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Q9UPS6

- SET1B_HUMAN

UniProt

Q9UPS6 - SET1B_HUMAN

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Protein

Histone-lysine N-methyltransferase SETD1B

Gene

SETD1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1943 – 19431S-adenosyl-L-methioninePROSITE-ProRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleotide binding Source: InterPro
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. histone H3-K4 methylation Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.43)
Alternative name(s):
Lysine N-methyltransferase 2G
SET domain-containing protein 1B
Short name:
hSET1B
Gene namesi
Name:SETD1B
Synonyms:KIAA1076, KMT2G, SET1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29187. SETD1B.

Subcellular locationi

Nucleus speckle 1 Publication. Chromosome 1 Publication
Note: Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. histone methyltransferase complex Source: UniProtKB
  3. nucleus Source: HPA
  4. Set1C/COMPASS complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi577 – 5771L → A: Abolishes interaction with RBM15. 1 Publication
Mutagenesisi579 – 5791D → A: Abolishes interaction with RBM15. 1 Publication

Organism-specific databases

PharmGKBiPA143485611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19661966Histone-lysine N-methyltransferase SETD1BPRO_0000316993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1659 – 16591Phosphoserine1 Publication
Modified residuei1663 – 16631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UPS6.
PaxDbiQ9UPS6.
PRIDEiQ9UPS6.

PTM databases

PhosphoSiteiQ9UPS6.

Expressioni

Gene expression databases

BgeeiQ9UPS6.
CleanExiHS_SETD1B.
GenevestigatoriQ9UPS6.

Organism-specific databases

HPAiHPA021667.

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with HCFC1 and ASH2L/ASH2. Interacts (via the RRM domain) with WDR82. Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. Interacts with RBM15.4 Publications

Protein-protein interaction databases

BioGridi116702. 11 interactions.
STRINGi9606.ENSP00000267197.

Structurei

Secondary structure

1
1966
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1747 – 17504Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UVOX-ray2.20B1745-1755[»]
4ES0X-ray1.82C1741-1754[»]
ProteinModelPortaliQ9UPS6.
SMRiQ9UPS6. Positions 98-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 18189RRMPROSITE-ProRule annotationAdd
BLAST
Domaini1827 – 1944118SETPROSITE-ProRule annotationAdd
BLAST
Domaini1950 – 196617Post-SETPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1173 – 120432Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi366 – 16711306Pro-richAdd
BLAST
Compositional biasi1040 – 1175136Ser-richAdd
BLAST
Compositional biasi1068 – 1312245Glu-richAdd
BLAST
Compositional biasi1103 – 113836Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00760000119228.
HOGENOMiHOG000168216.
HOVERGENiHBG055596.
InParanoidiQ9UPS6.
KOiK11422.
OMAiQHWPPLP.
OrthoDBiEOG7GQXTT.
TreeFamiTF106436.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPS6) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENSHPPHHH HQQPPPQPGP SGERRNHHWR SYKLMIDPAL KKGHHKLYRY
60 70 80 90 100
DGQHFSLAMS SNRPVEIVED PRVVGIWTKN KELELSVPKF KIDEFYVGPV
110 120 130 140 150
PPKQVTFAKL NDNIRENFLR DMCKKYGEVE EVEILYNPKT KKHLGIAKVV
160 170 180 190 200
FATVRGAKDA VQHLHSTSVM GNIIHVELDT KGETRMRFYE LLVTGRYTPQ
210 220 230 240 250
TLPVGELDAV SPIVNETLQL SDALKRLKDG GLSAGCGSGS SSVTPNSGGT
260 270 280 290 300
PFSQDTAYSS CRLDTPNSYG QGTPLTPRLG TPFSQDSSYS SRQPTPSYLF
310 320 330 340 350
SQDPAVTFKA RRHESKFTDA YNRRHEHHYV HNSPAVTAVA GATAAFRGSS
360 370 380 390 400
DLPFGAVGGT GGSSGPPFKA QPQDSATFAH TPPPAQATPA PGFKSAFSPY
410 420 430 440 450
QTPVAHFPPP PEEPTATAAF GARDSGEFRR APAPPPLPPA EPLAKEKPGT
460 470 480 490 500
PPGPPPPDTN SMELGGRPTF GWSPEPCDSP GTPTLESSPA GPEKPHDSLD
510 520 530 540 550
SRIEMLLKEQ RTKLLFLREP DSDTELQMEG SPISSSSSQL SPLAPFGTNS
560 570 580 590 600
QPGFRGPTPP SSRPSSTGLE DISPTPLPDS DEDEELDLGL GPRPPPEPGP
610 620 630 640 650
PDPAGLLSQT AEVALDLVGD RTPTSEKMDE GQQSSGEDME ISDDEMPSAP
660 670 680 690 700
ITSADCPKPM VVTPGAAAVA APSVLAPTLP LPPPPGFPPL PPPPPPPPPQ
710 720 730 740 750
PGFPMPPPLP PPPPPPPPAH PAVTVPPPPL PAPPGVPPPP ILPPLPPFPP
760 770 780 790 800
GLFPVMQVDM SHVLGGQWGG MPMSFQMQTQ VLSRLMTGQG ACPYPPFMAA
810 820 830 840 850
AAAAASAGLQ FVNLPPYRGP FSLSNSGPGR GQHWPPLPKF DPSVPPPGYM
860 870 880 890 900
PRQEDPHKAT VDGVLLVVLK ELKAIMKRDL NRKMVEVVAF RAFDEWWDKK
910 920 930 940 950
ERMAKASLTP VKSGEHKDED RPKPKDRIAS CLLESWGKGE GLGYEGLGLG
960 970 980 990 1000
IGLRGAIRLP SFKVKRKEPP DTTSSGDQKR LRPSTSVDEE DEESERERDR
1010 1020 1030 1040 1050
DMADTPCELA KRDPKGVGVR RRPARPLELD SGGEEDEKES LSASSSSSAS
1060 1070 1080 1090 1100
SSSGSSTTSP SSSASDKEEE QESTEEEEEA EEEEEEEVPR SQLSSSSTSS
1110 1120 1130 1140 1150
TSDKDDDDDD SDDRDESEND DEDTALSEAS EKDEGDSDEE ETVSIVTSKA
1160 1170 1180 1190 1200
EATSSSESSE SSEFESSSES SPSSSEDEEE VVAREEEEEE EEEEMVAEES
1210 1220 1230 1240 1250
MASAGPEDFE QDGEEAALAP GAPAVDSLGM EEEVDIETEA VAPEERPSML
1260 1270 1280 1290 1300
DEPPLPVGVE EPADSREPPE EPGLSQEGAM LLSPEPPAKE VEARPPLSPE
1310 1320 1330 1340 1350
RAPEHDLEVE PEPPMMLPLP LQPPLPPPRP PRPPSPPPEP ETTDASHPSV
1360 1370 1380 1390 1400
PPEPLAEDHP PHTPGLCGSL AKSQSTETVP ATPGGEPPLS GGSSGLSLSS
1410 1420 1430 1440 1450
PQVPGSPFSY PAPSPSLSSG GLPRTPGRDF SFTPTFSEPS GPLLLPVCPL
1460 1470 1480 1490 1500
PTGRRDERSG PLASPVLLET GLPLPLPLPL PLPLALPAVL RAQARAPTPL
1510 1520 1530 1540 1550
PPLLPAPLAS CPPPMKRKPG RPRRSPPSML SLDGPLVRPP AGAALGRELL
1560 1570 1580 1590 1600
LLPGQPQTPV FPSTHDPRTV TLDFRNAGIP APPPPLPPQP PPPPPPPPVE
1610 1620 1630 1640 1650
PTKLPFKELD NQWPSEAIPP GPRGRDEVTE EYMELAKSRG PWRRPPKKRH
1660 1670 1680 1690 1700
EDLVPPAGSP ELSPPQPLFR PRSEFEEMTI LYDIWNGGID EEDIRFLCVT
1710 1720 1730 1740 1750
YERLLQQDNG MDWLNDTLWV YHPSTSLSSA KKKKRDDGIR EHVTGCARSE
1760 1770 1780 1790 1800
GFYTIDKKDK LRYLNSSRAS TDEPPADTQG MSIPAQPHAS TRAGSERRSE
1810 1820 1830 1840 1850
QRRLLSSFTG SCDSDLLKFN QLKFRKKKLK FCKSHIHDWG LFAMEPIAAD
1860 1870 1880 1890 1900
EMVIEYVGQN IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF
1910 1920 1930 1940 1950
ARFINHSCNP NCYAKVITVE SQKKIVIYSK QHINVNEEIT YDYKFPIEDV
1960
KIPCLCGSEN CRGTLN
Length:1,966
Mass (Da):212,803
Last modified:March 19, 2014 - v3
Checksum:i164F81BC84EAD2C2
GO
Isoform 2 (identifier: Q9UPS6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1043-1068: Missing.
     1088-1104: Missing.

Show »
Length:1,923
Mass (Da):208,732
Checksum:i057CD0948D670243
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1043 – 106826Missing in isoform 2. CuratedVSP_053875Add
BLAST
Alternative sequencei1088 – 110417Missing in isoform 2. CuratedVSP_053876Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF813787 mRNA. Translation: AEG67286.1.
AC079360 Genomic DNA. No translation available.
AC084018 Genomic DNA. No translation available.
AB028999 mRNA. Translation: BAA83028.1.
CCDSiCCDS53838.1. [Q9UPS6-2]
RefSeqiNP_055863.1. NM_015048.1. [Q9UPS6-2]
XP_005253915.1. XM_005253858.2. [Q9UPS6-1]
XP_006719358.1. XM_006719295.1. [Q9UPS6-1]
XP_006719359.1. XM_006719296.1. [Q9UPS6-1]
UniGeneiHs.507122.

Genome annotation databases

EnsembliENST00000542440; ENSP00000442924; ENSG00000139718. [Q9UPS6-2]
ENST00000604567; ENSP00000474253; ENSG00000139718. [Q9UPS6-1]
ENST00000619791; ENSP00000481531; ENSG00000139718. [Q9UPS6-1]
GeneIDi23067.
KEGGihsa:23067.
UCSCiuc001ubi.3. human. [Q9UPS6-1]
uc021rfg.1. human.

Polymorphism databases

DMDMi166977692.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JF813787 mRNA. Translation: AEG67286.1 .
AC079360 Genomic DNA. No translation available.
AC084018 Genomic DNA. No translation available.
AB028999 mRNA. Translation: BAA83028.1 .
CCDSi CCDS53838.1. [Q9UPS6-2 ]
RefSeqi NP_055863.1. NM_015048.1. [Q9UPS6-2 ]
XP_005253915.1. XM_005253858.2. [Q9UPS6-1 ]
XP_006719358.1. XM_006719295.1. [Q9UPS6-1 ]
XP_006719359.1. XM_006719296.1. [Q9UPS6-1 ]
UniGenei Hs.507122.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UVO X-ray 2.20 B 1745-1755 [» ]
4ES0 X-ray 1.82 C 1741-1754 [» ]
ProteinModelPortali Q9UPS6.
SMRi Q9UPS6. Positions 98-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116702. 11 interactions.
STRINGi 9606.ENSP00000267197.

PTM databases

PhosphoSitei Q9UPS6.

Polymorphism databases

DMDMi 166977692.

Proteomic databases

MaxQBi Q9UPS6.
PaxDbi Q9UPS6.
PRIDEi Q9UPS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000542440 ; ENSP00000442924 ; ENSG00000139718 . [Q9UPS6-2 ]
ENST00000604567 ; ENSP00000474253 ; ENSG00000139718 . [Q9UPS6-1 ]
ENST00000619791 ; ENSP00000481531 ; ENSG00000139718 . [Q9UPS6-1 ]
GeneIDi 23067.
KEGGi hsa:23067.
UCSCi uc001ubi.3. human. [Q9UPS6-1 ]
uc021rfg.1. human.

Organism-specific databases

CTDi 23067.
GeneCardsi GC12P122243.
H-InvDB HIX0011090.
HGNCi HGNC:29187. SETD1B.
HPAi HPA021667.
MIMi 611055. gene.
neXtProti NX_Q9UPS6.
PharmGKBi PA143485611.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00760000119228.
HOGENOMi HOG000168216.
HOVERGENi HBG055596.
InParanoidi Q9UPS6.
KOi K11422.
OMAi QHWPPLP.
OrthoDBi EOG7GQXTT.
TreeFami TF106436.

Miscellaneous databases

GenomeRNAii 23067.
NextBioi 35510195.
PROi Q9UPS6.
SOURCEi Search...

Gene expression databases

Bgeei Q9UPS6.
CleanExi HS_SETD1B.
Genevestigatori Q9UPS6.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00508. PostSET. 1 hit.
SM00360. RRM. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50102. RRM. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation."
    Lee J.H., Skalnik D.G.
    PLoS ONE 7:E42965-E42965(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RBM15, MUTAGENESIS OF LEU-577 AND ASP-579.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1163-1966 (ISOFORM 1/2).
    Tissue: Brain.
  4. "Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."
    Lee J.-H., Tate C.M., You J.-S., Skalnik D.G.
    J. Biol. Chem. 282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE SET1 COMPLEX.
  5. "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
    Lee J.H., Skalnik D.G.
    Mol. Cell. Biol. 28:609-618(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SET1 COMPLEX, INTERACTION WITH WDR82; ASH2L AND POLR2A.
  6. "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
    Wu M., Wang P.F., Lee J.S., Martin-Brown S., Florens L., Washburn M., Shilatifard A.
    Mol. Cell. Biol. 28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN SET1 COMPLEX.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1659 AND SER-1663, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSET1B_HUMAN
AccessioniPrimary (citable) accession number: Q9UPS6
Secondary accession number(s): F6MFW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 19, 2014
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3