlasiQ9UPS8. baseline and differential.
GenevisibleiQ9UPS8. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR26_HUMAN
AccessioniPrimary (citable) accession number: Q9UPS8
Secondary accession number(s): A6NH29
, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.