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Q9UPS8 (ANR26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 26
Gene names
Name:ANKRD26
Synonyms:KIAA1074
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1709 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 5 ANK repeats.

Sequence caution

The sequence BAA83026.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UPS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UPS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-443: Missing.
     444-545: KEKNIGNEQA...REGSENNQPQ → MNHMFHIKRH...EKEKVQLQKE
     605-605: S → SS
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9UPS8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     605-605: S → SS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17091709Ankyrin repeat domain-containing protein 26
PRO_0000240843

Regions

Repeat45 – 7531ANK 1
Repeat79 – 10830ANK 2
Repeat112 – 14130ANK 3
Repeat145 – 17430ANK 4
Repeat178 – 20730ANK 5
Coiled coil529 – 56638 Potential
Coiled coil742 – 872131 Potential
Coiled coil904 – 1471568 Potential
Coiled coil1516 – 158671 Potential
Coiled coil1648 – 167326 Potential
Compositional bias25 – 284Poly-Gly
Compositional bias574 – 5796Poly-Asp

Amino acid modifications

Modified residue2411Phosphoserine By similarity

Natural variations

Alternative sequence1 – 443443Missing in isoform 2.
VSP_019434
Alternative sequence444 – 545102KEKNI…NNQPQ → MNHMFHIKRHSISAGTDAYK KTKPIQNLFQKPLYDHCSAN NYKSMEPELENVRSSPPRGD RTSKVSLKEELQQDMQRFKN EIGMLKVEFQALEKEKVQLQ KE in isoform 2.
VSP_019435
Alternative sequence6051S → SS in isoform 2 and isoform 3.
VSP_021022
Natural variant201Q → R. Ref.1 Ref.3
Corresponds to variant rs7897309 [ dbSNP | Ensembl ].
VAR_026833
Natural variant4251I → V.
Corresponds to variant rs12359281 [ dbSNP | Ensembl ].
VAR_055513
Natural variant12191V → L.
Corresponds to variant rs12572862 [ dbSNP | Ensembl ].
VAR_055514
Natural variant13041V → I. Ref.3
Corresponds to variant rs10829163 [ dbSNP | Ensembl ].
VAR_026834
Natural variant15131F → L. Ref.3
Corresponds to variant rs2274741 [ dbSNP | Ensembl ].
VAR_026835

Experimental info

Sequence conflict13461D → G in BAC87508. Ref.3
Sequence conflict1516 – 15227NNFASMK → KQDLPDS in BAC87508. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 27, 2006. Version 3.
Checksum: C01DDA23FA478E2D

FASTA1,709196,324
        10         20         30         40         50         60 
MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI HKAASAGNVA 

        70         80         90        100        110        120 
KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV DRKCQLNVCD NENRTALMKA 

       130        140        150        160        170        180 
VQCQEEKCAT ILLEHGADPN LADVHGNTAL HYAVYNEDIS VATKLLLYDA NIEAKNKDDL 

       190        200        210        220        230        240 
TPLLLAVSGK KQQMVEFLIK KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES 

       250        260        270        280        290        300 
SEDSLSRLSG KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR 

       310        320        330        340        350        360 
TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK SLANPGLMKE 

       370        380        390        400        410        420 
EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN RSDMMSALGL GQEEDIESPW 

       430        440        450        460        470        480 
DSESISENFP QKYVDPLAGA ADGKEKNIGN EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV 

       490        500        510        520        530        540 
GMPVAHMESP ERYLHLKPTI EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE 

       550        560        570        580        590        600 
NNQPQVEEER KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN 

       610        620        630        640        650        660 
KEYASGPALQ MKEVKSTEKE KRTSKESVNS PVFGKASLLT GGLLQVDDDS SLSEIDEDEG 

       670        680        690        700        710        720 
RPTKKTSNEK NKVKNQIQSM DDVDDLTQSS ETASEDCELP HSSYKNFMLL IEQLGMECKD 

       730        740        750        760        770        780 
SVSLLKIQDA ALSCERLLEL KKNHCELLTV KIKKMEDKVN VLQRELSETK EIKSQLEHQK 

       790        800        810        820        830        840 
VEWERELCSL RFSLNQEEEK RRNADTLYEK IREQLRRKEE QYRKEVEVKQ QLELSLQTLE 

       850        860        870        880        890        900 
MELRTVKSNL NQVVQERNDA QRQLSREQNA RMLQDGILTN HLSKQKEIEM AQKKMNSENS 

       910        920        930        940        950        960 
HSHEEEKDLS HKNSMLQEEI AMLRLEIDTI KNQNQEKEKK CFEDLKIVKE KNEDLQKTIK 

       970        980        990       1000       1010       1020 
QNEETLTQTI SQYNGRLSVL TAENAMLNSK LENEKQSKER LEAEVESYHS RLAAAIHDRD 

      1030       1040       1050       1060       1070       1080 
QSETSKRELE LAFQRARDEC SRLQDKMNFD VSNLKDNNEI LSQQLFKTES KLNSLEIEFH 

      1090       1100       1110       1120       1130       1140 
HTRDALREKT LGLERVQKDL SQTQCQMKEM EQKYQNEQVK VNKYIGKQES VEERLSQLQS 

      1150       1160       1170       1180       1190       1200 
ENMLLRQQLD DAHNKADNKE KTVINIQDQF HAIVQKLQAE SEKQSLLLEE RNKELISECN 

      1210       1220       1230       1240       1250       1260 
HLKERQYQYE NEKAEREVVV RQLQQELADT LKKQSMSEAS LEVTSRYRIN LEDETQDLKK 

      1270       1280       1290       1300       1310       1320 
KLGQIRNQLQ EAQDRHTEAV RCAEKMQDHK QKLEKDNAKL KVTVKKQMDK IEELQKNLLN 

      1330       1340       1350       1360       1370       1380 
ANLSEDEKEQ LKKLMELKQS LECNLDQEMK KNVELEREIT GFKNLLKMTR KKLNEYENGE 

      1390       1400       1410       1420       1430       1440 
FSFHGDLKTS QFEMDIQINK LKHKIDDLTA ELETAGSKCL HLDTKNQILQ EELLSMKTVQ 

      1450       1460       1470       1480       1490       1500 
KKCEKLQKNK KKLEQEVINL RSHIERNMVE LGQVKQYKQE IEERARQEIA EKLKEVNLFL 

      1510       1520       1530       1540       1550       1560 
QAQAASQENL EQFRENNFAS MKSQMELRIK DLESELSKIK TSQEDFNKTE LEKYKQLYLE 

      1570       1580       1590       1600       1610       1620 
ELKVRKSLSS KLTKTNERLA EVNTKLLVEK QQSRSLFTTL TTRPVMEPPC VGNLNNSLDL 

      1630       1640       1650       1660       1670       1680 
NRKLIPRENL VISTSNPRAS NNSMENYLSK MQQELEKNIT RELKEAAAEL ESGSIASPLG 

      1690       1700 
STDESNLNQD LVWKASREYV QVLKKNYMI 

« Hide

Isoform 2 [UniParc].

Checksum: 3F635BC067B3CBDE
Show »

FASTA1,267148,309
Isoform 3 [UniParc].

Checksum: 01CBF9BADB894872
Show »

FASTA1,710196,411

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-20.
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1522 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-546 (ISOFORM 1), VARIANTS ARG-20; ILE-1304 AND LEU-1513.
Tissue: Embryo and Trachea.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1337-1709.
Tissue: Melanoma and Testis.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1545-1709.
Tissue: Lymph.
[6]"Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains."
Hahn Y., Bera T.K., Pastan I.H., Lee B.
Gene 366:238-245(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028997 mRNA. Translation: BAA83026.2. Different initiation.
AL162272 Genomic DNA. Translation: CAC19649.1.
AK001137 mRNA. Translation: BAA91516.1.
AK128577 mRNA. Translation: BAC87508.1.
AL137351 mRNA. Translation: CAB70706.1.
AL162063 mRNA. Translation: CAB82401.1.
BC110646 mRNA. Translation: AAI10647.1.
CCDSCCDS41499.1. [Q9UPS8-3]
PIRT46425.
T47167.
RefSeqNP_001242982.1. NM_001256053.1. [Q9UPS8-1]
NP_055730.2. NM_014915.2. [Q9UPS8-3]
UniGeneHs.361041.

3D structure databases

ProteinModelPortalQ9UPS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116523. 6 interactions.
IntActQ9UPS8. 3 interactions.
STRING9606.ENSP00000365255.

PTM databases

PhosphoSiteQ9UPS8.

Polymorphism databases

DMDM109940217.

Proteomic databases

MaxQBQ9UPS8.
PaxDbQ9UPS8.
PRIDEQ9UPS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376070; ENSP00000365238; ENSG00000107890. [Q9UPS8-2]
ENST00000376087; ENSP00000365255; ENSG00000107890. [Q9UPS8-3]
GeneID22852.
KEGGhsa:22852.
UCSCuc001ith.2. human. [Q9UPS8-1]
uc009xku.1. human. [Q9UPS8-3]

Organism-specific databases

CTD22852.
GeneCardsGC10M027280.
H-InvDBHIX0008724.
HIX0010691.
HIX0026961.
HIX0037339.
HGNCHGNC:29186. ANKRD26.
HPAHPA040654.
HPA041460.
MIM610855. gene.
neXtProtNX_Q9UPS8.
Orphanet168629. Autosomal thrombocytopenia with normal platelets.
PharmGKBPA134926710.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOVERGENHBG079895.
InParanoidQ9UPS8.
OrthoDBEOG7N63KX.
PhylomeDBQ9UPS8.
TreeFamTF333496.

Gene expression databases

ArrayExpressQ9UPS8.
BgeeQ9UPS8.
CleanExHS_ANKRD26.
GenevestigatorQ9UPS8.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR021885. DUF3496.
[Graphical view]
PfamPF00023. Ank. 2 hits.
PF12796. Ank_2. 1 hit.
PF12001. DUF3496. 1 hit.
[Graphical view]
PRINTSPR01415. ANKYRIN.
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiANKRD26.
GenomeRNAi22852.
NextBio43329.
PROQ9UPS8.
SOURCESearch...

Entry information

Entry nameANR26_HUMAN
AccessionPrimary (citable) accession number: Q9UPS8
Secondary accession number(s): A6NH29 expand/collapse secondary AC list , Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM