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Q9UPS6

- SET1B_HUMAN

UniProt

Q9UPS6 - SET1B_HUMAN

Protein

Histone-lysine N-methyltransferase SETD1B

Gene

SETD1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (19 Mar 2014)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1943 – 19431S-adenosyl-L-methioninePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. nucleotide binding Source: InterPro
    3. protein binding Source: UniProtKB
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. histone H3-K4 methylation Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.43)
    Alternative name(s):
    Lysine N-methyltransferase 2G
    SET domain-containing protein 1B
    Short name:
    hSET1B
    Gene namesi
    Name:SETD1B
    Synonyms:KIAA1076, KMT2G, SET1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29187. SETD1B.

    Subcellular locationi

    Nucleus speckle 1 Publication. Chromosome 1 Publication
    Note: Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. histone methyltransferase complex Source: UniProtKB
    3. nuclear speck Source: UniProtKB-SubCell
    4. nucleus Source: HPA
    5. Set1C/COMPASS complex Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi577 – 5771L → A: Abolishes interaction with RBM15. 1 Publication
    Mutagenesisi579 – 5791D → A: Abolishes interaction with RBM15. 1 Publication

    Organism-specific databases

    PharmGKBiPA143485611.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19661966Histone-lysine N-methyltransferase SETD1BPRO_0000316993Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1659 – 16591Phosphoserine1 Publication
    Modified residuei1663 – 16631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPS6.
    PaxDbiQ9UPS6.
    PRIDEiQ9UPS6.

    PTM databases

    PhosphoSiteiQ9UPS6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UPS6.
    BgeeiQ9UPS6.
    CleanExiHS_SETD1B.
    GenevestigatoriQ9UPS6.

    Organism-specific databases

    HPAiHPA021667.

    Interactioni

    Subunit structurei

    Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with HCFC1 and ASH2L/ASH2. Interacts (via the RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. Interacts with RBM15.4 Publications

    Protein-protein interaction databases

    BioGridi116702. 10 interactions.
    STRINGi9606.ENSP00000267197.

    Structurei

    Secondary structure

    1
    1966
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1747 – 17504

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UVOX-ray2.20B1745-1755[»]
    4ES0X-ray1.82C1741-1754[»]
    ProteinModelPortaliQ9UPS6.
    SMRiQ9UPS6. Positions 98-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 18189RRMPROSITE-ProRule annotationAdd
    BLAST
    Domaini1827 – 1944118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini1950 – 196617Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1173 – 120432Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi366 – 16711306Pro-richAdd
    BLAST
    Compositional biasi1040 – 1175136Ser-richAdd
    BLAST
    Compositional biasi1068 – 1312245Glu-richAdd
    BLAST
    Compositional biasi1103 – 113836Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000168216.
    HOVERGENiHBG055596.
    InParanoidiQ9UPS6.
    KOiK11422.
    OMAiQHWPPLP.
    OrthoDBiEOG7GQXTT.
    TreeFamiTF106436.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UPS6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENSHPPHHH HQQPPPQPGP SGERRNHHWR SYKLMIDPAL KKGHHKLYRY     50
    DGQHFSLAMS SNRPVEIVED PRVVGIWTKN KELELSVPKF KIDEFYVGPV 100
    PPKQVTFAKL NDNIRENFLR DMCKKYGEVE EVEILYNPKT KKHLGIAKVV 150
    FATVRGAKDA VQHLHSTSVM GNIIHVELDT KGETRMRFYE LLVTGRYTPQ 200
    TLPVGELDAV SPIVNETLQL SDALKRLKDG GLSAGCGSGS SSVTPNSGGT 250
    PFSQDTAYSS CRLDTPNSYG QGTPLTPRLG TPFSQDSSYS SRQPTPSYLF 300
    SQDPAVTFKA RRHESKFTDA YNRRHEHHYV HNSPAVTAVA GATAAFRGSS 350
    DLPFGAVGGT GGSSGPPFKA QPQDSATFAH TPPPAQATPA PGFKSAFSPY 400
    QTPVAHFPPP PEEPTATAAF GARDSGEFRR APAPPPLPPA EPLAKEKPGT 450
    PPGPPPPDTN SMELGGRPTF GWSPEPCDSP GTPTLESSPA GPEKPHDSLD 500
    SRIEMLLKEQ RTKLLFLREP DSDTELQMEG SPISSSSSQL SPLAPFGTNS 550
    QPGFRGPTPP SSRPSSTGLE DISPTPLPDS DEDEELDLGL GPRPPPEPGP 600
    PDPAGLLSQT AEVALDLVGD RTPTSEKMDE GQQSSGEDME ISDDEMPSAP 650
    ITSADCPKPM VVTPGAAAVA APSVLAPTLP LPPPPGFPPL PPPPPPPPPQ 700
    PGFPMPPPLP PPPPPPPPAH PAVTVPPPPL PAPPGVPPPP ILPPLPPFPP 750
    GLFPVMQVDM SHVLGGQWGG MPMSFQMQTQ VLSRLMTGQG ACPYPPFMAA 800
    AAAAASAGLQ FVNLPPYRGP FSLSNSGPGR GQHWPPLPKF DPSVPPPGYM 850
    PRQEDPHKAT VDGVLLVVLK ELKAIMKRDL NRKMVEVVAF RAFDEWWDKK 900
    ERMAKASLTP VKSGEHKDED RPKPKDRIAS CLLESWGKGE GLGYEGLGLG 950
    IGLRGAIRLP SFKVKRKEPP DTTSSGDQKR LRPSTSVDEE DEESERERDR 1000
    DMADTPCELA KRDPKGVGVR RRPARPLELD SGGEEDEKES LSASSSSSAS 1050
    SSSGSSTTSP SSSASDKEEE QESTEEEEEA EEEEEEEVPR SQLSSSSTSS 1100
    TSDKDDDDDD SDDRDESEND DEDTALSEAS EKDEGDSDEE ETVSIVTSKA 1150
    EATSSSESSE SSEFESSSES SPSSSEDEEE VVAREEEEEE EEEEMVAEES 1200
    MASAGPEDFE QDGEEAALAP GAPAVDSLGM EEEVDIETEA VAPEERPSML 1250
    DEPPLPVGVE EPADSREPPE EPGLSQEGAM LLSPEPPAKE VEARPPLSPE 1300
    RAPEHDLEVE PEPPMMLPLP LQPPLPPPRP PRPPSPPPEP ETTDASHPSV 1350
    PPEPLAEDHP PHTPGLCGSL AKSQSTETVP ATPGGEPPLS GGSSGLSLSS 1400
    PQVPGSPFSY PAPSPSLSSG GLPRTPGRDF SFTPTFSEPS GPLLLPVCPL 1450
    PTGRRDERSG PLASPVLLET GLPLPLPLPL PLPLALPAVL RAQARAPTPL 1500
    PPLLPAPLAS CPPPMKRKPG RPRRSPPSML SLDGPLVRPP AGAALGRELL 1550
    LLPGQPQTPV FPSTHDPRTV TLDFRNAGIP APPPPLPPQP PPPPPPPPVE 1600
    PTKLPFKELD NQWPSEAIPP GPRGRDEVTE EYMELAKSRG PWRRPPKKRH 1650
    EDLVPPAGSP ELSPPQPLFR PRSEFEEMTI LYDIWNGGID EEDIRFLCVT 1700
    YERLLQQDNG MDWLNDTLWV YHPSTSLSSA KKKKRDDGIR EHVTGCARSE 1750
    GFYTIDKKDK LRYLNSSRAS TDEPPADTQG MSIPAQPHAS TRAGSERRSE 1800
    QRRLLSSFTG SCDSDLLKFN QLKFRKKKLK FCKSHIHDWG LFAMEPIAAD 1850
    EMVIEYVGQN IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF 1900
    ARFINHSCNP NCYAKVITVE SQKKIVIYSK QHINVNEEIT YDYKFPIEDV 1950
    KIPCLCGSEN CRGTLN 1966
    Length:1,966
    Mass (Da):212,803
    Last modified:March 19, 2014 - v3
    Checksum:i164F81BC84EAD2C2
    GO
    Isoform 2 (identifier: Q9UPS6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1043-1068: Missing.
         1088-1104: Missing.

    Show »
    Length:1,923
    Mass (Da):208,732
    Checksum:i057CD0948D670243
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1043 – 106826Missing in isoform 2. CuratedVSP_053875Add
    BLAST
    Alternative sequencei1088 – 110417Missing in isoform 2. CuratedVSP_053876Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF813787 mRNA. Translation: AEG67286.1.
    AC079360 Genomic DNA. No translation available.
    AC084018 Genomic DNA. No translation available.
    AB028999 mRNA. Translation: BAA83028.1.
    CCDSiCCDS53838.1. [Q9UPS6-2]
    RefSeqiNP_055863.1. NM_015048.1. [Q9UPS6-2]
    XP_005253915.1. XM_005253858.2. [Q9UPS6-1]
    XP_006719358.1. XM_006719295.1. [Q9UPS6-1]
    XP_006719359.1. XM_006719296.1. [Q9UPS6-1]
    UniGeneiHs.507122.

    Genome annotation databases

    EnsembliENST00000267197; ENSP00000267197; ENSG00000139718. [Q9UPS6-2]
    ENST00000542440; ENSP00000442924; ENSG00000139718. [Q9UPS6-2]
    ENST00000604567; ENSP00000474253; ENSG00000139718. [Q9UPS6-1]
    GeneIDi23067.
    KEGGihsa:23067.
    UCSCiuc001ubi.3. human. [Q9UPS6-1]

    Polymorphism databases

    DMDMi166977692.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JF813787 mRNA. Translation: AEG67286.1 .
    AC079360 Genomic DNA. No translation available.
    AC084018 Genomic DNA. No translation available.
    AB028999 mRNA. Translation: BAA83028.1 .
    CCDSi CCDS53838.1. [Q9UPS6-2 ]
    RefSeqi NP_055863.1. NM_015048.1. [Q9UPS6-2 ]
    XP_005253915.1. XM_005253858.2. [Q9UPS6-1 ]
    XP_006719358.1. XM_006719295.1. [Q9UPS6-1 ]
    XP_006719359.1. XM_006719296.1. [Q9UPS6-1 ]
    UniGenei Hs.507122.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UVO X-ray 2.20 B 1745-1755 [» ]
    4ES0 X-ray 1.82 C 1741-1754 [» ]
    ProteinModelPortali Q9UPS6.
    SMRi Q9UPS6. Positions 98-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116702. 10 interactions.
    STRINGi 9606.ENSP00000267197.

    PTM databases

    PhosphoSitei Q9UPS6.

    Polymorphism databases

    DMDMi 166977692.

    Proteomic databases

    MaxQBi Q9UPS6.
    PaxDbi Q9UPS6.
    PRIDEi Q9UPS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267197 ; ENSP00000267197 ; ENSG00000139718 . [Q9UPS6-2 ]
    ENST00000542440 ; ENSP00000442924 ; ENSG00000139718 . [Q9UPS6-2 ]
    ENST00000604567 ; ENSP00000474253 ; ENSG00000139718 . [Q9UPS6-1 ]
    GeneIDi 23067.
    KEGGi hsa:23067.
    UCSCi uc001ubi.3. human. [Q9UPS6-1 ]

    Organism-specific databases

    CTDi 23067.
    GeneCardsi GC12P122243.
    H-InvDB HIX0011090.
    HGNCi HGNC:29187. SETD1B.
    HPAi HPA021667.
    MIMi 611055. gene.
    neXtProti NX_Q9UPS6.
    PharmGKBi PA143485611.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000168216.
    HOVERGENi HBG055596.
    InParanoidi Q9UPS6.
    KOi K11422.
    OMAi QHWPPLP.
    OrthoDBi EOG7GQXTT.
    TreeFami TF106436.

    Miscellaneous databases

    GenomeRNAii 23067.
    NextBioi 35510195.
    PROi Q9UPS6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPS6.
    Bgeei Q9UPS6.
    CleanExi HS_SETD1B.
    Genevestigatori Q9UPS6.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00360. RRM. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50102. RRM. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation."
      Lee J.H., Skalnik D.G.
      PLoS ONE 7:E42965-E42965(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RBM15, MUTAGENESIS OF LEU-577 AND ASP-579.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1163-1966 (ISOFORM 1/2).
      Tissue: Brain.
    4. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."
      Lee J.-H., Tate C.M., You J.-S., Skalnik D.G.
      J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SET1 COMPLEX.
    5. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
      Lee J.H., Skalnik D.G.
      Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH WDR82; ASH2L AND POLR2A.
    6. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
      Wu M., Wang P.F., Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A.
      Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN SET1 COMPLEX.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1659 AND SER-1663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiSET1B_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPS6
    Secondary accession number(s): F6MFW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 19, 2014
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3