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Q9UPR5

- NAC2_HUMAN

UniProt

Q9UPR5 - NAC2_HUMAN

Protein

Sodium/calcium exchanger 2

Gene

SLC8A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Rapidly transports Ca2+ during excitation-contraction coupling. Ca2+ is extruded from the cell during relaxation so as to prevent overloading of intracellular stores By similarity.By similarity

    Enzyme regulationi

    By ATP.By similarity

    GO - Molecular functioni

    1. calcium:sodium antiporter activity Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cell communication Source: InterPro
    3. ion transport Source: Reactome
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Calcium, Calmodulin-binding, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19320. Sodium/Calcium exchangers.
    REACT_23765. Reduction of cytosolic Ca++ levels.

    Protein family/group databases

    TCDBi2.A.19.3.5. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/calcium exchanger 2
    Alternative name(s):
    Na(+)/Ca(2+)-exchange protein 2
    Solute carrier family 8 member 2
    Gene namesi
    Name:SLC8A2
    Synonyms:KIAA1087, NCX2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11069. SLC8A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 921901Sodium/calcium exchanger 2PRO_0000019382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi817 – 8171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9UPR5.
    PaxDbiQ9UPR5.
    PRIDEiQ9UPR5.

    PTM databases

    PhosphoSiteiQ9UPR5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UPR5.
    BgeeiQ9UPR5.
    CleanExiHS_SLC8A2.
    GenevestigatoriQ9UPR5.

    Organism-specific databases

    HPAiHPA050818.
    HPA054671.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000236877.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPR5.
    SMRiQ9UPR5. Positions 394-674.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 6848ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini91 – 13040CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini153 – 16412ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini186 – 19611CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini220 – 2223ExtracellularSequence Analysis
    Topological domaini247 – 720474CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini741 – 7477ExtracellularSequence Analysis
    Topological domaini771 – 7722CytoplasmicSequence Analysis
    Topological domaini792 – 82231ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini844 – 85411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini876 – 89217ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini910 – 92112CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei69 – 9022HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei223 – 24624HelicalSequence AnalysisAdd
    BLAST
    Transmembranei721 – 74020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei748 – 77023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei773 – 79119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei823 – 84321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei855 – 87521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei893 – 90917HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati135 – 17541Alpha-1Add
    BLAST
    Domaini384 – 483100Calx-beta 1Add
    BLAST
    Domaini512 – 612101Calx-beta 2Add
    BLAST
    Repeati790 – 82637Alpha-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 26720Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi29 – 324Poly-Pro
    Compositional biasi638 – 6414Poly-Glu

    Sequence similaritiesi

    Contains 2 Calx-beta domains.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241889.
    HOGENOMiHOG000266971.
    HOVERGENiHBG006441.
    InParanoidiQ9UPR5.
    KOiK05849.
    OMAiTMEVTVV.
    OrthoDBiEOG7S4X56.
    PhylomeDBiQ9UPR5.
    TreeFamiTF314308.

    Family and domain databases

    InterProiIPR003644. Calx_beta.
    IPR004836. Na_Ca_Ex.
    IPR004837. NaCa_Exmemb.
    [Graphical view]
    PfamiPF03160. Calx-beta. 2 hits.
    PF01699. Na_Ca_ex. 2 hits.
    [Graphical view]
    PRINTSiPR01259. NACAEXCHNGR.
    SMARTiSM00237. Calx_beta. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00845. caca. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9UPR5-1 [UniParc]FASTAAdd to Basket

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    MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ    50
    PGVLLPVWEP DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI 100
    TSKEKEITIT KANGETSVGT VRIWNETVSN LTLMALGSSA PEILLSVIEV 150
    CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC IYVIPAGESR KIKHLRVFFV 200
    TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV VFAWMADKRL 250
    LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP 300
    GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR 350
    AFYRIQATRL MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP 400
    SLYHCLENCG SVLLSVTCQG GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT 450
    LVFKPGETQK ELRIGIIDDD IFEEDEHFFV RLLNLRVGDA QGMFEPDGGG 500
    RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT VDVRVVRSSG 550
    ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE 600
    YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK 650
    PVLGENCRLE VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT 700
    VSAGDEEEEE DGSREERLPS CFDYVMHFLT VFWKVLFACV PPTEYCHGWA 750
    CFGVSILVIG LLTALIGDLA SHFGCTVGLK DSVNAVVFVA LGTSIPDTFA 800
    SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY WAVQGRPFEV 850
    RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL 900
    GLWLLYILFA SLEAYCHIRG F 921
    Length:921
    Mass (Da):100,368
    Last modified:December 1, 2000 - v2
    Checksum:i798CDF7E32B9410C
    GO

    Sequence cautioni

    The sequence BAA83039.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti429 – 4291V → L.
    Corresponds to variant rs17759929 [ dbSNP | Ensembl ].
    VAR_050226

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029010 mRNA. Translation: BAA83039.1. Different initiation.
    AK302552 mRNA. Translation: BAG63821.1.
    CH471126 Genomic DNA. Translation: EAW57485.1.
    CCDSiCCDS33065.1.
    RefSeqiNP_055878.1. NM_015063.2.
    UniGeneiHs.172884.

    Genome annotation databases

    EnsembliENST00000236877; ENSP00000236877; ENSG00000118160.
    GeneIDi6543.
    KEGGihsa:6543.
    UCSCiuc002pgx.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029010 mRNA. Translation: BAA83039.1 . Different initiation.
    AK302552 mRNA. Translation: BAG63821.1 .
    CH471126 Genomic DNA. Translation: EAW57485.1 .
    CCDSi CCDS33065.1.
    RefSeqi NP_055878.1. NM_015063.2.
    UniGenei Hs.172884.

    3D structure databases

    ProteinModelPortali Q9UPR5.
    SMRi Q9UPR5. Positions 394-674.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000236877.

    Protein family/group databases

    TCDBi 2.A.19.3.5. the ca(2+):cation antiporter (caca) family.

    PTM databases

    PhosphoSitei Q9UPR5.

    Proteomic databases

    MaxQBi Q9UPR5.
    PaxDbi Q9UPR5.
    PRIDEi Q9UPR5.

    Protocols and materials databases

    DNASUi 6543.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236877 ; ENSP00000236877 ; ENSG00000118160 .
    GeneIDi 6543.
    KEGGi hsa:6543.
    UCSCi uc002pgx.3. human.

    Organism-specific databases

    CTDi 6543.
    GeneCardsi GC19M047931.
    HGNCi HGNC:11069. SLC8A2.
    HPAi HPA050818.
    HPA054671.
    MIMi 601901. gene.
    neXtProti NX_Q9UPR5.
    PharmGKBi PA313.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241889.
    HOGENOMi HOG000266971.
    HOVERGENi HBG006441.
    InParanoidi Q9UPR5.
    KOi K05849.
    OMAi TMEVTVV.
    OrthoDBi EOG7S4X56.
    PhylomeDBi Q9UPR5.
    TreeFami TF314308.

    Enzyme and pathway databases

    Reactomei REACT_19320. Sodium/Calcium exchangers.
    REACT_23765. Reduction of cytosolic Ca++ levels.

    Miscellaneous databases

    GenomeRNAii 6543.
    NextBioi 25461.
    PROi Q9UPR5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPR5.
    Bgeei Q9UPR5.
    CleanExi HS_SLC8A2.
    Genevestigatori Q9UPR5.

    Family and domain databases

    InterProi IPR003644. Calx_beta.
    IPR004836. Na_Ca_Ex.
    IPR004837. NaCa_Exmemb.
    [Graphical view ]
    Pfami PF03160. Calx-beta. 2 hits.
    PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    PRINTSi PR01259. NACAEXCHNGR.
    SMARTi SM00237. Calx_beta. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00845. caca. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiNAC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPR5
    Secondary accession number(s): B4DYQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3