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Q9UPS6

- SET1B_HUMAN

UniProt

Q9UPS6 - SET1B_HUMAN

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Protein
Histone-lysine N-methyltransferase SETD1B
Gene
SETD1B, KIAA1076, KMT2G, SET1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1943 – 19431S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. nucleotide binding Source: InterPro
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. histone H3-K4 methylation Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.43)
Alternative name(s):
Lysine N-methyltransferase 2G
SET domain-containing protein 1B
Short name:
hSET1B
Gene namesi
Name:SETD1B
Synonyms:KIAA1076, KMT2G, SET1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29187. SETD1B.

Subcellular locationi

Nucleus speckle. Chromosome
Note: Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.1 Publication

GO - Cellular componenti

  1. Set1C/COMPASS complex Source: UniProtKB
  2. chromosome Source: UniProtKB-SubCell
  3. histone methyltransferase complex Source: UniProtKB
  4. nuclear speck Source: UniProtKB-SubCell
  5. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi577 – 5771L → A: Abolishes interaction with RBM15. 1 Publication
Mutagenesisi579 – 5791D → A: Abolishes interaction with RBM15. 1 Publication

Organism-specific databases

PharmGKBiPA143485611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19661966Histone-lysine N-methyltransferase SETD1B
PRO_0000316993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1659 – 16591Phosphoserine1 Publication
Modified residuei1663 – 16631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UPS6.
PaxDbiQ9UPS6.
PRIDEiQ9UPS6.

PTM databases

PhosphoSiteiQ9UPS6.

Expressioni

Gene expression databases

ArrayExpressiQ9UPS6.
BgeeiQ9UPS6.
CleanExiHS_SETD1B.
GenevestigatoriQ9UPS6.

Organism-specific databases

HPAiHPA021667.

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with HCFC1 and ASH2L/ASH2. Interacts (via the RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. Interacts with RBM15.4 Publications

Protein-protein interaction databases

BioGridi116702. 10 interactions.
STRINGi9606.ENSP00000267197.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1747 – 17504

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UVOX-ray2.20B1745-1755[»]
4ES0X-ray1.82C1741-1754[»]
ProteinModelPortaliQ9UPS6.
SMRiQ9UPS6. Positions 98-203.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 18189RRM
Add
BLAST
Domaini1827 – 1944118SET
Add
BLAST
Domaini1950 – 196617Post-SET
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1173 – 120432 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi366 – 16711306Pro-rich
Add
BLAST
Compositional biasi1040 – 1175136Ser-rich
Add
BLAST
Compositional biasi1068 – 1312245Glu-rich
Add
BLAST
Compositional biasi1103 – 113836Asp-rich
Add
BLAST

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 SET domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000168216.
HOVERGENiHBG055596.
InParanoidiQ9UPS6.
KOiK11422.
OMAiQHWPPLP.
OrthoDBiEOG7GQXTT.
TreeFamiTF106436.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPS6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MENSHPPHHH HQQPPPQPGP SGERRNHHWR SYKLMIDPAL KKGHHKLYRY     50
DGQHFSLAMS SNRPVEIVED PRVVGIWTKN KELELSVPKF KIDEFYVGPV 100
PPKQVTFAKL NDNIRENFLR DMCKKYGEVE EVEILYNPKT KKHLGIAKVV 150
FATVRGAKDA VQHLHSTSVM GNIIHVELDT KGETRMRFYE LLVTGRYTPQ 200
TLPVGELDAV SPIVNETLQL SDALKRLKDG GLSAGCGSGS SSVTPNSGGT 250
PFSQDTAYSS CRLDTPNSYG QGTPLTPRLG TPFSQDSSYS SRQPTPSYLF 300
SQDPAVTFKA RRHESKFTDA YNRRHEHHYV HNSPAVTAVA GATAAFRGSS 350
DLPFGAVGGT GGSSGPPFKA QPQDSATFAH TPPPAQATPA PGFKSAFSPY 400
QTPVAHFPPP PEEPTATAAF GARDSGEFRR APAPPPLPPA EPLAKEKPGT 450
PPGPPPPDTN SMELGGRPTF GWSPEPCDSP GTPTLESSPA GPEKPHDSLD 500
SRIEMLLKEQ RTKLLFLREP DSDTELQMEG SPISSSSSQL SPLAPFGTNS 550
QPGFRGPTPP SSRPSSTGLE DISPTPLPDS DEDEELDLGL GPRPPPEPGP 600
PDPAGLLSQT AEVALDLVGD RTPTSEKMDE GQQSSGEDME ISDDEMPSAP 650
ITSADCPKPM VVTPGAAAVA APSVLAPTLP LPPPPGFPPL PPPPPPPPPQ 700
PGFPMPPPLP PPPPPPPPAH PAVTVPPPPL PAPPGVPPPP ILPPLPPFPP 750
GLFPVMQVDM SHVLGGQWGG MPMSFQMQTQ VLSRLMTGQG ACPYPPFMAA 800
AAAAASAGLQ FVNLPPYRGP FSLSNSGPGR GQHWPPLPKF DPSVPPPGYM 850
PRQEDPHKAT VDGVLLVVLK ELKAIMKRDL NRKMVEVVAF RAFDEWWDKK 900
ERMAKASLTP VKSGEHKDED RPKPKDRIAS CLLESWGKGE GLGYEGLGLG 950
IGLRGAIRLP SFKVKRKEPP DTTSSGDQKR LRPSTSVDEE DEESERERDR 1000
DMADTPCELA KRDPKGVGVR RRPARPLELD SGGEEDEKES LSASSSSSAS 1050
SSSGSSTTSP SSSASDKEEE QESTEEEEEA EEEEEEEVPR SQLSSSSTSS 1100
TSDKDDDDDD SDDRDESEND DEDTALSEAS EKDEGDSDEE ETVSIVTSKA 1150
EATSSSESSE SSEFESSSES SPSSSEDEEE VVAREEEEEE EEEEMVAEES 1200
MASAGPEDFE QDGEEAALAP GAPAVDSLGM EEEVDIETEA VAPEERPSML 1250
DEPPLPVGVE EPADSREPPE EPGLSQEGAM LLSPEPPAKE VEARPPLSPE 1300
RAPEHDLEVE PEPPMMLPLP LQPPLPPPRP PRPPSPPPEP ETTDASHPSV 1350
PPEPLAEDHP PHTPGLCGSL AKSQSTETVP ATPGGEPPLS GGSSGLSLSS 1400
PQVPGSPFSY PAPSPSLSSG GLPRTPGRDF SFTPTFSEPS GPLLLPVCPL 1450
PTGRRDERSG PLASPVLLET GLPLPLPLPL PLPLALPAVL RAQARAPTPL 1500
PPLLPAPLAS CPPPMKRKPG RPRRSPPSML SLDGPLVRPP AGAALGRELL 1550
LLPGQPQTPV FPSTHDPRTV TLDFRNAGIP APPPPLPPQP PPPPPPPPVE 1600
PTKLPFKELD NQWPSEAIPP GPRGRDEVTE EYMELAKSRG PWRRPPKKRH 1650
EDLVPPAGSP ELSPPQPLFR PRSEFEEMTI LYDIWNGGID EEDIRFLCVT 1700
YERLLQQDNG MDWLNDTLWV YHPSTSLSSA KKKKRDDGIR EHVTGCARSE 1750
GFYTIDKKDK LRYLNSSRAS TDEPPADTQG MSIPAQPHAS TRAGSERRSE 1800
QRRLLSSFTG SCDSDLLKFN QLKFRKKKLK FCKSHIHDWG LFAMEPIAAD 1850
EMVIEYVGQN IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF 1900
ARFINHSCNP NCYAKVITVE SQKKIVIYSK QHINVNEEIT YDYKFPIEDV 1950
KIPCLCGSEN CRGTLN 1966
Length:1,966
Mass (Da):212,803
Last modified:March 19, 2014 - v3
Checksum:i164F81BC84EAD2C2
GO
Isoform 2 (identifier: Q9UPS6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1043-1068: Missing.
     1088-1104: Missing.

Show »
Length:1,923
Mass (Da):208,732
Checksum:i057CD0948D670243
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1043 – 106826Missing in isoform 2.
VSP_053875Add
BLAST
Alternative sequencei1088 – 110417Missing in isoform 2.
VSP_053876Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF813787 mRNA. Translation: AEG67286.1.
AC079360 Genomic DNA. No translation available.
AC084018 Genomic DNA. No translation available.
AB028999 mRNA. Translation: BAA83028.1.
CCDSiCCDS53838.1. [Q9UPS6-2]
RefSeqiNP_055863.1. NM_015048.1. [Q9UPS6-2]
XP_005253915.1. XM_005253858.2. [Q9UPS6-1]
XP_006719358.1. XM_006719295.1. [Q9UPS6-1]
XP_006719359.1. XM_006719296.1. [Q9UPS6-1]
UniGeneiHs.507122.

Genome annotation databases

EnsembliENST00000267197; ENSP00000267197; ENSG00000139718.
ENST00000542440; ENSP00000442924; ENSG00000139718.
ENST00000604567; ENSP00000474253; ENSG00000139718.
GeneIDi23067.
KEGGihsa:23067.
UCSCiuc001ubi.3. human. [Q9UPS6-1]

Polymorphism databases

DMDMi166977692.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF813787 mRNA. Translation: AEG67286.1 .
AC079360 Genomic DNA. No translation available.
AC084018 Genomic DNA. No translation available.
AB028999 mRNA. Translation: BAA83028.1 .
CCDSi CCDS53838.1. [Q9UPS6-2 ]
RefSeqi NP_055863.1. NM_015048.1. [Q9UPS6-2 ]
XP_005253915.1. XM_005253858.2. [Q9UPS6-1 ]
XP_006719358.1. XM_006719295.1. [Q9UPS6-1 ]
XP_006719359.1. XM_006719296.1. [Q9UPS6-1 ]
UniGenei Hs.507122.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UVO X-ray 2.20 B 1745-1755 [» ]
4ES0 X-ray 1.82 C 1741-1754 [» ]
ProteinModelPortali Q9UPS6.
SMRi Q9UPS6. Positions 98-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116702. 10 interactions.
STRINGi 9606.ENSP00000267197.

PTM databases

PhosphoSitei Q9UPS6.

Polymorphism databases

DMDMi 166977692.

Proteomic databases

MaxQBi Q9UPS6.
PaxDbi Q9UPS6.
PRIDEi Q9UPS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267197 ; ENSP00000267197 ; ENSG00000139718 .
ENST00000542440 ; ENSP00000442924 ; ENSG00000139718 .
ENST00000604567 ; ENSP00000474253 ; ENSG00000139718 .
GeneIDi 23067.
KEGGi hsa:23067.
UCSCi uc001ubi.3. human. [Q9UPS6-1 ]

Organism-specific databases

CTDi 23067.
GeneCardsi GC12P122243.
H-InvDB HIX0011090.
HGNCi HGNC:29187. SETD1B.
HPAi HPA021667.
MIMi 611055. gene.
neXtProti NX_Q9UPS6.
PharmGKBi PA143485611.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000168216.
HOVERGENi HBG055596.
InParanoidi Q9UPS6.
KOi K11422.
OMAi QHWPPLP.
OrthoDBi EOG7GQXTT.
TreeFami TF106436.

Miscellaneous databases

GenomeRNAii 23067.
NextBioi 35510195.
PROi Q9UPS6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9UPS6.
Bgeei Q9UPS6.
CleanExi HS_SETD1B.
Genevestigatori Q9UPS6.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation."
    Lee J.H., Skalnik D.G.
    PLoS ONE 7:E42965-E42965(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RBM15, MUTAGENESIS OF LEU-577 AND ASP-579.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1163-1966 (ISOFORM 1/2).
    Tissue: Brain.
  4. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."
    Lee J.-H., Tate C.M., You J.-S., Skalnik D.G.
    J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SET1 COMPLEX.
  5. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
    Lee J.H., Skalnik D.G.
    Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH WDR82; ASH2L AND POLR2A.
  6. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
    Wu M., Wang P.F., Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A.
    Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SET1 COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1659 AND SER-1663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSET1B_HUMAN
AccessioniPrimary (citable) accession number: Q9UPS6
Secondary accession number(s): F6MFW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 19, 2014
Last modified: September 3, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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