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Protein

Zinc finger RNA-binding protein 2

Gene

ZFR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger RNA-binding protein 2
Gene namesi
Name:ZFR2
Synonyms:KIAA1086
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29189. ZFR2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409746.

Polymorphism and mutation databases

BioMutaiZFR2.
DMDMi296453074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 939939Zinc finger RNA-binding protein 2PRO_0000308958Add
BLAST

Proteomic databases

PaxDbiQ9UPR6.
PRIDEiQ9UPR6.

PTM databases

PhosphoSiteiQ9UPR6.

Expressioni

Gene expression databases

BgeeiQ9UPR6.
CleanExiHS_ZFR2.
ExpressionAtlasiQ9UPR6. baseline and differential.
GenevisibleiQ9UPR6. HS.

Organism-specific databases

HPAiHPA055678.

Interactioni

Protein-protein interaction databases

BioGridi116824. 2 interactions.
STRINGi9606.ENSP00000262961.

Structurei

3D structure databases

ProteinModelPortaliQ9UPR6.
SMRiQ9UPR6. Positions 588-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini570 – 935366DZFPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili516 – 54934Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi187 – 26579Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 DZF domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3792. Eukaryota.
ENOG410XPBY. LUCA.
GeneTreeiENSGT00550000074528.
HOGENOMiHOG000232147.
HOVERGENiHBG108765.
InParanoidiQ9UPR6.
OMAiQDPCERD.
OrthoDBiEOG72ZCDC.
PhylomeDBiQ9UPR6.
TreeFamiTF320194.

Family and domain databases

InterProiIPR006561. DZF_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00572. DZF. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]
PROSITEiPS51703. DZF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSQYFDFA QGGGPQYSAQ PPTLPLPTVG ASYTAQPTPG MDPAVNPAFP
60 70 80 90 100
PAAPAGYGGY QPHSGQDFAY GSRPQEPVPT ATTMATYQDS YSYGQSAAAR
110 120 130 140 150
SYEDRPYFQS AALQSGRMTA ADSGQPGTQE ACGQPSPHGS HSHAQPPQQA
160 170 180 190 200
PIVESGQPAS TLSSGYTYPT ATGVQPESSA SIVTSYPPPS YNPTCTAYTA
210 220 230 240 250
PSYPNYDASV YSAASPFYPP AQPPPPPGPP QQLPPPPAPA GSGSSPRADS
260 270 280 290 300
KPPLPSKLPR PKAGPRQLQL HYCDICKISC AGPQTYREHL GGQKHRKKEA
310 320 330 340 350
AQKTGVQPNG SPRGVQAQLH CDLCAVSCTG ADAYAAHIRG SKHQKVFKLH
360 370 380 390 400
AKLGKPIPTL EPALATESPP GAEAKPTSPT GPSVCASSRP ALAKRPVASK
410 420 430 440 450
ALCEGPPEPQ AAGCRPQWGK PAQPKLEGPG APTQGGSKEA PAGCSDAQPV
460 470 480 490 500
GPEYVEEVFS DEGRVLRFHC KLCECSFNDL NAKDLHVRGR RHRLQYRKKV
510 520 530 540 550
NPDLPIATEP SSRARKVLEE RMRKQRHLAE ERLEQLRRWH AERRRLEEEP
560 570 580 590 600
PQDVPPHAPP DWAQPLLMGR PESPASAPLQ PGRRPASSDD RHVMCKHATI
610 620 630 640 650
YPTEQELLAV QRAVSHAERA LKLVSDTLAE EDRGRREEEG DKRSSVAPQT
660 670 680 690 700
RVLKGVMRVG ILAKGLLLRG DRNVRLALLC SEKPTHSLLR RIAQQLPRQL
710 720 730 740 750
QMVTEDEYEV SSDPEANIVI SSCEEPRMQV TISVTSPLMR EDPSTDPGVE
760 770 780 790 800
EPQADAGDVL SPKKCLESLA ALRHARWFQA RASGLQPCVI VIRVLRDLCR
810 820 830 840 850
RVPTWGALPA WAMELLVEKA VSSAAGPLGP GDAVRRVLEC VATGTLLTDG
860 870 880 890 900
PGLQDPCERD QTDALEPMTL QEREDVTASA QHALRMLAFR QTHKVLGMDL
910 920 930
LPPRHRLGAR FRKRQRGPGE GEEGAGEKKR GRRGGEGLV
Length:939
Mass (Da):101,330
Last modified:May 18, 2010 - v3
Checksum:i94E63C2C1C13C845
GO
Isoform 2 (identifier: Q9UPR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-70: AQPPTLPLPT...QPHSGQDFAY → PEVETTPPAL...ICSILWDPAW
     71-939: Missing.

Show »
Length:70
Mass (Da):7,235
Checksum:i3D115F3601E7AED2
GO
Isoform 3 (identifier: Q9UPR6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-366: VFKLHAKLGKPIPTLEPALAT → GLLSHRQQAADPSGGNQPNLN
     367-939: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):38,122
Checksum:iB09C9C1D0E66D7EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811S → F in DA237746 (PubMed:10470851).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti164 – 1641S → L.
Corresponds to variant rs2240235 [ dbSNP | Ensembl ].
VAR_036886
Natural varianti183 – 1831V → M.1 Publication
Corresponds to variant rs2240234 [ dbSNP | Ensembl ].
VAR_036887
Natural varianti210 – 2101V → L.
Corresponds to variant rs2240233 [ dbSNP | Ensembl ].
VAR_036888
Natural varianti235 – 2351P → L.
Corresponds to variant rs2240232 [ dbSNP | Ensembl ].
VAR_036889
Natural varianti577 – 5771A → T.
Corresponds to variant rs2301843 [ dbSNP | Ensembl ].
VAR_036890
Natural varianti589 – 5891D → N.
Corresponds to variant rs2301839 [ dbSNP | Ensembl ].
VAR_036891
Natural varianti718 – 7181I → M.
Corresponds to variant rs45465594 [ dbSNP | Ensembl ].
VAR_061730

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei19 – 7052AQPPT…QDFAY → PEVETTPPALASGLPCALPW TVGCSGSDAVTALCPSLRGL ACICSILWDPAW in isoform 2. 1 PublicationVSP_040635Add
BLAST
Alternative sequencei71 – 939869Missing in isoform 2. 1 PublicationVSP_040636Add
BLAST
Alternative sequencei346 – 36621VFKLH…PALAT → GLLSHRQQAADPSGGNQPNL N in isoform 3. 1 PublicationVSP_057301Add
BLAST
Alternative sequencei367 – 939573Missing in isoform 3. 1 PublicationVSP_057302Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295037 mRNA. Translation: BAG58091.1.
DA237746 mRNA. No translation available.
AC004598 Genomic DNA. No translation available.
AC005777 Genomic DNA. No translation available.
AC093078 Genomic DNA. No translation available.
BC034005 mRNA. No translation available.
AB029009 mRNA. Translation: BAA83038.1.
CCDSiCCDS45921.1. [Q9UPR6-1]
CCDS45922.1. [Q9UPR6-2]
RefSeqiNP_001139112.1. NM_001145640.1. [Q9UPR6-2]
NP_055989.1. NM_015174.1. [Q9UPR6-1]
UniGeneiHs.65750.

Genome annotation databases

EnsembliENST00000262961; ENSP00000262961; ENSG00000105278. [Q9UPR6-1]
ENST00000438164; ENSP00000388974; ENSG00000105278. [Q9UPR6-3]
ENST00000439086; ENSP00000388567; ENSG00000105278. [Q9UPR6-2]
GeneIDi23217.
KEGGihsa:23217.
UCSCiuc002lyw.3. human. [Q9UPR6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295037 mRNA. Translation: BAG58091.1.
DA237746 mRNA. No translation available.
AC004598 Genomic DNA. No translation available.
AC005777 Genomic DNA. No translation available.
AC093078 Genomic DNA. No translation available.
BC034005 mRNA. No translation available.
AB029009 mRNA. Translation: BAA83038.1.
CCDSiCCDS45921.1. [Q9UPR6-1]
CCDS45922.1. [Q9UPR6-2]
RefSeqiNP_001139112.1. NM_001145640.1. [Q9UPR6-2]
NP_055989.1. NM_015174.1. [Q9UPR6-1]
UniGeneiHs.65750.

3D structure databases

ProteinModelPortaliQ9UPR6.
SMRiQ9UPR6. Positions 588-902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116824. 2 interactions.
STRINGi9606.ENSP00000262961.

PTM databases

PhosphoSiteiQ9UPR6.

Polymorphism and mutation databases

BioMutaiZFR2.
DMDMi296453074.

Proteomic databases

PaxDbiQ9UPR6.
PRIDEiQ9UPR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262961; ENSP00000262961; ENSG00000105278. [Q9UPR6-1]
ENST00000438164; ENSP00000388974; ENSG00000105278. [Q9UPR6-3]
ENST00000439086; ENSP00000388567; ENSG00000105278. [Q9UPR6-2]
GeneIDi23217.
KEGGihsa:23217.
UCSCiuc002lyw.3. human. [Q9UPR6-1]

Organism-specific databases

CTDi23217.
GeneCardsiZFR2.
H-InvDBHIX0202695.
HGNCiHGNC:29189. ZFR2.
HPAiHPA055678.
neXtProtiNX_Q9UPR6.
PharmGKBiPA162409746.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3792. Eukaryota.
ENOG410XPBY. LUCA.
GeneTreeiENSGT00550000074528.
HOGENOMiHOG000232147.
HOVERGENiHBG108765.
InParanoidiQ9UPR6.
OMAiQDPCERD.
OrthoDBiEOG72ZCDC.
PhylomeDBiQ9UPR6.
TreeFamiTF320194.

Miscellaneous databases

ChiTaRSiZFR2. human.
GenomeRNAii23217.
NextBioi35471981.
PROiQ9UPR6.

Gene expression databases

BgeeiQ9UPR6.
CleanExiHS_ZFR2.
ExpressionAtlasiQ9UPR6. baseline and differential.
GenevisibleiQ9UPR6. HS.

Family and domain databases

InterProiIPR006561. DZF_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF07528. DZF. 1 hit.
[Graphical view]
SMARTiSM00572. DZF. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SM00451. ZnF_U1. 3 hits.
[Graphical view]
PROSITEiPS51703. DZF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-188 (ISOFORM 1).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-939 (ISOFORM 1), VARIANT MET-183.
    Tissue: Brain.

Entry informationi

Entry nameiZFR2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPR6
Secondary accession number(s): B4DHD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: March 16, 2016
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.