Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9UPR5 (NAC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/calcium exchanger 2
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 2
Solute carrier family 8 member 2
Gene names
Name:SLC8A2
Synonyms:KIAA1087, NCX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length921 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores By similarity.

Enzyme regulation

By ATP By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.

Contains 2 Calx-beta domains.

Sequence caution

The sequence BAA83039.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 921901Sodium/calcium exchanger 2
PRO_0000019382

Regions

Topological domain21 – 6848Extracellular Potential
Transmembrane69 – 9022Helical; Potential
Topological domain91 – 13040Cytoplasmic Potential
Transmembrane131 – 15222Helical; Potential
Topological domain153 – 16412Extracellular Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 19611Cytoplasmic Potential
Transmembrane197 – 21923Helical; Potential
Topological domain220 – 2223Extracellular Potential
Transmembrane223 – 24624Helical; Potential
Topological domain247 – 720474Cytoplasmic Potential
Transmembrane721 – 74020Helical; Potential
Topological domain741 – 7477Extracellular Potential
Transmembrane748 – 77023Helical; Potential
Topological domain771 – 7722Cytoplasmic Potential
Transmembrane773 – 79119Helical; Potential
Topological domain792 – 82231Extracellular Potential
Transmembrane823 – 84321Helical; Potential
Topological domain844 – 85411Cytoplasmic Potential
Transmembrane855 – 87521Helical; Potential
Topological domain876 – 89217Extracellular Potential
Transmembrane893 – 90917Helical; Potential
Topological domain910 – 92112Cytoplasmic Potential
Repeat135 – 17541Alpha-1
Domain384 – 483100Calx-beta 1
Domain512 – 612101Calx-beta 2
Repeat790 – 82637Alpha-2
Region248 – 26720Calmodulin-binding By similarity
Compositional bias29 – 324Poly-Pro
Compositional bias638 – 6414Poly-Glu

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation8171N-linked (GlcNAc...) Potential

Natural variations

Natural variant4291V → L.
Corresponds to variant rs17759929 [ dbSNP | Ensembl ].
VAR_050226

Sequences

Sequence LengthMass (Da)Tools
Q9UPR5 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 798CDF7E32B9410C

FASTA921100,368
        10         20         30         40         50         60 
MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ PGVLLPVWEP 

        70         80         90        100        110        120 
DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI TSKEKEITIT KANGETSVGT 

       130        140        150        160        170        180 
VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC 

       190        200        210        220        230        240 
IYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV 

       250        260        270        280        290        300 
VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP 

       310        320        330        340        350        360 
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR AFYRIQATRL 

       370        380        390        400        410        420 
MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP SLYHCLENCG SVLLSVTCQG 

       430        440        450        460        470        480 
GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV 

       490        500        510        520        530        540 
RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT 

       550        560        570        580        590        600 
VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE 

       610        620        630        640        650        660 
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK PVLGENCRLE 

       670        680        690        700        710        720 
VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT VSAGDEEEEE DGSREERLPS 

       730        740        750        760        770        780 
CFDYVMHFLT VFWKVLFACV PPTEYCHGWA CFGVSILVIG LLTALIGDLA SHFGCTVGLK 

       790        800        810        820        830        840 
DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY 

       850        860        870        880        890        900 
WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL 

       910        920 
GLWLLYILFA SLEAYCHIRG F 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029010 mRNA. Translation: BAA83039.1. Different initiation.
AK302552 mRNA. Translation: BAG63821.1.
CH471126 Genomic DNA. Translation: EAW57485.1.
RefSeqNP_055878.1. NM_015063.2.
UniGeneHs.172884.

3D structure databases

ProteinModelPortalQ9UPR5.
SMRQ9UPR5. Positions 394-674, 748-841.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000236877.

Protein family/group databases

TCDB2.A.19.3.5. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSiteQ9UPR5.

Polymorphism databases

DMDM10720116.

Proteomic databases

PaxDbQ9UPR5.
PRIDEQ9UPR5.

Protocols and materials databases

DNASU6543.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000236877; ENSP00000236877; ENSG00000118160.
GeneID6543.
KEGGhsa:6543.
UCSCuc002pgx.3. human.

Organism-specific databases

CTD6543.
GeneCardsGC19M047931.
HGNCHGNC:11069. SLC8A2.
HPAHPA050818.
HPA054671.
MIM601901. gene.
neXtProtNX_Q9UPR5.
PharmGKBPA313.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG241889.
HOGENOMHOG000266971.
HOVERGENHBG006441.
InParanoidQ9UPR5.
KOK05849.
OMATMEVTVV.
OrthoDBEOG7S4X56.
PhylomeDBQ9UPR5.
TreeFamTF314308.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

ArrayExpressQ9UPR5.
BgeeQ9UPR5.
CleanExHS_SLC8A2.
GenevestigatorQ9UPR5.

Family and domain databases

InterProIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamPF03160. Calx-beta. 2 hits.
PF01699. Na_Ca_ex. 2 hits.
[Graphical view]
PRINTSPR01259. NACAEXCHNGR.
SMARTSM00237. Calx_beta. 2 hits.
[Graphical view]
TIGRFAMsTIGR00845. caca. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi6543.
NextBio25461.
PROQ9UPR5.
SOURCESearch...

Entry information

Entry nameNAC2_HUMAN
AccessionPrimary (citable) accession number: Q9UPR5
Secondary accession number(s): B4DYQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM